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Protein

UPF0692 protein C19orf54

Gene

C19orf54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33091-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0692 protein C19orf54
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24758. C19orf54.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188493.
PharmGKBiPA147358417.

Polymorphism and mutation databases

BioMutaiC19orf54.
DMDMi308153429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976591 – 351UPF0692 protein C19orf54Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5BKX5.
MaxQBiQ5BKX5.
PaxDbiQ5BKX5.
PeptideAtlasiQ5BKX5.
PRIDEiQ5BKX5.

PTM databases

iPTMnetiQ5BKX5.
PhosphoSitePlusiQ5BKX5.

Expressioni

Gene expression databases

BgeeiENSG00000188493.
CleanExiHS_C19orf54.
ExpressionAtlasiQ5BKX5. baseline and differential.
GenevisibleiQ5BKX5. HS.

Organism-specific databases

HPAiHPA059043.
HPA059628.

Interactioni

Protein-protein interaction databases

BioGridi129828. 4 interactors.
IntActiQ5BKX5. 3 interactors.
STRINGi9606.ENSP00000367564.

Structurei

3D structure databases

ProteinModelPortaliQ5BKX5.
SMRiQ5BKX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 69Pro-richAdd BLAST66

Sequence similaritiesi

Belongs to the UPF0692 family.Curated

Phylogenomic databases

eggNOGiENOG410IJKK. Eukaryota.
ENOG410XSMD. LUCA.
GeneTreeiENSGT00390000012368.
HOGENOMiHOG000015241.
HOVERGENiHBG107765.
InParanoidiQ5BKX5.
OMAiMTSPCSP.
OrthoDBiEOG091G0KWQ.
PhylomeDBiQ5BKX5.
TreeFamiTF314051.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BKX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSPCSPPLK PPISPPKTPV PQASSIPSPP LPPSPLDFSA LPSPPWSQQT
60 70 80 90 100
PVPPPLPLPP PPAATGPAPR HVFGLEKSQL LKEAFDKAGP VPKGREDVKR
110 120 130 140 150
LLKLHKDRFR GDLRWILFCA DLPSLIQEGP QCGLVALWMA GTLLSPPSGV
160 170 180 190 200
PLERLIRVAT ERGYTAQGEM FSVADMGRLA QEVLGCQAKL LSGGLGGPNR
210 220 230 240 250
DLVLQHLVTG HPLLIPYDED FNHEPCQRKG HKAHWAVSAG VLLGVRAVPS
260 270 280 290 300
LGYTEDPELP GLFHPVLGTP CQPPSLPEEG SPGAVYLLSK QGKSWHYQLW
310 320 330 340 350
DYDQVRESNL QLTDFSPSRA TDGRVYVVPV GGVRAGLCGQ ALLLTPQDCS

H
Note: No experimental confirmation available.
Length:351
Mass (Da):37,779
Last modified:October 5, 2010 - v2
Checksum:iB1CE78515DC3A553
GO
Isoform 2 (identifier: Q5BKX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS
     305-351: VRESNLQLTDFSPSRATDGRVYVVPVGGVRAGLCGQALLLTPQDCSH → GPPLSSH

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):15,107
Checksum:i82E3B29750E4BA53
GO
Isoform 3 (identifier: Q5BKX5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):19,398
Checksum:i1318759D86E77445
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70R → P in BC020262 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0398841 – 216MTSPC…PLLIP → MRAGGLVDGRYSPVAPQWRP PGETHTGGHGKRLHGPGRDV LSTS in isoform 2 and isoform 3. 2 PublicationsAdd BLAST216
Alternative sequenceiVSP_039885305 – 351VRESN…QDCSH → GPPLSSH in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298068 mRNA. Translation: BAG60359.1.
AC020945 Genomic DNA. No translation available.
BC020262 mRNA. No translation available.
BC090894 mRNA. Translation: AAH90894.1.
CCDSiCCDS12564.2. [Q5BKX5-1]
RefSeqiNP_940878.3. NM_198476.3. [Q5BKX5-1]
XP_005258835.1. XM_005258778.4. [Q5BKX5-3]
XP_016882116.1. XM_017026627.1. [Q5BKX5-3]
UniGeneiHs.585105.

Genome annotation databases

EnsembliENST00000378313; ENSP00000367564; ENSG00000188493. [Q5BKX5-1]
GeneIDi284325.
KEGGihsa:284325.
UCSCiuc002oou.1. human. [Q5BKX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298068 mRNA. Translation: BAG60359.1.
AC020945 Genomic DNA. No translation available.
BC020262 mRNA. No translation available.
BC090894 mRNA. Translation: AAH90894.1.
CCDSiCCDS12564.2. [Q5BKX5-1]
RefSeqiNP_940878.3. NM_198476.3. [Q5BKX5-1]
XP_005258835.1. XM_005258778.4. [Q5BKX5-3]
XP_016882116.1. XM_017026627.1. [Q5BKX5-3]
UniGeneiHs.585105.

3D structure databases

ProteinModelPortaliQ5BKX5.
SMRiQ5BKX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129828. 4 interactors.
IntActiQ5BKX5. 3 interactors.
STRINGi9606.ENSP00000367564.

PTM databases

iPTMnetiQ5BKX5.
PhosphoSitePlusiQ5BKX5.

Polymorphism and mutation databases

BioMutaiC19orf54.
DMDMi308153429.

Proteomic databases

EPDiQ5BKX5.
MaxQBiQ5BKX5.
PaxDbiQ5BKX5.
PeptideAtlasiQ5BKX5.
PRIDEiQ5BKX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378313; ENSP00000367564; ENSG00000188493. [Q5BKX5-1]
GeneIDi284325.
KEGGihsa:284325.
UCSCiuc002oou.1. human. [Q5BKX5-1]

Organism-specific databases

CTDi284325.
GeneCardsiC19orf54.
H-InvDBHIX0027474.
HGNCiHGNC:24758. C19orf54.
HPAiHPA059043.
HPA059628.
neXtProtiNX_Q5BKX5.
OpenTargetsiENSG00000188493.
PharmGKBiPA147358417.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJKK. Eukaryota.
ENOG410XSMD. LUCA.
GeneTreeiENSGT00390000012368.
HOGENOMiHOG000015241.
HOVERGENiHBG107765.
InParanoidiQ5BKX5.
OMAiMTSPCSP.
OrthoDBiEOG091G0KWQ.
PhylomeDBiQ5BKX5.
TreeFamiTF314051.

Enzyme and pathway databases

BioCyciZFISH:G66-33091-MONOMER.

Miscellaneous databases

GenomeRNAii284325.
PROiQ5BKX5.

Gene expression databases

BgeeiENSG00000188493.
CleanExiHS_C19orf54.
ExpressionAtlasiQ5BKX5. baseline and differential.
GenevisibleiQ5BKX5. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCS054_HUMAN
AccessioniPrimary (citable) accession number: Q5BKX5
Secondary accession number(s): A8MSZ5, B4DNU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.