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Protein

Solute carrier family 45 member 4

Gene

SLC45A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.2.4.7. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 45 member 4
Gene namesi
Name:SLC45A4
Synonyms:KIAA1126
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29196. SLC45A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Transmembranei518 – 53821HelicalSequence analysisAdd
BLAST
Transmembranei560 – 58021HelicalSequence analysisAdd
BLAST
Transmembranei592 – 61221HelicalSequence analysisAdd
BLAST
Transmembranei614 – 63421HelicalSequence analysisAdd
BLAST
Transmembranei666 – 68621HelicalSequence analysisAdd
BLAST
Transmembranei695 – 71521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi189046188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 768768Solute carrier family 45 member 4PRO_0000333803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei454 – 4541PhosphoserineCombined sources
Modified residuei485 – 4851PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5BKX6.
PaxDbiQ5BKX6.
PRIDEiQ5BKX6.

PTM databases

iPTMnetiQ5BKX6.
PhosphoSiteiQ5BKX6.

Expressioni

Gene expression databases

BgeeiQ5BKX6.
CleanExiHS_SLC45A4.
ExpressionAtlasiQ5BKX6. baseline and differential.
GenevisibleiQ5BKX6. HS.

Organism-specific databases

HPAiHPA023154.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000024061.

Structurei

3D structure databases

ProteinModelPortaliQ5BKX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410XPTR. LUCA.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000154239.
HOVERGENiHBG108452.
InParanoidiQ5BKX6.
KOiK15378.
OrthoDBiEOG70W3CZ.
PhylomeDBiQ5BKX6.
TreeFamiTF325412.

Family and domain databases

InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BKX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMAPQNADP ESMQVQELSV PLPDPQKAGG AEAENCETIS EGSIDRIPMR
60 70 80 90 100
LWVMHGAVMF GREFCYAMET ALVTPILLQI GLPEQYYSLT WFLSPILGLI
110 120 130 140 150
FTPLIGSASD RCTLSWGRRR PFILALCVGV LFGVALFLNG SAIGLALGDV
160 170 180 190 200
PNRQPIGIVL TVLGVVVLDF SADATEGPIR AYLLDVVDSE EQDMALNIHA
210 220 230 240 250
FSAGLGGAIG YVLGGLDWTQ TFLGSWFRTQ NQVLFFFAAI IFTVSVALHL
260 270 280 290 300
FSIDEEQYSP QQERSAEEPG ALDGGEPHGV PAFPDEVQSE HELALDYPDV
310 320 330 340 350
DIMRSKSDSA LHVPDTALDL EPELLFLHDI EPSIFHDASY PATPRSTSQE
360 370 380 390 400
LAKTKLPRLA TFLKEAAKED ETLLDNHLNE AKVPNGSGSP TKDALGGYTR
410 420 430 440 450
VDTKPSATSS SMRRRRHAFR RQASSTFSYY GKLGSHCYRY RRANAVVLIK
460 470 480 490 500
PSRSMSDLYD MQKRQRQHRH RNQSGATTSS GDTESEEGEG ETTVRLLWLS
510 520 530 540 550
MLKMPRELMR LCLCHLLTWF SVIAEAVFYT DFMGQVIFEG DPKAPSNSTA
560 570 580 590 600
WQAYNAGVKM GCWGLVIYAA TGAICSALLQ KYLDNYDLSV RVIYVLGTLG
610 620 630 640 650
FSVGTAVMAM FPNVYVAMVT ISTMGIVSMS ISYCPYALLG QYHDIKQYIH
660 670 680 690 700
HSPGNSKRGF GIDCAILSCQ VYISQILVAS ALGGVVDAVG TVRVIPMVAS
710 720 730 740 750
VGSFLGFLTA TFLVIYPNVS EEAKEEQKGL SSPLAGEGRA GGNSEKPTVL
760
KLTRKEGLQG PVETESVV
Length:768
Mass (Da):83,878
Last modified:May 20, 2008 - v2
Checksum:i8FAC1B4D0B918363
GO
Isoform 2 (identifier: Q5BKX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     52-80: WVMHGAVMFGREFCYAMETALVTPILLQI → MGKASPASGLSRPKTLVSPLRSNQWSLQK

Show »
Length:717
Mass (Da):78,182
Checksum:i6FD092AE5EDABDCE
GO
Isoform 3 (identifier: Q5BKX6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     52-80: WVMHGAVMFGREFCYAMETALVTPILLQI → MGKASPASGLSRPKTLVSPLRSNQWSLQK
     766-768: SVV → RLQVLTSVRS...AGPGGLGRRQ

