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Protein

Solute carrier family 46 member 3

Gene

Slc46a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 46 member 3
Gene namesi
Name:Slc46a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1307594. Slc46a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 70ExtracellularSequence analysisAdd BLAST45
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 103CytoplasmicSequence analysisAdd BLAST12
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 135ExtracellularSequence analysisAdd BLAST11
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 170CytoplasmicSequence analysisAdd BLAST14
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 197ExtracellularSequence analysis6
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 260CytoplasmicSequence analysisAdd BLAST42
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 301ExtracellularSequence analysisAdd BLAST20
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 324CytoplasmicSequence analysis2
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 347ExtracellularSequence analysis2
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 381CytoplasmicSequence analysisAdd BLAST13
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 415ExtracellularSequence analysisAdd BLAST13
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 461CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000030725626 – 461Solute carrier family 46 member 3Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5BK75.
PRIDEiQ5BK75.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000937.
GenevisibleiQ5BK75. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001243.

Structurei

3D structure databases

ProteinModelPortaliQ5BK75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2816. Eukaryota.
ENOG410ZVCA. LUCA.
GeneTreeiENSGT00530000063076.
HOGENOMiHOG000074207.
HOVERGENiHBG108453.
InParanoidiQ5BK75.
KOiK20840.
OMAiGWEEGSY.
OrthoDBiEOG091G08MP.
PhylomeDBiQ5BK75.
TreeFamiTF315701.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISFIEPAI LLYAFAMTLT IPLTAQYVYR RIWEETGNYT FTSSSNVSEC
60 70 80 90 100
EQNKSSSTFA FQEEVQKKAS LFSLQVEISG LIPGLVSTFM LLSSSDNHGR
110 120 130 140 150
KLPMVLSSLG SLGTNLWLCA MSYFDLPLQL LVASTFIGAL FGNYTTFWGA
160 170 180 190 200
CFAYIVDQEK EYKHRIIRIA VLDFMLGVVT GLTGLSSGYF IRELGFAWSY
210 220 230 240 250
FIIAVVVLVN LAYILFFLSD PIKESSSQIV TMSCSESLKD LFYRTYMLFK
260 270 280 290 300
NGSCKRRSLL CLLIFTLVVY FFVVFGITPV FTLYELGPPL CWNEVYIGYG
310 320 330 340 350
SALGSLSFLS SFLGIWLFSY CLKDIHIAYV GIFTTMVGMM LTAFTRTTLM
360 370 380 390 400
MFLVRISFFF TIMPLSILRS MLSKVVHSTE QGVLFACIAF LETLGGVTST
410 420 430 440 450
SAYNGIYSAT VAWYPGFVFL LSAGLLVLPA VSLCMVKCIG WEEGSYTLLI
460
HDEPSEHTSD S
Length:461
Mass (Da):51,527
Last modified:April 12, 2005 - v1
Checksum:iCB7DCE21883D0656
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091179 mRNA. Translation: AAH91179.1.
RefSeqiNP_001020139.1. NM_001024968.1.
XP_006248895.1. XM_006248833.3.
UniGeneiRn.16498.

Genome annotation databases

EnsembliENSRNOT00000001243; ENSRNOP00000001243; ENSRNOG00000000937.
GeneIDi288454.
KEGGirno:288454.
UCSCiRGD:1307594. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091179 mRNA. Translation: AAH91179.1.
RefSeqiNP_001020139.1. NM_001024968.1.
XP_006248895.1. XM_006248833.3.
UniGeneiRn.16498.

3D structure databases

ProteinModelPortaliQ5BK75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001243.

Proteomic databases

PaxDbiQ5BK75.
PRIDEiQ5BK75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001243; ENSRNOP00000001243; ENSRNOG00000000937.
GeneIDi288454.
KEGGirno:288454.
UCSCiRGD:1307594. rat.

Organism-specific databases

CTDi283537.
RGDi1307594. Slc46a3.

Phylogenomic databases

eggNOGiKOG2816. Eukaryota.
ENOG410ZVCA. LUCA.
GeneTreeiENSGT00530000063076.
HOGENOMiHOG000074207.
HOVERGENiHBG108453.
InParanoidiQ5BK75.
KOiK20840.
OMAiGWEEGSY.
OrthoDBiEOG091G08MP.
PhylomeDBiQ5BK75.
TreeFamiTF315701.

Miscellaneous databases

PROiQ5BK75.

Gene expression databases

BgeeiENSRNOG00000000937.
GenevisibleiQ5BK75. RN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS46A3_RAT
AccessioniPrimary (citable) accession number: Q5BK75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 12, 2005
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.