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Protein

DNA ligase

Gene

cgd3_3820

Organism
Cryptosporidium parvum (strain Iowa II)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:cgd3_3820Imported
OrganismiCryptosporidium parvum (strain Iowa II)Imported
Taxonomic identifieri353152 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaCryptosporidiidaeCryptosporidium
ProteomesiUP000006726 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiCryptoDB:cgd3_3820.

Interactioni

Protein-protein interaction databases

STRINGi5807.cgd3_3820.

Structurei

3D structure databases

ProteinModelPortaliQ5CU85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiQ5CU85.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5CU85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKCLDSLF NEEDDMNEII ETEDSIIDSK ETIINEKISL DSILGRELMS
60 70 80 90 100
NVKKDEKRSK KIKLDSNIQQ KLSFNFGTGN TPSSVNKSKP TKLEKVPENE
110 120 130 140 150
ESGDSCTKNG SESLSKKIKP SNAGLFSPFS INITTGDEDI QSPMFDPCNI
160 170 180 190 200
SKEKIMAKGK SNSILFSVLT DAFSRIEQLK GSGSGSKKGC IVILANLFRL
210 220 230 240 250
IIHHNPSDLI DAVYICMNKV APDYEGKESG VGDSILIKCI SESSDKSEKR
260 270 280 290 300
IKEDQISGKF EDLGEIAAIC KKQMRLLFEP QRLTIHDVYS DLYSLTEITG
310 320 330 340 350
KQSQQLKKDK IKKLLVSGKQ DEVKYIVRFL QGRLRIGIQQ TTVYQALASA
360 370 380 390 400
FVLTKNIPGD NLASFSDYRL AKNEKKYKNL QELDCEILEM ETSLRSSLCQ
410 420 430 440 450
LPNIEKIINV AIQGASSDEI SAKCKLTTGI PCEPMLARPT KGIQDVLNRF
460 470 480 490 500
ENFLFTAEYK YDGERAQIHV YKDKSNKRVI KIFTRNLESA TDRYPDLIQY
510 520 530 540 550
LNQSLNSSVE DCILDSEVVA YSKSEDKILP FQVLSTRKRK NVAFDDIQIQ
560 570 580 590 600
ICLMLFDCMG FNGESLLKKS LFERRQYLRK CINEGQSEYI KFTTSTETNK
610 620 630 640 650
LDHLDSFLSE SIENNCEGLM VKTLHDNASY EPSKRSLNWL KIKKDYVDGL
660 670 680 690 700
TDSIDVVPIA ACYGKGKRNG VFGTFLLAVY NTEEEVYETV CKAGTGFSDE
710 720 730 740 750
ILQSLYTSLK DHIIAEGAPK SYYKFDSSGQ LSSLKQDVWF EPKFVWEVKG
760 770 780 790 800
ADLSLSPVHT AAIGTIDENR GIGLRFPRFI RIRDDKSPEQ ATSSIQIMEM
810 820
YNSQLITNNT KNETNFSDDQ FQEDD
Length:825
Mass (Da):93,061
Last modified:April 11, 2005 - v1
Checksum:i1B9BD6A63ABAF8CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEE01000004 Genomic DNA. Translation: EAK88972.1.
RefSeqiXP_626929.1. XM_626929.1.

Genome annotation databases

GeneIDi3373851.
KEGGicpv:cgd3_3820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEE01000004 Genomic DNA. Translation: EAK88972.1.
RefSeqiXP_626929.1. XM_626929.1.

3D structure databases

ProteinModelPortaliQ5CU85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5807.cgd3_3820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3373851.
KEGGicpv:cgd3_3820.

Organism-specific databases

EuPathDBiCryptoDB:cgd3_3820.

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiQ5CU85.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Iowa IIImported.

Entry informationi

Entry nameiQ5CU85_CRYPI
AccessioniPrimary (citable) accession number: Q5CU85
Entry historyi
Integrated into UniProtKB/TrEMBL: April 11, 2005
Last sequence update: April 11, 2005
Last modified: January 6, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.