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Protein

Fibrous sheath-interacting protein 2

Gene

FSIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrous sheath-interacting protein 2
Gene namesi
Name:FSIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:21675. FSIP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi300669711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 69076907Fibrous sheath-interacting protein 2PRO_0000331750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei430 – 4301PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5CZC0.
MaxQBiQ5CZC0.
PaxDbiQ5CZC0.
PRIDEiQ5CZC0.

PTM databases

iPTMnetiQ5CZC0.
PhosphoSiteiQ5CZC0.
UniCarbKBiQ5CZC0.

Expressioni

Gene expression databases

BgeeiQ5CZC0.
CleanExiHS_FSIP2.
ExpressionAtlasiQ5CZC0. baseline and differential.
GenevisibleiQ5CZC0. HS.

Organism-specific databases

HPAiHPA036139.

Interactioni

Subunit structurei

May interact with AKAP4.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000344403.

Structurei

3D structure databases

ProteinModelPortaliQ5CZC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5738 – 576629Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ISIK. Eukaryota.
ENOG4112BP1. LUCA.
GeneTreeiENSGT00680000100018.
HOVERGENiHBG107933.
InParanoidiQ5CZC0.
OrthoDBiEOG7JHM4G.
PhylomeDBiQ5CZC0.

Family and domain databases

InterProiIPR031554. FSIP2_C.
[Graphical view]
PfamiPF15783. FSIP2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5CZC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELYLGACSK PAKVAVTKTV ASVLAADTQQ CRDGVHKTHF AGVGPAQLLD
60 70 80 90 100
LPLGVKLPVI PGSNAVFYTT NFGEKLFRPS YGFNLTDPYC RLLENQYKSL
110 120 130 140 150
HDPHLKAYYK RKDILKRLKK GGYITSNNKV VCTLRELNKY RQYLTSLKLD
160 170 180 190 200
FERNYIKEQR ILAKQLHNIP ENNQIPQHCD VAQVQNWLLK EGTESIKDQE
210 220 230 240 250
RLMRHRYLDM ISRKLEQLER TAEEQRLFLM DREERRQREH TRRKLTLRRK
260 270 280 290 300
IEEEWKTKEM LLLTRMAEDV KREERIEEQQ HRNREESDRK KQDLLEKKMA
310 320 330 340 350
YHLQKMQDTG FNGEDIGKNT FKYRGQDGTH ASPKNKKKTS EDIMLVYPAG
360 370 380 390 400
