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Q5CZZ9

- PI51B_RAT

UniProt

Q5CZZ9 - PI51B_RAT

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Protein
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Gene
Pip5k1b, Pip5k1a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion By similarity.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198600. Synthesis of PIPs at the plasma membrane.
    REACT_205007. WNT mediated activation of DVL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (EC:2.7.1.68)
    Short name:
    PIP5K1-beta
    Short name:
    PtdIns(4)P-5-kinase 1 beta
    Alternative name(s):
    Phosphatidylinositol 4-phosphate 5-kinase type I alpha
    Short name:
    PIP5KIalpha
    Phosphatidylinositol 4-phosphate 5-kinase type I beta
    Short name:
    PIP5KIbeta
    Gene namesi
    Name:Pip5k1b
    Synonyms:Pip5k1a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1310914. Pip5k1b.

    Subcellular locationi

    Endomembrane system By similarity
    Note: Associated with membranes By similarity.

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-KW
    3. uropod Source: Ensembl
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 539539Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
    PRO_0000185460Add
    BLAST

    Proteomic databases

    PaxDbiQ5CZZ9.

    PTM databases

    PhosphoSiteiQ5CZZ9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5CZZ9.

    Interactioni

    Subunit structurei

    Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1 By similarity.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000063506.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5CZZ9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 395371PIPK
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 PIPK domain.

    Phylogenomic databases

    eggNOGiCOG5253.
    GeneTreeiENSGT00690000101870.
    HOGENOMiHOG000193876.
    HOVERGENiHBG052818.
    InParanoidiQ5CZZ9.
    KOiK00889.
    OMAiEHYPHDR.
    OrthoDBiEOG70W3DM.
    PhylomeDBiQ5CZZ9.
    TreeFamiTF319618.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 1 hit.
    InterProiIPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF01504. PIP5K. 1 hit.
    [Graphical view]
    SMARTiSM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5CZZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTAENGDA VPGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER    50
    DVLMQDFYVV ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI 100
    KPDDYLYSIC SEPLIELSNP GASGSLFFLT SDDEFIIKTV QHKEAEFLQK 150
    LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG INIRIVVMNN VLPRAMRMHL 200
    TYDLKGSTYK RRASRKEREK PNPTFKDLDF LQDMHEGLYF DTETYNALMK 250
    TLQRDCRVLE SFKIMDYSLL LGIHILDHSL KDKEEEPLQN APDAKRPGMQ 300
    KVLYSTAMES IQGPGKSADG IIAENPDTMG GIPAKSHKGE KLLLFMGIID 350
    ILQSYRLMKK LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ 400
    ALKASPSKKR CNSIAALKAT SQEILSSISQ EWKDEKQDLL TEGQSFSSLD 450
    EEALGSRHRP DLVPSTPSLF EAASLATTIS SSSLYVGEHY PHDRTTLYSN 500
    SKGLPSSSTF TLEEGTIYLT AEPNALETQD DASVLDVYL 539
    Length:539
    Mass (Da):60,733
    Last modified:March 29, 2005 - v1
    Checksum:iEB3F487BAD88A350
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC090349 mRNA. Translation: AAH90349.1.
    RefSeqiNP_001012761.1. NM_001012743.1.
    XP_006231250.1. XM_006231188.1.
    UniGeneiRn.203303.

    Genome annotation databases

    EnsembliENSRNOT00000068645; ENSRNOP00000063506; ENSRNOG00000015232.
    GeneIDi309419.
    KEGGirno:309419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC090349 mRNA. Translation: AAH90349.1 .
    RefSeqi NP_001012761.1. NM_001012743.1.
    XP_006231250.1. XM_006231188.1.
    UniGenei Rn.203303.

    3D structure databases

    ProteinModelPortali Q5CZZ9.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000063506.

    PTM databases

    PhosphoSitei Q5CZZ9.

    Proteomic databases

    PaxDbi Q5CZZ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000068645 ; ENSRNOP00000063506 ; ENSRNOG00000015232 .
    GeneIDi 309419.
    KEGGi rno:309419.

    Organism-specific databases

    CTDi 8395.
    RGDi 1310914. Pip5k1b.

    Phylogenomic databases

    eggNOGi COG5253.
    GeneTreei ENSGT00690000101870.
    HOGENOMi HOG000193876.
    HOVERGENi HBG052818.
    InParanoidi Q5CZZ9.
    KOi K00889.
    OMAi EHYPHDR.
    OrthoDBi EOG70W3DM.
    PhylomeDBi Q5CZZ9.
    TreeFami TF319618.

    Enzyme and pathway databases

    Reactomei REACT_198600. Synthesis of PIPs at the plasma membrane.
    REACT_205007. WNT mediated activation of DVL.

    Miscellaneous databases

    NextBioi 660738.
    PROi Q5CZZ9.

    Gene expression databases

    Genevestigatori Q5CZZ9.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 1 hit.
    InterProi IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF01504. PIP5K. 1 hit.
    [Graphical view ]
    SMARTi SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPI51B_RAT
    AccessioniPrimary (citable) accession number: Q5CZZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: March 29, 2005
    Last modified: September 3, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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