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Protein

Inactive pancreatic lipase-related protein 1

Gene

Pnliprp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity).By similarity

Miscellaneous

Expression is gender and species-specific.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171NucleophileBy similarity1
Active sitei194Charge relay systemPROSITE-ProRule annotation1
Metal bindingi205Calcium; via carbonyl oxygenBy similarity1
Metal bindingi208Calcium; via carbonyl oxygenBy similarity1
Metal bindingi210CalciumBy similarity1
Metal bindingi213CalciumBy similarity1
Active sitei281Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Protein family/group databases

ESTHERimouse-1plrp Pancreatic_lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive pancreatic lipase-related protein 1
Short name:
PL-RP1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:97723 Pnliprp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice have no visible phenotype during the first 10 weeks after birth and are fertile. Adult mice have normal body weight, but higher than normal body fat and lower than normal lean mass. They display impaired glucose tolerance and decreased insulin sensitivity, and obesity and insulin resistance are exacerbated by high-fat diet. Their pancreatic juice has greater ability to hydrolyze triglycerides than that from wild-type littermates.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001779118 – 473Inactive pancreatic lipase-related protein 1Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation
Disulfide bondi255 ↔ 279PROSITE-ProRule annotation
Disulfide bondi303 ↔ 314PROSITE-ProRule annotation
Disulfide bondi317 ↔ 322PROSITE-ProRule annotation
Disulfide bondi451 ↔ 467PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ5BKQ4
PaxDbiQ5BKQ4
PeptideAtlasiQ5BKQ4
PRIDEiQ5BKQ4

Expressioni

Tissue specificityi

Expressed in female, but not in male, lacrimal gland. Expressed in male and female sublingual gland and pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000042179
CleanExiMM_PNLIPRP1
GenevisibleiQ5BKQ4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045465

Structurei

3D structure databases

ProteinModelPortaliQ5BKQ4
SMRiQ5BKQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 467PLATPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHRX Eukaryota
ENOG410Y92X LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiQ5BKQ4
KOiK14074
OMAiDQGCPQM
OrthoDBiEOG091G0DJ5
PhylomeDBiQ5BKQ4
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BKQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLILWTIPLF LLGAAQGKEV CYDNLGCFSD AEPWAGTAIR PLKLLPWSPE
60 70 80 90 100
KINTRFLLYT NENPTAFQTL QLSDPSTIEA SNFQVARKTR FIIHGFIDKG
110 120 130 140 150
EENWVVDMCK NMFQVEEVNC ICVDWKRGSQ TTYTQAANNV RVVGAQVAQM
160 170 180 190 200
IDILVRNFNY SASKVHLIGH SLGAHVAGEA GSRTPGLGRI TGLDPVEANF
210 220 230 240 250
EGTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQMVG HFDFFPNGGQ
260 270 280 290 300
YMPGCKKNAL SQIVDIDGIW SGTRDFVACN HLRSYKYYLE SILNPDGFAA
310 320 330 340 350
YPCASYRDFE SNKCFPCPDQ GCPQMGHYAD KFANNTSVEP QKFFLNTGEA
360 370 380 390 400
KNFARWRYRV SLTFSGRTVT GQVKVSLFGS NGNTRQCDIF RGIIKPGATH
410 420 430 440 450
SNEFDAKLDV GTIEKVKFLW NNHVVNPSFP KVGAAKITVQ KGEERTEHNF
460 470
CSEETVREDI LLTLLPCKTS DTM
Length:473
Mass (Da):52,696
Last modified:June 21, 2005 - v2
Checksum:iFB11C08E6BBC2763
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59Y → H in AAH90985 (PubMed:15489334).Curated1
Sequence conflicti97 – 115IDKGE…NMFQV → RPTSWPPGPSSGNNAEYAG in AAH68266 (PubMed:16141072).CuratedAdd BLAST19
Sequence conflicti159 – 161NYS → KYY in AAH68266 (PubMed:16141072).Curated3
Sequence conflicti159N → D in AAH90985 (PubMed:15489334).Curated1
Sequence conflicti282L → P in AAH68266 (PubMed:16141072).Curated1
Sequence conflicti351K → R in AAH68266 (PubMed:16141072).Curated1
Sequence conflicti407K → E in AAH68266 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061274 mRNA Translation: AAC15774.1
AK028105 mRNA Translation: BAC25750.1
BC068266 mRNA Translation: AAH68266.1
BC090985 mRNA Translation: AAH90985.1
CCDSiCCDS29931.1
RefSeqiNP_061362.1, NM_018874.2
UniGeneiMm.10753

Genome annotation databases

EnsembliENSMUST00000048644; ENSMUSP00000045465; ENSMUSG00000042179
GeneIDi18946
KEGGimmu:18946
UCSCiuc008iat.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLIPR1_MOUSE
AccessioniPrimary (citable) accession number: Q5BKQ4
Secondary accession number(s): O70478, Q6NV82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health