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Protein

Ceramide glucosyltransferase

Gene

ugcg

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Glycosphingolipids are required for convergence extension movements during early development.By similarity

Catalytic activityi

UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.By similarity

Pathwayi

GO - Molecular functioni

  1. ceramide glucosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. glucosylceramide biosynthetic process Source: GO_Central
  2. glycosphingolipid catabolic process Source: UniProtKB
  3. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiREACT_324982. Glycosphingolipid metabolism.
UniPathwayiUPA00222.

Protein family/group databases

CAZyiGT21. Glycosyltransferase Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide glucosyltransferaseBy similarity (EC:2.4.1.80)
Alternative name(s):
UDP-glucose ceramide glucosyltransferaseImported
Gene namesi
Name:ugcg
ORF Names:TEgg030g03.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unplaced

Organism-specific databases

XenbaseiXB-GENE-944694. ugcg.

Subcellular locationi

Golgi apparatus membrane Sequence AnalysisBy similarity; Multi-pass membrane protein Sequence AnalysisBy similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010LumenalSequence Analysis
Transmembranei11 – 3222HelicalSequence AnalysisAdd
BLAST
Topological domaini33 – 195163CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei196 – 21520HelicalSequence AnalysisAdd
BLAST
Topological domaini216 – 28772LumenalSequence AnalysisAdd
BLAST
Transmembranei288 – 30417HelicalSequence AnalysisAdd
BLAST
Topological domaini305 – 3095CytoplasmicSequence Analysis
Transmembranei310 – 32819HelicalSequence AnalysisAdd
BLAST
Topological domaini329 – 34820LumenalSequence AnalysisAdd
BLAST
Transmembranei349 – 36921HelicalSequence AnalysisAdd
BLAST
Topological domaini370 – 39425CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Ceramide glucosyltransferasePRO_0000376856Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5BL38.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000022548.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1215.
GeneTreeiENSGT00390000012898.
HOGENOMiHOG000039663.
InParanoidiQ5BL38.
KOiK00720.
OMAiFRECISI.
OrthoDBiEOG70KGPR.
TreeFamiTF314564.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF13506. Glyco_transf_21. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BL38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLDLALQG LAIFGCVLFF VLWFMHFLSI VYTRLHLNKK VSDKQPYSKL
60 70 80 90 100
PGVSLLKPLK GVDPNLINNL ETFFELDYPK FEILLCVQDL DDPAVDVCKK
110 120 130 140 150
LLGKYPSVDA KLFIGGKKVG INPKINNLMP GYEVAKYDLI WICDSGIKVK
160 170 180 190 200
PDTLTDMANQ MTEKVGLVHG LPYVADRQGF AATLEQVYFG TSHPRSYISA
210 220 230 240 250
NVTGFKCVTG MSCLMRKEVL DQAGGLIAFA QYIAEDYFMA KAIADRGWKF
260 270 280 290 300
SMATQVAMQN SGCYSISQFQ SRMIRWAKLR INMLPATIIC EPISECFVAS
310 320 330 340 350
LIIGWAAHHI FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG PLNFSKLDYA
360 370 380 390
VAWFIRESMT IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV
Length:394
Mass (Da):44,638
Last modified:April 12, 2005 - v1
Checksum:i1CF7077F02358BD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762041 mRNA. Translation: CAJ81500.1.
BC090614 mRNA. Translation: AAH90614.1.
RefSeqiNP_001016133.1. NM_001016133.2.
UniGeneiStr.20419.

Genome annotation databases

EnsembliENSXETT00000005911; ENSXETP00000005911; ENSXETG00000010219.
GeneIDi548887.
KEGGixtr:548887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762041 mRNA. Translation: CAJ81500.1.
BC090614 mRNA. Translation: AAH90614.1.
RefSeqiNP_001016133.1. NM_001016133.2.
UniGeneiStr.20419.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000022548.

Protein family/group databases

CAZyiGT21. Glycosyltransferase Family 21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000005911; ENSXETP00000005911; ENSXETG00000010219.
GeneIDi548887.
KEGGixtr:548887.

Organism-specific databases

CTDi7357.
XenbaseiXB-GENE-944694. ugcg.

Phylogenomic databases

eggNOGiCOG1215.
GeneTreeiENSGT00390000012898.
HOGENOMiHOG000039663.
InParanoidiQ5BL38.
KOiK00720.
OMAiFRECISI.
OrthoDBiEOG70KGPR.
TreeFamiTF314564.

Enzyme and pathway databases

UniPathwayiUPA00222.
ReactomeiREACT_324982. Glycosphingolipid metabolism.

Gene expression databases

BgeeiQ5BL38.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF13506. Glyco_transf_21. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EggImported.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tail budImported.

Entry informationi

Entry nameiCEGT_XENTR
AccessioniPrimary (citable) accession number: Q5BL38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: April 12, 2005
Last modified: April 1, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.