Q5CZA5 (ZN805_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 805

Gene names

Name:

ZNF805

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	627 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 13 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence CAI56760.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5CZA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on similarity to orthologs.

Isoform 2 (identifier: Q5CZA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 627	627	Zinc finger protein 805		PRO_0000304624
Regions
	Domain	13 – 84	72	KRAB
	Zinc finger	203 – 225	23	C2H2-type 1
	Zinc finger	231 – 253	23	C2H2-type 2
	Zinc finger	259 – 281	23	C2H2-type 3
	Zinc finger	287 – 309	23	C2H2-type 4
	Zinc finger	315 – 337	23	C2H2-type 5
	Zinc finger	343 – 365	23	C2H2-type 6
	Zinc finger	371 – 393	23	C2H2-type 7
	Zinc finger	399 – 421	23	C2H2-type 8
	Zinc finger	427 – 449	23	C2H2-type 9
	Zinc finger	455 – 477	23	C2H2-type 10
	Zinc finger	483 – 505	23	C2H2-type 11
	Zinc finger	511 – 533	23	C2H2-type 12
	Zinc finger	539 – 561	23	C2H2-type 13
Natural variations
	Alternative sequence	1 – 133	133	Missing in isoform 2.		VSP_040823
	Natural variant	68	1	G → E. Corresponds to variant rs2014572 [ dbSNP | Ensembl ].		VAR_057454

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: E87A25500E198AD7	FASTA	627	71,143
	10 20 30 40 50 60 MAMALTDPAQ VSVTFDDVAV TFTQEEWGQL DLAQRTLYQE VMLENCGLLV SLGCPVPRPE 70 80 90 100 110 120 LIYHLEHGQE PWTRKEDLSQ GTCPGDKGKP KSTEPTTCEL ALSEGISFWG QLTQGASGDS 130 140 150 160 170 180 QLGQPKDQDG FSEMQGERLR PGLDSQKEKL PGKMSPKHDG LGTADSVCSR IIQDRVSLGD 190 200 210 220 230 240 DVHDCDSHGS GKNPVIQEEE NIFKCNECEK VFNKKRLLAR HERIHSGVKP YECTECGKTF 250 260 270 280 290 300 SKSTYLLQHH MVHTGEKPYK CMECGKAFNR KSHLTQHQRI HSGEKPYKCS ECGKAFTHRS 310 320 330 340 350 360 TFVLHNRSHT GEKPFVCKEC GKAFRDRPGF IRHYIIHSGE NPYECFECGK VFKHRSYLMW 370 380 390 400 410 420 HQQTHTGEKP YECSECGKAF CESAALIHHY VIHTGEKPFE CLECGKAFNH RSYLKRHQRI 430 440 450 460 470 480 HTGEKPYVCS ECGKAFTHCS TFILHKRAHT GEKPFECKEC GKAFSNRADL IRHFSIHTGE 490 500 510 520 530 540 KPYECMECGK AFNRRSGLTR HQRIHSGEKP YECIECGKTF CWSTNLIRHS IIHTGEKPYE 550 560 570 580 590 600 CSECGKAFSR SSSLTQHQRM HTGRNPISVT DVGRPFTSGQ TSVNIQELLL GKNFLNVTTE 610 620 ENLLQEEASY MASDRTYQRE TPQVSSL
	Isoform 2 [UniParc]. Checksum: AB9EEFEC88DB45A3	FASTA	494	56,616
	10 20 30 40 50 60 MQGERLRPGL DSQKEKLPGK MSPKHDGLGT ADSVCSRIIQ DRVSLGDDVH DCDSHGSGKN 70 80 90 100 110 120 PVIQEEENIF KCNECEKVFN KKRLLARHER IHSGVKPYEC TECGKTFSKS TYLLQHHMVH 130 140 150 160 170 180 TGEKPYKCME CGKAFNRKSH LTQHQRIHSG EKPYKCSECG KAFTHRSTFV LHNRSHTGEK 190 200 210 220 230 240 PFVCKECGKA FRDRPGFIRH YIIHSGENPY ECFECGKVFK HRSYLMWHQQ THTGEKPYEC 250 260 270 280 290 300 SECGKAFCES AALIHHYVIH TGEKPFECLE CGKAFNHRSY LKRHQRIHTG EKPYVCSECG 310 320 330 340 350 360 KAFTHCSTFI LHKRAHTGEK PFECKECGKA FSNRADLIRH FSIHTGEKPY ECMECGKAFN 370 380 390 400 410 420 RRSGLTRHQR IHSGEKPYEC IECGKTFCWS TNLIRHSIIH TGEKPYECSE CGKAFSRSSS 430 440 450 460 470 480 LTQHQRMHTG RNPISVTDVG RPFTSGQTSV NIQELLLGKN FLNVTTEENL LQEEASYMAS 490 DRTYQRETPQ VSSL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 206-627. Tissue: Fetal kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK297977 mRNA. Translation: BAG60287.1. AC005261 Genomic DNA. No translation available. CR936617 mRNA. Translation: CAI56760.1. Different initiation.
IPI	IPI00397000. IPI00920950.
RefSeq	NP_001018857.2. NM_001023563.3. NP_001138550.1. NM_001145078.1.
UniGene	Hs.22488.
3D structure databases
HSSP	HSSP built from PDB template 1X6E based on UniProtKB P17028.
ProteinModelPortal	Q5CZA5.
SMR	Q5CZA5. Positions 13-53, 168-597.
ModBase	Search...
PTM databases
PhosphoSite	Q5CZA5.
Polymorphism databases
DMDM	158563866.
Proteomic databases
PaxDb	Q5CZA5.
PRIDE	Q5CZA5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354309; ENSP00000365414; ENSG00000204524. ENST00000414468; ENSP00000412999; ENSG00000204524. ENST00000535550; ENSP00000440067; ENSG00000204524.
GeneID	390980.
KEGG	hsa:390980.
UCSC	uc010ygt.2. human.
Organism-specific databases
CTD	390980.
GeneCards	GC19P057752.
HGNC	HGNC:23272. ZNF805.
neXtProt	NX_Q5CZA5.
PharmGKB	PA162410601.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
OMA	QDGFSEM.
OrthoDB	EOG4QJRMQ.
Gene expression databases
ArrayExpress	Q5CZA5.
Bgee	Q5CZA5.
CleanEx	HS_ZNF805.
Genevestigator	Q5CZA5.
Family and domain databases
Gene3D	3.30.160.60. 13 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 13 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390980.
NextBio	104196.

Entry information

Entry name

ZN805_HUMAN

Accession

Primary (citable) accession number: Q5CZA5
Secondary accession number(s): B4DNM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.