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Q5BL38

- CEGT_XENTR

UniProt

Q5BL38 - CEGT_XENTR

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Protein
Ceramide glucosyltransferase
Gene
ugcg, TEgg030g03.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Glycosphingolipids are required for convergence extension movements during early development.By similarity

Catalytic activityi

UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.By similarity

Pathwayi

GO - Molecular functioni

  1. ceramide glucosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. glycosphingolipid catabolic process Source: UniProtKB
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiREACT_203894. Glycosphingolipid metabolism.
UniPathwayiUPA00222.

Protein family/group databases

CAZyiGT21. Glycosyltransferase Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide glucosyltransferase (EC:2.4.1.80)
Alternative name(s):
UDP-glucose ceramide glucosyltransferase
Gene namesi
Name:ugcg
ORF Names:TEgg030g03.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-944694. ugcg.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein By similarity By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Lumenal Reviewed prediction
Transmembranei11 – 3222Helical; Reviewed prediction
Add
BLAST
Topological domaini33 – 195163Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei196 – 21520Helical; Reviewed prediction
Add
BLAST
Topological domaini216 – 28772Lumenal Reviewed prediction
Add
BLAST
Transmembranei288 – 30417Helical; Reviewed prediction
Add
BLAST
Topological domaini305 – 3095Cytoplasmic Reviewed prediction
Transmembranei310 – 32819Helical; Reviewed prediction
Add
BLAST
Topological domaini329 – 34820Lumenal Reviewed prediction
Add
BLAST
Transmembranei349 – 36921Helical; Reviewed prediction
Add
BLAST
Topological domaini370 – 39425Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Ceramide glucosyltransferase
PRO_0000376856Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5BL38.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000022548.

Structurei

3D structure databases

ProteinModelPortaliQ5BL38.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1215.
GeneTreeiENSGT00390000012898.
HOGENOMiHOG000039663.
InParanoidiQ5BL38.
KOiK00720.
OMAiSHETMAL.
OrthoDBiEOG70KGPR.
TreeFamiTF314564.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF13506. Glyco_transf_21. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BL38-1 [UniParc]FASTAAdd to Basket

« Hide

MAVLDLALQG LAIFGCVLFF VLWFMHFLSI VYTRLHLNKK VSDKQPYSKL    50
PGVSLLKPLK GVDPNLINNL ETFFELDYPK FEILLCVQDL DDPAVDVCKK 100
LLGKYPSVDA KLFIGGKKVG INPKINNLMP GYEVAKYDLI WICDSGIKVK 150
PDTLTDMANQ MTEKVGLVHG LPYVADRQGF AATLEQVYFG TSHPRSYISA 200
NVTGFKCVTG MSCLMRKEVL DQAGGLIAFA QYIAEDYFMA KAIADRGWKF 250
SMATQVAMQN SGCYSISQFQ SRMIRWAKLR INMLPATIIC EPISECFVAS 300
LIIGWAAHHI FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG PLNFSKLDYA 350
VAWFIRESMT IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV 394
Length:394
Mass (Da):44,638
Last modified:April 12, 2005 - v1
Checksum:i1CF7077F02358BD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR762041 mRNA. Translation: CAJ81500.1.
BC090614 mRNA. Translation: AAH90614.1.
RefSeqiNP_001016133.1. NM_001016133.2.
UniGeneiStr.20419.

Genome annotation databases

EnsembliENSXETT00000005911; ENSXETP00000005911; ENSXETG00000010219.
GeneIDi548887.
KEGGixtr:548887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR762041 mRNA. Translation: CAJ81500.1 .
BC090614 mRNA. Translation: AAH90614.1 .
RefSeqi NP_001016133.1. NM_001016133.2.
UniGenei Str.20419.

3D structure databases

ProteinModelPortali Q5BL38.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000022548.

Protein family/group databases

CAZyi GT21. Glycosyltransferase Family 21.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000005911 ; ENSXETP00000005911 ; ENSXETG00000010219 .
GeneIDi 548887.
KEGGi xtr:548887.

Organism-specific databases

CTDi 7357.
Xenbasei XB-GENE-944694. ugcg.

Phylogenomic databases

eggNOGi COG1215.
GeneTreei ENSGT00390000012898.
HOGENOMi HOG000039663.
InParanoidi Q5BL38.
KOi K00720.
OMAi SHETMAL.
OrthoDBi EOG70KGPR.
TreeFami TF314564.

Enzyme and pathway databases

UniPathwayi UPA00222 .
Reactomei REACT_203894. Glycosphingolipid metabolism.

Gene expression databases

Bgeei Q5BL38.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF13506. Glyco_transf_21. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tail bud.

Entry informationi

Entry nameiCEGT_XENTR
AccessioniPrimary (citable) accession number: Q5BL38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: April 12, 2005
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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