DQNTYKETHG HTANAAHQRQ NSSNNFTKKN SASVVYQADV QDNGINQKRD
410 420 430 440 450
GMVSKNSSIF DDRGGINISG QGSIISAQVS PTRNFSRVSQ AFLDPSKEEK
460 470 480 490 500
ETNADWDGRP TKRSSYLCES GPQAHATDPG IFSSPVYTNM QQNLLQNCLQ
510 520 530 540 550
EKVTSEELNI IIQNVMTWVV ATVTSILYPA ITKYEKRLQN NTYPVSDDSI
560 570 580 590 600
LSSDSSSFCS TCSEDFTYRS YTSATTKTFQ AEPCAFVVDT SVRRPTTPIK
610 620 630 640 650
PPPAHVEKTV VGKTCHIKGQ SIISKHKYNK TNLLYSYPKL RSCKSDSHLL
660 670 680 690 700
ASFETGTKKS KDATTETDSL GSSLHCDKTA KAMDEMKNLK NVFVNFKCYL
710 720 730 740 750
KGETEVILES ILREIMSDLT QAIPSLSSVT AEVFVEQCER EKEILLSNAH
760 770 780 790 800
IPSVASEIVE NMLEKLESAV EKKCVEMFSQ DLSVDIKPSL AASDELLTSS
810 820 830 840 850
NGKPLKNSMP HTLDPMCDIA EDMVHAILEK LMTLVSFKQN EFLHLKDTNK
860 870 880 890 900
LSCQQHKTDP ICMFLQRAGK NKSSLESDEA SLIVNEEVQN LISNIFSQSS
910 920 930 940 950
LVAYIEEAIN AILGYIQTEL NNERIIASEE TVVLLQLLED ILFQLHQEPV
960 970 980 990 1000
NESFQKSRQP RISSPSDTKE KYRLTGTRLS NSPRSGRPFP PINVPGMVLY
1010 1020 1030 1040 1050
SDDENEEIDN IVKNVLDSTF KDEKVKSQEQ IPNHWFTKGN TCFECKRNIK
1060 1070 1080 1090 1100
PPTKPGSRSK AAFHDWELKT EPPSTNHEDI LKKKLSSNKD ISTFSQDQKH
1110 1120 1130 1140 1150
QIEKASENIV TSILKEMLKD ISSVPFGHLD SKTGSEASVL VSEKPQGLSH
1160 1170 1180 1190 1200
QEWIDQMFSV SEISTVAQEI TDSVLNILHK ASNYISNTTK SSISSSVHQI
1210 1220 1230 1240 1250
SLHNSDTEHI VKEAPNKYPL KTWFDSEKKM KYLSLFDVDP EKPPWLKSGK
1260 1270 1280 1290 1300
SEPKPVDDIN DKIIRTIFKR LKSFICPKLH MGFKSSLRSQ LSKYTAKIVN
1310 1320 1330 1340 1350
IVLCAIQNEL ELHKENLNLR EIDHTKSLTD KGFFANTDKK LESLVTSIDD
1360 1370 1380 1390 1400
DILASPLLTC IYDMLLSSEN AHQRSISLSS RKPKSATDSV DVQSILPNRQ
1410 1420 1430 1440 1450
DKKSFHKYLA TPCTHHSVNG GNHIKENAKL QVLERIGETL HEMLSKLLGT
1460 1470 1480 1490 1500
HLHSQLSCSQ QSREMTNKNQ KMAAALQSNI QLISKAILDY ILAKLCGVDM
1510 1520 1530 1540 1550
DTSFASCGLK AISESLDIDN PSFASIIEKM AKSTKIISSI VSRRVQEDNK
1560 1570 1580 1590 1600
EETKSKAKPV APVSSKTPST KEMHPNKLKA VASDILNMVF AKLEGFANGH
1610 1620 1630 1640 1650
LEILGAINDG NKKSNKIGWE YESTNISRDT HEASFLSALY MHAKKVSSAI
1660 1670 1680 1690 1700
LKVIQTELNV TSSDLKTSVE NPPPETQILK YVVKLILDAV SSDMFNEMES
1710 1720 1730 1740 1750
