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Protein

Neuropeptide-like protein C4orf48

Gene

C4orf48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide-like protein C4orf48
Gene namesi
Name:C4orf48
ORF Names:Chr4_55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:34437. C4orf48.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717315.

Polymorphism and mutation databases

DMDMi327478590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Chaini35 – 9561Neuropeptide-like protein C4orf48PRO_0000342194Add
BLAST

Proteomic databases

EPDiQ5BLP8.
PaxDbiQ5BLP8.
PeptideAtlasiQ5BLP8.
PRIDEiQ5BLP8.

Expressioni

Tissue specificityi

Brain-specific (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000243449.
CleanExiHS_C4orf48.
GenevisibleiQ5BLP8. HS.

Organism-specific databases

HPAiHPA052447.

Structurei

3D structure databases

ProteinModelPortaliQ5BLP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3EK. Eukaryota.
ENOG411250K. LUCA.
GeneTreeiENSGT00390000013043.
HOGENOMiHOG000082438.
HOVERGENiHBG107629.
InParanoidiQ5BLP8.
OMAiMAPLPPC.
OrthoDBiEOG091G11T7.
PhylomeDBiQ5BLP8.
TreeFamiTF336171.

Family and domain databases

InterProiIPR028147. Neuropep-like.
[Graphical view]
PfamiPF15161. Neuropep_like. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BLP8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPPACRSP MSPPPPPLLL LLLSLALLGA RARAEPAGSA VPAQSRPCVD
60 70 80 90
CHAFEFMQRA LQDLRKTACS LDARTETLLL QAERRALCAC WPAGH
Length:95
Mass (Da):10,170
Last modified:April 5, 2011 - v3
Checksum:i99CEDC5826CDE2A2
GO
Isoform 2 (identifier: Q5BLP8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGNPGGVGSERMRVARRTRNVCRCPRAAGPGVPEPRAAPLPLLAM

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):14,747
Checksum:i283CFFA7A1540410
GO
Isoform 3 (identifier: Q5BLP8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRVARRTRNVCRCPRAAGPGVPEPRAAPLPLLAM

Show »
Length:128
Mass (Da):13,705
Checksum:iD941BA3C271AEACB
GO

Sequence cautioni

The sequence CAX14865 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171P → L in AI929674 (Ref. 4) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MGNPGGVGSERMRVARRTRN VCRCPRAAGPGVPEPRAAPL PLLAM in isoform 2. CuratedVSP_040898
Alternative sequencei1 – 11M → MRVARRTRNVCRCPRAAGPG VPEPRAAPLPLLAM in isoform 3. VSP_057610

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132868 Genomic DNA. Translation: CAX14864.1.
AL132868 Genomic DNA. Translation: CAX14865.1. Different initiation.
BC047038 mRNA. No translation available.
AY947524 mRNA. Translation: AAX21785.1.
AI929674 mRNA. No translation available.
CCDSiCCDS47000.2. [Q5BLP8-1]
CCDS54707.1. [Q5BLP8-3]
UniGeneiHs.446474.

Genome annotation databases

EnsembliENST00000409248; ENSP00000386807; ENSG00000243449. [Q5BLP8-3]
ENST00000409860; ENSP00000386528; ENSG00000243449. [Q5BLP8-1]
UCSCiuc003gep.4. human. [Q5BLP8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132868 Genomic DNA. Translation: CAX14864.1.
AL132868 Genomic DNA. Translation: CAX14865.1. Different initiation.
BC047038 mRNA. No translation available.
AY947524 mRNA. Translation: AAX21785.1.
AI929674 mRNA. No translation available.
CCDSiCCDS47000.2. [Q5BLP8-1]
CCDS54707.1. [Q5BLP8-3]
UniGeneiHs.446474.

3D structure databases

ProteinModelPortaliQ5BLP8.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi327478590.

Proteomic databases

EPDiQ5BLP8.
PaxDbiQ5BLP8.
PeptideAtlasiQ5BLP8.
PRIDEiQ5BLP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409248; ENSP00000386807; ENSG00000243449. [Q5BLP8-3]
ENST00000409860; ENSP00000386528; ENSG00000243449. [Q5BLP8-1]
UCSCiuc003gep.4. human. [Q5BLP8-1]

Organism-specific databases

GeneCardsiC4orf48.
HGNCiHGNC:34437. C4orf48.
HPAiHPA052447.
MIMi614690. gene.
neXtProtiNX_Q5BLP8.
PharmGKBiPA164717315.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3EK. Eukaryota.
ENOG411250K. LUCA.
GeneTreeiENSGT00390000013043.
HOGENOMiHOG000082438.
HOVERGENiHBG107629.
InParanoidiQ5BLP8.
OMAiMAPLPPC.
OrthoDBiEOG091G11T7.
PhylomeDBiQ5BLP8.
TreeFamiTF336171.

Miscellaneous databases

ChiTaRSiC4orf48. human.
PROiQ5BLP8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243449.
CleanExiHS_C4orf48.
GenevisibleiQ5BLP8. HS.

Family and domain databases

InterProiIPR028147. Neuropep-like.
[Graphical view]
PfamiPF15161. Neuropep_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD048_HUMAN
AccessioniPrimary (citable) accession number: Q5BLP8
Secondary accession number(s): B6ZDN0
, B7ZBI7, B7ZBI8, X6RBU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Share similarities with neuropeptides, however functional characterization is required to confirm this hypothesis.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.