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Protein

Transmembrane emp24 domain-containing protein 1

Gene

Tmed1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 1
Alternative name(s):
Interleukin-1 receptor-like 1 ligand
p24 family protein gamma-1
Short name:
p24gamma1
Gene namesi
Name:Tmed1
Synonyms:Il1rl1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1311679. Tmed1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 194ExtracellularSequence analysisAdd BLAST170
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 227CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000024802224 – 227Transmembrane emp24 domain-containing protein 1Add BLAST204

Proteomic databases

PaxDbiQ5BK85.
PRIDEiQ5BK85.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008037.
GenevisibleiQ5BK85. RN.

Interactioni

Subunit structurei

Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. May interact with IL1RL1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi261034. 1 interactor.
MINTiMINT-4580629.
STRINGi10116.ENSRNOP00000057728.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 125GOLDPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 170Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi218 – 227COPI vesicle coat-bindingSequence analysis10
Motifi218 – 219COPII vesicle coat-bindingSequence analysis2

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated
Contains 1 GOLD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
GeneTreeiENSGT00670000097656.
HOGENOMiHOG000039809.
HOVERGENiHBG000271.
InParanoidiQ5BK85.
KOiK20348.
OMAiAGRSECF.
OrthoDBiEOG091G0RNG.
PhylomeDBiQ5BK85.
TreeFamiTF313000.

Family and domain databases

InterProiIPR009038. GOLD_dom.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
SMARTiSM01190. EMP24_GP25L. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAAGAAVAL ALWLLLPAVG VGEAGPPPIQ DGEFTFLLPA GRKQCFYQSA
60 70 80 90 100
PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA
110 120 130 140 150
GDYRLCFDNS FSTISEKLVF FELIFDSFQD EEEVEGWAEA VEPEEMLDVK
160 170 180 190 200
MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEDNL ERVNFWSAAN
210 220
VAVLLLVAVL QVCTLKRFFH DKCPVPT
Length:227
Mass (Da):25,210
Last modified:April 12, 2005 - v1
Checksum:iF37FC38E4E1B4495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091167 mRNA. Translation: AAH91167.1.
RefSeqiNP_001013450.1. NM_001013432.1.
UniGeneiRn.162983.

Genome annotation databases

EnsembliENSRNOT00000061009; ENSRNOP00000057728; ENSRNOG00000008037.
GeneIDi315461.
KEGGirno:315461.
UCSCiRGD:1311679. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091167 mRNA. Translation: AAH91167.1.
RefSeqiNP_001013450.1. NM_001013432.1.
UniGeneiRn.162983.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi261034. 1 interactor.
MINTiMINT-4580629.
STRINGi10116.ENSRNOP00000057728.

Proteomic databases

PaxDbiQ5BK85.
PRIDEiQ5BK85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061009; ENSRNOP00000057728; ENSRNOG00000008037.
GeneIDi315461.
KEGGirno:315461.
UCSCiRGD:1311679. rat.

Organism-specific databases

CTDi11018.
RGDi1311679. Tmed1.

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
GeneTreeiENSGT00670000097656.
HOGENOMiHOG000039809.
HOVERGENiHBG000271.
InParanoidiQ5BK85.
KOiK20348.
OMAiAGRSECF.
OrthoDBiEOG091G0RNG.
PhylomeDBiQ5BK85.
TreeFamiTF313000.

Miscellaneous databases

PROiQ5BK85.

Gene expression databases

BgeeiENSRNOG00000008037.
GenevisibleiQ5BK85. RN.

Family and domain databases

InterProiIPR009038. GOLD_dom.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
SMARTiSM01190. EMP24_GP25L. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMED1_RAT
AccessioniPrimary (citable) accession number: Q5BK85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.