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Protein

Nucleolar MIF4G domain-containing protein 1

Gene

NOM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in targeting PPP1CA to the nucleolus.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar MIF4G domain-containing protein 1
Alternative name(s):
SGD1 homolog
Gene namesi
Name:NOM1
Synonyms:C7orf3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13244. NOM1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi308 – 3081V → A: Loss of interaction with PPP1CA and loss of ability to relocalize PPP1CA to the nucleolus; when associated with A-310. 1 Publication
Mutagenesisi310 – 3101F → A: Loss of interaction with PPP1CA and loss of ability to relocalize PPP1CA to the nucleolus; when associated with A-308. 1 Publication

Organism-specific databases

PharmGKBiPA25946.

Polymorphism and mutation databases

BioMutaiNOM1.
DMDMi74707675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Nucleolar MIF4G domain-containing protein 1PRO_0000286823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571PhosphoserineCombined sources
Modified residuei139 – 1391PhosphoserineCombined sources
Modified residuei317 – 3171PhosphoserineCombined sources
Modified residuei320 – 3201PhosphoserineCombined sources
Modified residuei321 – 3211PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5C9Z4.
MaxQBiQ5C9Z4.
PaxDbiQ5C9Z4.
PeptideAtlasiQ5C9Z4.
PRIDEiQ5C9Z4.

PTM databases

iPTMnetiQ5C9Z4.
PhosphoSiteiQ5C9Z4.

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ5C9Z4.
CleanExiHS_NOM1.
GenevisibleiQ5C9Z4. HS.

Organism-specific databases

HPAiHPA019866.
HPA051624.

Interactioni

Subunit structurei

May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF4A3P389193EBI-2685618,EBI-299104

Protein-protein interaction databases

BioGridi122182. 15 interactions.
IntActiQ5C9Z4. 30 interactions.
MINTiMINT-1185381.
STRINGi9606.ENSP00000275820.

Structurei

3D structure databases

ProteinModelPortaliQ5C9Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini362 – 559198MIF4GPROSITE-ProRule annotationAdd
BLAST
Domaini654 – 770117MIPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 269269Necessary for nucleolar localization and for targeting PPP1CA to the nucleolusAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi307 – 3104Required for efficient binding to PPP1CA and for targeting PPP1CA to the nucleolus

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi237 – 32286Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the CWC22 family.Curated
Contains 1 MI domain.PROSITE-ProRule annotation
Contains 1 MIF4G domain.Curated

Phylogenomic databases

eggNOGiKOG2141. Eukaryota.
ENOG410XNNQ. LUCA.
GeneTreeiENSGT00550000075087.
HOGENOMiHOG000044155.
HOVERGENiHBG098839.
InParanoidiQ5C9Z4.
KOiK17583.
OMAiRLQKQCK.
OrthoDBiEOG7SR4M4.
PhylomeDBiQ5C9Z4.
TreeFamiTF312808.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51366. MI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5C9Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASRSAGEA GPGGSQGRVV RMKRRGGRGP RRGPAGGGEK ALKRLKLAVE
60 70 80 90 100
EFVHATSEGE APGGCEGRGA PVSFRPGGRK SRKELRKEKR HLRKARRLQR
110 120 130 140 150
TAGPEQGPGL GGRSGAEEAS GHRQDTEERA RPAPSRDPSP PRKPRPSRVK
160 170 180 190 200
AKATAATAKT RPSAAATAAA RKRALLAANE EEDREIRKLE RCLGLNKRKK
210 220 230 240 250
KDGSSSVPLS FARDGLDYIL GALESGKNSG LYDSSGEEEE DAGQTLPESD
260 270 280 290 300
LESDSQDESE EEEEGDVEKE KKAQEAEAQS EDDDEDTEEE QGEEKEKGAQ
310 320 330 340 350
EKRRGKRVRF AEDEEKSENS SEDGDITDKS LCGSGEKYIP PHVRQAEETV
360 370 380 390 400
DFKKKEELER LKKHVKGLLN RLSEPNMASI SGQLEELYMA HSRKDMNDTL
410 420 430 440 450
TSALMGACVT ASAMPSRLMM EHVLLVSILH HTVGIEVGAH FLEAVVRKFD
460 470 480 490 500
AIYKYGSEGK ECDNLFTVIA HLYNFHVVQS LLIFDILKKL IGTFTEKDIE
510 520 530 540 550
LILLMLKNVG FSLRKDDALS LKELITEAQT KASGAGSEFQ DQTRIRFMLE
560 570 580 590 600
TMLALKNNDM RKIPGYDPEP VEKLRKLQRA LVRNAGSGSE TQLRVSWDSV
610 620 630 640 650
LSAEQTGRWW IVGSAWSGAP MIDNSHHTHL QKQLVGTVSS KILELARKQR
660 670 680 690 700
MNTDIRRNIF CTIMTSEDFL DAFEKLLKLG LKDQQEREII HVLMDCCLQE
710 720 730 740 750
KTYNPFYAFL ASKFCEYERR FQMTFQFSIW DKFRDLENLP ATNFSNLVHL
760 770 780 790 800
VAHLLKTKSL SLSILKVVEF SELDKPRVRF LRKVLSILLM ETEVEDLSLI
810 820 830 840 850
FTRVSDNPKL GVLREGLKLF ISHFLLKNAQ AHRSADEANV LREKADLATK
860
CLQGKASLRM
Length:860
Mass (Da):96,257
Last modified:April 12, 2005 - v1
Checksum:iD4FAB8FB9AC3B5C9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241R → G.
Corresponds to variant rs6969990 [ dbSNP | Ensembl ].
VAR_061999
Natural varianti122 – 1221H → P.
Corresponds to variant rs6952214 [ dbSNP | Ensembl ].
VAR_032187
Natural varianti723 – 7231M → V.
Corresponds to variant rs12919 [ dbSNP | Ensembl ].
VAR_053051
Natural varianti779 – 7791R → H.
Corresponds to variant rs2302445 [ dbSNP | Ensembl ].
VAR_032188
Natural varianti804 – 8041V → L.
Corresponds to variant rs2302443 [ dbSNP | Ensembl ].
VAR_032189
Natural varianti812 – 8121V → M.
Corresponds to variant rs12919 [ dbSNP | Ensembl ].
VAR_032190

