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Q5BKQ4 (LIPR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive pancreatic lipase-related protein 1
Short name=PL-RP1
Gene names
Name:Pnliprp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) By similarity.

Subcellular location

Secreted. Note: Secreted in acinar cells. Ref.1

Tissue specificity

Expressed in female, but not in male, lacrimal gland. Expressed in male and female sublingual gland and pancreas. Ref.1

Disruption phenotype

Mice have no visible phenotype during the first 10 weeks after birth and are fertile. Adult mice have normal body weight, but higher than normal body fat and lower than normal lean mass. They display impaired glucose tolerance and decreased insulin sensitivity, and obesity and insulin resistance are exacerbated by high-fat diet. Their pancreatic juice has greater ability to hydrolyze triglycerides than that from wild-type littermates. Ref.4

Miscellaneous

Expression is gender and species-specific.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Contains 1 PLAT domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Metal-binding
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from sequence or structural similarity. Source: UniProtKB

triglyceride lipase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 473456Inactive pancreatic lipase-related protein 1
PRO_0000017791

Regions

Domain356 – 467112PLAT

Sites

Active site1711Nucleophile By similarity
Active site1941Charge relay system By similarity
Active site2811Charge relay system By similarity
Metal binding2051Calcium; via carbonyl oxygen By similarity
Metal binding2081Calcium; via carbonyl oxygen By similarity
Metal binding2101Calcium By similarity
Metal binding2131Calcium By similarity

Amino acid modifications

Disulfide bond21 ↔ 27 By similarity
Disulfide bond109 ↔ 120 By similarity
Disulfide bond255 ↔ 279 By similarity
Disulfide bond303 ↔ 314 By similarity
Disulfide bond317 ↔ 322 By similarity
Disulfide bond451 ↔ 467 By similarity

Experimental info

Sequence conflict591Y → H in AAH90985. Ref.3
Sequence conflict97 – 11519IDKGE…NMFQV → RPTSWPPGPSSGNNAEYAG in AAH68266. Ref.2
Sequence conflict159 – 1613NYS → KYY in AAH68266. Ref.2
Sequence conflict1591N → D in AAH90985. Ref.3
Sequence conflict2821L → P in AAH68266. Ref.2
Sequence conflict3511K → R in AAH68266. Ref.2
Sequence conflict4071K → E in AAH68266. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q5BKQ4 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: FB11C08E6BBC2763

FASTA47352,696
        10         20         30         40         50         60 
MLILWTIPLF LLGAAQGKEV CYDNLGCFSD AEPWAGTAIR PLKLLPWSPE KINTRFLLYT 

        70         80         90        100        110        120 
NENPTAFQTL QLSDPSTIEA SNFQVARKTR FIIHGFIDKG EENWVVDMCK NMFQVEEVNC 

       130        140        150        160        170        180 
ICVDWKRGSQ TTYTQAANNV RVVGAQVAQM IDILVRNFNY SASKVHLIGH SLGAHVAGEA 

       190        200        210        220        230        240 
GSRTPGLGRI TGLDPVEANF EGTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQMVG 

       250        260        270        280        290        300 
HFDFFPNGGQ YMPGCKKNAL SQIVDIDGIW SGTRDFVACN HLRSYKYYLE SILNPDGFAA 

       310        320        330        340        350        360 
YPCASYRDFE SNKCFPCPDQ GCPQMGHYAD KFANNTSVEP QKFFLNTGEA KNFARWRYRV 

       370        380        390        400        410        420 
SLTFSGRTVT GQVKVSLFGS NGNTRQCDIF RGIIKPGATH SNEFDAKLDV GTIEKVKFLW 

       430        440        450        460        470 
NNHVVNPSFP KVGAAKITVQ KGEERTEHNF CSEETVREDI LLTLLPCKTS DTM

« Hide

References

« Hide 'large scale' references
[1]"Pancreatic lipase-related protein 1 mRNA in female mouse lacrimal gland."
Remington S.G., Lima P.H., Nelson J.D.
Invest. Ophthalmol. Vis. Sci. 40:1081-1090(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Swiss Webster.
Tissue: Lacrimal gland.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Pancreas.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[4]"Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1."
Ren J., Chen Z., Zhang W., Li L., Sun R., Deng C., Fei Z., Sheng Z., Wang L., Sun X., Wang Z., Fei J.
J. Nutr. Biochem. 22:691-698(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF061274 mRNA. Translation: AAC15774.1.
AK028105 mRNA. Translation: BAC25750.1.
BC068266 mRNA. Translation: AAH68266.1.
BC090985 mRNA. Translation: AAH90985.1.
IPIIPI00118355.
RefSeqNP_061362.1. NM_018874.2.
UniGeneMm.10753.

3D structure databases

ProteinModelPortalQ5BKQ4.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000045465.

PTM databases

PhosphoSiteQ5BKQ4.

Proteomic databases

PaxDbQ5BKQ4.
PRIDEQ5BKQ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048644; ENSMUSP00000045465; ENSMUSG00000042179.
GeneID18946.
KEGGmmu:18946.
UCSCuc008iat.1. mouse.

Organism-specific databases

CTD5407.
MGIMGI:97723. Pnliprp1.

Phylogenomic databases

eggNOGNOG40923.
GeneTreeENSGT00560000076769.
HOGENOMHOG000038552.
HOVERGENHBG003243.
InParanoidQ5BKQ4.
KOK14074.
OMAKGDESWV.
OrthoDBEOG4WH8KM.

Gene expression databases

BgeeQ5BKQ4.
CleanExMM_PNLIPRP1.
GenevestigatorQ5BKQ4.
GermOnlineENSMUSG00000042179. Mus musculus.

Family and domain databases

Gene3D2.60.60.20. 1 hit.
InterProIPR000734. Lipase.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. LipOase_LH2.
IPR016272. Lipoprotein_lipase_LIPH.
[Graphical view]
PANTHERPTHR11610. PTHR11610. 1 hit.
PTHR11610:SF8. PTHR11610:SF8. 1 hit.
PfamPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMSSF49723. Lipase_LipOase. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPNLIPRP1. mouse.
NextBio295280.
SOURCESearch...

Entry information

Entry nameLIPR1_MOUSE
AccessionPrimary (citable) accession number: Q5BKQ4
Secondary accession number(s): O70478, Q6NV82
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: April 3, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents