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Protein

HSPB1-associated protein 1

Gene

Hspbap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cellular stress response.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
HSPB1-associated protein 1
Alternative name(s):
27 kDa heat shock protein-associated protein 1
Protein associated with small stress protein 1
Gene namesi
Name:Hspbap1
Synonyms:Pass1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi620870. Hspbap1.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479HSPB1-associated protein 1PRO_0000284115Add
BLAST

Proteomic databases

PaxDbiQ5BKC6.
PRIDEiQ5BKC6.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed by Sertoli cells in testis (at protein level).1 Publication

Gene expression databases

ExpressionAtlasiQ5BKC6. baseline and differential.
GenevisibleiQ5BKC6. RN.

Interactioni

Subunit structurei

Interacts with CRYAB and HSPB1.1 Publication

Protein-protein interaction databases

BioGridi251267. 1 interaction.
STRINGi10116.ENSRNOP00000003060.

Structurei

3D structure databases

ProteinModelPortaliQ5BKC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 288165JmjCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 208121Interaction with HSPB1Add
BLAST

Sequence similaritiesi

Contains 1 JmjC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2132. Eukaryota.
ENOG410XQDR. LUCA.
GeneTreeiENSGT00530000062914.
HOGENOMiHOG000068192.
HOVERGENiHBG099816.
InParanoidiQ5BKC6.
KOiK19375.
OMAiNCHYLNG.
OrthoDBiEOG7ZWD2P.
PhylomeDBiQ5BKC6.
TreeFamiTF315056.

Family and domain databases

InterProiIPR013296. HSPB1-associated_protein_1.
IPR003347. JmjC_dom.
[Graphical view]
PRINTSiPR01886. PASS1.
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BKC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAGCEGSSP QTLGERTMGE EGERVKPFTP EKAKEVIMSL QQPAIFCNMV
60 70 80 90 100
FDWPSRHWTA KHLSKVLEGK QIRFRMGLRS TGTVPQFETE CSYVDATLEE
110 120 130 140 150
FLAWNCDQSR ISGPFKKYDH SKFWAYADYK YFVTLFEDKT DVFQEVMWSD
160 170 180 190 200
FGFPGRNGQE STLWIGSLGA HTPCHLDSYG CNLVFQVQGR KRWHLFPPED
210 220 230 240 250
TPFLYPTRIP YEESSVFSKI NVVNPDLKRF PQFQKARRHM VTLSPGQVLF
260 270 280 290 300
VPRHWWHYVE SLDPVTVSIN SWIELEEDHL ARVEEAVTRM LVCTLKTAED
310 320 330 340 350
PHHPRTWLNP TEVEETSHEV NSCYLNSAVC AFFDHCERAK EVEMQAPRAN
360 370 380 390 400
GEEPGVQEHM EVEQARDPSS DVGAGKQEAA SPFGPDLVPV TPASEERGGA
410 420 430 440 450
LEGDSQECTS RNGEHCAELP CARRQQASKG ARAEAGQSAP RYPVAPSRVF
460 470
VSTDDLLDCL VNPQVTRMVA QLLIQGKSL
Length:479
Mass (Da):54,209
Last modified:April 12, 2005 - v1
Checksum:i09144F7779CD6527
GO

Sequence cautioni

The sequence AAD48846.1 differs from that shown. Reason: Frameshift at position 355. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti371 – 3711D → E in AAD48846 (PubMed:10751411).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168362 mRNA. Translation: AAD48846.1. Frameshift.
BC091125 mRNA. Translation: AAH91125.1.
RefSeqiNP_599246.2. NM_134419.2.
UniGeneiRn.37915.

Genome annotation databases

EnsembliENSRNOT00000081875; ENSRNOP00000073471; ENSRNOG00000002241.
GeneIDi171460.
KEGGirno:171460.
UCSCiRGD:620870. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168362 mRNA. Translation: AAD48846.1. Frameshift.
BC091125 mRNA. Translation: AAH91125.1.
RefSeqiNP_599246.2. NM_134419.2.
UniGeneiRn.37915.

3D structure databases

ProteinModelPortaliQ5BKC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251267. 1 interaction.
STRINGi10116.ENSRNOP00000003060.

Proteomic databases

PaxDbiQ5BKC6.
PRIDEiQ5BKC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000081875; ENSRNOP00000073471; ENSRNOG00000002241.
GeneIDi171460.
KEGGirno:171460.
UCSCiRGD:620870. rat.

Organism-specific databases

CTDi79663.
RGDi620870. Hspbap1.

Phylogenomic databases

eggNOGiKOG2132. Eukaryota.
ENOG410XQDR. LUCA.
GeneTreeiENSGT00530000062914.
HOGENOMiHOG000068192.
HOVERGENiHBG099816.
InParanoidiQ5BKC6.
KOiK19375.
OMAiNCHYLNG.
OrthoDBiEOG7ZWD2P.
PhylomeDBiQ5BKC6.
TreeFamiTF315056.

Miscellaneous databases

NextBioi622416.
PROiQ5BKC6.

Gene expression databases

ExpressionAtlasiQ5BKC6. baseline and differential.
GenevisibleiQ5BKC6. RN.

Family and domain databases

InterProiIPR013296. HSPB1-associated_protein_1.
IPR003347. JmjC_dom.
[Graphical view]
PRINTSiPR01886. PASS1.
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27."
    Liu C., Gilmont R.R., Benndorf R., Welsh M.J.
    J. Biol. Chem. 275:18724-18731(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CRYAB AND HSPB1, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: Fischer.
    Tissue: Sertoli cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiHBAP1_RAT
AccessioniPrimary (citable) accession number: Q5BKC6
Secondary accession number(s): Q9R153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 12, 2005
Last modified: February 17, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.