EGGGIETYRY RPTYGSLPGG AESDSFLEDD AYTAKKIIDE RSPQREEVKT
1760 1770 1780 1790 1800
RSLKQWALEK TLNKIEVKLK EPHISPIAPI IRNILNEIFQ STLINQLNVL
1810 1820 1830 1840 1850
SLSHSNFNGM PHNVDEPTPQ TSVQFMDKMM DPLLSEADIT IVTDNIVRTV
1860 1870 1880 1890 1900
FHKLYSAAMT ERNVRENRYK TITFSANVSS HEHTYKGKSS VTALDENPCT
1910 1920 1930 1940 1950
FQSRFSVADK ETKVNLAEDI VQAILTNLET FATSKVKSLF YSQVNFTVPV
1960 1970 1980 1990 2000
ALPIQQDHST LSKALSAKDS YSDEQFSCCS VDHTKSGKTN LCQLSLSKLN
2010 2020 2030 2040 2050
TYALQVARRN LQGIKQELDK ERENPFLTHD IGISESIASQ IVNALLDIIS
2060 2070 2080 2090 2100
RKGKCDKNSS DKEIDLDQQK GVIEKLLNET KYRKVLQLQI QDTIEGILCD
2110 2120 2130 2140 2150
IYEKTLFQNN LSFATPTLKC SIADKHSEEN SEMFMEGANK IIPKLSVPKS
2160 2170 2180 2190 2200
DVILISNDIV NIVLHNLSSA ATLVINAKNP TSARLPLTFC DTFPKIDCQQ
2210 2220 2230 2240 2250
PLKGSKTERK TERFSYSRNQ KSAYADDNQI TVVEKEDTQK SATDSCEENA
2260 2270 2280 2290 2300
NFITKTIFKR LESFATERID SLITLAFQSK EKSFVIPELE NCKQNDSIFY
2310 2320 2330 2340 2350
DSSQVESDVN VLKISATETI LSQELTDFTF VGRREKLGST IHLSQARLKT
2360 2370 2380 2390 2400
YADVIASAIL KLIKNDLDLE IQKIYPYQNN ILFQENIIVS EIVDSMLKML
2410 2420 2430 2440 2450
DDKRSVKEIC FNSKENSNFS QLALSNEILL GHKEKERSTK QSLFTKYPLE
2460 2470 2480 2490 2500
QNQMILENKR QIIVLEEIFM RNGESKNKEK GELLIAVEEL LNKLYQRVRE
2510 2520 2530 2540 2550
VTGHLPPLNE TANFISNSKI KTSDTTQKNS FQSHINSVAN DIVESVLGKM
2560 2570 2580 2590 2600
YLVVVTSLYE NNKSRTEVEI SDHNDSLLMK PLRFRETKQA GKISNSPRYA
2610 2620 2630 2640 2650
ISQAYSYVDS QNISVMENTL LPYLPLQVKK DLIQMVLNKI TNFVSLPLKV
2660 2670 2680 2690 2700
SPKDNPKPCF KAHLKTRSKI TTLPKFTKKT HLGLSAAKAK SKTKLGPGEK
2710 2720 2730 2740 2750
TLKDSRSKTA IGLSHIMSAG DAKNLLDTKL PTSELKIYAK DIIINILETI
2760 2770 2780 2790 2800
VKEFGKVKQT KALPSDQIIA AGKIVNTVLQ ELYVTNNCNL AYPMKSSHLR
2810 2820 2830 2840 2850
LSQGNIGTGS LPKQQACFYL ENVSSQLEHI FPREGIFKKL FDKWQTESND
2860 2870 2880 2890 2900
KENEKCKLLM IAENVLTEIS IKAKELEYSL SLLNLPPLEN CESRFYNHFK
2910 2920 2930 2940 2950
GASTRAEDTK AQINMFGREI VEMLLEKLQL CFLSQIPTPD SEETLSNSKE
2960 2970 2980 2990 3000
HITAKSKYGF PNKHSLSSLP IYNTKTKDQI SVGSSNQIVQ EIVETVLNML
3010 3020 3030 3040 3050
