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Protein

Muscle-related coiled-coil protein

Gene

MURC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Muscle-related coiled-coil protein
Alternative name(s):
Muscle-restricted coiled-coil protein
Gene namesi
Name:MURC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:33742. MURC.

Subcellular locationi

  • Cytoplasmmyofibrilsarcomere By similarity
  • Cytoplasm By similarity

  • Note: In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723237.

Polymorphism and mutation databases

DMDMi172045939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Muscle-related coiled-coil proteinPRO_0000325763Add
BLAST

Proteomic databases

PaxDbiQ5BKX8.
PRIDEiQ5BKX8.

PTM databases

PhosphoSiteiQ5BKX8.

Expressioni

Gene expression databases

BgeeiQ5BKX8.
GenevisibleiQ5BKX8. HS.

Organism-specific databases

HPAiHPA020973.
HPA020987.
HPA021021.

Interactioni

Subunit structurei

Interacts with SDPR; this augments the transactivation of NPPA.1 Publication

Protein-protein interaction databases

BioGridi131419. 1 interaction.
STRINGi9606.ENSP00000418668.

Structurei

3D structure databases

ProteinModelPortaliQ5BKX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili44 – 7734Sequence AnalysisAdd
BLAST
Coiled coili202 – 22625Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the PTRF/SDPR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG25053.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000293135.
InParanoidiQ5BKX8.
OMAiHSNTGHI.
OrthoDBiEOG7JDQZ7.
PhylomeDBiQ5BKX8.
TreeFamiTF331031.

Family and domain databases

InterProiIPR026752. Cavin_fam.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BKX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHNGSASNA DKIHQNRLSS VTEDEDQDAA LTIVTVLDKV ASIVDSVQAS
60 70 80 90 100
QKRIEERHRE MENAIKSVQI DLLKLSQSHS NTGHIINKLF EKTRKVSAHI
110 120 130 140 150
KDVKARVEKQ QIHVKKVEVK QEEIMKKNKF RVVIFQEKFR CPTSLSVVKD
160 170 180 190 200
RNLTENQEED DDDIFDPPVD LSSDEEYYVE ESRSARLRKS GKEHIDNIKK
210 220 230 240 250
AFSKENMQKT RQNLDKKVNR IRTRIVTPER RERLRQSGER LRQSGERLRQ
260 270 280 290 300
SGERFKKSIS NAAPSKEAFK MRSLRKGKDR TVAEGEECAR EMGVDIIARS
310 320 330 340 350
ESLGPISELY SDELSEPEHE AARPVYPPHE GREIPTPEPL KVTFKSQVKV
360
EDDESLLLDL KHSS
Length:364
Mass (Da):41,899
Last modified:March 18, 2008 - v2
Checksum:i5EF86C58E970FC29
GO

Sequence cautioni

The sequence AAH90888.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341V → A in BAG61900 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU487253 mRNA. Translation: ACA62935.1.
AK300099 mRNA. Translation: BAG61900.1.
AL354917 Genomic DNA. No translation available.
BC090888 mRNA. Translation: AAH90888.1. Different initiation.
CCDSiCCDS35083.1.
RefSeqiNP_001018126.1. NM_001018116.2.
UniGeneiHs.733374.
Hs.99004.

Genome annotation databases

EnsembliENST00000307584; ENSP00000418668; ENSG00000170681.
GeneIDi347273.
KEGGihsa:347273.
UCSCiuc004bba.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU487253 mRNA. Translation: ACA62935.1.
AK300099 mRNA. Translation: BAG61900.1.
AL354917 Genomic DNA. No translation available.
BC090888 mRNA. Translation: AAH90888.1. Different initiation.
CCDSiCCDS35083.1.
RefSeqiNP_001018126.1. NM_001018116.2.
UniGeneiHs.733374.
Hs.99004.

3D structure databases

ProteinModelPortaliQ5BKX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131419. 1 interaction.
STRINGi9606.ENSP00000418668.

PTM databases

PhosphoSiteiQ5BKX8.

Polymorphism and mutation databases

DMDMi172045939.

Proteomic databases

PaxDbiQ5BKX8.
PRIDEiQ5BKX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307584; ENSP00000418668; ENSG00000170681.
GeneIDi347273.
KEGGihsa:347273.
UCSCiuc004bba.3. human.

Organism-specific databases

CTDi347273.
GeneCardsiGC09P103341.
H-InvDBHIX0025822.
HIX0169332.
HGNCiHGNC:33742. MURC.
HPAiHPA020973.
HPA020987.
HPA021021.
neXtProtiNX_Q5BKX8.
PharmGKBiPA164723237.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25053.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000293135.
InParanoidiQ5BKX8.
OMAiHSNTGHI.
OrthoDBiEOG7JDQZ7.
PhylomeDBiQ5BKX8.
TreeFamiTF331031.

Miscellaneous databases

ChiTaRSiMURC. human.
GenomeRNAii347273.
NextBioi99080.
PROiQ5BKX8.

Gene expression databases

BgeeiQ5BKX8.
GenevisibleiQ5BKX8. HS.

Family and domain databases

InterProiIPR026752. Cavin_fam.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance."
    Ogata T., Ueyama T., Isodono K., Tagawa M., Takehara N., Kawashima T., Harada K., Takahashi T., Shioi T., Matsubara H., Oh H.
    Mol. Cell. Biol. 28:3424-3436(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SDPR.
    Tissue: Heart.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pericardium.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-364.
    Tissue: Muscle.

Entry informationi

Entry nameiMURC_HUMAN
AccessioniPrimary (citable) accession number: Q5BKX8
Secondary accession number(s): B1PRL3, B4DT88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 22, 2015
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.