Q5BKX8 (MURC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Muscle-related coiled-coil protein

Alternative name(s):
Muscle-restricted coiled-coil protein

Gene names

Name:

MURC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway. Ref.1
Subunit structure	Interacts with SDPR; this augments the transactivation of NPPA. Ref.1
Subcellular location	Cytoplasm › myofibril › sarcomere By similarity. Cytoplasm By similarity. Note: In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm By similarity.
Sequence similarities	Belongs to the PTRF/SDPR family.
Sequence caution	The sequence AAH90888.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Myogenesis Transcription Transcription regulation
Cellular component	Cytoplasm
Domain	Coiled coil
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW muscle organ development Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Z disc Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Muscle-related coiled-coil protein		PRO_0000325763
Regions
	Coiled coil	44 – 77	34	Potential
	Coiled coil	202 – 226	25	Potential
Experimental info
	Sequence conflict	34	1	V → A in BAG61900. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5BKX8 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 5EF86C58E970FC29	FASTA	364	41,899
	10 20 30 40 50 60 MEHNGSASNA DKIHQNRLSS VTEDEDQDAA LTIVTVLDKV ASIVDSVQAS QKRIEERHRE 70 80 90 100 110 120 MENAIKSVQI DLLKLSQSHS NTGHIINKLF EKTRKVSAHI KDVKARVEKQ QIHVKKVEVK 130 140 150 160 170 180 QEEIMKKNKF RVVIFQEKFR CPTSLSVVKD RNLTENQEED DDDIFDPPVD LSSDEEYYVE 190 200 210 220 230 240 ESRSARLRKS GKEHIDNIKK AFSKENMQKT RQNLDKKVNR IRTRIVTPER RERLRQSGER 250 260 270 280 290 300 LRQSGERLRQ SGERFKKSIS NAAPSKEAFK MRSLRKGKDR TVAEGEECAR EMGVDIIARS 310 320 330 340 350 360 ESLGPISELY SDELSEPEHE AARPVYPPHE GREIPTPEPL KVTFKSQVKV EDDESLLLDL KHSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance." Ogata T., Ueyama T., Isodono K., Tagawa M., Takehara N., Kawashima T., Harada K., Takahashi T., Shioi T., Matsubara H., Oh H. Mol. Cell. Biol. 28:3424-3436(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SDPR. Tissue: Heart.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pericardium.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-364. Tissue: Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU487253 mRNA. Translation: ACA62935.1. AK300099 mRNA. Translation: BAG61900.1. AL354917 Genomic DNA. No translation available. BC090888 mRNA. Translation: AAH90888.1. Different initiation.
IPI	IPI00249656.
RefSeq	NP_001018126.1. NM_001018116.1.
UniGene	Hs.99004.
3D structure databases
ProteinModelPortal	Q5BKX8.
ModBase	Search...
PTM databases
PhosphoSite	Q5BKX8.
Polymorphism databases
DMDM	172045939.
Proteomic databases
PaxDb	Q5BKX8.
PRIDE	Q5BKX8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307584; ENSP00000418668; ENSG00000170681.
GeneID	347273.
KEGG	hsa:347273.
UCSC	uc004bba.3. human.
Organism-specific databases
CTD	347273.
GeneCards	GC09P103341.
H-InvDB	HIX0025822. HIX0169332.
HGNC	HGNC:33742. MURC.
HPA	HPA020973. HPA020987. HPA021021.
neXtProt	NX_Q5BKX8.
PharmGKB	PA164723237.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25053.
HOGENOM	HOG000293135.
InParanoid	Q5BKX8.
OMA	DRNLTEN.
OrthoDB	EOG46HGB0.
Gene expression databases
Bgee	Q5BKX8.
Genevestigator	Q5BKX8.
Family and domain databases
InterPro	IPR026752. Cavin_fam. [Graphical view]
PANTHER	PTHR15240. PTHR15240. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	347273.
NextBio	99080.

Entry information

Entry name

MURC_HUMAN

Accession

Primary (citable) accession number: Q5BKX8
Secondary accession number(s): B1PRL3, B4DT88

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	April 3, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.