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Protein

UPF0692 protein C19orf54

Gene

C19orf54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0692 protein C19orf54
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24758. C19orf54.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351UPF0692 protein C19orf54PRO_0000297659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei316 – 3161Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5BKX5.
PaxDbiQ5BKX5.
PRIDEiQ5BKX5.

PTM databases

PhosphoSiteiQ5BKX5.

Expressioni

Gene expression databases

BgeeiQ5BKX5.
CleanExiHS_C19orf54.
ExpressionAtlasiQ5BKX5. baseline and differential.
GenevestigatoriQ5BKX5.

Organism-specific databases

HPAiHPA059043.
HPA059628.

Interactioni

Protein-protein interaction databases

BioGridi129828. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5BKX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 6966Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0692 family.Curated

Phylogenomic databases

eggNOGiNOG78145.
GeneTreeiENSGT00390000012368.
HOGENOMiHOG000015241.
HOVERGENiHBG107765.
InParanoidiQ5BKX5.
OMAiIQDGPQC.
OrthoDBiEOG76HQ4Q.
PhylomeDBiQ5BKX5.
TreeFamiTF314051.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BKX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSPCSPPLK PPISPPKTPV PQASSIPSPP LPPSPLDFSA LPSPPWSQQT
60 70 80 90 100
PVPPPLPLPP PPAATGPAPR HVFGLEKSQL LKEAFDKAGP VPKGREDVKR
110 120 130 140 150
LLKLHKDRFR GDLRWILFCA DLPSLIQEGP QCGLVALWMA GTLLSPPSGV
160 170 180 190 200
PLERLIRVAT ERGYTAQGEM FSVADMGRLA QEVLGCQAKL LSGGLGGPNR
210 220 230 240 250
DLVLQHLVTG HPLLIPYDED FNHEPCQRKG HKAHWAVSAG VLLGVRAVPS
260 270 280 290 300
LGYTEDPELP GLFHPVLGTP CQPPSLPEEG SPGAVYLLSK QGKSWHYQLW
310 320 330 340 350
DYDQVRESNL QLTDFSPSRA TDGRVYVVPV GGVRAGLCGQ ALLLTPQDCS

H

Note: No experimental confirmation available.

Length:351
Mass (Da):37,779
Last modified:October 5, 2010 - v2
Checksum:iB1CE78515DC3A553
GO
Isoform 2 (identifier: Q5BKX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS
     305-351: VRESNLQLTDFSPSRATDGRVYVVPVGGVRAGLCGQALLLTPQDCSH → GPPLSSH

Note: No experimental confirmation available.

Show »
Length:139
Mass (Da):15,107
Checksum:i82E3B29750E4BA53
GO
Isoform 3 (identifier: Q5BKX5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS

Note: No experimental confirmation available.

Show »
Length:179
Mass (Da):19,398
Checksum:i1318759D86E77445
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701R → P in BC020262 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 216216MTSPC…PLLIP → MRAGGLVDGRYSPVAPQWRP PGETHTGGHGKRLHGPGRDV LSTS in isoform 2 and isoform 3. 2 PublicationsVSP_039884Add
BLAST
Alternative sequencei305 – 35147VRESN…QDCSH → GPPLSSH in isoform 2. 1 PublicationVSP_039885Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298068 mRNA. Translation: BAG60359.1.
AC020945 Genomic DNA. No translation available.
BC020262 mRNA. No translation available.
BC090894 mRNA. Translation: AAH90894.1.
CCDSiCCDS12564.2. [Q5BKX5-1]
RefSeqiNP_940878.3. NM_198476.3. [Q5BKX5-1]
XP_005258835.1. XM_005258778.2. [Q5BKX5-3]
UniGeneiHs.585105.

Genome annotation databases

EnsembliENST00000378313; ENSP00000367564; ENSG00000188493. [Q5BKX5-1]
GeneIDi284325.
KEGGihsa:284325.
UCSCiuc002oou.1. human. [Q5BKX5-1]
uc002oow.1. human. [Q5BKX5-3]

Polymorphism databases

DMDMi308153429.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298068 mRNA. Translation: BAG60359.1.
AC020945 Genomic DNA. No translation available.
BC020262 mRNA. No translation available.
BC090894 mRNA. Translation: AAH90894.1.
CCDSiCCDS12564.2. [Q5BKX5-1]
RefSeqiNP_940878.3. NM_198476.3. [Q5BKX5-1]
XP_005258835.1. XM_005258778.2. [Q5BKX5-3]
UniGeneiHs.585105.

3D structure databases

ProteinModelPortaliQ5BKX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129828. 4 interactions.

PTM databases

PhosphoSiteiQ5BKX5.

Polymorphism databases

DMDMi308153429.

Proteomic databases

MaxQBiQ5BKX5.
PaxDbiQ5BKX5.
PRIDEiQ5BKX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378313; ENSP00000367564; ENSG00000188493. [Q5BKX5-1]
GeneIDi284325.
KEGGihsa:284325.
UCSCiuc002oou.1. human. [Q5BKX5-1]
uc002oow.1. human. [Q5BKX5-3]

Organism-specific databases

CTDi284325.
GeneCardsiGC19M041246.
H-InvDBHIX0027474.
HGNCiHGNC:24758. C19orf54.
HPAiHPA059043.
HPA059628.
neXtProtiNX_Q5BKX5.
PharmGKBiPA147358417.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78145.
GeneTreeiENSGT00390000012368.
HOGENOMiHOG000015241.
HOVERGENiHBG107765.
InParanoidiQ5BKX5.
OMAiIQDGPQC.
OrthoDBiEOG76HQ4Q.
PhylomeDBiQ5BKX5.
TreeFamiTF314051.

Miscellaneous databases

GenomeRNAii284325.
NextBioi94728.

Gene expression databases

BgeeiQ5BKX5.
CleanExiHS_C19orf54.
ExpressionAtlasiQ5BKX5. baseline and differential.
GenevestigatoriQ5BKX5.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Melanoma and Testis.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCS054_HUMAN
AccessioniPrimary (citable) accession number: Q5BKX5
Secondary accession number(s): A8MSZ5, B4DNU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: January 7, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.