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Protein

DNA ligase

Gene

cgd3_3820

Organism
Cryptosporidium parvum (strain Iowa II)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:cgd3_3820Imported
OrganismiCryptosporidium parvum (strain Iowa II)Imported
Taxonomic identifieri353152 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaCryptosporidiidaeCryptosporidium
Proteomesi
  • UP000006726 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiCryptoDB:cgd3_3820

Interactioni

Protein-protein interaction databases

STRINGi353152.XP_626929.1

Structurei

3D structure databases

ProteinModelPortaliQ5CU85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini544 – 681DNA_LIGASE_A3InterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
HOGENOMiHOG000036006
InParanoidiQ5CU85
KOiK10747
OMAiWIKYKRD

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5CU85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKCLDSLF NEEDDMNEII ETEDSIIDSK ETIINEKISL DSILGRELMS
60 70 80 90 100
NVKKDEKRSK KIKLDSNIQQ KLSFNFGTGN TPSSVNKSKP TKLEKVPENE
110 120 130 140 150
ESGDSCTKNG SESLSKKIKP SNAGLFSPFS INITTGDEDI QSPMFDPCNI
160 170 180 190 200
SKEKIMAKGK SNSILFSVLT DAFSRIEQLK GSGSGSKKGC IVILANLFRL
210 220 230 240 250
IIHHNPSDLI DAVYICMNKV APDYEGKESG VGDSILIKCI SESSDKSEKR
260 270 280 290 300
IKEDQISGKF EDLGEIAAIC KKQMRLLFEP QRLTIHDVYS DLYSLTEITG
310 320 330 340 350
KQSQQLKKDK IKKLLVSGKQ DEVKYIVRFL QGRLRIGIQQ TTVYQALASA
360 370 380 390 400
FVLTKNIPGD NLASFSDYRL AKNEKKYKNL QELDCEILEM ETSLRSSLCQ
410 420 430 440 450
LPNIEKIINV AIQGASSDEI SAKCKLTTGI PCEPMLARPT KGIQDVLNRF
460 470 480 490 500
ENFLFTAEYK YDGERAQIHV YKDKSNKRVI KIFTRNLESA TDRYPDLIQY
510 520 530 540 550
LNQSLNSSVE DCILDSEVVA YSKSEDKILP FQVLSTRKRK NVAFDDIQIQ
560 570 580 590 600
ICLMLFDCMG FNGESLLKKS LFERRQYLRK CINEGQSEYI KFTTSTETNK
610 620 630 640 650
LDHLDSFLSE SIENNCEGLM VKTLHDNASY EPSKRSLNWL KIKKDYVDGL
660 670 680 690 700
TDSIDVVPIA ACYGKGKRNG VFGTFLLAVY NTEEEVYETV CKAGTGFSDE
710 720 730 740 750
ILQSLYTSLK DHIIAEGAPK SYYKFDSSGQ LSSLKQDVWF EPKFVWEVKG
760 770 780 790 800
ADLSLSPVHT AAIGTIDENR GIGLRFPRFI RIRDDKSPEQ ATSSIQIMEM
810 820
YNSQLITNNT KNETNFSDDQ FQEDD
Length:825
Mass (Da):93,061
Last modified:April 12, 2005 - v1
Checksum:i1B9BD6A63ABAF8CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEE01000004 Genomic DNA Translation: EAK88972.1
RefSeqiXP_626929.1, XM_626929.1

Genome annotation databases

EnsemblProtistsiEAK88972; EAK88972; cgd3_3820
GeneIDi3373851
KEGGicpv:cgd3_3820

Similar proteinsi

Entry informationi

Entry nameiQ5CU85_CRYPI
AccessioniPrimary (citable) accession number: Q5CU85
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health