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Protein

UPF0691 protein C9orf116

Gene

C9orf116

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0691 protein C9orf116
Alternative name(s):
p53-induced expression in RB-null cells protein 1
Short name:
Pierce1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28435. C9orf116.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878696.

Polymorphism and mutation databases

BioMutaiC9orf116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136UPF0691 protein C9orf116PRO_0000089728Add
BLAST

Proteomic databases

PaxDbiQ5BN46.
PeptideAtlasiQ5BN46.
PRIDEiQ5BN46.

PTM databases

iPTMnetiQ5BN46.
PhosphoSiteiQ5BN46.

Expressioni

Developmental stagei

May be up-regulated during progression from G1 to S phase of the cell cycle. Maximal expression in S or G2 phase.1 Publication

Gene expression databases

BgeeiENSG00000160345.
CleanExiHS_C9orf116.
ExpressionAtlasiQ5BN46. baseline and differential.
GenevisibleiQ5BN46. HS.

Organism-specific databases

HPAiHPA021439.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136433EBI-10243636,EBI-741101

Protein-protein interaction databases

BioGridi126503. 2 interactions.
IntActiQ5BN46. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5BN46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0691 family.Curated

Phylogenomic databases

eggNOGiENOG410IX5S. Eukaryota.
ENOG4111ZK1. LUCA.
GeneTreeiENSGT00510000049377.
HOGENOMiHOG000111655.
HOVERGENiHBG055120.
InParanoidiQ5BN46.
OMAiFHPSYNV.
OrthoDBiEOG091G15IX.
PhylomeDBiQ5BN46.
TreeFamiTF323876.

Family and domain databases

InterProiIPR026507. UPF0691.
[Graphical view]
PANTHERiPTHR20899. PTHR20899. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BN46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEECPRACA EPVAPKATAP PERTSDYYRV SADLPGRFNN PGWFRGYRTQ
60 70 80 90 100
KAVSVYRTSN QAYGSRAPTV HEMPKVFYPN SNKFSQQLAA GGMFRNNTLN
110 120 130
VYLEKSIVTG PDNCITSCDR LNFHPSYNIN RPSICD
Length:136
Mass (Da):15,260
Last modified:April 12, 2005 - v1
Checksum:i40EF2889FC52E775
GO
Isoform 2 (identifier: Q5BN46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-92: KVFYPNSNKFSQQLAAGG → RVECSGTILSMFTWRKAS
     93-136: Missing.

Show »
Length:92
Mass (Da):10,318
Checksum:iCC7E80830492B1AC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 9218KVFYP…LAAGG → RVECSGTILSMFTWRKAS in isoform 2. 1 PublicationVSP_014466Add
BLAST
Alternative sequencei93 – 13644Missing in isoform 2. 1 PublicationVSP_014467Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY927868 mRNA. Translation: AAX22217.1.
AL161452 Genomic DNA. Translation: CAI14049.1.
AL161452 Genomic DNA. Translation: CAI14048.1.
BC021261 mRNA. Translation: AAH21261.1.
CCDSiCCDS43899.1. [Q5BN46-1]
CCDS6989.1. [Q5BN46-2]
RefSeqiNP_001041730.1. NM_001048265.1. [Q5BN46-1]
NP_653255.1. NM_144654.2. [Q5BN46-2]
UniGeneiHs.414028.

Genome annotation databases

EnsembliENST00000371789; ENSP00000360854; ENSG00000160345. [Q5BN46-2]
ENST00000371791; ENSP00000360856; ENSG00000160345. [Q5BN46-2]
ENST00000429260; ENSP00000395281; ENSG00000160345. [Q5BN46-1]
GeneIDi138162.
KEGGihsa:138162.
UCSCiuc004cfs.2. human. [Q5BN46-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY927868 mRNA. Translation: AAX22217.1.
AL161452 Genomic DNA. Translation: CAI14049.1.
AL161452 Genomic DNA. Translation: CAI14048.1.
BC021261 mRNA. Translation: AAH21261.1.
CCDSiCCDS43899.1. [Q5BN46-1]
CCDS6989.1. [Q5BN46-2]
RefSeqiNP_001041730.1. NM_001048265.1. [Q5BN46-1]
NP_653255.1. NM_144654.2. [Q5BN46-2]
UniGeneiHs.414028.

3D structure databases

ProteinModelPortaliQ5BN46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126503. 2 interactions.
IntActiQ5BN46. 1 interaction.

PTM databases

iPTMnetiQ5BN46.
PhosphoSiteiQ5BN46.

Polymorphism and mutation databases

BioMutaiC9orf116.

Proteomic databases

PaxDbiQ5BN46.
PeptideAtlasiQ5BN46.
PRIDEiQ5BN46.

Protocols and materials databases

DNASUi138162.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371789; ENSP00000360854; ENSG00000160345. [Q5BN46-2]
ENST00000371791; ENSP00000360856; ENSG00000160345. [Q5BN46-2]
ENST00000429260; ENSP00000395281; ENSG00000160345. [Q5BN46-1]
GeneIDi138162.
KEGGihsa:138162.
UCSCiuc004cfs.2. human. [Q5BN46-1]

Organism-specific databases

CTDi138162.
GeneCardsiC9orf116.
HGNCiHGNC:28435. C9orf116.
HPAiHPA021439.
MIMi614502. gene.
neXtProtiNX_Q5BN46.
PharmGKBiPA134878696.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX5S. Eukaryota.
ENOG4111ZK1. LUCA.
GeneTreeiENSGT00510000049377.
HOGENOMiHOG000111655.
HOVERGENiHBG055120.
InParanoidiQ5BN46.
OMAiFHPSYNV.
OrthoDBiEOG091G15IX.
PhylomeDBiQ5BN46.
TreeFamiTF323876.

Miscellaneous databases

GenomeRNAii138162.
PROiQ5BN46.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160345.
CleanExiHS_C9orf116.
ExpressionAtlasiQ5BN46. baseline and differential.
GenevisibleiQ5BN46. HS.

Family and domain databases

InterProiIPR026507. UPF0691.
[Graphical view]
PANTHERiPTHR20899. PTHR20899. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCI116_HUMAN
AccessioniPrimary (citable) accession number: Q5BN46
Secondary accession number(s): Q5T897, Q8WU44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.