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Q5D078

- Q5D078_MOUSE

UniProt

Q5D078 - Q5D078_MOUSE

Protein
Submitted name:

Regulator of G-protein signaling 4

Gene

Rgs4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: MGI
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Regulator of G-protein signaling 4Imported
    Submitted name:
    Regulator of G-protein-signaling 4Imported
    Submitted name:
    Rgs4 proteinImported
    Gene namesi
    Name:Rgs4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:108409. Rgs4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytosol Source: Ensembl
    3. plasma membrane Source: RefGenome
    4. protein complex Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ5D078.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RGS domain.UniRule annotation
    Contains RGS domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117382.
    HOVERGENiHBG013233.
    InParanoidiQ5D078.
    KOiK16449.
    OMAiDCPSLVP.
    OrthoDBiEOG7VHSZ5.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5D078-1 [UniParc]FASTAAdd to Basket

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    MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR    50
    VSQEEVKKWA ESLENLIHHE CGLAAFKAFL KSEYSEENID FWISCEEYKK 100
    IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLQPTITCFD 150
    EAQKKIFNLM EKDSYRRFLK SRFYLDLTNP SSCGAEKQKG AKSSADCTSL 200
    VSQCA 205
    Length:205
    Mass (Da):23,261
    Last modified:May 10, 2005 - v1
    Checksum:i5D795809DE9D1B7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115766 Genomic DNA. No translation available.
    BC055293 mRNA. Translation: AAH55293.1.
    DQ346659 mRNA. Translation: ABC94587.1.
    DQ346660 mRNA. Translation: ABC94588.1.
    DQ346661 mRNA. Translation: ABC94589.1.
    AK030536 mRNA. Translation: BAC27009.1.
    AK039134 mRNA. Translation: BAC30249.1.
    RefSeqiNP_033088.2. NM_009062.3.
    UniGeneiMm.41642.

    Genome annotation databases

    EnsembliENSMUST00000027991; ENSMUSP00000027991; ENSMUSG00000038530.
    GeneIDi19736.
    KEGGimmu:19736.
    UCSCiuc007dln.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115766 Genomic DNA. No translation available.
    BC055293 mRNA. Translation: AAH55293.1 .
    DQ346659 mRNA. Translation: ABC94587.1 .
    DQ346660 mRNA. Translation: ABC94588.1 .
    DQ346661 mRNA. Translation: ABC94589.1 .
    AK030536 mRNA. Translation: BAC27009.1 .
    AK039134 mRNA. Translation: BAC30249.1 .
    RefSeqi NP_033088.2. NM_009062.3.
    UniGenei Mm.41642.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027991 ; ENSMUSP00000027991 ; ENSMUSG00000038530 .
    GeneIDi 19736.
    KEGGi mmu:19736.
    UCSCi uc007dln.1. mouse.

    Organism-specific databases

    CTDi 5999.
    MGIi MGI:108409. Rgs4.

    Phylogenomic databases

    GeneTreei ENSGT00750000117382.
    HOVERGENi HBG013233.
    InParanoidi Q5D078.
    KOi K16449.
    OMAi DCPSLVP.
    OrthoDBi EOG7VHSZ5.
    TreeFami TF315837.

    Miscellaneous databases

    ChiTaRSi RGS4. mouse.
    NextBioi 297176.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q5D078.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HypothalamusImported and Pituitary glandImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HypothalamusImported and Pituitary glandImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HypothalamusImported and Pituitary glandImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HypothalamusImported and Pituitary glandImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HypothalamusImported and Pituitary glandImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HypothalamusImported and Pituitary glandImported.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EyeImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HypothalamusImported and Pituitary glandImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HypothalamusImported and Pituitary glandImported.
    10. "Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain."
      Ding L., Mychaleckyj J.C., Hegde A.N.
      Gene 401:46-60(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    12. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ5D078_MOUSE
    AccessioniPrimary (citable) accession number: Q5D078
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3