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Q5BLY5

- ACPH1_APIME

UniProt

Q5BLY5 - ACPH1_APIME

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Protein

Venom acid phosphatase Acph-1

Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei26 – 261Nucleophile By similarity
Active sitei273 – 2731Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Venom acid phosphatase Acph-1 (EC:3.1.3.2)
Alternative name(s):
Allergen: Api m 3
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis
ProteomesiUP000005203: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei2778. Api m A1-A2-A3.
3090. Api m 3.0101.
47. Api m 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed predictionAdd
BLAST
Chaini16 – 388373Venom acid phosphatase Acph-1PRO_5000095341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi145 ↔ 355 By similarity
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi330 ↔ 334 By similarity
Glycosylationi366 – 3661N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5BLY5.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ5BLY5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG291245.
InParanoidiQ5BLY5.
OMAiGHENNIA.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR029630. Api_m_3.
IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PANTHERiPTHR11567:SF22. PTHR11567:SF22. 1 hit.
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BLY5-1 [UniParc]FASTAAdd to Basket

« Hide

MSVIAILAMV VGVQAELKQI NVIFRHGDRI PDEKNEMYPK DPYLYYDFYP    50
LERGELTNSG KMREYQLGQF LRERYGDFLG DIYTEESVSA LSSFYDRTKM 100
SLQLVLAALY PPNKLQQWNE DLNWQPIATK YLRRYEDNIF LPEDCLLFTI 150
ELDRVLESPR GKYEFSKYDK LKKKLEEWTG KNITTPWDYY YIYHTLVAEQ 200
SYGLTLPSWT NNIFPRGELF DATVFTYNIT NSTPLLKKLY GGPLLRIFTK 250
HMLDVVSGTQ KKKRKIYLFS GHESNIASVL HALQLYYPHV PEYSSSIIME 300
LHNIEGTHYV KIVYYLGIPS EARELQLPGC EVLCPLYKYL QLIENVIPSN 350
EELICDKRFV DESANNLSIE ELDFVKLNLI RIAGTENK 388
Length:388
Mass (Da):45,389
Last modified:April 12, 2005 - v1
Checksum:iDD3327ECC2B03C6B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521L → F in ACI25605. 1 Publication
Sequence conflicti278 – 2781S → A in ACI25605. 1 Publication
Sequence conflicti323 – 3231R → G in ACI25605. 1 Publication
Sequence conflicti360 – 3601V → A in ACI25605. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY939855 mRNA. Translation: AAX33235.1.
FJ200211 mRNA. Translation: ACI25605.1.
DQ058012 mRNA. Translation: AAY57281.1.
RefSeqiNP_001013377.2. NM_001013359.2.
UniGeneiAme.7483.

Genome annotation databases

EnsemblMetazoaiGB12546-RA; GB12546-PA; GB12546.
GeneIDi411830.
KEGGiame:411830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY939855 mRNA. Translation: AAX33235.1 .
FJ200211 mRNA. Translation: ACI25605.1 .
DQ058012 mRNA. Translation: AAY57281.1 .
RefSeqi NP_001013377.2. NM_001013359.2.
UniGenei Ame.7483.

3D structure databases

ProteinModelPortali Q5BLY5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 2778. Api m A1-A2-A3.
3090. Api m 3.0101.
47. Api m 3.

Proteomic databases

PaxDbi Q5BLY5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai GB12546-RA ; GB12546-PA ; GB12546 .
GeneIDi 411830.
KEGGi ame:411830.

Organism-specific databases

CTDi 48445.

Phylogenomic databases

eggNOGi NOG291245.
InParanoidi Q5BLY5.
OMAi GHENNIA.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR029630. Api_m_3.
IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
PANTHERi PTHR11567:SF22. PTHR11567:SF22. 1 hit.
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and characterization of honeybee venom acid phosphatase."
    Hoffman D.R., Weimer E.T., Sakell R.H., Schmidt M.
    J. Allergy Clin. Immunol. 115:S107-S107(2005)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-53; 62-72; 75-130; 134-154 AND 312-381, IDENTIFICATION BY MASS SPECTROMETRY, ALLERGEN.
    Tissue: Venom and Venom gland.
  2. "Molecular cloning of honeybee venom allergen acid phosphatase."
    Zhang Q., Liu Z., Wu Y.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  3. "Insights into social insects from the genome of the honeybee Apis mellifera."
    Honeybee genome sequencing consortium
    Nature 443:931-949(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3)."
    Grunwald T., Bockisch B., Spillner E., Ring J., Bredehorst R., Ollert M.W.
    J. Allergy Clin. Immunol. 117:848-854(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-388, ALLERGEN.
    Tissue: Venom gland.
  5. Cited for: REVIEW.

Entry informationi

Entry nameiACPH1_APIME
AccessioniPrimary (citable) accession number: Q5BLY5
Secondary accession number(s): B6E2X9, Q4TUB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: April 12, 2005
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi