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Protein
Submitted name:

Ikbkb protein

Gene

Ikbkb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-168638 NOD1/2 Signaling Pathway
R-MMU-1810476 RIP-mediated NFkB activation via ZBP1
R-MMU-202424 Downstream TCR signaling
R-MMU-209543 p75NTR recruits signalling complexes
R-MMU-209560 NF-kB is activated and signals survival
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-5357905 Regulation of TNFR1 signaling
R-MMU-5357956 TNFR1-induced NFkappaB signaling pathway
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-MMU-9020702 Interleukin-1 signaling
R-MMU-933542 TRAF6 mediated NF-kB activation
R-MMU-937039 IRAK1 recruits IKK complex
R-MMU-937041 IKK complex recruitment mediated by RIP1
R-MMU-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Names & Taxonomyi

Protein namesi
Submitted name:
Ikbkb proteinImported
Submitted name:
Inhibitor of kappaB kinase beta, isoform CRA_bImported
Submitted name:
Inhibitor of nuclear factor kappa-B kinase subunit betaImported
Gene namesi
Name:IkbkbImported
ORF Names:mCG_6974Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1338071 Ikbkb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000031537

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 300Protein kinaseInterPro annotationAdd BLAST286

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili560 – 580Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4250 Eukaryota
ENOG410XRMU LUCA
GeneTreeiENSGT00910000144033
HOVERGENiHBG018241
KOiK07209
OMAiRTLDMDL
OrthoDBiEOG091G02VC
TreeFamiTF324269

Family and domain databases

InterProiView protein in InterPro
IPR022007 IKKbetaNEMObind
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12179 IKKbetaNEMObind, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM01239 IKKbetaNEMObind, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q5D0E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQATGEQ IAIKQCRQEL
60 70 80 90 100
SPKNRDRWCL EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ
110 120 130 140 150
GGDLRRYLNQ FENCCGLREG AVLTLLSDIA SALRYLHENR IIHRDLKPEN
160 170 180 190 200
IVLQQGEKRL IHKIIDLGYA KELDQGSLCT SFVGTLQYLA PELLEQQKYT
210 220 230 240 250
VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE VDIVVSEDLN
260 270 280 290 300
GAVKFSSSLP FPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPQYGPNGCF
310 320 330 340 350
RALDDILNLK LVHVLNMVTG TVHTYPVTED ESLQSLKTRI QEDTGILETD
360 370 380 390 400
QELLQEAGLV LLPDKPATQC ISDSKTNEGL TLDMDLVFLF DNSKINYETQ
410 420 430 440 450
ITPRPQPESV SCILQEPKRN LSFFQLRKVW GQVWHSIQTL KEDCNRLQQG
460 470 480 490 500
QRAAMMSLLR NNSCLSKMKN AMASTAQQLK AKLDFFKTSI QIDLEKYKEQ
510 520 530 540 550
TEFGITSDKL LLAWREMEQA VEQCGRENDV KHLVERMMAL QTDIVDLQRS
560 570 580 590 600
PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS
610 620 630 640 650
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE RTVVRLQEKR
660 670 680 690 700
QKELWNLLKI ACSKVRGPVS GSPDSMNVSR LSHPGQLMSQ PSSACDSLPE
710 720 730 740 750
SDKKSEELVA EAHALCSRLE SALQDTVKEQ DRSFTTLDWS WLQMEDEERC

SLEQACD
Length:757
Mass (Da):86,786
Last modified:May 10, 2005 - v1
Checksum:i64CFF64F3958AE0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121835 Genomic DNA No translation available.
BC037723 mRNA Translation: AAH37723.1
AK144603 mRNA Translation: BAE25962.1
AK151955 mRNA Translation: BAE30827.1
AK153151 mRNA Translation: BAE31761.1
CH466580 Genomic DNA Translation: EDL32881.1
RefSeqiNP_001153246.1, NM_001159774.1
NP_034676.1, NM_010546.2
UniGeneiMm.277886

Genome annotation databases

EnsembliENSMUST00000033939; ENSMUSP00000033939; ENSMUSG00000031537
GeneIDi16150
KEGGimmu:16150
UCSCiuc009ldm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ5D0E0_MOUSE
AccessioniPrimary (citable) accession number: Q5D0E0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health