Q5CU85 (Q5CU85_CRYPI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

ORF Names:

cgd3_3820 EMBL EAK88972.1

Organism

Cryptosporidium parvum (strain Iowa II) [Complete proteome]

Taxonomic identifier

353152 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Conoidasida › Coccidia › Eucoccidiorida › Eimeriorina › Cryptosporidiidae › Cryptosporidium › Cryptosporidium parvum

Protein attributes

Sequence length	825 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617 EMBL EAK88972.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5CU85 [UniParc]. Last modified April 12, 2005. Version 1. Checksum: 1B9BD6A63ABAF8CA	FASTA	825	93,061
	10 20 30 40 50 60 MTGKCLDSLF NEEDDMNEII ETEDSIIDSK ETIINEKISL DSILGRELMS NVKKDEKRSK 70 80 90 100 110 120 KIKLDSNIQQ KLSFNFGTGN TPSSVNKSKP TKLEKVPENE ESGDSCTKNG SESLSKKIKP 130 140 150 160 170 180 SNAGLFSPFS INITTGDEDI QSPMFDPCNI SKEKIMAKGK SNSILFSVLT DAFSRIEQLK 190 200 210 220 230 240 GSGSGSKKGC IVILANLFRL IIHHNPSDLI DAVYICMNKV APDYEGKESG VGDSILIKCI 250 260 270 280 290 300 SESSDKSEKR IKEDQISGKF EDLGEIAAIC KKQMRLLFEP QRLTIHDVYS DLYSLTEITG 310 320 330 340 350 360 KQSQQLKKDK IKKLLVSGKQ DEVKYIVRFL QGRLRIGIQQ TTVYQALASA FVLTKNIPGD 370 380 390 400 410 420 NLASFSDYRL AKNEKKYKNL QELDCEILEM ETSLRSSLCQ LPNIEKIINV AIQGASSDEI 430 440 450 460 470 480 SAKCKLTTGI PCEPMLARPT KGIQDVLNRF ENFLFTAEYK YDGERAQIHV YKDKSNKRVI 490 500 510 520 530 540 KIFTRNLESA TDRYPDLIQY LNQSLNSSVE DCILDSEVVA YSKSEDKILP FQVLSTRKRK 550 560 570 580 590 600 NVAFDDIQIQ ICLMLFDCMG FNGESLLKKS LFERRQYLRK CINEGQSEYI KFTTSTETNK 610 620 630 640 650 660 LDHLDSFLSE SIENNCEGLM VKTLHDNASY EPSKRSLNWL KIKKDYVDGL TDSIDVVPIA 670 680 690 700 710 720 ACYGKGKRNG VFGTFLLAVY NTEEEVYETV CKAGTGFSDE ILQSLYTSLK DHIIAEGAPK 730 740 750 760 770 780 SYYKFDSSGQ LSSLKQDVWF EPKFVWEVKG ADLSLSPVHT AAIGTIDENR GIGLRFPRFI 790 800 810 820 RIRDDKSPEQ ATSSIQIMEM YNSQLITNNT KNETNFSDDQ FQEDD

References

[1]

"Complete genome sequence of the apicomplexan, Cryptosporidium parvum." Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G., Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P., Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L., Anantharaman V., Aravind L., Kapur V. Science 304:441-445(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Iowa II.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAEE01000004 Genomic DNA. Translation: EAK88972.1.
RefSeq	XP_626929.1. XM_626929.1.
3D structure databases
ProteinModelPortal	Q5CU85.
ModBase	Search...
Protein-protein interaction databases
STRING	5807.cgd3_3820.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3373851.
KEGG	cpv:cgd3_3820.
Organism-specific databases
EuPathDB	CryptoDB:cgd3_3820.
Phylogenomic databases
HOGENOM	HOG000036006.
KO	K10747.
ProtClustDB	CLSZ2495809.
Family and domain databases
Gene3D	1.10.3260.10. 1 hit. 2.40.50.140. 1 hit.
InterPro	IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5CU85_CRYPI

Accession

Primary (citable) accession number: Q5CU85

Entry history

Integrated into UniProtKB/TrEMBL:	April 12, 2005
Last sequence update:	April 12, 2005
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)