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Protein

Zinc finger protein 805

Gene

ZNF805

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 805
Gene namesi
Name:ZNF805
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23272. ZNF805.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Zinc finger protein 805PRO_0000304624Add
BLAST

Proteomic databases

PaxDbiQ5CZA5.
PRIDEiQ5CZA5.

PTM databases

PhosphoSiteiQ5CZA5.

Expressioni

Gene expression databases

BgeeiQ5CZA5.
CleanExiHS_ZNF805.
ExpressionAtlasiQ5CZA5. baseline.
GenevestigatoriQ5CZA5.

Organism-specific databases

HPAiHPA058895.

Structurei

3D structure databases

ProteinModelPortaliQ5CZA5.
SMRiQ5CZA5. Positions 168-597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 8472KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5CZA5.
OMAiQDGFSEM.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5CZA5.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5CZA5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMALTDPAQ VSVTFDDVAV TFTQEEWGQL DLAQRTLYQE VMLENCGLLV
60 70 80 90 100
SLGCPVPRPE LIYHLEHGQE PWTRKEDLSQ GTCPGDKGKP KSTEPTTCEL
110 120 130 140 150
ALSEGISFWG QLTQGASGDS QLGQPKDQDG FSEMQGERLR PGLDSQKEKL
160 170 180 190 200
PGKMSPKHDG LGTADSVCSR IIQDRVSLGD DVHDCDSHGS GKNPVIQEEE
210 220 230 240 250
NIFKCNECEK VFNKKRLLAR HERIHSGVKP YECTECGKTF SKSTYLLQHH
260 270 280 290 300
MVHTGEKPYK CMECGKAFNR KSHLTQHQRI HSGEKPYKCS ECGKAFTHRS
310 320 330 340 350
TFVLHNRSHT GEKPFVCKEC GKAFRDRPGF IRHYIIHSGE NPYECFECGK
360 370 380 390 400
VFKHRSYLMW HQQTHTGEKP YECSECGKAF CESAALIHHY VIHTGEKPFE
410 420 430 440 450
CLECGKAFNH RSYLKRHQRI HTGEKPYVCS ECGKAFTHCS TFILHKRAHT
460 470 480 490 500
GEKPFECKEC GKAFSNRADL IRHFSIHTGE KPYECMECGK AFNRRSGLTR
510 520 530 540 550
HQRIHSGEKP YECIECGKTF CWSTNLIRHS IIHTGEKPYE CSECGKAFSR
560 570 580 590 600
SSSLTQHQRM HTGRNPISVT DVGRPFTSGQ TSVNIQELLL GKNFLNVTTE
610 620
ENLLQEEASY MASDRTYQRE TPQVSSL

Note: Gene prediction based on similarity to orthologs.

Length:627
Mass (Da):71,143
Last modified:April 5, 2011 - v3
Checksum:iE87A25500E198AD7
GO
Isoform 2 (identifier: Q5CZA5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:494
Mass (Da):56,616
Checksum:iAB9EEFEC88DB45A3
GO

Sequence cautioni

The sequence CAI56760.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681G → E.
Corresponds to variant rs2014572 [ dbSNP | Ensembl ].
VAR_057454

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 133133Missing in isoform 2. 1 PublicationVSP_040823Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297977 mRNA. Translation: BAG60287.1.
AC005261 Genomic DNA. No translation available.
CR936617 mRNA. Translation: CAI56760.1. Different initiation.
CCDSiCCDS46207.1. [Q5CZA5-1]
CCDS46208.1. [Q5CZA5-2]
RefSeqiNP_001018857.2. NM_001023563.3. [Q5CZA5-1]
NP_001138550.1. NM_001145078.1. [Q5CZA5-2]
UniGeneiHs.22488.

Genome annotation databases

EnsembliENST00000354309; ENSP00000365414; ENSG00000204524. [Q5CZA5-2]
ENST00000414468; ENSP00000412999; ENSG00000204524. [Q5CZA5-1]
GeneIDi390980.
KEGGihsa:390980.
UCSCiuc010ygt.2. human. [Q5CZA5-1]

Polymorphism databases

DMDMi327478550.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297977 mRNA. Translation: BAG60287.1.
AC005261 Genomic DNA. No translation available.
CR936617 mRNA. Translation: CAI56760.1. Different initiation.
CCDSiCCDS46207.1. [Q5CZA5-1]
CCDS46208.1. [Q5CZA5-2]
RefSeqiNP_001018857.2. NM_001023563.3. [Q5CZA5-1]
NP_001138550.1. NM_001145078.1. [Q5CZA5-2]
UniGeneiHs.22488.

3D structure databases

ProteinModelPortaliQ5CZA5.
SMRiQ5CZA5. Positions 168-597.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ5CZA5.

Polymorphism databases

DMDMi327478550.

Proteomic databases

PaxDbiQ5CZA5.
PRIDEiQ5CZA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354309; ENSP00000365414; ENSG00000204524. [Q5CZA5-2]
ENST00000414468; ENSP00000412999; ENSG00000204524. [Q5CZA5-1]
GeneIDi390980.
KEGGihsa:390980.
UCSCiuc010ygt.2. human. [Q5CZA5-1]

Organism-specific databases

CTDi390980.
GeneCardsiGC19P057752.
HGNCiHGNC:23272. ZNF805.
HPAiHPA058895.
neXtProtiNX_Q5CZA5.
PharmGKBiPA162410601.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5CZA5.
OMAiQDGFSEM.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5CZA5.
TreeFamiTF341817.

Miscellaneous databases

GenomeRNAii390980.
NextBioi104196.
PROiQ5CZA5.

Gene expression databases

BgeeiQ5CZA5.
CleanExiHS_ZNF805.
ExpressionAtlasiQ5CZA5. baseline.
GenevestigatoriQ5CZA5.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 206-627.
    Tissue: Fetal kidney.

Entry informationi

Entry nameiZN805_HUMAN
AccessioniPrimary (citable) accession number: Q5CZA5
Secondary accession number(s): B4DNM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 5, 2011
Last modified: January 7, 2015
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.