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Protein

Transcription initiation factor TFIID subunit 9

Gene

Taf9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity).By similarity

GO - Biological processi

  • DNA-templated transcription, initiation Source: InterPro
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • response to L-glutamate Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 9
Alternative name(s):
RNA polymerase II TBP-associated factor subunit G
Transcription initiation factor TFIID 31 kDa subunit
Short name:
TAFII-31
Short name:
TAFII31
Transcription initiation factor TFIID 32 kDa subunit
Short name:
TAFII-32
Short name:
TAFII32
Gene namesi
Name:Taf9Imported
Synonyms:Taf2gBy similarity, Tafii31By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi727861. Taf9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Transcription initiation factor TFIID subunit 9PRO_0000118890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei5 – 51N6-acetyllysineBy similarity
Modified residuei149 – 1491PhosphoserineBy similarity
Modified residuei155 – 1551PhosphoserineBy similarity
Modified residuei158 – 1581PhosphoserineBy similarity
Modified residuei159 – 1591PhosphothreonineBy similarity
Modified residuei161 – 1611PhosphothreonineBy similarity
Modified residuei164 – 1641PhosphothreonineBy similarity
Modified residuei178 – 1781PhosphothreonineBy similarity
Modified residuei181 – 1811PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5BKE0.

Expressioni

Gene expression databases

ExpressionAtlasiQ5BKE0. baseline.
GenevisibleiQ5BKE0. RN.

Interactioni

Subunit structurei

Component of TFIID, the TATA-binding protein-free TAF complex (TFTC), the PCAF complex and the STAGA transcription coactivator-HAT complex. The PCAF complex consists at least of TADA2L/ADA2, SUPT3H/SPT3, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. The STAGA transcription coactivator-HAT complex consists at least of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Binds N-terminal domain of p53/TP53 which is essential for transcription. Binds TFIIB and the Herpes simplex virus activator VP16. Forms a heterodimer with TAF6/TAFII80 in a complex with the TAF4B/TAFII105-TAF12/TAFII20 heterodimer. Also interacts with TAF5. Binds directly DNA. Increased DNA binding when complexed with TAF6/TAFII80 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5BKE0.
SMRiQ5BKE0. Positions 13-76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi251 – 26212Poly-AspSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TAF9 family.Sequence analysis

Phylogenomic databases

HOGENOMiHOG000231730.
HOVERGENiHBG002304.
InParanoidiQ5BKE0.
KOiK14535.
PhylomeDBiQ5BKE0.
TreeFamiTF351417.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003162. TFIID-31.
[Graphical view]
PfamiPF02291. TFIID-31kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BKE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGKMASPK SMPKDAQMMA QILKDMGITE YEPRVINQML EFAFRYVTTI
60 70 80 90 100
LDDAKIYSSH AKKPTVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQRN
110 120 130 140 150
QTPLPLIKPY SGPRLPPDRY CLTAPNYRLK SLQKKAPTPA GRITVPRLSV
160 170 180 190 200
GSVSSRPSTP TLGTPTPQAM SVSTKVGTPM SLTGQRFTVQ MPASQSPAVK
210 220 230 240 250
ASIPATPAVQ NVLINPSLIG SKNILITTNM VSQNTANESA NALKRKREEE
260
DDDDDDDDDD YDNL
Length:264
Mass (Da):28,994
Last modified:April 12, 2005 - v1
Checksum:i71BA6B214FC30297
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441F → L in AAQ56726 (PubMed:15309719).Curated
Sequence conflicti74 – 741A → P in AAQ56726 (PubMed:15309719).Curated
Sequence conflicti81 – 811Q → H in AAQ56726 (PubMed:15309719).Curated
Sequence conflicti170 – 1701M → V in AAQ56726 (PubMed:15309719).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091109 mRNA. Translation: AAH91109.1.
AY325235 mRNA. Translation: AAP92636.1.
AY359819 mRNA. Translation: AAQ56726.1.
RefSeqiNP_001032387.1. NM_001037310.1.
NP_908937.2. NM_184048.2.
UniGeneiRn.8139.

Genome annotation databases

EnsembliENSRNOT00000076484; ENSRNOP00000068397; ENSRNOG00000051258.
GeneIDi373541.
KEGGirno:373541.
UCSCiRGD:727861. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091109 mRNA. Translation: AAH91109.1.
AY325235 mRNA. Translation: AAP92636.1.
AY359819 mRNA. Translation: AAQ56726.1.
RefSeqiNP_001032387.1. NM_001037310.1.
NP_908937.2. NM_184048.2.
UniGeneiRn.8139.

3D structure databases

ProteinModelPortaliQ5BKE0.
SMRiQ5BKE0. Positions 13-76.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5BKE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000076484; ENSRNOP00000068397; ENSRNOG00000051258.
GeneIDi373541.
KEGGirno:373541.
UCSCiRGD:727861. rat.

Organism-specific databases

CTDi6880.
RGDi727861. Taf9.

Phylogenomic databases

HOGENOMiHOG000231730.
HOVERGENiHBG002304.
InParanoidiQ5BKE0.
KOiK14535.
PhylomeDBiQ5BKE0.
TreeFamiTF351417.

Miscellaneous databases

PROiQ5BKE0.

Gene expression databases

ExpressionAtlasiQ5BKE0. baseline.
GenevisibleiQ5BKE0. RN.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003162. TFIID-31.
[Graphical view]
PfamiPF02291. TFIID-31kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  2. "Gene expression differences of regenerating rat liver in a short interval successive partial hepatectomy."
    Xu C.S., Zhang A.S., Han H.P., Yuan J.Y., Chang C.F., Li W.Q., Yang K.J., Zhao L.F., Li Y.C., Zhang H.Y., Rahman S., Zhang J.B.
    World J. Gastroenterol. 10:2680-2689(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-264.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiTAF9_RAT
AccessioniPrimary (citable) accession number: Q5BKE0
Secondary accession number(s): Q6UV34, Q7TP20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: April 12, 2005
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.