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Q5BMR2 (PLD_PHYIN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospholipase D
EC=3.1.4.4
Alternative name(s):
PiPLD1
Gene names
Name:PLD
OrganismPhytophthora infestans (Potato late blight fungus)
Taxonomic identifier4787 [NCBI]
Taxonomic lineageEukaryota › stramenopiles › Oomycetes › Peronosporales › Phytophthora

Protein attributes

Sequence length1807 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.

Catalytic activity

A phosphatidylcholine + H2O = choline + a phosphatidate.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the phospholipase D family. TM-PLD subfamily.

Contains 2 PLD phosphodiesterase domains.

Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological processglycerophospholipid catabolic process

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular componentintegral to membrane

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular functionNAPE-specific phospholipase D activity

Inferred from electronic annotation. Source: EC

phospholipase D activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18071807Phospholipase D
PRO_0000239465

Regions

Transmembrane257 – 27721Helical; Potential
Transmembrane305 – 32521Helical; Potential
Transmembrane587 – 60721Helical; Potential
Domain853 – 88028PLD phosphodiesterase 1
Domain1249 – 127628PLD phosphodiesterase 2

Sites

Active site8581 Potential
Active site8601 Potential
Active site8651 Potential
Active site12541 Potential
Active site12561 Potential
Active site12611 Potential

Sequences

Sequence LengthMass (Da)Tools
Q5BMR2 [UniParc].

Last modified April 12, 2005. Version 1.
Checksum: A3F18D62F52E0A56

FASTA1,807203,320
        10         20         30         40         50         60 
MPGPDDDVRE PTAAARTNNS GYGLRAAPSS ITSGLDSVVS VNSYRSSELN AEEVNVDDQE 

        70         80         90        100        110        120 
CADSDILESP NDGMTIMNDD DADLSEEEEE VMENSIDFSV NRATVTKAGV IPCCVFVGRV 

       130        140        150        160        170        180 
RWGTTDWEIY FGQKQLLRLH FNLHLYSLFN RHKLLRGVHL PCTIWREKRA EKRVMDVYVV 

       190        200        210        220        230        240 
QDYIRQLLKD RDLRNSEPLL SFLEVSPSRA MLRLGPSLKE GYVHMRINGP FQLPLYTCFN 

       250        260        270        280        290        300 
RTIEALYRHL YRAWMRIAFV SAIVGFIFPI CLVIVTSLPT FFSPQKELVN SDSGTKEVST 

       310        320        330        340        350        360 
KLNTAGVFLG LAVLGGILFF AVFVYKFFQH RLGVIRRWVV LKPSCFAAYR NRNDREPSEV 

       370        380        390        400        410        420 
FLFDKNFTAR KGSYRQGVSW MPSGLVVGSK AGDIEIDTGH YYTRLTAFVA LMGVCYGIMR 

       430        440        450        460        470        480 
LSNSIYDFEY LSLDKSMGVP ITNASGYENW TESRDAEYCG YYFIVPKGTT VYVESKDDSA 

       490        500        510        520        530        540 
VISQLQMPSS NSMTANLGFF WQSDSMGYSL NVITNAVGAG TMVSVVKPID AKNDRFFESG 

       550        560        570        580        590        600 
TNYSMPTVGN LTLEGVKTDI DVQSFSNVES FCAITVRIAP LTWRSYVYYI LFLFAGGIIA 

       610        620        630        640        650        660 
PVVGFLANYF VTYLGIWHPH VRRDHWFRCV RRLQKLKRQE TSTRFNSFAP QHISTIDDDE 

       670        680        690        700        710        720 
SATITAKAKA AKLAIGNTPT SNINQVVDSV VKQEAETASR MGTGNLAPAS SRVDSSTQSE 

       730        740        750        760        770        780 
DSFEAPKPPP SSVSWHVDAE DTYAAMYKAI SNAKYEILIA GWWVCPDLFL LRPGRKLPPR 

