Reviewed,
UniProtKB/Swiss-Prot Q5CD18 (TGFR1_PIG)
Last modified
February 9, 2010.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (1) |
 Third-party data |
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Names and origin
| Protein names | Recommended name: TGF-beta receptor type-1 Short name=TGFR-1 EC=2.7.11.30 Alternative name(s): Transforming growth factor-beta receptor type I Short name=TGF-beta receptor type I Short name=TbetaR-I TGF-beta type I receptor | ||
| Gene names |
| ||
| Organism | Sus scrofa (Pig) | ||
| Taxonomic identifier | 9823 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Protein attributes
| Sequence length | 503 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta By similarity. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subunit structure | Interacts with CD109 and RBPMS. The unphosphorylated protein interacts with FKBP1A and is stabilized the inactive conformation. Phosphorylation of the GS region abrogates FKBP1A binding. Interacts with SMAD2 when phosphorylated on several residues in the GS region. Interacts with TRAF6 By similarity. |
| Subcellular location | Membrane; Single-pass type I membrane protein By similarity. |
| Post-translational modification | Phosphorylated at basal levels in the absence of ligand binding. Activated by multiple phosphorylation, mainly in the GS region By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW manganese ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q5CD18-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q5CD18-2) The sequence of this isoform differs from the canonical sequence as follows: 111-114: Missing. | ||||||
| Note: May be due to a competing donnor splice site. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 29 | 29 | Potential | ||||||
| Chain | 30 – 503 | 474 | TGF-beta receptor type-1 | PRO_0000260305 | |||||
Regions | |||||||||
| Topological domain | 30 – 126 | 97 | Extracellular Potential | ||||||
| Transmembrane | 127 – 147 | 21 | Potential | ||||||
| Topological domain | 148 – 503 | 356 | Cytoplasmic Potential | ||||||
| Domain | 175 – 204 | 30 | GS | ||||||
| Domain | 205 – 495 | 291 | Protein kinase | ||||||
| Nucleotide binding | 211 – 219 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 333 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 232 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 165 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 185 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 186 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 187 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 189 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 191 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 41 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 111 – 114 | 4 | Missing in isoform 2. | VSP_021594 | |||||
| Natural variant | 8 | 1 | P → S | ||||||
| Natural variant | 417 | 1 | I → V | ||||||
Sequences
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References
| [1] | "Structure and polymorphism analysis of transforming growth factor beta receptor 1 (TGFBR1) in pigs." Shimanuki S., Mikawa A., Miyake Y., Hamasima N., Mikawa S., Awata T. Biochem. Genet. 43:491-500(2005) [PubMed: 16341765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS SER-8 AND VAL-417. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB182259 mRNA. Translation: BAD91022.1. AB182260 mRNA. Translation: BAD91023.1. |
| RefSeq | NP_001033728.1. |
| UniGene | Ssc.23794 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAS based on UniProtKB P36897. |
| SMR | Q5CD18. Positions 29-107, 171-500. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSSSCT00000005922; ENSSSCP00000005775; ENSSSCG00000005382; Sus scrofa. [Genome view] |
| GeneID | 396665. |
| KEGG | ssc:396665. |
Organism-specific databases | |
| CTD | 396665. |
Phylogenomic databases | |
| HOVERGEN | Q5CD18. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.30. 249. |
Family and domain databases | |
| InterPro | IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view] |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view] |
| SMART | SM00467. GS. 1 hit. [Graphical view] |
| PROSITE | PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TGFR1_PIG | ||||||||
| Accession | Primary (citable) accession number: Q5CD18 Secondary accession number(s): Q5CD19 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