ESFVDLQFKH ISKYEFSEIV KMPIENLSSI QQKLLNKKML PKLQPLKMFS
3060 3070 3080 3090 3100
DKSESNTINF KENIQNILLR VHSFHSQLLT YAVNIISDML AVIKNKLDNE
3110 3120 3130 3140 3150
ISQMEPSSIS ILKENIVASE IIGTLMDQCT YFNESLIQNL SRESLFQGAE
3160 3170 3180 3190 3200
NAYTVNQVEL ATNMKMFTSK LKEGSLGINP SQVSKTGFVF CSDEDMKEKY
3210 3220 3230 3240 3250
RVSSDLPTSV RSSVEDTVKN SEPTKRPDSE TMPSCSTRNK VQDHRPRESN
3260 3270 3280 3290 3300
FGSFDQTMKG NSYLPEGSFL QKLLRKASDS TEAALKQVLS FIEMGKGENL
3310 3320 3330 3340 3350
RVFHYENLKP VVEPNQIQTT ISPLKICLAA ENIVNTVLSS CGFPSQPHTN
3360 3370 3380 3390 3400
ENREIMKPFF ISKQSSLSEV SGGQKDNEKS LLRMQDKKIN YIPEEENENL
3410 3420 3430 3440 3450
EASREDSSFL QKLKKKEYPK IETVKEVEAF TFADHEMGSN EVHLIARHVT
3460 3470 3480 3490 3500
TSVVTYLKNF ETTVFSEEKM SVSTWSRKKY ESKQFLRNIY DDSSIYQCCE
3510 3520 3530 3540 3550
HLTESVLYHL TSSISDGTKK GREKEKAWEI QEATFSKIIS IHSQVFESRS
3560 3570 3580 3590 3600
ISIGELALCI SEIIIKILFN NKIIQADIAQ KMVAIPTKYT YCPGIVSGGF
3610 3620 3630 3640 3650
DDLFQDLLVG VIHVLSKEIE VDYHFESNVR NKSFSMHRNN SVPLCNKINR
3660 3670 3680 3690 3700
QASPRDWQFS TQQIGQLFQK NKLSYLACKL NSLVGNLKTS ESKEVVNKVF
3710 3720 3730 3740 3750
NIVSDLFSPD ECLDTGMDSG KIQRTYFYSS NNEQPNSILT NNLQLSSKSV
3760 3770 3780 3790 3800
FLLNVVCEKL IRILLEECTS TAFPDKGSVS EETSAEECQL LKMLQSVEDG
3810 3820 3830 3840 3850
KSDYRKGGMD CECLQVDYMS DLLENVAEID QDLLTSDSML TIISHSLVKS
3860 3870 3880 3890 3900
LMDKLSHSIQ QAPESLPFAN KHLNYRTREI QSSFIKARKS ELIELGQSKS
3910 3920 3930 3940 3950
SLELRSYDSN SLTVSLNNPS VVSSKIQAPF NKHCAVKSSS VSPFERQRTK
3960 3970 3980 3990 4000
EMDKVAIHNK LHQEGIYAGV YSATFLEGII SELFFNLSMS LWGKNKNITV
4010 4020 4030 4040 4050
SWLNEMNTLF VNNVVNEFNN AQVTVLRNAE ERLCFPPVHT ETVSKIVDSV
4060 4070 4080 4090 4100
YYDVLQQYEL KVACGNNPVY DNASIAEQIT NGILLEILDY KLPSCFKEHL
4110 4120 4130 4140 4150
IPHSYYPLKP EIILQKLQSN LTEFTSLPRS SSDYSTMLSH SFLEDVIRRL
4160 4170 4180 4190 4200
LSQLIPPPIT CSSLGKKYLM SSDFNEMSTC IINKVMSAIS KHKIWFTIYD
4210 4220 4230 4240 4250
NQYLYTGKNL QKMVDSVYCN ILQMSDSLVS IQKSIVSRSP IMIDQIASFI
4260 4270 4280 4290 4300
IQEIIENHLQ PFLSGEVLCH PRTPLDPVST IVTQVLSEVI ESHRPQKQSP
