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Q5BL38 (CEGT_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ceramide glucosyltransferase

EC=2.4.1.80
Alternative name(s):
UDP-glucose ceramide glucosyltransferase
Gene names
Name:ugcg
ORF Names:TEgg030g03.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Glycosphingolipids are required for convergence extension movements during early development. UniProtKB Q8AY29

Catalytic activity

UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. UniProtKB Q8AY29

Pathway

Lipid metabolism; sphingolipid metabolism. UniProtKB Q8AY29

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein By similarity UniProtKB Q8AY29.

Sequence similarities

Belongs to the glycosyltransferase 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Ceramide glucosyltransferase
PRO_0000376856

Regions

Topological domain1 – 1010Lumenal Potential
Transmembrane11 – 3222Helical; Potential
Topological domain33 – 195163Cytoplasmic Potential
Transmembrane196 – 21520Helical; Potential
Topological domain216 – 28772Lumenal Potential
Transmembrane288 – 30417Helical; Potential
Topological domain305 – 3095Cytoplasmic Potential
Transmembrane310 – 32819Helical; Potential
Topological domain329 – 34820Lumenal Potential
Transmembrane349 – 36921Helical; Potential
Topological domain370 – 39425Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q5BL38 [UniParc].

Last modified April 12, 2005. Version 1.
Checksum: 1CF7077F02358BD0

FASTA39444,638
        10         20         30         40         50         60 
MAVLDLALQG LAIFGCVLFF VLWFMHFLSI VYTRLHLNKK VSDKQPYSKL PGVSLLKPLK 

        70         80         90        100        110        120 
GVDPNLINNL ETFFELDYPK FEILLCVQDL DDPAVDVCKK LLGKYPSVDA KLFIGGKKVG 

       130        140        150        160        170        180 
INPKINNLMP GYEVAKYDLI WICDSGIKVK PDTLTDMANQ MTEKVGLVHG LPYVADRQGF 

       190        200        210        220        230        240 
AATLEQVYFG TSHPRSYISA NVTGFKCVTG MSCLMRKEVL DQAGGLIAFA QYIAEDYFMA 

       250        260        270        280        290        300 
KAIADRGWKF SMATQVAMQN SGCYSISQFQ SRMIRWAKLR INMLPATIIC EPISECFVAS 

       310        320        330        340        350        360 
LIIGWAAHHI FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG PLNFSKLDYA VAWFIRESMT 

       370        380        390 
IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tail bud.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR762041 mRNA. Translation: CAJ81500.1.
BC090614 mRNA. Translation: AAH90614.1.
RefSeqNP_001016133.1. NM_001016133.2.
UniGeneStr.20419.

3D structure databases

ProteinModelPortalQ5BL38.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000022548.

Protein family/group databases

CAZyGT21. Glycosyltransferase Family 21.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000005911; ENSXETP00000005911; ENSXETG00000010219.
GeneID548887.
KEGGxtr:548887.

Organism-specific databases

CTD7357.
XenbaseXB-GENE-944694. ugcg.

Phylogenomic databases

eggNOGCOG1215.
GeneTreeENSGT00390000012898.
HOGENOMHOG000039663.
InParanoidQ5BL38.
KOK00720.
OMASHETMAL.
OrthoDBEOG70KGPR.
TreeFamTF314564.

Enzyme and pathway databases

UniPathwayUPA00222.

Gene expression databases

BgeeQ5BL38.

Family and domain databases

InterProIPR025993. Ceramide_glucosylTrfase.
[Graphical view]
PfamPF13506. Glyco_transf_21. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCEGT_XENTR
AccessionPrimary (citable) accession number: Q5BL38
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: April 12, 2005
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways