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Protein

Zinc finger protein 805

Gene

ZNF805

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 225C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-30861-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 805
Gene namesi
Name:ZNF805
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23272. ZNF805.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi390980.
OpenTargetsiENSG00000204524.
PharmGKBiPA162410601.

Polymorphism and mutation databases

BioMutaiZNF805.
DMDMi327478550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003046241 – 627Zinc finger protein 805Add BLAST627

Proteomic databases

EPDiQ5CZA5.
MaxQBiQ5CZA5.
PaxDbiQ5CZA5.
PeptideAtlasiQ5CZA5.
PRIDEiQ5CZA5.

PTM databases

iPTMnetiQ5CZA5.
PhosphoSitePlusiQ5CZA5.

Expressioni

Gene expression databases

BgeeiENSG00000204524.
CleanExiHS_ZNF805.

Organism-specific databases

HPAiHPA057665.
HPA058895.

Interactioni

Protein-protein interaction databases

BioGridi133751. 1 interactor.
STRINGi9606.ENSP00000412999.

Structurei

3D structure databases

ProteinModelPortaliQ5CZA5.
SMRiQ5CZA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 84KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 225C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5CZA5.
OMAiDDVHDCD.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5CZA5.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5CZA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMALTDPAQ VSVTFDDVAV TFTQEEWGQL DLAQRTLYQE VMLENCGLLV
60 70 80 90 100
SLGCPVPRPE LIYHLEHGQE PWTRKEDLSQ GTCPGDKGKP KSTEPTTCEL
110 120 130 140 150
ALSEGISFWG QLTQGASGDS QLGQPKDQDG FSEMQGERLR PGLDSQKEKL
160 170 180 190 200
PGKMSPKHDG LGTADSVCSR IIQDRVSLGD DVHDCDSHGS GKNPVIQEEE
210 220 230 240 250
NIFKCNECEK VFNKKRLLAR HERIHSGVKP YECTECGKTF SKSTYLLQHH
260 270 280 290 300
MVHTGEKPYK CMECGKAFNR KSHLTQHQRI HSGEKPYKCS ECGKAFTHRS
310 320 330 340 350
TFVLHNRSHT GEKPFVCKEC GKAFRDRPGF IRHYIIHSGE NPYECFECGK
360 370 380 390 400
VFKHRSYLMW HQQTHTGEKP YECSECGKAF CESAALIHHY VIHTGEKPFE
410 420 430 440 450
CLECGKAFNH RSYLKRHQRI HTGEKPYVCS ECGKAFTHCS TFILHKRAHT
460 470 480 490 500
GEKPFECKEC GKAFSNRADL IRHFSIHTGE KPYECMECGK AFNRRSGLTR
510 520 530 540 550
HQRIHSGEKP YECIECGKTF CWSTNLIRHS IIHTGEKPYE CSECGKAFSR
560 570 580 590 600
SSSLTQHQRM HTGRNPISVT DVGRPFTSGQ TSVNIQELLL GKNFLNVTTE
610 620
ENLLQEEASY MASDRTYQRE TPQVSSL
Note: Gene prediction based on similarity to orthologs.
Length:627
Mass (Da):71,143
Last modified:April 5, 2011 - v3
Checksum:iE87A25500E198AD7
GO
Isoform 2 (identifier: Q5CZA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:494
Mass (Da):56,616
Checksum:iAB9EEFEC88DB45A3
GO

Sequence cautioni

The sequence CAI56760 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05745468G → E.Corresponds to variant rs2014572dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0408231 – 133Missing in isoform 2. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297977 mRNA. Translation: BAG60287.1.
AC005261 Genomic DNA. No translation available.
CR936617 mRNA. Translation: CAI56760.1. Different initiation.
CCDSiCCDS46207.1. [Q5CZA5-1]
CCDS46208.1. [Q5CZA5-2]
RefSeqiNP_001018857.2. NM_001023563.3. [Q5CZA5-1]
NP_001138550.1. NM_001145078.1. [Q5CZA5-2]
UniGeneiHs.22488.

Genome annotation databases

EnsembliENST00000354309; ENSP00000365414; ENSG00000204524. [Q5CZA5-2]
ENST00000414468; ENSP00000412999; ENSG00000204524. [Q5CZA5-1]
GeneIDi390980.
KEGGihsa:390980.
UCSCiuc010ygt.3. human. [Q5CZA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297977 mRNA. Translation: BAG60287.1.
AC005261 Genomic DNA. No translation available.
CR936617 mRNA. Translation: CAI56760.1. Different initiation.
CCDSiCCDS46207.1. [Q5CZA5-1]
CCDS46208.1. [Q5CZA5-2]
RefSeqiNP_001018857.2. NM_001023563.3. [Q5CZA5-1]
NP_001138550.1. NM_001145078.1. [Q5CZA5-2]
UniGeneiHs.22488.

3D structure databases

ProteinModelPortaliQ5CZA5.
SMRiQ5CZA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133751. 1 interactor.
STRINGi9606.ENSP00000412999.

PTM databases

iPTMnetiQ5CZA5.
PhosphoSitePlusiQ5CZA5.

Polymorphism and mutation databases

BioMutaiZNF805.
DMDMi327478550.

Proteomic databases

EPDiQ5CZA5.
MaxQBiQ5CZA5.
PaxDbiQ5CZA5.
PeptideAtlasiQ5CZA5.
PRIDEiQ5CZA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354309; ENSP00000365414; ENSG00000204524. [Q5CZA5-2]
ENST00000414468; ENSP00000412999; ENSG00000204524. [Q5CZA5-1]
GeneIDi390980.
KEGGihsa:390980.
UCSCiuc010ygt.3. human. [Q5CZA5-1]

Organism-specific databases

CTDi390980.
DisGeNETi390980.
GeneCardsiZNF805.
HGNCiHGNC:23272. ZNF805.
HPAiHPA057665.
HPA058895.
neXtProtiNX_Q5CZA5.
OpenTargetsiENSG00000204524.
PharmGKBiPA162410601.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5CZA5.
OMAiDDVHDCD.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5CZA5.
TreeFamiTF341817.

Enzyme and pathway databases

BioCyciZFISH:G66-30861-MONOMER.

Miscellaneous databases

GenomeRNAii390980.
PROiQ5CZA5.

Gene expression databases

BgeeiENSG00000204524.
CleanExiHS_ZNF805.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN805_HUMAN
AccessioniPrimary (citable) accession number: Q5CZA5
Secondary accession number(s): B4DNM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.