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Protein

Mitochondrial sodium/hydrogen exchanger 9B2

Gene

Slc9b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Electroneutral exchange of protons for Na+ across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei278 – 2781Important for cation transportBy similarity
Sitei279 – 2791Important for cation transportBy similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of osteoclast development Source: MGI
  • sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiport, Hydrogen ion transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial sodium/hydrogen exchanger 9B2
Alternative name(s):
Mitochondrial Na(+)/H(+) exchanger NHA2
NHA-oc
Na(+)/H(+) exchanger-like domain-containing protein 2
Short name:
NHE domain-containing protein 2
Sodium/hydrogen exchanger-like domain-containing protein 2
Solute carrier family 9 subfamily B member 2
Gene namesi
Name:Slc9b2
Synonyms:Nha2, Nhedc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2140077. Slc9b2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence analysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence analysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence analysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence analysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence analysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence analysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence analysisAdd
BLAST
Transmembranei493 – 51321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Mitochondrial sodium/hydrogen exchanger 9B2PRO_0000331271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BKR2.
PeptideAtlasiQ5BKR2.
PRIDEiQ5BKR2.

PTM databases

PhosphoSiteiQ5BKR2.

Expressioni

Tissue specificityi

Detected in calvaria, jaw bone, around tooth buds, in mandible, maxilla, occipital bone, clavicle and femur. Not detectable in the other tissues tested.1 Publication

Inductioni

Not detectable during the early stages of osteoclast differentiation induced by TNFSF11/RANKL. Up-regulated during the later stages of osteoclast differentiation, five days after treatment with TNFSF11/RANKL. Up-regulated in macrophages and blood mononuclear cells treated with TNFSF11/RANKL.2 Publications

Gene expression databases

BgeeiENSMUSG00000037994.
ExpressionAtlasiQ5BKR2. baseline and differential.
GenevisibleiQ5BKR2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060640.

Structurei

3D structure databases

ProteinModelPortaliQ5BKR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3826. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00390000013285.
HOGENOMiHOG000060325.
HOVERGENiHBG108184.
InParanoidiQ5BKR2.
OMAiKIVAVAW.
OrthoDBiEOG091G06PH.
TreeFamiTF319087.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR030187. NHA2.
[Graphical view]
PANTHERiPTHR31102:SF6. PTHR31102:SF6. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BKR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDEDKTAEC QHSKPPTGIT HEAPPHHELQ EERVMSLRGT DRSEPTEGSN
60 70 80 90 100
LLTSGEKKPQ DSPTEPNGLQ SLRRFLACPP RGCLARVITN GTMVVLLWAM
110 120 130 140 150
VWSVTGPECL PGGNLFGIII LFYCSITGGK LFGLIKFPTL PPLPPLLGML
160 170 180 190 200
LAGFLLRNIP VINDSVRIQH KWSSSLRSIA LSVILVRAGL GLDSKALRKL
210 220 230 240 250
KGVCVRLAMG PCIVEACASA ILSHFLMGLP WQWGFILGFV VGAVSPAVVV
260 270 280 290 300
PSMLLLQEGG YGVGKGIPTL LMAAGSFDDI LAITGFNTCL GVAFSTGSTV
310 320 330 340 350
FNIFRGILEV VIGVAAGSFL GFFIQYFPSR DQDNLVWKRA FLVLGFAVLA
360 370 380 390 400
VFSSVYFSFP GSGGLCTLVM AFLAGMRWTD KKSEVEKVIA VTWDVFQPLL
410 420 430 440 450
FGLIGAEVSI VSLRAETVGL CVATLSIAVL IRILTTFLMV CFAGFNIKEK
460 470 480 490 500
IFISFAWLPK ATVQAAIGSV ALDTARSHGE KQLEDYGMDV LTVAFLAILI
510 520 530 540
TAPIGSLLIG LLGPRVLQKS EHRTEEEVQG ETSAHIQRKP EDSITEA
Length:547
Mass (Da):58,934
Last modified:July 27, 2011 - v2
Checksum:iB1F2A99BBF70BE96
GO
Isoform 2 (identifier: Q5BKR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.

Note: No experimental confirmation available.
Show »
Length:295
Mass (Da):31,746
Checksum:iE028B9650DEE92B1
GO
Isoform 3 (identifier: Q5BKR2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-438: Missing.

Note: No experimental confirmation available.
Show »
Length:109
Mass (Da):11,866
Checksum:iB9CA134FB6C748D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301Q → R in AAH90977 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 438438Missing in isoform 3. 1 PublicationVSP_033154Add
BLAST
Alternative sequencei1 – 252252Missing in isoform 2. 1 PublicationVSP_033155Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029417 mRNA. Translation: BAC26441.1.
AK039655 mRNA. Translation: BAC30408.1.
AC104874 Genomic DNA. No translation available.
BC090977 mRNA. Translation: AAH90977.1.
CCDSiCCDS17854.1. [Q5BKR2-1]
RefSeqiNP_849208.4. NM_178877.6. [Q5BKR2-1]
XP_006502461.1. XM_006502398.2. [Q5BKR2-1]
XP_006502462.1. XM_006502399.2. [Q5BKR2-1]
UniGeneiMm.441764.

Genome annotation databases

EnsembliENSMUST00000051849; ENSMUSP00000060640; ENSMUSG00000037994. [Q5BKR2-1]
GeneIDi97086.
KEGGimmu:97086.
UCSCiuc008rld.2. mouse. [Q5BKR2-1]
uc008rle.2. mouse. [Q5BKR2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029417 mRNA. Translation: BAC26441.1.
AK039655 mRNA. Translation: BAC30408.1.
AC104874 Genomic DNA. No translation available.
BC090977 mRNA. Translation: AAH90977.1.
CCDSiCCDS17854.1. [Q5BKR2-1]
RefSeqiNP_849208.4. NM_178877.6. [Q5BKR2-1]
XP_006502461.1. XM_006502398.2. [Q5BKR2-1]
XP_006502462.1. XM_006502399.2. [Q5BKR2-1]
UniGeneiMm.441764.

3D structure databases

ProteinModelPortaliQ5BKR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060640.

PTM databases

PhosphoSiteiQ5BKR2.

Proteomic databases

PaxDbiQ5BKR2.
PeptideAtlasiQ5BKR2.
PRIDEiQ5BKR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051849; ENSMUSP00000060640; ENSMUSG00000037994. [Q5BKR2-1]
GeneIDi97086.
KEGGimmu:97086.
UCSCiuc008rld.2. mouse. [Q5BKR2-1]
uc008rle.2. mouse. [Q5BKR2-3]

Organism-specific databases

CTDi133308.
MGIiMGI:2140077. Slc9b2.

Phylogenomic databases

eggNOGiKOG3826. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00390000013285.
HOGENOMiHOG000060325.
HOVERGENiHBG108184.
InParanoidiQ5BKR2.
OMAiKIVAVAW.
OrthoDBiEOG091G06PH.
TreeFamiTF319087.

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Miscellaneous databases

PROiQ5BKR2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037994.
ExpressionAtlasiQ5BKR2. baseline and differential.
GenevisibleiQ5BKR2. MM.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR030187. NHA2.
[Graphical view]
PANTHERiPTHR31102:SF6. PTHR31102:SF6. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSL9B2_MOUSE
AccessioniPrimary (citable) accession number: Q5BKR2
Secondary accession number(s): Q8CA47, Q8CDX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.