Q5BKW9 (ASGL1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-asparaginase
EC=3.5.1.1

Alternative name(s):
Asparaginase-like protein 1
L-asparagine amidohydrolase

Gene names

Name:	asrgl1
ORF Names:	zgc:103568

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts in asparagine catabolism By similarity.
Catalytic activity	L-asparagine + H2O = L-aspartate + NH3.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Ntn-hydrolase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	asparagine catabolic process via L-aspartate Inferred from sequence or structural similarity. Source: UniProtKB protein maturation Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	L-asparaginase		PRO_0000305208
Sites
	Active site	167	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5BKW9 [UniParc]. Last modified April 12, 2005. Version 1. Checksum: 2CFE4C0E019CC3F9	FASTA	310	32,929
	10 20 30 40 50 60 MLPVVVVHGG AGHIPKERTE ESTIGVKEAA RTGYAILQRG GSAVDAVVEA VALMETNPRF 70 80 90 100 110 120 NAGRGSVLNI KGEVEMDALV MDGRTLDSGA VSAVRRIANP VQLARLVMEK TKHLCLTAEG 130 140 150 160 170 180 ASKFARSMGV PEVPEESLIT DYAKMRWKKN LEPDANPVEC QMGKMGTVGA VAVDMDGNIA 190 200 210 220 230 240 CATSTGGMIN KMEGRVGDTP CVGCGGYADN KIGAVSPTGH GEAIMKVTLS RLVLFHMEQG 250 260 270 280 290 300 KTPEEASDLA LAYMKERVDG LGGVVVVDHN GTWAARFSSL QMSWAAAQQG KLHFGLFHGD 310 HFTEPVEEHT

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC090901 mRNA. Translation: AAH90901.1.
IPI	IPI00500426.
RefSeq	NP_001013547.1. NM_001013529.1.
UniGene	Dr.38131.
3D structure databases
HSSP	HSSP built from PDB template 1K2X based on UniProtKB P37595.
ProteinModelPortal	Q5BKW9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000029521; ENSDARP00000033788; ENSDARG00000021681.
GeneID	541402.
KEGG	dre:541402.
Organism-specific databases
ZFIN	ZDB-GENE-050320-102. zgc:103568.
Phylogenomic databases
eggNOG	fiNOG14277.
GeneTree	ENSGT00530000063034.
HOGENOM	HBG735787.
HOVERGEN	HBG101662.
InParanoid	Q5BKW9.
OMA	ATGHGEF.
OrthoDB	EOG4ZS93Q.
PhylomeDB	Q5BKW9.
Gene expression databases
Bgee	Q5BKW9.
Family and domain databases
InterPro	IPR000246. Peptidase_T2. [Graphical view]
KO	K13051.
PANTHER	PTHR10188. Peptidase_T2. 1 hit.
Pfam	PF01112. Asparaginase_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASGL1_DANRE

Accession

Primary (citable) accession number: Q5BKW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	April 12, 2005
Last modified:	November 16, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program