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Protein

Caveolae-associated protein 4

Gene

CAVIN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105).By similarity1 Publication

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein
Biological processDifferentiation, Myogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolae-associated protein 4Imported
Alternative name(s):
Muscle-related coiled-coil protein
Muscle-restricted coiled-coil protein
Gene namesi
Name:CAVIN4Imported
Synonyms:MURC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000170681.6.
HGNCiHGNC:33742. CAVIN4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi347273.
OpenTargetsiENSG00000170681.
PharmGKBiPA164723237.

Polymorphism and mutation databases

DMDMi172045939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003257631 – 364Caveolae-associated protein 4Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei326PhosphotyrosineBy similarity1
Modified residuei336PhosphothreonineBy similarity1
Modified residuei355PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5BKX8.
PaxDbiQ5BKX8.
PeptideAtlasiQ5BKX8.
PRIDEiQ5BKX8.

PTM databases

iPTMnetiQ5BKX8.
PhosphoSitePlusiQ5BKX8.

Expressioni

Gene expression databases

BgeeiENSG00000170681.
GenevisibleiQ5BKX8. HS.

Organism-specific databases

HPAiHPA020973.
HPA020987.
HPA021021.

Interactioni

Subunit structurei

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4 (By similarity). Interacts with CAVIN1, ADRA1A and ADRA1B (PubMed:24567387). Interacts with CAVIN2; this augments the transactivation of NPPA (PubMed:18332105, PubMed:24567387). Interacts with CAV3 (PubMed:26497963, PubMed:24567387). Interacts with MAPK1 and MAPK3 (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi131419. 1 interactor.
IntActiQ5BKX8. 1 interactor.
STRINGi9606.ENSP00000418668.

Structurei

3D structure databases

ProteinModelPortaliQ5BKX8.
SMRiQ5BKX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili44 – 77Sequence analysisAdd BLAST34
Coiled coili202 – 226Sequence analysisAdd BLAST25

Domaini

The coiled coil domain (residues 44-77) is essential for membrane-targeting in cardiomyocytes.1 Publication

Sequence similaritiesi

Belongs to the CAVIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGHQ. Eukaryota.
ENOG411021K. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000293135.
InParanoidiQ5BKX8.
OMAiHSNTGHI.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ5BKX8.
TreeFamiTF331031.

Family and domain databases

InterProiView protein in InterPro
IPR033299. Cavin4.
IPR026752. Cavin_fam.
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF8. PTHR15240:SF8. 1 hit.
PfamiView protein in Pfam
PF15237. PTRF_SDPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BKX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHNGSASNA DKIHQNRLSS VTEDEDQDAA LTIVTVLDKV ASIVDSVQAS
60 70 80 90 100
QKRIEERHRE MENAIKSVQI DLLKLSQSHS NTGHIINKLF EKTRKVSAHI
110 120 130 140 150
KDVKARVEKQ QIHVKKVEVK QEEIMKKNKF RVVIFQEKFR CPTSLSVVKD
160 170 180 190 200
RNLTENQEED DDDIFDPPVD LSSDEEYYVE ESRSARLRKS GKEHIDNIKK
210 220 230 240 250
AFSKENMQKT RQNLDKKVNR IRTRIVTPER RERLRQSGER LRQSGERLRQ
260 270 280 290 300
SGERFKKSIS NAAPSKEAFK MRSLRKGKDR TVAEGEECAR EMGVDIIARS
310 320 330 340 350
ESLGPISELY SDELSEPEHE AARPVYPPHE GREIPTPEPL KVTFKSQVKV
360
EDDESLLLDL KHSS
Length:364
Mass (Da):41,899
Last modified:March 18, 2008 - v2
Checksum:i5EF86C58E970FC29
GO

Sequence cautioni

The sequence AAH90888 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34V → A in BAG61900 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU487253 mRNA. Translation: ACA62935.1.
AK300099 mRNA. Translation: BAG61900.1.
AL354917 Genomic DNA. No translation available.
BC090888 mRNA. Translation: AAH90888.1. Different initiation.
CCDSiCCDS35083.1.
RefSeqiNP_001018126.1. NM_001018116.2.
UniGeneiHs.733374.
Hs.99004.

Genome annotation databases

EnsembliENST00000307584; ENSP00000418668; ENSG00000170681.
GeneIDi347273.
KEGGihsa:347273.
UCSCiuc004bba.5. human.

Similar proteinsi

Entry informationi

Entry nameiCAVN4_HUMAN
AccessioniPrimary (citable) accession number: Q5BKX8
Secondary accession number(s): B1PRL3, B4DT88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 27, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families