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY576779 mRNA. Translation: AAT39521.1.
AF107455 mRNA. No translation available.
BC007902 mRNA. Translation: AAH07902.2.
CCDSiCCDS34787.1.
RefSeqiNP_612409.1. NM_138400.1.
UniGeneiHs.15825.

Genome annotation databases

EnsembliENST00000275820; ENSP00000275820; ENSG00000146909.
GeneIDi64434.
KEGGihsa:64434.
UCSCiuc003wmy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY576779 mRNA. Translation: AAT39521.1.
AF107455 mRNA. No translation available.
BC007902 mRNA. Translation: AAH07902.2.
CCDSiCCDS34787.1.
RefSeqiNP_612409.1. NM_138400.1.
UniGeneiHs.15825.

3D structure databases

ProteinModelPortaliQ5C9Z4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122182. 15 interactions.
IntActiQ5C9Z4. 30 interactions.
MINTiMINT-1185381.
STRINGi9606.ENSP00000275820.

PTM databases

iPTMnetiQ5C9Z4.
PhosphoSiteiQ5C9Z4.

Polymorphism and mutation databases

BioMutaiNOM1.
DMDMi74707675.

Proteomic databases

EPDiQ5C9Z4.
MaxQBiQ5C9Z4.
PaxDbiQ5C9Z4.
PeptideAtlasiQ5C9Z4.
PRIDEiQ5C9Z4.

Protocols and materials databases

DNASUi64434.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275820; ENSP00000275820; ENSG00000146909.
GeneIDi64434.
KEGGihsa:64434.
UCSCiuc003wmy.3. human.

Organism-specific databases

CTDi64434.
GeneCardsiNOM1.
HGNCiHGNC:13244. NOM1.
HPAiHPA019866.
HPA051624.
MIMi611269. gene.
neXtProtiNX_Q5C9Z4.
PharmGKBiPA25946.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2141. Eukaryota.
ENOG410XNNQ. LUCA.
GeneTreeiENSGT00550000075087.
HOGENOMiHOG000044155.
HOVERGENiHBG098839.
InParanoidiQ5C9Z4.
KOiK17583.
OMAiRLQKQCK.
OrthoDBiEOG7SR4M4.
PhylomeDBiQ5C9Z4.
TreeFamiTF312808.

Miscellaneous databases

ChiTaRSiNOM1. human.
GeneWikiiNOM1.
GenomeRNAii64434.
PROiQ5C9Z4.
SOURCEiSearch...

Gene expression databases

BgeeiQ5C9Z4.
CleanExiHS_NOM1.
GenevisibleiQ5C9Z4. HS.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51366. MI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia."
    Simmons H.M., Ruis B.L., Kapoor M., Hudacek A.W., Conklin K.F.
    Gene 347:137-145(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE INTERACTION WITH EIF4A1; EIF4A2 AND EIF4A3, SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 180-860, TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 566-860.
    Tissue: Muscle.
  4. Cited for: FUNCTION, INTERACTION WITH PPP1CA AND PPP1CC, SUBCELLULAR LOCATION, MUTAGENESIS OF VAL-308 AND PHE-310.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-320 AND SER-321, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-320 AND SER-321, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-320 AND SER-321, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57 AND SER-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiNOM1_HUMAN
AccessioniPrimary (citable) accession number: Q5C9Z4
Secondary accession number(s): Q96I08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: April 12, 2005
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.