Q5CZZ9 (PI51B_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Short name=PIP5K1-beta
Short name=PtdIns(4)P-5-kinase 1 beta
EC=2.7.1.68

Alternative name(s):
Phosphatidylinositol 4-phosphate 5-kinase type I alpha
Short name=PIP5KIalpha
Phosphatidylinositol 4-phosphate 5-kinase type I beta
Short name=PIP5KIbeta

Gene names

Name:	Pip5k1b
Synonyms:	Pip5k1a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	539 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion By similarity.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Subunit structure	Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1 By similarity.
Subcellular location	Endomembrane system By similarity. Note: Associated with membranes By similarity.
Sequence similarities	Contains 1 PIPK domain.
Caution	There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.

Ontologies

Keywords
Cellular component	Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylinositol phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-KW uropod Inferred from electronic annotation. Source: Compara
Molecular_function	1-phosphatidylinositol-4-phosphate 5-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 539	539	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta		PRO_0000185460
Regions
	Domain	25 – 395	371	PIPK

Sequences

	Sequence		Length	Mass (Da)
	Q5CZZ9 [UniParc]. Last modified March 29, 2005. Version 1. Checksum: EB3F487BAD88A350	FASTA	539	60,733
	10 20 30 40 50 60 MSSTAENGDA VPGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER DVLMQDFYVV 70 80 90 100 110 120 ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP 130 140 150 160 170 180 GASGSLFFLT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG 190 200 210 220 230 240 INIRIVVMNN VLPRAMRMHL TYDLKGSTYK RRASRKEREK PNPTFKDLDF LQDMHEGLYF 250 260 270 280 290 300 DTETYNALMK TLQRDCRVLE SFKIMDYSLL LGIHILDHSL KDKEEEPLQN APDAKRPGMQ 310 320 330 340 350 360 KVLYSTAMES IQGPGKSADG IIAENPDTMG GIPAKSHKGE KLLLFMGIID ILQSYRLMKK 370 380 390 400 410 420 LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ ALKASPSKKR CNSIAALKAT 430 440 450 460 470 480 SQEILSSISQ EWKDEKQDLL TEGQSFSSLD EEALGSRHRP DLVPSTPSLF EAASLATTIS 490 500 510 520 530 SSSLYVGEHY PHDRTTLYSN SKGLPSSSTF TLEEGTIYLT AEPNALETQD DASVLDVYL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC090349 mRNA. Translation: AAH90349.1.
IPI	IPI00205662.
RefSeq	NP_001012761.1. NM_001012743.1.
UniGene	Rn.203303.
3D structure databases
ProteinModelPortal	Q5CZZ9.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000063506.
PTM databases
PhosphoSite	Q5CZZ9.
Proteomic databases
PaxDb	Q5CZZ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000068645; ENSRNOP00000063506; ENSRNOG00000015232.
GeneID	309419.
KEGG	rno:309419.
Organism-specific databases
CTD	8395.
RGD	1310914. Pip5k1b.
Phylogenomic databases
eggNOG	COG5253.
GeneTree	ENSGT00690000101870.
HOGENOM	HOG000193876.
HOVERGEN	HBG052818.
InParanoid	Q5CZZ9.
KO	K00889.
OMA	EHYPHDR.
OrthoDB	EOG41G33V.
Gene expression databases
ArrayExpress	Q5CZZ9.
Genevestigator	Q5CZZ9.
Family and domain databases
InterPro	IPR023610. PInositol-4-P-5-kinase. IPR002498. PInositol-4-P-5-kinase_core. IPR016034. PInositol-4P-5-kinase_core_sub. [Graphical view]
PANTHER	PTHR23086. PTHR23086. 1 hit.
Pfam	PF01504. PIP5K. 1 hit. [Graphical view]
SMART	SM00330. PIPKc. 1 hit. [Graphical view]
PROSITE	PS51455. PIPK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	660738.

Entry information

Entry name

PI51B_RAT

Accession

Primary (citable) accession number: Q5CZZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	March 29, 2005
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program