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Protein

Leucine-rich repeat-containing protein 10

Gene

LRRC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play important roles in cardiac development and/or cardiac function.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 10
Gene namesi
Name:LRRC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:20264. LRRC10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198812.
PharmGKBiPA134896853.

Polymorphism and mutation databases

BioMutaiLRRC10.
DMDMi74762168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844701 – 277Leucine-rich repeat-containing protein 10Add BLAST277

Proteomic databases

PaxDbiQ5BKY1.
PeptideAtlasiQ5BKY1.
PRIDEiQ5BKY1.

PTM databases

iPTMnetiQ5BKY1.
PhosphoSitePlusiQ5BKY1.

Expressioni

Gene expression databases

BgeeiENSG00000198812.
CleanExiHS_LRRC10.

Organism-specific databases

HPAiHPA040117.
HPA040159.

Interactioni

Protein-protein interaction databases

BioGridi132004. 6 interactors.
IntActiQ5BKY1. 1 interactor.
STRINGi9606.ENSP00000355166.

Structurei

3D structure databases

ProteinModelPortaliQ5BKY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 74LRR 1Add BLAST22
Repeati76 – 97LRR 2Add BLAST22
Repeati99 – 120LRR 3Add BLAST22
Repeati122 – 143LRR 4Add BLAST22
Repeati145 – 167LRR 5Add BLAST23
Repeati168 – 189LRR 6Add BLAST22
Repeati191 – 212LRR 7Add BLAST22

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000113359.
HOVERGENiHBG055066.
InParanoidiQ5BKY1.
OMAiIDVDRNS.
OrthoDBiEOG091G0HMZ.
PhylomeDBiQ5BKY1.
TreeFamiTF332853.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BKY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTIRALVA FIPADRCQNY VVRDLREMPL DKMVDLSGSQ LRRFPLHVCS
60 70 80 90 100
FRELVKLYLS DNHLNSLPPE LGQLQNLQIL ALDFNNFKAL PQVVCTLKQL
110 120 130 140 150
CILYLGNNKL CDLPSELSLL QNLRTLWIEA NCLTQLPDVV CELSLLKTLH
160 170 180 190 200
AGSNALRLLP GQLRRLQELR TIWLSGNRLT DFPTVLLHMP FLEVIDVDWN
210 220 230 240 250
SIRYFPSLAH LSSLKLVIYD HNPCRNAPKV AKGVRRVGRW AEETPEPDPR
260 270
KARRYALVRE ESQELQAPVP LLPPTNS
Length:277
Mass (Da):31,642
Last modified:April 12, 2005 - v1
Checksum:i95F326D838980589
GO

Sequence cautioni

The sequence BAC85724 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123908 mRNA. Translation: BAC85724.1. Different initiation.
BC090881 mRNA. Translation: AAH90881.1.
CCDSiCCDS31856.1.
RefSeqiNP_963844.2. NM_201550.3.
UniGeneiHs.448708.

Genome annotation databases

EnsembliENST00000361484; ENSP00000355166; ENSG00000198812.
GeneIDi376132.
KEGGihsa:376132.
UCSCiuc001svc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123908 mRNA. Translation: BAC85724.1. Different initiation.
BC090881 mRNA. Translation: AAH90881.1.
CCDSiCCDS31856.1.
RefSeqiNP_963844.2. NM_201550.3.
UniGeneiHs.448708.

3D structure databases

ProteinModelPortaliQ5BKY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132004. 6 interactors.
IntActiQ5BKY1. 1 interactor.
STRINGi9606.ENSP00000355166.

PTM databases

iPTMnetiQ5BKY1.
PhosphoSitePlusiQ5BKY1.

Polymorphism and mutation databases

BioMutaiLRRC10.
DMDMi74762168.

Proteomic databases

PaxDbiQ5BKY1.
PeptideAtlasiQ5BKY1.
PRIDEiQ5BKY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361484; ENSP00000355166; ENSG00000198812.
GeneIDi376132.
KEGGihsa:376132.
UCSCiuc001svc.4. human.

Organism-specific databases

CTDi376132.
GeneCardsiLRRC10.
HGNCiHGNC:20264. LRRC10.
HPAiHPA040117.
HPA040159.
MIMi610846. gene.
neXtProtiNX_Q5BKY1.
OpenTargetsiENSG00000198812.
PharmGKBiPA134896853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000113359.
HOVERGENiHBG055066.
InParanoidiQ5BKY1.
OMAiIDVDRNS.
OrthoDBiEOG091G0HMZ.
PhylomeDBiQ5BKY1.
TreeFamiTF332853.

Enzyme and pathway databases

BioCyciZFISH:G66-31457-MONOMER.

Miscellaneous databases

GenomeRNAii376132.
PROiQ5BKY1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198812.
CleanExiHS_LRRC10.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC10_HUMAN
AccessioniPrimary (citable) accession number: Q5BKY1
Secondary accession number(s): Q6ZVY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 12, 2005
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.