Vav 1 guanine nucleotide exchange factor

Contribute

Send feedback

Read comments (0) or add your own

Unreviewed, UniProtKB/TrEMBL Q5BK91 (Q5BK91_RAT)

Last modified November 3, 2009. Version 44. History...

Clusters with 100%, 90%, 50% identity |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Hide | Top

Names and origin

Protein names

Submitted name:
Vav 1 guanine nucleotide exchange factor EMBL AAH91160.1
Submitted name:
Vav 1 oncogene EMBL EDL83565.1

Gene names

Name:	Vav1 RGD 3951
ORF Names:	rCG_45074 EMBL EDL83565.1

Organism

Rattus norvegicus (Rat) EMBL AAH91160.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Hide | Top

Protein attributes

Sequence length	843 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Hide | Top

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. Spearmint SPM000219

Contains 1 PH domain. RuleBase RU003350V0

Contains 1 SH2 domain. Spearmint SPM020473

Contains 2 SH3 domains. RuleBase RU003338V3

Hide | Top

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338V3
Ligand	Metal-binding Spearmint SPM002219 Zinc Spearmint SPM002219
Gene Ontology (GO)
Biological process	cell development Traceable author statement. Source: RGD immune response-regulating cell surface receptor signaling pathway Inferred from expression pattern. Source: RGD intracellular signaling cascade Inferred from electronic annotation. Source: InterPro regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

Q5BK91-1 [UniParc].

Last modified April 12, 2005. Version 1.
Checksum: 33C5CB8F3095CA46
Show »

FASTA

843

97,971

        10         20         30         40         50         60 
MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV 

        70         80         90        100        110        120 
NLWPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 

       130        140        150        160        170        180 
AQNKGIMPFP TEDSALGDED IYSGLSDQID DTAEEDEDLY DCVENEEAEG DEIYEDLMRS 

       190        200        210        220        230        240 
ESVPTPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDMETIFVNI 

       250        260        270        280        290        300 
EELLSVHTHF LKELKDALSG PGATMLYQVF IKYKERFLVY GRYCSQVESA SKHLDQVATA 

       310        320        330        340        350        360 
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDT TEKENLRLAL 

       370        380        390        400        410        420 
DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLANY GRPKIDGELK ITSVERRSKT 

       430        440        450        460        470        480 
DRYAFLLDKA LLICKRRGDS YDLKASVNLH SFQVRDDSSG ERDNKKWSHM FLLIEDQGAQ 

       490        500        510        520        530        540 
GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF 

       550        560        570        580        590        600 
YQGYRCYRCR APAHKECLGR VPPCGRQDFS GTMKKDKLHR RAQDKKRNEL GLPKMEVCQE 

       610        620        630        640        650        660 
YYGIPPPPGA FGPFLRLNPG DIVELTKAEA EHNWWEGRNT ATNEVGWFPC NRVRPYVHGP 

       670        680        690        700        710        720 
PQDLSVHLWY AGPMERAGAE GILTNRSDGT YLVRQRVKDT AEFAISIKYN VEVKHIKIMT 

       730        740        750        760        770        780 
SEGLYRITEK KAFRGLPELV EFYQQNSLKD CFKSLDTTLQ FPYKEPERRA INKPPVGSTK 

       790        800        810        820        830        840 
YFGTAKARYD FCARDRSELS LKEGDIIKIL NKKGQQGWWR GEIYGRIGWF PSNYVEEDYS 


EYC

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen EMBL AAH91160.1.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed: 15632090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL83565.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL83565.1.

Hide | Top

Cross-references

Sequence databases
	BC091160 mRNA. Translation: AAH91160.1. CH474092 Genomic DNA. Translation: EDL83565.1.
IPI	IPI00882506.
RefSeq	NP_036891.2.
UniGene	Rn.48861
3D structure databases
SMR	Q5BK91. Positions 1-135, 169-375, 642-773.
ModBase	Search...
Genome annotation databases
GeneID	25156.
KEGG	rno:25156.
Organism-specific databases
CTD	25156.
Phylogenomic databases
HOVERGEN	Q5BK91.
Gene expression databases
Genevestigator	Q5BK91.
Family and domain databases
InterPro	IPR016146. Calponin-homology. IPR001715. Calponin_act_bd. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001849. Pleckstrin_homology. IPR002219. Prot_Kinase_C-like_PE/DAG_bd. IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain. IPR020473. SH3_region. IPR003096. SM22_calponin. [Graphical view]
Gene3D	G3DSA:1.10.418.10. Calponin-homology. 1 hit. G3DSA:1.20.900.10. RhoGEF. 1 hit. G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF00130. C1_1. 1 hit. PF00307. CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00888. SM22CALPONIN.
ProDom	PD000093. SH2. 1 hit. PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00109. C1. 1 hit. SM00033. CH. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 2 hits. [Graphical view]
PROSITE	PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 2 hits. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	605615.

Hide | Top

Entry information

Entry name

Q5BK91_RAT

Accession

Primary (citable) accession number: Q5BK91

Entry history

Integrated into UniProtKB/TrEMBL:	April 12, 2005
Last sequence update:	April 12, 2005
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information