Reviewed,
UniProtKB/Swiss-Prot Q5BLE8 (RETST_DANRE)
Last modified
January 19, 2010.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative all-trans-retinol 13,14-reductase EC=1.3.99.23 Alternative name(s): All-trans-13,14-dihydroretinol saturase Short name=RetSat | ||||
| Gene names |
| ||||
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) | ||||
| Taxonomic identifier | 7955 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Protein attributes
| Sequence length | 607 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol By similarity. |
| Catalytic activity | All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor. |
| Cofactor | NAD, NADP, or FAD By similarity. |
| Subcellular location | Membrane; Peripheral membrane protein By similarity. |
| Sequence similarities | Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal |
| Ligand | FAD Flavoprotein NAD NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | all-trans-retinol 13,14-reductase activity Inferred from direct assay. Source: ZFIN |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||
| Chain | 23 – 607 | 585 | Putative all-trans-retinol 13,14-reductase | PRO_0000225669 | |||||
Regions | |||||||||
| Nucleotide binding | 65 – 93 | 29 | FAD or NAD or NADP Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 572 | 1 | L → S in AAH78372. Ref.1 | ||||||
Sequences
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References
| [1] | NIH - Zebrafish Gene Collection (ZGC) project Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC078372 mRNA. Translation: AAH78372.1. BC090469 mRNA. Translation: AAH90469.1. |
| IPI | IPI00495382. |
| RefSeq | NP_001015061.1. |
| UniGene | Dr.80063 |
3D structure databases | |
| SMR | Q5BLE8. Positions 18-120, 59-365. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5BLE8. |
Genome annotation databases | |
| Ensembl | ENSDART00000013167; ENSDARP00000024120; ENSDARG00000018600; Danio rerio. [Genome view] |
| GeneID | 325922. |
| KEGG | dre:325922. |
Organism-specific databases | |
| CTD | 325922. |
| ZFIN | ZDB-GENE-050320-11. retsat. |
Phylogenomic databases | |
| eggNOG | fiNOG06874. |
| HOGENOM | HBG443934. |
| HOVERGEN | Q5BLE8. |
| InParanoid | Q5BLE8. |
| OMA | GQDIFTC. |
| OrthoDB | EOG912PQT. |
Enzyme and pathway databases | |
| BRENDA | 1.3.99.23. 96826. |
Gene expression databases | |
| ArrayExpress | Q5BLE8. |
| Bgee | Q5BLE8. |
Family and domain databases | |
| InterPro | IPR002937. Amino_oxidase. [Graphical view] |
| Pfam | PF01593. Amino_oxidase. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RETST_DANRE | ||||||||
| Accession | Primary (citable) accession number: Q5BLE8 Secondary accession number(s): Q6DBT4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Zebrafish annotation project | ||||||||

Clusters with


