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Protein

WD repeat domain-containing protein 83

Gene

Wdr83

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation (By similarity). Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator. May also be involved in pre-mRNA splicing.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain-containing protein 83
Alternative name(s):
Mitogen-activated protein kinase organizer 1
Short name:
MAPK organizer 1
Gene namesi
Name:Wdr83
Synonyms:Morg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306947. Wdr83.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Predominantly cytoplasmic. Partially nuclear.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315WD repeat domain-containing protein 83PRO_0000235265Add
BLAST

Proteomic databases

PaxDbiQ5BLX8.
PRIDEiQ5BLX8.

Expressioni

Tissue specificityi

Highly expressed in testis and brain. Expressed at intermediate level in heart, liver and kidney. Weakly expressed in spleen and lung and absent in muscle.1 Publication

Interactioni

Subunit structurei

Identified in the spliceosome C complex (By similarity). Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Interacts with EGLN3/PHD3.By similarity1 Publication

Protein-protein interaction databases

BioGridi252752. 1 interaction.
STRINGi10116.ENSRNOP00000005917.

Structurei

3D structure databases

ProteinModelPortaliQ5BLX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 6240WD 1Add
BLAST
Repeati65 – 10440WD 2Add
BLAST
Repeati107 – 14640WD 3Add
BLAST
Repeati151 – 18838WD 4Add
BLAST
Repeati190 – 22839WD 5Add
BLAST
Repeati231 – 27242WD 6Add
BLAST
Repeati275 – 31339WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat MORG1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0316. Eukaryota.
ENOG410XRZ0. LUCA.
HOVERGENiHBG105288.
InParanoidiQ5BLX8.
KOiK13124.
PhylomeDBiQ5BLX8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BLX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPEPKPRA PELPRKQLKT LDCGQGAVRA VRFNVDGNYC LTCGSDKTLK
60 70 80 90 100
LWNPLRGTLL RTYSGHGYEV LDAAGSFDNS HLCSGGGDKT VVLWDVATGQ
110 120 130 140 150
VVRKFRGHAG KVNTVQFNEE ATVILSGSID SSVRCWDCRS RKPEPVQTLD
160 170 180 190 200
EARDGISSVK VSDHEILAGS VDGRVRRYDL RMGQVTSDYV GSPITCTCFS
210 220 230 240 250
RDGQCTLISS LDSTLRLLDK DTGELLGEYV GHKNQKYKLD CCLSERDTHV
260 270 280 290 300
VSCSEDGKVF FWDLVEGSLA LALPVGSNVV QSLAYHPADP CLLTAMGGSI
310
QYWREETYEA EGGAG
Length:315
Mass (Da):34,382
Last modified:April 12, 2005 - v1
Checksum:iC2F85DBEF658FD4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY940050 mRNA. Translation: AAX23986.1.
RefSeqiNP_001041312.1. NM_001047847.1.
UniGeneiRn.3570.

Genome annotation databases

GeneIDi288924.
KEGGirno:288924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY940050 mRNA. Translation: AAX23986.1.
RefSeqiNP_001041312.1. NM_001047847.1.
UniGeneiRn.3570.

3D structure databases

ProteinModelPortaliQ5BLX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252752. 1 interaction.
STRINGi10116.ENSRNOP00000005917.

Proteomic databases

PaxDbiQ5BLX8.
PRIDEiQ5BLX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi288924.
KEGGirno:288924.

Organism-specific databases

CTDi84292.
RGDi1306947. Wdr83.

Phylogenomic databases

eggNOGiKOG0316. Eukaryota.
ENOG410XRZ0. LUCA.
HOVERGENiHBG105288.
InParanoidiQ5BLX8.
KOiK13124.
PhylomeDBiQ5BLX8.

Miscellaneous databases

PROiQ5BLX8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR83_RAT
AccessioniPrimary (citable) accession number: Q5BLX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: April 12, 2005
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.