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Protein

Venom acid phosphatase Acph-1

Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei26NucleophileBy similarity1
Active sitei273Proton donorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.3.2. 387.

Names & Taxonomyi

Protein namesi
Recommended name:
Venom acid phosphatase Acph-1 (EC:3.1.3.2)
Alternative name(s):
Allergen: Api m 3
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei2778. Api m A1-A2-A3.
3090. Api m 3.0101.
47. Api m 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_500009534116 – 388Venom acid phosphatase Acph-1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi145 ↔ 355By similarity
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi330 ↔ 334By similarity
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5BLY5.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Protein-protein interaction databases

STRINGi7460.GB12546-PA.

Structurei

3D structure databases

ProteinModelPortaliQ5BLY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
InParanoidiQ5BLY5.
KOiK19283.
OMAiIPEWAKP.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR033379. Acid_Pase_AS.
IPR029630. Api_m_3.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PANTHERiPTHR11567:SF22. PTHR11567:SF22. 1 hit.
PfamiPF00328. His_Phos_2. 2 hits.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BLY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIAILAMV VGVQAELKQI NVIFRHGDRI PDEKNEMYPK DPYLYYDFYP
60 70 80 90 100
LERGELTNSG KMREYQLGQF LRERYGDFLG DIYTEESVSA LSSFYDRTKM
110 120 130 140 150
SLQLVLAALY PPNKLQQWNE DLNWQPIATK YLRRYEDNIF LPEDCLLFTI
160 170 180 190 200
ELDRVLESPR GKYEFSKYDK LKKKLEEWTG KNITTPWDYY YIYHTLVAEQ
210 220 230 240 250
SYGLTLPSWT NNIFPRGELF DATVFTYNIT NSTPLLKKLY GGPLLRIFTK
260 270 280 290 300
HMLDVVSGTQ KKKRKIYLFS GHESNIASVL HALQLYYPHV PEYSSSIIME
310 320 330 340 350
LHNIEGTHYV KIVYYLGIPS EARELQLPGC EVLCPLYKYL QLIENVIPSN
360 370 380
EELICDKRFV DESANNLSIE ELDFVKLNLI RIAGTENK
Length:388
Mass (Da):45,389
Last modified:April 12, 2005 - v1
Checksum:iDD3327ECC2B03C6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152L → F in ACI25605 (Ref. 2) Curated1
Sequence conflicti278S → A in ACI25605 (Ref. 2) Curated1
Sequence conflicti323R → G in ACI25605 (Ref. 2) Curated1
Sequence conflicti360V → A in ACI25605 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY939855 mRNA. Translation: AAX33235.1.
FJ200211 mRNA. Translation: ACI25605.1.
DQ058012 mRNA. Translation: AAY57281.1.
RefSeqiNP_001013377.2. NM_001013359.2.
UniGeneiAme.7483.

Genome annotation databases

GeneIDi411830.
KEGGiame:411830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY939855 mRNA. Translation: AAX33235.1.
FJ200211 mRNA. Translation: ACI25605.1.
DQ058012 mRNA. Translation: AAY57281.1.
RefSeqiNP_001013377.2. NM_001013359.2.
UniGeneiAme.7483.

3D structure databases

ProteinModelPortaliQ5BLY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7460.GB12546-PA.

Protein family/group databases

Allergomei2778. Api m A1-A2-A3.
3090. Api m 3.0101.
47. Api m 3.

Proteomic databases

PaxDbiQ5BLY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi411830.
KEGGiame:411830.

Organism-specific databases

CTDi48445.

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
InParanoidiQ5BLY5.
KOiK19283.
OMAiIPEWAKP.

Enzyme and pathway databases

BRENDAi3.1.3.2. 387.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR033379. Acid_Pase_AS.
IPR029630. Api_m_3.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PANTHERiPTHR11567:SF22. PTHR11567:SF22. 1 hit.
PfamiPF00328. His_Phos_2. 2 hits.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACPH1_APIME
AccessioniPrimary (citable) accession number: Q5BLY5
Secondary accession number(s): B6E2X9, Q4TUB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.