Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM133B

Gene

FAM133B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32651-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM133B
Gene namesi
Name:FAM133B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:28629. FAM133B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000234545.
PharmGKBiPA162386138.

Polymorphism and mutation databases

DMDMi74736047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876161 – 247Protein FAM133BAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5BKY9.
MaxQBiQ5BKY9.
PaxDbiQ5BKY9.
PeptideAtlasiQ5BKY9.
PRIDEiQ5BKY9.

PTM databases

iPTMnetiQ5BKY9.
PhosphoSitePlusiQ5BKY9.

Expressioni

Gene expression databases

BgeeiENSG00000234545.
CleanExiHS_FAM133B.
ExpressionAtlasiQ5BKY9. baseline and differential.
GenevisibleiQ5BKY9. HS.

Interactioni

Protein-protein interaction databases

BioGridi129218. 7 interactors.
IntActiQ5BKY9. 4 interactors.
MINTiMINT-4719736.
STRINGi9606.ENSP00000398401.

Structurei

3D structure databases

ProteinModelPortaliQ5BKY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 238Lys-richAdd BLAST194
Compositional biasi82 – 157Ser-richAdd BLAST76

Sequence similaritiesi

Belongs to the FAM133 family.Curated

Phylogenomic databases

eggNOGiENOG410IY68. Eukaryota.
ENOG41123P0. LUCA.
GeneTreeiENSGT00730000111097.
HOGENOMiHOG000059590.
HOVERGENiHBG088046.
InParanoidiQ5BKY9.
OMAiKADRGDG.
OrthoDBiEOG091G0ZD9.
TreeFamiTF350193.

Family and domain databases

InterProiIPR026766. Fam133.
[Graphical view]
PANTHERiPTHR31911. PTHR31911. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BKY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKRDNRVAY MNPIAMARSR GPIQSSGPTI QDYLNRPRPT WEEVKEQLEK
60 70 80 90 100
KKKGSKALAE FEEKMNENWK KELEKHREKL LSGSESSSKK RQRKKKEKKK
110 120 130 140 150
SGRYSSSSSS SSDSSSSSSD SEDEDKKQGK RRKKKKNRSH KSSESSMSET
160 170 180 190 200
ESDSKDSLKK KKKSKDGTEK EKDIKGLSKK RKMYSEDKPL SSESLSESEY
210 220 230 240
IEEVRAKKKK SSEEREKATE KTKKKKKHKK HSKKKKKKAA SSSPDSP
Length:247
Mass (Da):28,385
Last modified:April 12, 2005 - v1
Checksum:iE6713614B2BE0D48
GO
Isoform 2 (identifier: Q5BKY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:237
Mass (Da):27,194
Checksum:iE2A9AA702B378154
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0255711 – 10Missing in isoform 2. 3 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313692 mRNA. Translation: BAG36441.1.
AL833918 mRNA. Translation: CAD38774.1.
CH236949 Genomic DNA. Translation: EAL24147.1.
CH471091 Genomic DNA. Translation: EAW76831.1.
BC017874 mRNA. Translation: AAH17874.1. Different termination.
BC032461 mRNA. Translation: AAH32461.1.
BC057771 mRNA. Translation: AAH57771.1.
BC062706 mRNA. Translation: AAH62706.1. Different termination.
BC090868 mRNA. Translation: AAH90868.1.
CCDSiCCDS47640.1. [Q5BKY9-1]
CCDS47641.1. [Q5BKY9-2]
RefSeqiNP_001035146.1. NM_001040057.2. [Q5BKY9-2]
NP_001275513.1. NM_001288584.1. [Q5BKY9-2]
NP_690002.2. NM_152789.3. [Q5BKY9-1]
XP_011514306.1. XM_011516004.2. [Q5BKY9-2]
UniGeneiHs.18564.
Hs.470311.
Hs.489105.

Genome annotation databases

EnsembliENST00000427372; ENSP00000402843; ENSG00000234545. [Q5BKY9-2]
ENST00000438306; ENSP00000389783; ENSG00000234545. [Q5BKY9-2]
ENST00000445716; ENSP00000398401; ENSG00000234545. [Q5BKY9-1]
GeneIDi257415.
KEGGihsa:257415.
UCSCiuc003umb.5. human. [Q5BKY9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313692 mRNA. Translation: BAG36441.1.
AL833918 mRNA. Translation: CAD38774.1.
CH236949 Genomic DNA. Translation: EAL24147.1.
CH471091 Genomic DNA. Translation: EAW76831.1.
BC017874 mRNA. Translation: AAH17874.1. Different termination.
BC032461 mRNA. Translation: AAH32461.1.
BC057771 mRNA. Translation: AAH57771.1.
BC062706 mRNA. Translation: AAH62706.1. Different termination.
BC090868 mRNA. Translation: AAH90868.1.
CCDSiCCDS47640.1. [Q5BKY9-1]
CCDS47641.1. [Q5BKY9-2]
RefSeqiNP_001035146.1. NM_001040057.2. [Q5BKY9-2]
NP_001275513.1. NM_001288584.1. [Q5BKY9-2]
NP_690002.2. NM_152789.3. [Q5BKY9-1]
XP_011514306.1. XM_011516004.2. [Q5BKY9-2]
UniGeneiHs.18564.
Hs.470311.
Hs.489105.

3D structure databases

ProteinModelPortaliQ5BKY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129218. 7 interactors.
IntActiQ5BKY9. 4 interactors.
MINTiMINT-4719736.
STRINGi9606.ENSP00000398401.

PTM databases

iPTMnetiQ5BKY9.
PhosphoSitePlusiQ5BKY9.

Polymorphism and mutation databases

DMDMi74736047.

Proteomic databases

EPDiQ5BKY9.
MaxQBiQ5BKY9.
PaxDbiQ5BKY9.
PeptideAtlasiQ5BKY9.
PRIDEiQ5BKY9.

Protocols and materials databases

DNASUi257415.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427372; ENSP00000402843; ENSG00000234545. [Q5BKY9-2]
ENST00000438306; ENSP00000389783; ENSG00000234545. [Q5BKY9-2]
ENST00000445716; ENSP00000398401; ENSG00000234545. [Q5BKY9-1]
GeneIDi257415.
KEGGihsa:257415.
UCSCiuc003umb.5. human. [Q5BKY9-1]

Organism-specific databases

CTDi257415.
GeneCardsiFAM133B.
H-InvDBHIX0006843.
HGNCiHGNC:28629. FAM133B.
neXtProtiNX_Q5BKY9.
OpenTargetsiENSG00000234545.
PharmGKBiPA162386138.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY68. Eukaryota.
ENOG41123P0. LUCA.
GeneTreeiENSGT00730000111097.
HOGENOMiHOG000059590.
HOVERGENiHBG088046.
InParanoidiQ5BKY9.
OMAiKADRGDG.
OrthoDBiEOG091G0ZD9.
TreeFamiTF350193.

Enzyme and pathway databases

BioCyciZFISH:G66-32651-MONOMER.

Miscellaneous databases

ChiTaRSiFAM133B. human.
GenomeRNAii257415.
PROiQ5BKY9.

Gene expression databases

BgeeiENSG00000234545.
CleanExiHS_FAM133B.
ExpressionAtlasiQ5BKY9. baseline and differential.
GenevisibleiQ5BKY9. HS.

Family and domain databases

InterProiIPR026766. Fam133.
[Graphical view]
PANTHERiPTHR31911. PTHR31911. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF133B_HUMAN
AccessioniPrimary (citable) accession number: Q5BKY9
Secondary accession number(s): B2R994
, Q05D67, Q6P5S6, Q8N0W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.