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Protein

Frizzled-7

Gene

fzd7

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Acts in both canonical and non-canonical Wnt pathways. Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists. In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal axis of the embryo and induce dorsal mesoderm formation. In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension movements in gastrulation. Triggers phosphorylation of dvl2/dsh and its translocation to the plasma membrane. In a third branch of Wnt signaling, acts in a non-canonical pathway via trimeric G proteins, and independently of dvl2/dsh, to recruit protein kinase C (PKC) to the membrane and thus activate PKC. PKC signaling controls cell sorting and tissue separation during gastrulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-7
Short name:
Frz7
Short name:
Fz-7
Gene namesi
Name:fzd7Imported
ORF Names:TNeu065e03.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-483731. fzd7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 230ExtracellularSequence analysisAdd BLAST211
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 262CytoplasmicSequence analysisAdd BLAST11
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 310ExtracellularSequence analysisAdd BLAST27
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 353CytoplasmicSequence analysisAdd BLAST22
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 397ExtracellularSequence analysisAdd BLAST23
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 444CytoplasmicSequence analysisAdd BLAST26
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 502ExtracellularSequence analysisAdd BLAST37
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Topological domaini524 – 548CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000028295020 – 548Frizzled-7Sequence analysisAdd BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 97PROSITE-ProRule annotation
Disulfide bondi44 ↔ 90PROSITE-ProRule annotation
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi81 ↔ 118PROSITE-ProRule annotation
Disulfide bondi107 ↔ 147PROSITE-ProRule annotation
Disulfide bondi111 ↔ 135PROSITE-ProRule annotation
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5BL72.

Interactioni

Subunit structurei

Interacts with wnt11 and sdc4. The extracellular domain interacts with the extracellular domain of pcdh8/papc (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027115.

Structurei

3D structure databases

ProteinModelPortaliQ5BL72.
SMRiQ5BL72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 150FZPROSITE-ProRule annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi526 – 531Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi546 – 548PDZ-bindingSequence analysis3

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity
The extracellular domain interacts with Wnt proteins and the intracellular C-terminus transmits the Wnt signal.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor Fz/Smo family.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiQ5BL72.
KOiK02432.
OrthoDBiEOG091G0N5M.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR000539. Frizzled/Smoothened_TM.
IPR020067. Frizzled_dom.
IPR036790. Frizzled_dom_sf.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BL72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFATVSLLFC LLLQPSPSAQ QYHGEKGISV PDHGFCQPIS IPLCTDIAYN
60 70 80 90 100
QTIMPNLLGH TNQEDAGLEV HQFYPLVKVQ CSPELRFFLC SMYAPVCTVL
110 120 130 140 150
EQAIPPCRSL CERARQGCEA LMNKFGFQWP ERLRCENFPV HGAGEICVGQ
160 170 180 190 200
NTSDNSPSGP TARPTPYLPD SITFHPHPNR DFTCPRQLKV PPYLGYRFLG
210 220 230 240 250
EKDCGAPCEP GKANGLMYFK EEEVRFARLW VGIWAILCGI STLFTVLTYL
260 270 280 290 300
VDMRRFSYPE RPIIFLSGCY FMVAVAYTAG FLLEERGVCV ERFSEDSYRT
310 320 330 340 350
VAQGTKKEGC TILFMILYFF GMASSIWWVI LSLTWFLAAG MKWGHEAIEA
360 370 380 390 400
NSQYFHLAAW AVPAVKTITI LAMGQVDGDI LSGVCYVGIN SVDSLRGFVL
410 420 430 440 450
APLFVYLFIG TSFLLAGFVS LFRIRTIMKH DGTKTEKLEK LMVRIGVFSV
460 470 480 490 500
MYTVPATIVL ACYFYEQAFR DTWEKTWLVQ TCKGFAVPCP NYNFAPMSPD
510 520 530 540
FTVFMIKYLM TMIVGITSSF WIWSGKTLQS WRRFYHRLSN GGKGETAV
Length:548
Mass (Da):61,872
Last modified:April 12, 2005 - v1
Checksum:i6DC7815D767F54C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140V → I in CAJ82817 (Ref. 2) Curated1
Sequence conflicti178P → L in CAJ82817 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149036 Genomic DNA. Translation: AAZ06130.1.
CR759995 mRNA. Translation: CAJ82817.1.
BC090579 mRNA. Translation: AAH90579.1.
RefSeqiNP_001016741.1. NM_001016741.2.
UniGeneiStr.48717.

Genome annotation databases

GeneIDi549495.
KEGGixtr:549495.

Similar proteinsi

Entry informationi

Entry nameiFZD7_XENTR
AccessioniPrimary (citable) accession number: Q5BL72
Secondary accession number(s): Q28J97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 12, 2005
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families