Note: No experimental confirmation available.Curated
Show »
Length:798
Mass (Da):87,626
Checksum:i85AB7BB52564C5CD
GO

Sequence cautioni

The sequence AAH90891.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 3 (identifier: Q5BKX6-3)
Sequence conflicti787 – 7871E → K in BAC87328 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti277 – 2771P → L.
Corresponds to variant rs753778 [ dbSNP | Ensembl ].
VAR_043164
Natural varianti718 – 7181N → D.1 Publication
Corresponds to variant rs3739238 [ dbSNP | Ensembl ].
VAR_043165

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5151Missing in isoform 2 and isoform 3. 2 PublicationsVSP_033540Add
BLAST
Alternative sequencei52 – 8029WVMHG…ILLQI → MGKASPASGLSRPKTLVSPL RSNQWSLQK in isoform 2 and isoform 3. 2 PublicationsVSP_033541Add
BLAST
Alternative sequencei766 – 7683SVV → RLQVLTSVRSRHIGWCRSCW RVFFFMIILEKKFSFPQCGS LRRMTYLLFLSELDTLCPGQ PCPWAATAHQSWEEAGPGGL GRRQ in isoform 3. 1 PublicationVSP_033542

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128212 mRNA. Translation: BAC87328.1.
AC011676 Genomic DNA. No translation available.
BC090891 mRNA. Translation: AAH90891.1. Different initiation.
AB032952 mRNA. Translation: BAA86440.1.
CCDSiCCDS34948.1. [Q5BKX6-3]
CCDS69550.1. [Q5BKX6-2]
RefSeqiNP_001073900.1. NM_001080431.2. [Q5BKX6-3]
NP_001273575.1. NM_001286646.1.
NP_001273577.1. NM_001286648.1. [Q5BKX6-2]
UniGeneiHs.372492.

Genome annotation databases

EnsembliENST00000024061; ENSP00000024061; ENSG00000022567. [Q5BKX6-3]
ENST00000519067; ENSP00000429059; ENSG00000022567. [Q5BKX6-2]
GeneIDi57210.
KEGGihsa:57210.
UCSCiuc003ywc.3. human. [Q5BKX6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128212 mRNA. Translation: BAC87328.1.
AC011676 Genomic DNA. No translation available.
BC090891 mRNA. Translation: AAH90891.1. Different initiation.
AB032952 mRNA. Translation: BAA86440.1.
CCDSiCCDS34948.1. [Q5BKX6-3]
CCDS69550.1. [Q5BKX6-2]
RefSeqiNP_001073900.1. NM_001080431.2. [Q5BKX6-3]
NP_001273575.1. NM_001286646.1.
NP_001273577.1. NM_001286648.1. [Q5BKX6-2]
UniGeneiHs.372492.

3D structure databases

ProteinModelPortaliQ5BKX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000024061.

Protein family/group databases

TCDBi2.A.2.4.7. the glycoside-pentoside-hexuronide (gph):cation symporter family.

PTM databases

iPTMnetiQ5BKX6.
PhosphoSiteiQ5BKX6.

Polymorphism and mutation databases

DMDMi189046188.

Proteomic databases

MaxQBiQ5BKX6.
PaxDbiQ5BKX6.
PRIDEiQ5BKX6.

Protocols and materials databases

DNASUi57210.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000024061; ENSP00000024061; ENSG00000022567. [Q5BKX6-3]
ENST00000519067; ENSP00000429059; ENSG00000022567. [Q5BKX6-2]
GeneIDi57210.
KEGGihsa:57210.
UCSCiuc003ywc.3. human. [Q5BKX6-1]

Organism-specific databases

CTDi57210.
GeneCardsiSLC45A4.
HGNCiHGNC:29196. SLC45A4.
HPAiHPA023154.
neXtProtiNX_Q5BKX6.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410XPTR. LUCA.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000154239.
HOVERGENiHBG108452.
InParanoidiQ5BKX6.
KOiK15378.
OrthoDBiEOG70W3CZ.
PhylomeDBiQ5BKX6.
TreeFamiTF325412.

Miscellaneous databases

GenomeRNAii57210.
PROiQ5BKX6.

Gene expression databases

BgeeiQ5BKX6.
CleanExiHS_SLC45A4.
ExpressionAtlasiQ5BKX6. baseline and differential.
GenevisibleiQ5BKX6. HS.

Family and domain databases

InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-768 (ISOFORMS 1/2), VARIANT ASP-718.
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiS45A4_HUMAN
AccessioniPrimary (citable) accession number: Q5BKX6
Secondary accession number(s): Q6ZRI2, Q9ULU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 8, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.