4310 4320 4330 4340 4350
LDIHLDSFVR EIVARLLSKI FSPKHNTEIE LKNMTQRIVN SINRHFNKAK
4360 4370 4380 4390 4400
IHILYDDKEQ AFFSFNTDIV DELATSVYRN ALKQHGLDLA VDKESEDSGI
4410 4420 4430 4440 4450
FVENITNLIV AAISDYLLHP LFSGDFSAST YSNSVAENIV QDILSNISKS
4460 4470 4480 4490 4500
TEPSQSVPLY NTLLPYTFLE DMIRVLLSKL FSSASSLVLN RDTQKDISRV
4510 4520 4530 4540 4550
NFNDIASNLV SDIRMKVSQH EIRFSKEEEE TKFIYSEDDI QHLVDSVFAN
4560 4570 4580 4590 4600
VVQTSGSQES AVQNITSSND ILIDRIAGFI IKHICQKHLQ PFVSGKSLSS
4610 4620 4630 4640 4650
SDTYFDDERR QLFYTSVYSS TFLEDVISGV LRKIFHRVVG IVQTKSIRDS
4660 4670 4680 4690 4700
EDELFEKAEE LIHLITGEFS KAQVSIIDNT EERLCLPPVE RDVVKTIVDM
4710 4720 4730 4740 4750
VYSKVLQEYE MEVVPNKDFL NDTKTLAARI TNIILAEIFD FQIHPDLIAN
4760 4770 4780 4790 4800
LPFKSHSKLS ANVLIQRVQY DISKSRFQRQ ASTMYTTMLS HSHLEKIVTQ
4810 4820 4830 4840 4850
LTSQISPLNT SAEQSDTTKS DLSNTVIKLI NEIMSIISKH EICIIKYGNK
4860 4870 4880 4890 4900
KQSMISAKDI QSMVDSIYAD LSHSNIYQSI TKDKKSISDI PVSKIASFII
4910 4920 4930 4940 4950
KEIFNHHIQS FLSEDKTLLL AAVDQTYKLK AIDPKQRELS FIVNSSVFLE
4960 4970 4980 4990 5000
EVISELLCKI LYAFSHNMLV TENPDRVKLK LTRIVTTLVN SIVLEFTTSE
5010 5020 5030 5040 5050
ILVADNFDKN LCFSERYKEM VQKIVNSVYG KVLDQYKSLI QIHRVIQSDT
5060 5070 5080 5090 5100
ICFGRKIYYL LLEEIYDYQV QSLVSGELES SSYSYPQADN IIRNVLNIIT
5110 5120 5130 5140 5150
KDSHALPPYI TVLPHSLLED MVYRLLGHVF PSTHTENELK EKKFPPDDEF
5160 5170 5180 5190 5200
VEAASKLTDE IIKEISEHEI RLSMAEDNAE SMQLEPIENL VDSICNNILK
5210 5220 5230 5240 5250
TSEFQAEVQK DADKKGCSFL SKLAGFIMKE IMYHHLQPFL HGEESSFSDL
5260 5270 5280 5290 5300
SDYDHVSELA KSGKEKTQPS LYSATFLEDI IIDLVHKFCS LLIITEDSKK
5310 5320 5330 5340 5350
NEMAELDIMG LALKLANSLI REFKKSDIKV LPNAEKMFSF PPIDKETVDK
5360 5370 5380 5390 5400
ISNFVYEQFI EKCTSHDIQK GDESNIAIGM IAALTQKAIS AFRIQPLFSG
5410 5420 5430 5440 5450
DWSSTFFSFL NPDNITQRVQ HLPQNTFTQI SRCAKENQLS LPDQSYKDTS
5460 5470 5480 5490 5500
STPDCKNMMS TLEINRGTMN RKKSFKTKDT SVKKGDIQNP VLSSINAIMK
5510 5520 5530 5540 5550
SGMINLTSGL ATGVTNKKEV DENKVGICTQ KHSENVSKVT STTTVKSKDT
5560 5570 5580 5590 5600
QEPNLSETFN NNEIEKKRNL IPTDKKGKDD EIYTHFSLII DDTEYEKEVL
