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Q5CZA5 (ZN805_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 805
Gene names
Name:ZNF805
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 13 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence CAI56760.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5CZA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Gene prediction based on similarity to orthologs.
Isoform 2 (identifier: Q5CZA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 627627Zinc finger protein 805
PRO_0000304624

Regions

Domain13 – 8472KRAB
Zinc finger203 – 22523C2H2-type 1
Zinc finger231 – 25323C2H2-type 2
Zinc finger259 – 28123C2H2-type 3
Zinc finger287 – 30923C2H2-type 4
Zinc finger315 – 33723C2H2-type 5
Zinc finger343 – 36523C2H2-type 6
Zinc finger371 – 39323C2H2-type 7
Zinc finger399 – 42123C2H2-type 8
Zinc finger427 – 44923C2H2-type 9
Zinc finger455 – 47723C2H2-type 10
Zinc finger483 – 50523C2H2-type 11
Zinc finger511 – 53323C2H2-type 12
Zinc finger539 – 56123C2H2-type 13

Natural variations

Alternative sequence1 – 133133Missing in isoform 2.
VSP_040823
Natural variant681G → E.
Corresponds to variant rs2014572 [ dbSNP | Ensembl ].
VAR_057454

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 5, 2011. Version 3.
Checksum: E87A25500E198AD7

FASTA62771,143
        10         20         30         40         50         60 
MAMALTDPAQ VSVTFDDVAV TFTQEEWGQL DLAQRTLYQE VMLENCGLLV SLGCPVPRPE 

        70         80         90        100        110        120 
LIYHLEHGQE PWTRKEDLSQ GTCPGDKGKP KSTEPTTCEL ALSEGISFWG QLTQGASGDS 

       130        140        150        160        170        180 
QLGQPKDQDG FSEMQGERLR PGLDSQKEKL PGKMSPKHDG LGTADSVCSR IIQDRVSLGD 

       190        200        210        220        230        240 
DVHDCDSHGS GKNPVIQEEE NIFKCNECEK VFNKKRLLAR HERIHSGVKP YECTECGKTF 

       250        260        270        280        290        300 
SKSTYLLQHH MVHTGEKPYK CMECGKAFNR KSHLTQHQRI HSGEKPYKCS ECGKAFTHRS 

       310        320        330        340        350        360 
TFVLHNRSHT GEKPFVCKEC GKAFRDRPGF IRHYIIHSGE NPYECFECGK VFKHRSYLMW 

       370        380        390        400        410        420 
HQQTHTGEKP YECSECGKAF CESAALIHHY VIHTGEKPFE CLECGKAFNH RSYLKRHQRI 

       430        440        450        460        470        480 
HTGEKPYVCS ECGKAFTHCS TFILHKRAHT GEKPFECKEC GKAFSNRADL IRHFSIHTGE 

       490        500        510        520        530        540 
KPYECMECGK AFNRRSGLTR HQRIHSGEKP YECIECGKTF CWSTNLIRHS IIHTGEKPYE 

       550        560        570        580        590        600 
CSECGKAFSR SSSLTQHQRM HTGRNPISVT DVGRPFTSGQ TSVNIQELLL GKNFLNVTTE 

       610        620 
ENLLQEEASY MASDRTYQRE TPQVSSL 

« Hide

Isoform 2 [UniParc].

Checksum: AB9EEFEC88DB45A3
Show »

FASTA49456,616

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 206-627.
Tissue: Fetal kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK297977 mRNA. Translation: BAG60287.1.
AC005261 Genomic DNA. No translation available.
CR936617 mRNA. Translation: CAI56760.1. Different initiation.
RefSeqNP_001018857.2. NM_001023563.3.
NP_001138550.1. NM_001145078.1.
UniGeneHs.22488.

3D structure databases

ProteinModelPortalQ5CZA5.
SMRQ5CZA5. Positions 8-61, 197-622.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5CZA5.

Polymorphism databases

DMDM327478550.

Proteomic databases

PaxDbQ5CZA5.
PRIDEQ5CZA5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354309; ENSP00000365414; ENSG00000204524. [Q5CZA5-2]
ENST00000414468; ENSP00000412999; ENSG00000204524. [Q5CZA5-1]
ENST00000535550; ENSP00000440067; ENSG00000204524. [Q5CZA5-2]
GeneID390980.
KEGGhsa:390980.
UCSCuc010ygt.2. human. [Q5CZA5-1]

Organism-specific databases

CTD390980.
GeneCardsGC19P057752.
HGNCHGNC:23272. ZNF805.
HPAHPA058895.
neXtProtNX_Q5CZA5.
PharmGKBPA162410601.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
OMAQDGFSEM.
OrthoDBEOG7KSX7Q.
PhylomeDBQ5CZA5.
TreeFamTF341817.

Gene expression databases

ArrayExpressQ5CZA5.
BgeeQ5CZA5.
CleanExHS_ZNF805.
GenevestigatorQ5CZA5.

Family and domain databases

Gene3D3.30.160.60. 13 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi390980.
NextBio104196.
PROQ5CZA5.

Entry information

Entry nameZN805_HUMAN
AccessionPrimary (citable) accession number: Q5CZA5
Secondary accession number(s): B4DNM5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 5, 2011
Last modified: April 16, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM