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Q5BKX8

- MURC_HUMAN

UniProt

Q5BKX8 - MURC_HUMAN

Protein

Muscle-related coiled-coil protein

Gene

MURC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway.1 Publication

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. muscle organ development Source: UniProtKB-KW
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Myogenesis, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Muscle-related coiled-coil protein
    Alternative name(s):
    Muscle-restricted coiled-coil protein
    Gene namesi
    Name:MURC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:33742. MURC.

    Subcellular locationi

    Cytoplasmmyofibrilsarcomere By similarity. Cytoplasm By similarity
    Note: In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm By similarity.By similarity

    GO - Cellular componenti

    1. Z disc Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164723237.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Muscle-related coiled-coil proteinPRO_0000325763Add
    BLAST

    Proteomic databases

    PaxDbiQ5BKX8.
    PRIDEiQ5BKX8.

    PTM databases

    PhosphoSiteiQ5BKX8.

    Expressioni

    Gene expression databases

    BgeeiQ5BKX8.
    GenevestigatoriQ5BKX8.

    Organism-specific databases

    HPAiHPA020973.
    HPA020987.
    HPA021021.

    Interactioni

    Subunit structurei

    Interacts with SDPR; this augments the transactivation of NPPA.1 Publication

    Protein-protein interaction databases

    BioGridi131419. 2 interactions.
    STRINGi9606.ENSP00000418668.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5BKX8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili44 – 7734Sequence AnalysisAdd
    BLAST
    Coiled coili202 – 22625Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PTRF/SDPR family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG25053.
    HOGENOMiHOG000293135.
    InParanoidiQ5BKX8.
    OMAiDRNLTEN.
    OrthoDBiEOG7JDQZ7.
    PhylomeDBiQ5BKX8.
    TreeFamiTF331031.

    Family and domain databases

    InterProiIPR026752. Cavin_fam.
    [Graphical view]
    PANTHERiPTHR15240. PTHR15240. 1 hit.
    PfamiPF15237. PTRF_SDPR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5BKX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHNGSASNA DKIHQNRLSS VTEDEDQDAA LTIVTVLDKV ASIVDSVQAS    50
    QKRIEERHRE MENAIKSVQI DLLKLSQSHS NTGHIINKLF EKTRKVSAHI 100
    KDVKARVEKQ QIHVKKVEVK QEEIMKKNKF RVVIFQEKFR CPTSLSVVKD 150
    RNLTENQEED DDDIFDPPVD LSSDEEYYVE ESRSARLRKS GKEHIDNIKK 200
    AFSKENMQKT RQNLDKKVNR IRTRIVTPER RERLRQSGER LRQSGERLRQ 250
    SGERFKKSIS NAAPSKEAFK MRSLRKGKDR TVAEGEECAR EMGVDIIARS 300
    ESLGPISELY SDELSEPEHE AARPVYPPHE GREIPTPEPL KVTFKSQVKV 350
    EDDESLLLDL KHSS 364
    Length:364
    Mass (Da):41,899
    Last modified:March 18, 2008 - v2
    Checksum:i5EF86C58E970FC29
    GO

    Sequence cautioni

    The sequence AAH90888.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341V → A in BAG61900. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU487253 mRNA. Translation: ACA62935.1.
    AK300099 mRNA. Translation: BAG61900.1.
    AL354917 Genomic DNA. No translation available.
    BC090888 mRNA. Translation: AAH90888.1. Different initiation.
    CCDSiCCDS35083.1.
    RefSeqiNP_001018126.1. NM_001018116.2.
    UniGeneiHs.733374.
    Hs.99004.

    Genome annotation databases

    EnsembliENST00000307584; ENSP00000418668; ENSG00000170681.
    GeneIDi347273.
    KEGGihsa:347273.
    UCSCiuc004bba.3. human.

    Polymorphism databases

    DMDMi172045939.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU487253 mRNA. Translation: ACA62935.1 .
    AK300099 mRNA. Translation: BAG61900.1 .
    AL354917 Genomic DNA. No translation available.
    BC090888 mRNA. Translation: AAH90888.1 . Different initiation.
    CCDSi CCDS35083.1.
    RefSeqi NP_001018126.1. NM_001018116.2.
    UniGenei Hs.733374.
    Hs.99004.

    3D structure databases

    ProteinModelPortali Q5BKX8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131419. 2 interactions.
    STRINGi 9606.ENSP00000418668.

    PTM databases

    PhosphoSitei Q5BKX8.

    Polymorphism databases

    DMDMi 172045939.

    Proteomic databases

    PaxDbi Q5BKX8.
    PRIDEi Q5BKX8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307584 ; ENSP00000418668 ; ENSG00000170681 .
    GeneIDi 347273.
    KEGGi hsa:347273.
    UCSCi uc004bba.3. human.

    Organism-specific databases

    CTDi 347273.
    GeneCardsi GC09P103341.
    H-InvDB HIX0025822.
    HIX0169332.
    HGNCi HGNC:33742. MURC.
    HPAi HPA020973.
    HPA020987.
    HPA021021.
    neXtProti NX_Q5BKX8.
    PharmGKBi PA164723237.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25053.
    HOGENOMi HOG000293135.
    InParanoidi Q5BKX8.
    OMAi DRNLTEN.
    OrthoDBi EOG7JDQZ7.
    PhylomeDBi Q5BKX8.
    TreeFami TF331031.

    Miscellaneous databases

    GenomeRNAii 347273.
    NextBioi 99080.
    PROi Q5BKX8.

    Gene expression databases

    Bgeei Q5BKX8.
    Genevestigatori Q5BKX8.

    Family and domain databases

    InterProi IPR026752. Cavin_fam.
    [Graphical view ]
    PANTHERi PTHR15240. PTHR15240. 1 hit.
    Pfami PF15237. PTRF_SDPR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance."
      Ogata T., Ueyama T., Isodono K., Tagawa M., Takehara N., Kawashima T., Harada K., Takahashi T., Shioi T., Matsubara H., Oh H.
      Mol. Cell. Biol. 28:3424-3436(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SDPR.
      Tissue: Heart.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pericardium.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-364.
      Tissue: Muscle.

    Entry informationi

    Entry nameiMURC_HUMAN
    AccessioniPrimary (citable) accession number: Q5BKX8
    Secondary accession number(s): B1PRL3, B4DT88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3