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Protein

TBC1 domain family member 14

Gene

Tbc1d14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of starvation-induced autophagosome formation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 14
Alternative name(s):
Spermatogenesis-related factor 2
Short name:
SRF-2
Up-regulated in nephrectomized rat kidney #2
Gene namesi
Name:Tbc1d14
ORF Names:UR-NR#2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309993. Tbc1d14.

Subcellular locationi

  • Golgi apparatuscis-Golgi network By similarity
  • Golgi apparatustrans-Golgi network By similarity

  • Note: After amino acid starvation, Golgi apparatus-associated protein levels increase compared with fed conditions. May be cycling between the Golgi apparatus and an endosomal pool, redistributing to the Golgi apparatus upon starvation (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694TBC1 domain family member 14PRO_0000319418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921PhosphoserineBy similarity
Modified residuei296 – 2961PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5CD77.
PRIDEiQ5CD77.

PTM databases

PhosphoSiteiQ5CD77.

Expressioni

Tissue specificityi

PubMed:15758561 detected expression at the stage of sexual maturation in testis, mainly in the spermatocytes. No expression detected in the ovary, brain, heart, lung, liver and kidney. PubMed:15200410 detected expression in brain, heart, lung, liver, spleen and kidney but not in small intestine.2 Publications

Developmental stagei

First detected in the testis at 5 weeks. Level of expression increases up to 7 weeks and maintains even at 63 weeks.1 Publication

Inductioni

Up-regulated in nephrectomized kidney.1 Publication

Interactioni

Subunit structurei

Interacts with ULK1. May interact with RAB11A and RAB11B, but does not exhibit any GTPase-activating activity toward these proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055215.

Structurei

3D structure databases

ProteinModelPortaliQ5CD77.
SMRiQ5CD77. Positions 372-680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini402 – 612211Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2223. Eukaryota.
COG5210. LUCA.
HOGENOMiHOG000016604.
HOVERGENiHBG061665.
InParanoidiQ5CD77.
KOiK20167.
PhylomeDBiQ5CD77.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5CD77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDGNLSTSM NGVALMGILD GRPGDSLQEL QHLSIKAVPR SLSVPDYGPT
60 70 80 90 100
LKLGALEDRH SLQSVDSGIP TLEIGNPEPV PCSVVHVKRK QSESEIIPER
110 120 130 140 150
AFQSACPLPS CTPSAPTGSE REQAVRKSST FPRTGYDSVK LYSPTSKALS
160 170 180 190 200
RSDDVSVCSV SSLGTELSTT LSVSNEDILD LMVTSNSSAI VTLENDDDPQ
210 220 230 240 250
FTDVTLSSIK ETSDLHQQDC VAETEEGRKL RLLQPFSHFF TRNLLARKQN
260 270 280 290 300
ARLDRQRDLG WKLFGKVPLR ETAQKDSKKT QKEYEDKAGR PSRPPSPKQN
310 320 330 340 350
VRKNLDFEPL STTALILEDR PANLPAKPAE EAQKHRQQYE EMVVQAKKRE
360 370 380 390 400
LKEAQRRKKQ LEERCKVEES IGNAVLTWNN EILPNWETMW CSKKVRDLWW
410 420 430 440 450
QGIPPSVRGK VWSLAIGNEL NITHELFDIC LARAKERWRS LSTGGSEVEN
460 470 480 490 500
EDAGFSAADR EASLELIKLD ISRTFPNLCI FQQGGPYHDM LHSILGAYTC
510 520 530 540 550
YRPDVGYVQG MSFIAAVLIL NLDTADAFIA FSNLLNKPCQ MAFFRVDHGL
560 570 580 590 600
MLTYFAAFEV FFEENLPKLF AHFKKNNLTA DIYLIDWIFT LYSKSLPLDL
610 620 630 640 650
ACRIWDVFCR DGEEFLFRTA LGILKLFEDI LTRMDFIHSA QFLTRLPEDL
660 670 680 690
PADDVFAAIS TVQMQSRNKK WAQVLSALQK DSREMEEGSP SVRD
Length:694
Mass (Da):78,209
Last modified:February 26, 2008 - v2
Checksum:i6DAE2A6B5F47AA1F
GO

Sequence cautioni

The sequence AAH99760 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD23893 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD91010 differs from that shown. Reason: Frameshift at position 645. Curated
The sequence BAD91010 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2825KKTQK → GLASM in BAD23893 (PubMed:15200410).Curated
Sequence conflicti304 – 3041N → S in BAD23893 (PubMed:15200410).Curated
Sequence conflicti416 – 4161I → M in BAD23893 (PubMed:15200410).Curated
Sequence conflicti420 – 4201L → V in BAD23893 (PubMed:15200410).Curated
Sequence conflicti431 – 4311L → F in BAD23893 (PubMed:15200410).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117752 mRNA. Translation: BAD91010.1. Sequence problems.
BC099760 mRNA. Translation: AAH99760.1. Different initiation.
AB108668 mRNA. Translation: BAD23893.1. Different initiation.
RefSeqiNP_001012152.2. NM_001012152.2.
NP_001029193.2. NM_001034021.2.
NP_001106836.1. NM_001113365.1.
UniGeneiRn.203187.

Genome annotation databases

GeneIDi360956.
KEGGirno:360956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB117752 mRNA. Translation: BAD91010.1. Sequence problems.
BC099760 mRNA. Translation: AAH99760.1. Different initiation.
AB108668 mRNA. Translation: BAD23893.1. Different initiation.
RefSeqiNP_001012152.2. NM_001012152.2.
NP_001029193.2. NM_001034021.2.
NP_001106836.1. NM_001113365.1.
UniGeneiRn.203187.

3D structure databases

ProteinModelPortaliQ5CD77.
SMRiQ5CD77. Positions 372-680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055215.

PTM databases

PhosphoSiteiQ5CD77.

Proteomic databases

PaxDbiQ5CD77.
PRIDEiQ5CD77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360956.
KEGGirno:360956.

Organism-specific databases

CTDi57533.
RGDi1309993. Tbc1d14.

Phylogenomic databases

eggNOGiKOG2223. Eukaryota.
COG5210. LUCA.
HOGENOMiHOG000016604.
HOVERGENiHBG061665.
InParanoidiQ5CD77.
KOiK20167.
PhylomeDBiQ5CD77.

Miscellaneous databases

PROiQ5CD77.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBC14_RAT
AccessioniPrimary (citable) accession number: Q5CD77
Secondary accession number(s): Q499U3, Q6I7R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.