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Protein
Submitted name:

Ikbkb protein

Gene

Ikbkb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-168638. NOD1/2 Signaling Pathway.
R-MMU-1810476. RIP-mediated NFkB activation via ZBP1.
R-MMU-202424. Downstream TCR signaling.
R-MMU-209543. p75NTR recruits signalling complexes.
R-MMU-209560. NF-kB is activated and signals survival.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-446652. Interleukin-1 family signaling.
R-MMU-5357905. Regulation of TNFR1 signaling.
R-MMU-5357956. TNFR1-induced NFkappaB signaling pathway.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-MMU-933542. TRAF6 mediated NF-kB activation.
R-MMU-937039. IRAK1 recruits IKK complex.
R-MMU-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Ikbkb proteinImported
Submitted name:
Inhibitor of kappaB kinase beta, isoform CRA_bImported
Submitted name:
Inhibitor of nuclear factor kappa-B kinase subunit betaImported
Gene namesi
Name:IkbkbImported
ORF Names:mCG_6974Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1338071. Ikbkb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000031537.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 300Protein kinaseInterPro annotationAdd BLAST286

Phylogenomic databases

eggNOGiKOG4250. Eukaryota.
ENOG410XRMU. LUCA.
GeneTreeiENSGT00880000137876.
HOVERGENiHBG018241.
KOiK07209.
OMAiRTLDMDL.
OrthoDBiEOG091G02VC.
TreeFamiTF324269.

Family and domain databases

InterProiView protein in InterPro
IPR022007. IKKbetaNEMObind.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF12179. IKKbetaNEMObind. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM01239. IKKbetaNEMObind. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5D0E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQATGEQ IAIKQCRQEL
60 70 80 90 100
SPKNRDRWCL EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ
110 120 130 140 150
GGDLRRYLNQ FENCCGLREG AVLTLLSDIA SALRYLHENR IIHRDLKPEN
160 170 180 190 200
IVLQQGEKRL IHKIIDLGYA KELDQGSLCT SFVGTLQYLA PELLEQQKYT
210 220 230 240 250
VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE VDIVVSEDLN
260 270 280 290 300
GAVKFSSSLP FPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPQYGPNGCF
310 320 330 340 350
RALDDILNLK LVHVLNMVTG TVHTYPVTED ESLQSLKTRI QEDTGILETD
360 370 380 390 400
QELLQEAGLV LLPDKPATQC ISDSKTNEGL TLDMDLVFLF DNSKINYETQ
410 420 430 440 450
ITPRPQPESV SCILQEPKRN LSFFQLRKVW GQVWHSIQTL KEDCNRLQQG
460 470 480 490 500
QRAAMMSLLR NNSCLSKMKN AMASTAQQLK AKLDFFKTSI QIDLEKYKEQ
510 520 530 540 550
TEFGITSDKL LLAWREMEQA VEQCGRENDV KHLVERMMAL QTDIVDLQRS
560 570 580 590 600
PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS
610 620 630 640 650
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE RTVVRLQEKR
660 670 680 690 700
QKELWNLLKI ACSKVRGPVS GSPDSMNVSR LSHPGQLMSQ PSSACDSLPE
710 720 730 740 750
SDKKSEELVA EAHALCSRLE SALQDTVKEQ DRSFTTLDWS WLQMEDEERC

SLEQACD
Length:757
Mass (Da):86,786
Last modified:May 10, 2005 - v1
Checksum:i64CFF64F3958AE0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121835 Genomic DNA. No translation available.
BC037723 mRNA. Translation: AAH37723.1.
AK144603 mRNA. Translation: BAE25962.1.
AK151955 mRNA. Translation: BAE30827.1.
AK153151 mRNA. Translation: BAE31761.1.
CH466580 Genomic DNA. Translation: EDL32881.1.
RefSeqiNP_001153246.1. NM_001159774.1.
NP_034676.1. NM_010546.2.
UniGeneiMm.277886.

Genome annotation databases

EnsembliENSMUST00000033939; ENSMUSP00000033939; ENSMUSG00000031537.
GeneIDi16150.
KEGGimmu:16150.
UCSCiuc009ldm.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ5D0E0_MOUSE
AccessioniPrimary (citable) accession number: Q5D0E0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 27, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported