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Protein
Submitted name:

Malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase

Gene

cgd7_470

Organism
Cryptosporidium parvum (strain Iowa II)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei187 – 1871Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenaseImported
Gene namesi
ORF Names:cgd7_470Imported
OrganismiCryptosporidium parvum (strain Iowa II)Imported
Taxonomic identifieri353152 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaCryptosporidiidaeCryptosporidium
Proteomesi
  • UP000006726 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiCryptoDB:cgd7_470.

Interactioni

Protein-protein interaction databases

STRINGi353152.XP_628237.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HJRX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-328[»]
ProteinModelPortaliQ5CYZ3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5CYZ3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 154139Ldh_1_NInterPro annotationAdd
BLAST
Domaini158 – 322165Ldh_1_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
HOGENOMiHOG000213794.
InParanoidiQ5CYZ3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5CYZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LKKISYKYNT VIMRKKISII GAGQIGSTIA LLLGQKDLGD VYMFDIIEGV
60 70 80 90 100
PQGKALDLNH CMALIGSPAK IFGENNYEYL QNSDVVIITA GVPRKPNMTR
110 120 130 140 150
SDLLTVNAKI VGSVAENVGK YCPNAFVICI TNPLDAMVYY FKEKSGIPAN
160 170 180 190 200
KVCGMSGVLD SARFRCNLSR ALGVKPSDVS AIVVGGHGDE MIPLTSSVTI
210 220 230 240 250
GGILLSDFVE QGKITHSQIN EIIKKTAFGG GEIVELLKTG SAFYAPAASA
260 270 280 290 300
VAMAQAYLKD SKSVLVCSTY LTGQYNVNNL FVGVPVVIGK NGIEDVVIVN
310 320
LSDDEKSLFS KSVESIQNLV QDLKSLNL
Length:328
Mass (Da):35,080
Last modified:April 12, 2005 - v1
Checksum:iAD845C7533C9900F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEE01000001 Genomic DNA. Translation: EAK90670.1.
RefSeqiXP_628237.1. XM_628235.1.

Genome annotation databases

EnsemblProtistsiEAK90670; EAK90670; cgd7_470.
GeneIDi3371767.
KEGGicpv:cgd7_470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEE01000001 Genomic DNA. Translation: EAK90670.1.
RefSeqiXP_628237.1. XM_628235.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HJRX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-328[»]
ProteinModelPortaliQ5CYZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353152.XP_628237.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAK90670; EAK90670; cgd7_470.
GeneIDi3371767.
KEGGicpv:cgd7_470.

Organism-specific databases

EuPathDBiCryptoDB:cgd7_470.

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
HOGENOMiHOG000213794.
InParanoidiQ5CYZ3.

Miscellaneous databases

EvolutionaryTraceiQ5CYZ3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Iowa IIImported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).

Entry informationi

Entry nameiQ5CYZ3_CRYPI
AccessioniPrimary (citable) accession number: Q5CYZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.