Reviewed, UniProtKB/Swiss-Prot Q5BKL0 (HPPD_XENTR)

Names and origin

Protein names

Recommended name:
    4-hydroxyphenylpyruvate dioxygenase
    EC=1.13.11.27
Alternative name(s):
    4-hydroxyphenylpyruvic acid oxidase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD

Gene names

Name:

hpd

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088393
Sites
	Metal binding	184	1	Iron By similarity
	Metal binding	267	1	Iron By similarity
	Metal binding	350	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5BKL0-1 [UniParc]. Last modified April 12, 2005. Version 1. Checksum: A0347A1DE03EC07C	FASTA	394	44,989
	10 20 30 40 50 60 MTSYTDKGEK HARGRFLSFH HLTFWVGNAK QAASFYCDKF GFEPCAYKGL ETGSRDVVSH 70 80 90 100 110 120 AIKQDKIIFV FQSPLNPGNQ EMGQHMIKHG DGVKDVAFQV EDCDFLFQKA KDHGAVVVRE 130 140 150 160 170 180 PWIEEDEGGK VKYAVLQTYG DTTHTLLEYL GPYRGVFLPG YKEPLFRDPL LPTLPSGCLS 190 200 210 220 230 240 FIDHIVGNQP DNEMVPIVEW YQKCLLFHRF WSVDDKQIHT EYSSLRSIVV TNYEETIKMP 250 260 270 280 290 300 INEPAAGKKK SQIQEYVDYY GSAGVQHIAL NTSNIIKAVK NLKSRGIEFL SAPDTYYEEL 310 320 330 340 350 360 RKKLKTAKIT VKEDLNVLQE LKILVDYDDK GYLLQIFTKP MQDRPTLFLE VIQRYNHFGF 370 380 390 GAGNFKSLFE AIETDQDARG NLTIYAANGE HQVL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC091035 mRNA. Translation: AAH91035.1.
RefSeq	NP_001025588.1.
UniGene	Str.8493
3D structure databases
SMR	Q5BKL0. Positions 8-367.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5BKL0.
Genome annotation databases
Ensembl	ENSXETT00000017017; ENSXETP00000017017; ENSXETG00000007789; Xenopus tropicalis. [Genome view]
GeneID	594976.
KEGG	xtr:594976.
Organism-specific databases
CTD	594976.
Xenbase	XB-FEAT-986329.
Phylogenomic databases
HOGENOM	Q5BKL0.
HOVERGEN	Q5BKL0.
Enzyme and pathway databases
BRENDA	1.13.11.27. 279072.
Gene expression databases
Bgee	Q5BKL0.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 2 hits. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_XENTR

Accession

Primary (citable) accession number: Q5BKL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	April 12, 2005
Last modified:	September 22, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project