5610 5620 5630 5640 5650
GSDSEIGYKK KIDNARESSF KKDDKLFQLS SLKSKRNLGT TTDTLEIRIR
5660 5670 5680 5690 5700
TSSNEGRRDS PTQTCRDEEH HSDYEHVQNV IENIFEDVLE LSSSPEPAYY
5710 5720 5730 5740 5750
SKLSYDQSPP GDNVLNVIQE ISRDSAQSVT TKKVSSSTNK NISAKEKEEE
5760 5770 5780 5790 5800
EREKEKVREE IKSEPSKPDD PQNQRESKPG IFPAKFLEDV ITEMVKQLIF
5810 5820 5830 5840 5850
SSIPETQIQD RCQNVSDKQN QAKLYDTAMK LINSLLKEFS DAQIKVFRPD
5860 5870 5880 5890 5900
KGNQFPGGKV SSVPKVPPRY KEPTTDEAPS SIKIKSADKM PPMHKMMRKP
5910 5920 5930 5940 5950
SSDKIPSIDK TLVNKVVHSS VCNILNDYGS QDSIWKNINS NGENLARRLT
5960 5970 5980 5990 6000
SAVINEIFQR QVNLIFCDEV SVSACLPLES KDVVKKVQKL AQTASKECQT
6010 6020 6030 6040 6050
SSPYTIILPH KFLENVISAL FSKIFSTISS TKTKEPEDNL STELNFLQMK
6060 6070 6080 6090 6100
LVSAVATEIS QDKYMTIQYV ETLQSDDDEI IQLVVQSVYN NLLPQFGSQE
6110 6120 6130 6140 6150
IIQNCVTSGC KILSENIVDL VLREVASNQL QSYFCGELTP HQCVEVENIV
6160 6170 6180 6190 6200
EKILKDVFQT TDVPLPKPSH ADKLSYNIIE EIAVKFLSKL LSIFPKVHKE
6210 6220 6230 6240 6250
RTKSLETDMQ KITSKVLNSV QEFISKSKIK LVPPTKESPT VPVADNATIE
6260 6270 6280 6290 6300
NIVNSIYTSV LKHSGSYTSV FKDLMGKSNV LSDTIGFLMV NAISNSEFQP
6310 6320 6330 6340 6350
QVEEEVSNSE LVLEAVKIME KVIKIIDELK SKEKSSSRKG LTLDAKLLEE
6360 6370 6380 6390 6400
VLALFLAKLI RLPSSSSKDE KNLSKTELNK IASQLSKLVT AEISRSSISL
6410 6420 6430 6440 6450
IASDPEEHCL NPENTERIYQ VVDSVYSNIL QQSGTNKEFY YDIKDTNTAF
6460 6470 6480 6490 6500
PKKVASLIID GVSSFPLDTI NSTISNADLS GELDVNRIVQ KAQEHAFNVI
6510 6520 6530 6540 6550
PELEQEKLDQ NLSEEESPIK IVPHVGKKPV KIDPKIISEH LAVISIKTQP
6560 6570 6580 6590 6600
LEKLKQECLK RTGHSIAELR RASISGRNYS LGSPDLEKRK TERRTSLDKT
6610 6620 6630 6640 6650
GRLDVKPLEA VARNSFQNIR KPDITKVELL KDVQSKNDLI VRLVAHDIDQ
6660 6670 6680 6690 6700
VYLENYIKEE RDSDEDEVVL TQTFAKEEGI KVFEDQVKEV KKPIQSKLSP
6710 6720 6730 6740 6750
KSTLSTSSLK KFLSLSKCCQ TTASANIEST EAISNQVIES KETHVKRAVA
6760 6770 6780 6790 6800
ELDMATPKTM PETASSSWEE KPQCKKEEKN LVTEPTHYFI HRIMSSSSYN
6810 6820 6830 6840 6850
QEDLISSTGE AEDCHSDPSA KILEESSQEQ KPEHGNSVKF ITIFERSKDV
6860 6870 6880 6890 6900
LGSANPSKEV ISETPKPDVS KQGSKMLTKM SSTLSKVFSQ CNTNISRSSS

