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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

Chro.20028

Organism
Cryptosporidium hominis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321SubstrateUniRule annotation
Active sitei216 – 2161Proton acceptorUniRule annotation

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]UniRule annotation (EC:1.1.1.8UniRule annotation)
Gene namesi
ORF Names:Chro.20028Imported
OrganismiCryptosporidium hominisImported
Taxonomic identifieri237895 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaCryptosporidiidaeCryptosporidium
ProteomesiUP000002426: Unassembled WGS sequence

Organism-specific databases

EuPathDBiCryptoDB:Chro.20028.

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi237895.Q5CI42.

Structurei

3D structure databases

ProteinModelPortaliQ5CI42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni283 – 2842Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0240.
InParanoidiQ5CI42.
KOiK00006.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5CI42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCLRQHLRCS SLKVTIFGAG SFGSAISCVV GYNTERTLIF NSEVKLWLYD
60 70 80 90 100
EQLESGEYLA DVINRDHVNV KYLPDFKLPN NVRAVTDLKE ACEDCNLMIF
110 120 130 140 150
VIPSQFIRSV ASQIRKLDID FSRAVRAVSL TKGFLVENGH PFLISKIIEE
160 170 180 190 200
ELGIDCCVLS GANVASGLAA KEFGEATLAC SDYDDAYIWQ YLFDTPWFKI
210 220 230 240 250
DCVPDVICTE LFGGLKNIIA LLVGMIQGLG CGTNTVAAVM RLGVLEMILY
260 270 280 290 300
GSIFFNIRSS IMTRVFFESC GIADLVTTCL GGRNVRGGKA FTLSNGQKPW
310 320 330 340 350
EEIEAEVTGG QHLAGLVTLK EINETLEVLL IEKSIDVDKH FPLFRSCFKI
360 370 380 390 400
AYTGTPPRSL IDILGRNELR ELRFVPSGLL SLIDDSPNHG EVMQRSSSRQ
410
VGSLILSKTQ SCMQYE
Length:416
Mass (Da):46,065
Last modified:April 12, 2005 - v1
Checksum:i26571E1CAB97C261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEL01000202 Genomic DNA. Translation: EAL36273.1.
RefSeqiXP_666504.1. XM_661412.1.

Genome annotation databases

GeneIDi3413727.
KEGGicho:Chro.20028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEL01000202 Genomic DNA. Translation: EAL36273.1.
RefSeqiXP_666504.1. XM_661412.1.

3D structure databases

ProteinModelPortaliQ5CI42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi237895.Q5CI42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3413727.
KEGGicho:Chro.20028.

Organism-specific databases

EuPathDBiCryptoDB:Chro.20028.

Phylogenomic databases

eggNOGiCOG0240.
InParanoidiQ5CI42.
KOiK00006.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TU502Imported.

Entry informationi

Entry nameiQ5CI42_CRYHO
AccessioniPrimary (citable) accession number: Q5CI42
Entry historyi
Integrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: February 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.