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Q5BKX5

- CS054_HUMAN

UniProt

Q5BKX5 - CS054_HUMAN

Protein

UPF0692 protein C19orf54

Gene

C19orf54

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0692 protein C19orf54
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:24758. C19orf54.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA147358417.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351UPF0692 protein C19orf54PRO_0000297659Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei316 – 3161Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5BKX5.
    PaxDbiQ5BKX5.
    PRIDEiQ5BKX5.

    PTM databases

    PhosphoSiteiQ5BKX5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5BKX5.
    BgeeiQ5BKX5.
    CleanExiHS_C19orf54.
    GenevestigatoriQ5BKX5.

    Organism-specific databases

    HPAiHPA059043.
    HPA059628.

    Interactioni

    Protein-protein interaction databases

    BioGridi129828. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5BKX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 6966Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UPF0692 family.Curated

    Phylogenomic databases

    eggNOGiNOG78145.
    HOGENOMiHOG000015241.
    HOVERGENiHBG107765.
    OMAiIQDGPQC.
    OrthoDBiEOG76HQ4Q.
    PhylomeDBiQ5BKX5.
    TreeFamiTF314051.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5BKX5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSPCSPPLK PPISPPKTPV PQASSIPSPP LPPSPLDFSA LPSPPWSQQT    50
    PVPPPLPLPP PPAATGPAPR HVFGLEKSQL LKEAFDKAGP VPKGREDVKR 100
    LLKLHKDRFR GDLRWILFCA DLPSLIQEGP QCGLVALWMA GTLLSPPSGV 150
    PLERLIRVAT ERGYTAQGEM FSVADMGRLA QEVLGCQAKL LSGGLGGPNR 200
    DLVLQHLVTG HPLLIPYDED FNHEPCQRKG HKAHWAVSAG VLLGVRAVPS 250
    LGYTEDPELP GLFHPVLGTP CQPPSLPEEG SPGAVYLLSK QGKSWHYQLW 300
    DYDQVRESNL QLTDFSPSRA TDGRVYVVPV GGVRAGLCGQ ALLLTPQDCS 350
    H 351

    Note: No experimental confirmation available.

    Length:351
    Mass (Da):37,779
    Last modified:October 5, 2010 - v2
    Checksum:iB1CE78515DC3A553
    GO
    Isoform 2 (identifier: Q5BKX5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS
         305-351: VRESNLQLTDFSPSRATDGRVYVVPVGGVRAGLCGQALLLTPQDCSH → GPPLSSH

    Note: No experimental confirmation available.

    Show »
    Length:139
    Mass (Da):15,107
    Checksum:i82E3B29750E4BA53
    GO
    Isoform 3 (identifier: Q5BKX5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS

    Note: No experimental confirmation available.

    Show »
    Length:179
    Mass (Da):19,398
    Checksum:i1318759D86E77445
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701R → P in BC020262. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 216216MTSPC…PLLIP → MRAGGLVDGRYSPVAPQWRP PGETHTGGHGKRLHGPGRDV LSTS in isoform 2 and isoform 3. 2 PublicationsVSP_039884Add
    BLAST
    Alternative sequencei305 – 35147VRESN…QDCSH → GPPLSSH in isoform 2. 1 PublicationVSP_039885Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK298068 mRNA. Translation: BAG60359.1.
    AC020945 Genomic DNA. No translation available.
    BC020262 mRNA. No translation available.
    BC090894 mRNA. Translation: AAH90894.1.
    CCDSiCCDS12564.2. [Q5BKX5-1]
    RefSeqiNP_940878.3. NM_198476.3. [Q5BKX5-1]
    XP_005258835.1. XM_005258778.2. [Q5BKX5-3]
    UniGeneiHs.585105.

    Genome annotation databases

    EnsembliENST00000378313; ENSP00000367564; ENSG00000188493. [Q5BKX5-1]
    GeneIDi284325.
    KEGGihsa:284325.
    UCSCiuc002oou.1. human. [Q5BKX5-1]
    uc002oow.1. human. [Q5BKX5-3]

    Polymorphism databases

    DMDMi308153429.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK298068 mRNA. Translation: BAG60359.1 .
    AC020945 Genomic DNA. No translation available.
    BC020262 mRNA. No translation available.
    BC090894 mRNA. Translation: AAH90894.1 .
    CCDSi CCDS12564.2. [Q5BKX5-1 ]
    RefSeqi NP_940878.3. NM_198476.3. [Q5BKX5-1 ]
    XP_005258835.1. XM_005258778.2. [Q5BKX5-3 ]
    UniGenei Hs.585105.

    3D structure databases

    ProteinModelPortali Q5BKX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129828. 1 interaction.

    PTM databases

    PhosphoSitei Q5BKX5.

    Polymorphism databases

    DMDMi 308153429.

    Proteomic databases

    MaxQBi Q5BKX5.
    PaxDbi Q5BKX5.
    PRIDEi Q5BKX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378313 ; ENSP00000367564 ; ENSG00000188493 . [Q5BKX5-1 ]
    GeneIDi 284325.
    KEGGi hsa:284325.
    UCSCi uc002oou.1. human. [Q5BKX5-1 ]
    uc002oow.1. human. [Q5BKX5-3 ]

    Organism-specific databases

    CTDi 284325.
    GeneCardsi GC19M041246.
    H-InvDB HIX0027474.
    HGNCi HGNC:24758. C19orf54.
    HPAi HPA059043.
    HPA059628.
    neXtProti NX_Q5BKX5.
    PharmGKBi PA147358417.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78145.
    HOGENOMi HOG000015241.
    HOVERGENi HBG107765.
    OMAi IQDGPQC.
    OrthoDBi EOG76HQ4Q.
    PhylomeDBi Q5BKX5.
    TreeFami TF314051.

    Miscellaneous databases

    GenomeRNAii 284325.
    NextBioi 94728.

    Gene expression databases

    ArrayExpressi Q5BKX5.
    Bgeei Q5BKX5.
    CleanExi HS_C19orf54.
    Genevestigatori Q5BKX5.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Melanoma and Testis.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCS054_HUMAN
    AccessioniPrimary (citable) accession number: Q5BKX5
    Secondary accession number(s): A8MSZ5, B4DNU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3