PAHQDEH
Length:6,907
Mass (Da):780,607
Last modified:July 13, 2010 - v4
Checksum:iB0E81A627B82ABA2
GO
Isoform 2 (identifier: Q5CZC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3464-3466: VFS → GRC
     3467-6907: Missing.

Show »
Length:3,466
Mass (Da):391,703
Checksum:iD95CA55780A610BC
GO

Sequence cautioni

The sequence AAY14863.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AK126051 differs from that shown. Reason: Frameshift at position 6474. Curated
The sequence CAI46017.1 differs from that shown.Aberrant splicing.Curated
The sequence CAI46017.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411T → A in CAI56743 (PubMed:17974005).Curated
Sequence conflicti336 – 3361K → R in CAI56743 (PubMed:17974005).Curated
Sequence conflicti430 – 4301S → P in CAI56743 (PubMed:17974005).Curated
Sequence conflicti1288 – 12881R → Q in CAI56743 (PubMed:17974005).Curated
Sequence conflicti2499 – 24991R → M in BAC86432 (PubMed:14702039).Curated
Sequence conflicti2808 – 28081T → I in BAC86432 (PubMed:14702039).Curated
Sequence conflicti2895 – 28951F → L in BAC86432 (PubMed:14702039).Curated
Sequence conflicti2900 – 29001K → E in BAC86432 (PubMed:14702039).Curated
Sequence conflicti5357 – 53571E → D in BX648733 (PubMed:17974005).Curated
Sequence conflicti5523 – 55231N → D in AK126051 (PubMed:14702039).Curated
Sequence conflicti5564 – 55641I → V in BX648733 (PubMed:17974005).Curated
Sequence conflicti5583 – 55831Y → N in AK126051 (PubMed:14702039).Curated
Sequence conflicti5649 – 56491I → T in BX648733 (PubMed:17974005).Curated
Sequence conflicti5649 – 56491I → T in AK126051 (PubMed:14702039).Curated
Sequence conflicti5775 – 57751R → Q in AK126051 (PubMed:14702039).Curated
Sequence conflicti5824 – 58241L → P in CAI46017 (PubMed:17974005).Curated
Sequence conflicti5960 – 59601R → H in AK126051 (PubMed:14702039).Curated
Sequence conflicti5960 – 59601R → H in BAC86406 (PubMed:14702039).Curated
Sequence conflicti6165 – 61651L → Q in AK126051 (PubMed:14702039).Curated
Sequence conflicti6165 – 61651L → Q in BAC86406 (PubMed:14702039).Curated
Sequence conflicti6526 – 65261G → E in CAI46017 (PubMed:17974005).Curated
Sequence conflicti6591 – 65911T → I in BX648733 (PubMed:17974005).Curated
Sequence conflicti6622 – 66221P → S in CAI46017 (PubMed:17974005).Curated
Sequence conflicti6644 – 66441V → E in BAC86406 (PubMed:14702039).Curated
Sequence conflicti6730 – 67301T → I in BX648733 (PubMed:17974005).Curated
Sequence conflicti6736 – 67361Q → R in CAI46017 (PubMed:17974005).Curated
Sequence conflicti6760 – 67601M → V in BX648733 (PubMed:17974005).Curated
Sequence conflicti6794 – 67941M → V in BX648733 (PubMed:17974005).Curated
Sequence conflicti6883 – 68831T → A in BX648733 (PubMed:17974005).Curated
Sequence conflicti6883 – 68831T → A in CAI46017 (PubMed:17974005).Curated
Sequence conflicti6883 – 68831T → A in AK126051 (PubMed:14702039).Curated
Sequence conflicti6883 – 68831T → A in BAC86406 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti306 – 3061M → V.
Corresponds to variant rs9808218 [ dbSNP | Ensembl ].
VAR_042938
Natural varianti700 – 7001L → F Found in a patient with Joubert syndrome; unknown pathological significance. 1 Publication
VAR_075707
Natural varianti2764 – 27641P → T Found in a patient with Joubert syndrome; unknown pathological significance. 1 Publication
Corresponds to variant rs201794247 [ dbSNP | Ensembl ].
VAR_075708

