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Q5CZA5

- ZN805_HUMAN

UniProt

Q5CZA5 - ZN805_HUMAN

Protein

Zinc finger protein 805

Gene

ZNF805

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri427 – 44923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri455 – 47723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri483 – 50523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri511 – 53323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri539 – 56123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 805
    Gene namesi
    Name:ZNF805
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:23272. ZNF805.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410601.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Zinc finger protein 805PRO_0000304624Add
    BLAST

    Proteomic databases

    PaxDbiQ5CZA5.
    PRIDEiQ5CZA5.

    PTM databases

    PhosphoSiteiQ5CZA5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5CZA5.
    BgeeiQ5CZA5.
    CleanExiHS_ZNF805.
    GenevestigatoriQ5CZA5.

    Organism-specific databases

    HPAiHPA058895.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5CZA5.
    SMRiQ5CZA5. Positions 168-622.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 8472KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri427 – 44923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri455 – 47723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri483 – 50523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri511 – 53323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri539 – 56123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    OMAiQDGFSEM.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ5CZA5.
    TreeFamiTF341817.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5CZA5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMALTDPAQ VSVTFDDVAV TFTQEEWGQL DLAQRTLYQE VMLENCGLLV    50
    SLGCPVPRPE LIYHLEHGQE PWTRKEDLSQ GTCPGDKGKP KSTEPTTCEL 100
    ALSEGISFWG QLTQGASGDS QLGQPKDQDG FSEMQGERLR PGLDSQKEKL 150
    PGKMSPKHDG LGTADSVCSR IIQDRVSLGD DVHDCDSHGS GKNPVIQEEE 200
    NIFKCNECEK VFNKKRLLAR HERIHSGVKP YECTECGKTF SKSTYLLQHH 250
    MVHTGEKPYK CMECGKAFNR KSHLTQHQRI HSGEKPYKCS ECGKAFTHRS 300
    TFVLHNRSHT GEKPFVCKEC GKAFRDRPGF IRHYIIHSGE NPYECFECGK 350
    VFKHRSYLMW HQQTHTGEKP YECSECGKAF CESAALIHHY VIHTGEKPFE 400
    CLECGKAFNH RSYLKRHQRI HTGEKPYVCS ECGKAFTHCS TFILHKRAHT 450
    GEKPFECKEC GKAFSNRADL IRHFSIHTGE KPYECMECGK AFNRRSGLTR 500
    HQRIHSGEKP YECIECGKTF CWSTNLIRHS IIHTGEKPYE CSECGKAFSR 550
    SSSLTQHQRM HTGRNPISVT DVGRPFTSGQ TSVNIQELLL GKNFLNVTTE 600
    ENLLQEEASY MASDRTYQRE TPQVSSL 627

    Note: Gene prediction based on similarity to orthologs.

    Length:627
    Mass (Da):71,143
    Last modified:April 5, 2011 - v3
    Checksum:iE87A25500E198AD7
    GO
    Isoform 2 (identifier: Q5CZA5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-133: Missing.

    Show »
    Length:494
    Mass (Da):56,616
    Checksum:iAB9EEFEC88DB45A3
    GO

    Sequence cautioni

    The sequence CAI56760.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681G → E.
    Corresponds to variant rs2014572 [ dbSNP | Ensembl ].
    VAR_057454

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 133133Missing in isoform 2. 1 PublicationVSP_040823Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK297977 mRNA. Translation: BAG60287.1.
    AC005261 Genomic DNA. No translation available.
    CR936617 mRNA. Translation: CAI56760.1. Different initiation.
    CCDSiCCDS46207.1. [Q5CZA5-1]
    CCDS46208.1. [Q5CZA5-2]
    RefSeqiNP_001018857.2. NM_001023563.3. [Q5CZA5-1]
    NP_001138550.1. NM_001145078.1. [Q5CZA5-2]
    UniGeneiHs.22488.

    Genome annotation databases

    EnsembliENST00000354309; ENSP00000365414; ENSG00000204524. [Q5CZA5-2]
    ENST00000414468; ENSP00000412999; ENSG00000204524. [Q5CZA5-1]
    GeneIDi390980.
    KEGGihsa:390980.
    UCSCiuc010ygt.2. human. [Q5CZA5-1]

    Polymorphism databases

    DMDMi327478550.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK297977 mRNA. Translation: BAG60287.1 .
    AC005261 Genomic DNA. No translation available.
    CR936617 mRNA. Translation: CAI56760.1 . Different initiation.
    CCDSi CCDS46207.1. [Q5CZA5-1 ]
    CCDS46208.1. [Q5CZA5-2 ]
    RefSeqi NP_001018857.2. NM_001023563.3. [Q5CZA5-1 ]
    NP_001138550.1. NM_001145078.1. [Q5CZA5-2 ]
    UniGenei Hs.22488.

    3D structure databases

    ProteinModelPortali Q5CZA5.
    SMRi Q5CZA5. Positions 168-622.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5CZA5.

    Polymorphism databases

    DMDMi 327478550.

    Proteomic databases

    PaxDbi Q5CZA5.
    PRIDEi Q5CZA5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354309 ; ENSP00000365414 ; ENSG00000204524 . [Q5CZA5-2 ]
    ENST00000414468 ; ENSP00000412999 ; ENSG00000204524 . [Q5CZA5-1 ]
    GeneIDi 390980.
    KEGGi hsa:390980.
    UCSCi uc010ygt.2. human. [Q5CZA5-1 ]

    Organism-specific databases

    CTDi 390980.
    GeneCardsi GC19P057752.
    HGNCi HGNC:23272. ZNF805.
    HPAi HPA058895.
    neXtProti NX_Q5CZA5.
    PharmGKBi PA162410601.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    OMAi QDGFSEM.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q5CZA5.
    TreeFami TF341817.

    Miscellaneous databases

    GenomeRNAii 390980.
    NextBioi 104196.
    PROi Q5CZA5.

    Gene expression databases

    ArrayExpressi Q5CZA5.
    Bgeei Q5CZA5.
    CleanExi HS_ZNF805.
    Genevestigatori Q5CZA5.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 206-627.
      Tissue: Fetal kidney.

    Entry informationi

    Entry nameiZN805_HUMAN
    AccessioniPrimary (citable) accession number: Q5CZA5
    Secondary accession number(s): B4DNM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3