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Protein

Transmembrane emp24 domain-containing protein 1

Gene

Tmed1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 1
Alternative name(s):
Interleukin-1 receptor-like 1 ligand
p24 family protein gamma-1
Short name:
p24gamma1
Gene namesi
Name:Tmed1
Synonyms:Il1rl1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1311679 Tmed1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 194ExtracellularSequence analysisAdd BLAST170
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 227CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000024802224 – 227Transmembrane emp24 domain-containing protein 1Add BLAST204

Proteomic databases

PaxDbiQ5BK85
PRIDEiQ5BK85

Expressioni

Gene expression databases

BgeeiENSRNOG00000008037
GenevisibleiQ5BK85 RN

Interactioni

Subunit structurei

Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. May interact with IL1RL1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi261034, 1 interactor
STRINGi10116.ENSRNOP00000057728

Structurei

3D structure databases

SMRiQ5BK85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 125GOLDPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 170Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi218 – 227COPI vesicle coat-bindingSequence analysis10
Motifi218 – 219COPII vesicle coat-bindingSequence analysis2

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287 Eukaryota
ENOG410Z18S LUCA
GeneTreeiENSGT00670000097656
HOGENOMiHOG000039809
HOVERGENiHBG000271
InParanoidiQ5BK85
KOiK20348
OMAiRSRQMQT
OrthoDBiEOG091G0RNG
PhylomeDBiQ5BK85
TreeFamiTF313000

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAAGAAVAL ALWLLLPAVG VGEAGPPPIQ DGEFTFLLPA GRKQCFYQSA
60 70 80 90 100
PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA
110 120 130 140 150
GDYRLCFDNS FSTISEKLVF FELIFDSFQD EEEVEGWAEA VEPEEMLDVK
160 170 180 190 200
MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEDNL ERVNFWSAAN
210 220
VAVLLLVAVL QVCTLKRFFH DKCPVPT
Length:227
Mass (Da):25,210
Last modified:April 12, 2005 - v1
Checksum:iF37FC38E4E1B4495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091167 mRNA Translation: AAH91167.1
RefSeqiNP_001013450.1, NM_001013432.1
UniGeneiRn.162983

Genome annotation databases

EnsembliENSRNOT00000061009; ENSRNOP00000057728; ENSRNOG00000008037
GeneIDi315461
KEGGirno:315461
UCSCiRGD:1311679 rat

Similar proteinsi

Entry informationi

Entry nameiTMED1_RAT
AccessioniPrimary (citable) accession number: Q5BK85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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