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3464 – 34663VFS → GRC in isoform 2. 1 PublicationVSP_039412
Alternative sequencei3467 – 69073441Missing in isoform 2. 1 PublicationVSP_039413Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007966 Genomic DNA. Translation: AAY15001.1.
AC008174 Genomic DNA. Translation: AAY14863.1. Sequence problems.
BX647691 mRNA. Translation: CAI46017.1. Sequence problems.
BX648733 mRNA. No translation available.
CR936597 mRNA. Translation: CAI56743.1.
AK126036 mRNA. Translation: BAC86406.1.
AK126051 mRNA. No translation available.
AK126089 mRNA. Translation: BAC86432.1.
CCDSiCCDS54426.1. [Q5CZC0-1]
RefSeqiNP_775922.3. NM_173651.3. [Q5CZC0-1]
UniGeneiHs.98025.

Genome annotation databases

EnsembliENST00000424728; ENSP00000401306; ENSG00000188738. [Q5CZC0-1]
GeneIDi401024.
UCSCiuc061qle.1. human. [Q5CZC0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007966 Genomic DNA. Translation: AAY15001.1.
AC008174 Genomic DNA. Translation: AAY14863.1. Sequence problems.
BX647691 mRNA. Translation: CAI46017.1. Sequence problems.
BX648733 mRNA. No translation available.
CR936597 mRNA. Translation: CAI56743.1.
AK126036 mRNA. Translation: BAC86406.1.
AK126051 mRNA. No translation available.
AK126089 mRNA. Translation: BAC86432.1.
CCDSiCCDS54426.1. [Q5CZC0-1]
RefSeqiNP_775922.3. NM_173651.3. [Q5CZC0-1]
UniGeneiHs.98025.

3D structure databases

ProteinModelPortaliQ5CZC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344403.

PTM databases

iPTMnetiQ5CZC0.
PhosphoSiteiQ5CZC0.
UniCarbKBiQ5CZC0.

Polymorphism and mutation databases

DMDMi300669711.

Proteomic databases

EPDiQ5CZC0.
MaxQBiQ5CZC0.
PaxDbiQ5CZC0.
PRIDEiQ5CZC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424728; ENSP00000401306; ENSG00000188738. [Q5CZC0-1]
GeneIDi401024.
UCSCiuc061qle.1. human. [Q5CZC0-1]

Organism-specific databases

GeneCardsiFSIP2.
H-InvDBHIX0023962.
HIX0056430.
HGNCiHGNC:21675. FSIP2.
HPAiHPA036139.
MIMi615796. gene.
neXtProtiNX_Q5CZC0.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISIK. Eukaryota.
ENOG4112BP1. LUCA.
GeneTreeiENSGT00680000100018.
HOVERGENiHBG107933.
InParanoidiQ5CZC0.
OrthoDBiEOG7JHM4G.
PhylomeDBiQ5CZC0.

Miscellaneous databases

ChiTaRSiFSIP2. human.
PROiQ5CZC0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5CZC0.
CleanExiHS_FSIP2.
ExpressionAtlasiQ5CZC0. baseline and differential.
GenevisibleiQ5CZC0. HS.

Family and domain databases

InterProiIPR031554. FSIP2_C.
[Graphical view]
PfamiPF15783. FSIP2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-1736 AND 5244-6907 (ISOFORM 1).
    Tissue: Colon carcinoma, Fetal kidney and Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5499-6907 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2495-6907 (ISOFORM 2).
    Tissue: Testis.
  4. Cited for: VARIANTS PHE-700 AND THR-2764.

Entry informationi

Entry nameiFSIP2_HUMAN
AccessioniPrimary (citable) accession number: Q5CZC0
Secondary accession number(s): Q53TL3
, Q53TN5, Q5HYH2, Q6ZTZ5, Q6ZU14, Q6ZU21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 13, 2010
Last modified: April 13, 2016
This is version 73 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.