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Protein

WD repeat domain-containing protein 83

Gene

Wdr83

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation (By similarity). Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator. May also be involved in pre-mRNA splicing.By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain-containing protein 83
Alternative name(s):
Mitogen-activated protein kinase organizer 1
Short name:
MAPK organizer 1
Gene namesi
Name:Wdr83
Synonyms:Morg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1306947 Wdr83

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352651 – 315WD repeat domain-containing protein 83Add BLAST315

Proteomic databases

PaxDbiQ5BLX8
PRIDEiQ5BLX8

Expressioni

Tissue specificityi

Highly expressed in testis and brain. Expressed at intermediate level in heart, liver and kidney. Weakly expressed in spleen and lung and absent in muscle.1 Publication

Interactioni

Subunit structurei

Identified in the spliceosome C complex (By similarity). Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Interacts with EGLN3/PHD3.By similarity1 Publication

Protein-protein interaction databases

BioGridi252752, 1 interactor
STRINGi10116.ENSRNOP00000005917

Structurei

3D structure databases

ProteinModelPortaliQ5BLX8
SMRiQ5BLX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 62WD 1Add BLAST40
Repeati65 – 104WD 2Add BLAST40
Repeati107 – 146WD 3Add BLAST40
Repeati151 – 188WD 4Add BLAST38
Repeati190 – 228WD 5Add BLAST39
Repeati231 – 272WD 6Add BLAST42
Repeati275 – 313WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat MORG1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0316 Eukaryota
ENOG410XRZ0 LUCA
HOVERGENiHBG105288
InParanoidiQ5BLX8
KOiK13124
PhylomeDBiQ5BLX8

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BLX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPEPKPRA PELPRKQLKT LDCGQGAVRA VRFNVDGNYC LTCGSDKTLK
60 70 80 90 100
LWNPLRGTLL RTYSGHGYEV LDAAGSFDNS HLCSGGGDKT VVLWDVATGQ
110 120 130 140 150
VVRKFRGHAG KVNTVQFNEE ATVILSGSID SSVRCWDCRS RKPEPVQTLD
160 170 180 190 200
EARDGISSVK VSDHEILAGS VDGRVRRYDL RMGQVTSDYV GSPITCTCFS
210 220 230 240 250
RDGQCTLISS LDSTLRLLDK DTGELLGEYV GHKNQKYKLD CCLSERDTHV
260 270 280 290 300
VSCSEDGKVF FWDLVEGSLA LALPVGSNVV QSLAYHPADP CLLTAMGGSI
310
QYWREETYEA EGGAG
Length:315
Mass (Da):34,382
Last modified:April 12, 2005 - v1
Checksum:iC2F85DBEF658FD4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY940050 mRNA Translation: AAX23986.1
RefSeqiNP_001041312.1, NM_001047847.1
UniGeneiRn.3570

Genome annotation databases

GeneIDi288924
KEGGirno:288924

Entry informationi

Entry nameiWDR83_RAT
AccessioniPrimary (citable) accession number: Q5BLX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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