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Q5BKX8

- MURC_HUMAN

UniProt

Q5BKX8 - MURC_HUMAN

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Protein

Muscle-related coiled-coil protein

Gene

MURC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.1 Publication

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. muscle organ development Source: UniProtKB-KW
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Muscle-related coiled-coil protein
Alternative name(s):
Muscle-restricted coiled-coil protein
Gene namesi
Name:MURC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:33742. MURC.

Subcellular locationi

Cytoplasmmyofibrilsarcomere By similarity. Cytoplasm By similarity
Note: In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (By similarity).By similarity

GO - Cellular componenti

  1. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Muscle-related coiled-coil proteinPRO_0000325763Add
BLAST

Proteomic databases

PaxDbiQ5BKX8.
PRIDEiQ5BKX8.

PTM databases

PhosphoSiteiQ5BKX8.

Expressioni

Gene expression databases

BgeeiQ5BKX8.
GenevestigatoriQ5BKX8.

Organism-specific databases

HPAiHPA020973.
HPA020987.
HPA021021.

Interactioni

Subunit structurei

Interacts with SDPR; this augments the transactivation of NPPA.1 Publication

Protein-protein interaction databases

BioGridi131419. 2 interactions.
STRINGi9606.ENSP00000418668.

Structurei

3D structure databases

ProteinModelPortaliQ5BKX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili44 – 7734Sequence AnalysisAdd
BLAST
Coiled coili202 – 22625Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the PTRF/SDPR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG25053.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000293135.
InParanoidiQ5BKX8.
OMAiDRNLTEN.
OrthoDBiEOG7JDQZ7.
PhylomeDBiQ5BKX8.
TreeFamiTF331031.

Family and domain databases

InterProiIPR026752. Cavin_fam.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BKX8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHNGSASNA DKIHQNRLSS VTEDEDQDAA LTIVTVLDKV ASIVDSVQAS
60 70 80 90 100
QKRIEERHRE MENAIKSVQI DLLKLSQSHS NTGHIINKLF EKTRKVSAHI
110 120 130 140 150
KDVKARVEKQ QIHVKKVEVK QEEIMKKNKF RVVIFQEKFR CPTSLSVVKD
160 170 180 190 200
RNLTENQEED DDDIFDPPVD LSSDEEYYVE ESRSARLRKS GKEHIDNIKK
210 220 230 240 250
AFSKENMQKT RQNLDKKVNR IRTRIVTPER RERLRQSGER LRQSGERLRQ
260 270 280 290 300
SGERFKKSIS NAAPSKEAFK MRSLRKGKDR TVAEGEECAR EMGVDIIARS
310 320 330 340 350
ESLGPISELY SDELSEPEHE AARPVYPPHE GREIPTPEPL KVTFKSQVKV
360
EDDESLLLDL KHSS
Length:364
Mass (Da):41,899
Last modified:March 18, 2008 - v2
Checksum:i5EF86C58E970FC29
GO

Sequence cautioni

The sequence AAH90888.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341V → A in BAG61900. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU487253 mRNA. Translation: ACA62935.1.
AK300099 mRNA. Translation: BAG61900.1.
AL354917 Genomic DNA. No translation available.
BC090888 mRNA. Translation: AAH90888.1. Different initiation.
CCDSiCCDS35083.1.
RefSeqiNP_001018126.1. NM_001018116.2.
UniGeneiHs.733374.
Hs.99004.

Genome annotation databases

EnsembliENST00000307584; ENSP00000418668; ENSG00000170681.
GeneIDi347273.
KEGGihsa:347273.
UCSCiuc004bba.3. human.

Polymorphism databases

DMDMi172045939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU487253 mRNA. Translation: ACA62935.1 .
AK300099 mRNA. Translation: BAG61900.1 .
AL354917 Genomic DNA. No translation available.
BC090888 mRNA. Translation: AAH90888.1 . Different initiation.
CCDSi CCDS35083.1.
RefSeqi NP_001018126.1. NM_001018116.2.
UniGenei Hs.733374.
Hs.99004.

3D structure databases

ProteinModelPortali Q5BKX8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131419. 2 interactions.
STRINGi 9606.ENSP00000418668.

PTM databases

PhosphoSitei Q5BKX8.

Polymorphism databases

DMDMi 172045939.

Proteomic databases

PaxDbi Q5BKX8.
PRIDEi Q5BKX8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307584 ; ENSP00000418668 ; ENSG00000170681 .
GeneIDi 347273.
KEGGi hsa:347273.
UCSCi uc004bba.3. human.

Organism-specific databases

CTDi 347273.
GeneCardsi GC09P103341.
H-InvDB HIX0025822.
HIX0169332.
HGNCi HGNC:33742. MURC.
HPAi HPA020973.
HPA020987.
HPA021021.
neXtProti NX_Q5BKX8.
PharmGKBi PA164723237.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25053.
GeneTreei ENSGT00530000063058.
HOGENOMi HOG000293135.
InParanoidi Q5BKX8.
OMAi DRNLTEN.
OrthoDBi EOG7JDQZ7.
PhylomeDBi Q5BKX8.
TreeFami TF331031.

Miscellaneous databases

GenomeRNAii 347273.
NextBioi 99080.
PROi Q5BKX8.

Gene expression databases

Bgeei Q5BKX8.
Genevestigatori Q5BKX8.

Family and domain databases

InterProi IPR026752. Cavin_fam.
[Graphical view ]
PANTHERi PTHR15240. PTHR15240. 1 hit.
Pfami PF15237. PTRF_SDPR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance."
    Ogata T., Ueyama T., Isodono K., Tagawa M., Takehara N., Kawashima T., Harada K., Takahashi T., Shioi T., Matsubara H., Oh H.
    Mol. Cell. Biol. 28:3424-3436(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SDPR.
    Tissue: Heart.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pericardium.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-364.
    Tissue: Muscle.

Entry informationi

Entry nameiMURC_HUMAN
AccessioniPrimary (citable) accession number: Q5BKX8
Secondary accession number(s): B1PRL3, B4DT88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3