       790        800        810        820        830        840 
EADEDPDGQQ VNKTMLRQVL MKKAEAGVKI YVLIYREVKL ALTLNSAYTK RSLMVHPNIR 

       850        860        870        880        890        900 
VLRDPIFQIQ SLGFWSHHEK IVCIDQSLAF VGGLDLCFGR YDHHGHPISD PSDDPVWTGK 

       910        920        930        940        950        960 
DYSNPIIKDF VRVNKPFEDL IDRASQPRMP WHDVHCSISG PPVQDVAYHL IQRWNFVCSK 

       970        980        990       1000       1010       1020 
NDYQLRTGWC ICFRSRRFKF LPKCLVPMDF NGWTLQYPSS DPEPMRDGST RTTIPLVRED 

      1030       1040       1050       1060       1070       1080 
SLSMVEPFQV VQSVNPMYPC TATGPQWPPT SSLHPINPMR PPLTSASTTT GPLDDGEVLR 

      1090       1100       1110       1120       1130       1140 
AQRGESILQV FHPSANICNI QVCRSVSMWS AGVPTEASIQ AAYMDVIANS KHFLYIENQF 

      1150       1160       1170       1180       1190       1200 
FVSGMDGNGI VRNRILQALV DRIERAVQRD EKFRVYVVMP LLPAFEGNIR SHELTNLHAV 

      1210       1220       1230       1240       1250       1260 
MHWQFATICR GRYSLFEALK GVTNHPENYV AFFGLRKYGI MPNGCAATEQ IYIHSKLMIA 

      1270       1280       1290       1300       1310       1320 
DDRCAILGSA NINDRSMNGD RDSEIALVIE DMQYEDGVMN EKPYRRGVAA SKLRLQLFRE 

      1330       1340       1350       1360       1370       1380 
HLGLADDDLS VADPTSDHTW QAIKSTASSN TKIFEAVFDC APSNRMRAFV NFQSIEVTQI 

      1390       1400       1410       1420       1430       1440 
FENQRMNVLK VPGRSHVWDA QNLKDGDYAP WTDVNGVPIA ADRVDLRDFE VDNYRDKKKK 

      1450       1460       1470       1480       1490       1500 
LFSMDHDGWC YARNFSIFQE VRTMKTDYKK REKLQHLVAD RLMAQVRRRR WVKKGLLPPR 

      1510       1520       1530       1540       1550       1560 
DPRESSFSLA SDDEEHGRFY SLWRRLQQGD FSRSNSVSTP TNFSQLDTDG GISGSVSVGG 

      1570       1580       1590       1600       1610       1620 
TNHGRRLYNS NSMPSNASIL GDNPTTRPPV LGDAPSYPNS PSVASFQHTP QSPAIATGAR 

      1630       1640       1650       1660       1670       1680 
SVRSARTSSL LCTGAGVRTR GNTRSARGSF YGMFSVTGNR NLDTDDESSD AGSEYGGGHG 

      1690       1700       1710       1720       1730       1740 
IRASLKRWYS TMDVLDFGRR SKFNAEYFDT DEDHLHSDDP LLEDGRGSYH AATREGLLTE 

      1750       1760       1770       1780       1790       1800 
EAVEGSDDED AECQIGHVQT AATVRKEDET RARAQLSEIR GHLVEFPLDF LVEEILKPSV 


LPADIHI

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References

[1]"A transmembrane phospholipase D in Phytophthora; a novel PLD subfamily."
Meijer H.J.G., Latijnhouwers M., Ligterink W., Govers F.
Gene 350:173-182(2005) [PubMed: 15826868] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY929154 Genomic DNA. Translation: AAX28839.1.

3D structure databases

ProteinModelPortalQ5BMR2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR015679. PLipase_D.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERPTHR18896. Phospholipase_D. 1 hit.
PfamPF00614. PLDc. 1 hit.
[Graphical view]
SMARTSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLD_PHYIN
AccessionPrimary (citable) accession number: Q5BMR2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: April 12, 2005
Last modified: October 19, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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