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Protein

Phosphatidylinositol 4-phosphate 5-kinase type-1 beta

Gene

Pip5k1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).By similarity

Caution

There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.Curated

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1660499 Synthesis of PIPs at the plasma membrane
R-RNO-201688 WNT mediated activation of DVL
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (EC:2.7.1.68)
Short name:
PIP5K1-beta
Short name:
PtdIns(4)P-5-kinase 1 beta
Alternative name(s):
Phosphatidylinositol 4-phosphate 5-kinase type I alpha
Short name:
PIP5KIalpha
Phosphatidylinositol 4-phosphate 5-kinase type I beta
Short name:
PIP5KIbeta
Gene namesi
Name:Pip5k1b
Synonyms:Pip5k1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310914 Pip5k1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854601 – 539Phosphatidylinositol 4-phosphate 5-kinase type-1 betaAdd BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei445PhosphoserineCombined sources1
Modified residuei447PhosphoserineBy similarity1
Modified residuei448PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5CZZ9
PRIDEiQ5CZZ9

PTM databases

iPTMnetiQ5CZZ9
PhosphoSitePlusiQ5CZZ9

Expressioni

Gene expression databases

BgeeiENSRNOG00000015232
ExpressionAtlasiQ5CZZ9 baseline and differential
GenevisibleiQ5CZZ9 RN

Interactioni

Subunit structurei

Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063506

Structurei

3D structure databases

ProteinModelPortaliQ5CZZ9
SMRiQ5CZZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 395PIPKPROSITE-ProRule annotationAdd BLAST371

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000193876
HOVERGENiHBG052818
InParanoidiQ5CZZ9
KOiK00889
OMAiHYPHDRT
OrthoDBiEOG091G0A6L
PhylomeDBiQ5CZZ9
TreeFamiTF319618

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q5CZZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTAENGDA VPGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER
60 70 80 90 100
DVLMQDFYVV ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI
110 120 130 140 150
KPDDYLYSIC SEPLIELSNP GASGSLFFLT SDDEFIIKTV QHKEAEFLQK
160 170 180 190 200
LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG INIRIVVMNN VLPRAMRMHL
210 220 230 240 250
TYDLKGSTYK RRASRKEREK PNPTFKDLDF LQDMHEGLYF DTETYNALMK
260 270 280 290 300
TLQRDCRVLE SFKIMDYSLL LGIHILDHSL KDKEEEPLQN APDAKRPGMQ
310 320 330 340 350
KVLYSTAMES IQGPGKSADG IIAENPDTMG GIPAKSHKGE KLLLFMGIID
360 370 380 390 400
ILQSYRLMKK LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ
410 420 430 440 450
ALKASPSKKR CNSIAALKAT SQEILSSISQ EWKDEKQDLL TEGQSFSSLD
460 470 480 490 500
EEALGSRHRP DLVPSTPSLF EAASLATTIS SSSLYVGEHY PHDRTTLYSN
510 520 530
SKGLPSSSTF TLEEGTIYLT AEPNALETQD DASVLDVYL
Length:539
Mass (Da):60,733
Last modified:March 29, 2005 - v1
Checksum:iEB3F487BAD88A350
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090349 mRNA Translation: AAH90349.1
RefSeqiNP_001012761.1, NM_001012743.1
XP_017444762.1, XM_017589273.1
UniGeneiRn.203303

Genome annotation databases

EnsembliENSRNOT00000068645; ENSRNOP00000063506; ENSRNOG00000015232
GeneIDi309419
KEGGirno:309419

Similar proteinsi

Entry informationi

Entry nameiPI51B_RAT
AccessioniPrimary (citable) accession number: Q5CZZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 29, 2005
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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