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Protein

Solute carrier family 46 member 3

Gene

Slc46a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 46 member 3
Gene namesi
Name:Slc46a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1307594. Slc46a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 7045ExtracellularSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Topological domaini92 – 10312CytoplasmicSequence analysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST
Topological domaini125 – 13511ExtracellularSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Topological domaini157 – 17014CytoplasmicSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Topological domaini192 – 1976ExtracellularSequence analysis
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 26042CytoplasmicSequence analysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence analysisAdd
BLAST
Topological domaini282 – 30120ExtracellularSequence analysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence analysisAdd
BLAST
Topological domaini323 – 3242CytoplasmicSequence analysis
Transmembranei325 – 34521HelicalSequence analysisAdd
BLAST
Topological domaini346 – 3472ExtracellularSequence analysis
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 38113CytoplasmicSequence analysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence analysisAdd
BLAST
Topological domaini403 – 41513ExtracellularSequence analysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence analysisAdd
BLAST
Topological domaini437 – 46125CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 461436Solute carrier family 46 member 3PRO_0000307256Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5BK75.
PRIDEiQ5BK75.

Expressioni

Gene expression databases

GenevisibleiQ5BK75. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001243.

Structurei

3D structure databases

ProteinModelPortaliQ5BK75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2816. Eukaryota.
ENOG410ZVCA. LUCA.
GeneTreeiENSGT00530000063076.
HOGENOMiHOG000074207.
HOVERGENiHBG108453.
InParanoidiQ5BK75.
KOiK14613.
OMAiGWEEGSY.
OrthoDBiEOG7DNNVC.
PhylomeDBiQ5BK75.
TreeFamiTF315701.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISFIEPAI LLYAFAMTLT IPLTAQYVYR RIWEETGNYT FTSSSNVSEC
60 70 80 90 100
EQNKSSSTFA FQEEVQKKAS LFSLQVEISG LIPGLVSTFM LLSSSDNHGR
110 120 130 140 150
KLPMVLSSLG SLGTNLWLCA MSYFDLPLQL LVASTFIGAL FGNYTTFWGA
160 170 180 190 200
CFAYIVDQEK EYKHRIIRIA VLDFMLGVVT GLTGLSSGYF IRELGFAWSY
210 220 230 240 250
FIIAVVVLVN LAYILFFLSD PIKESSSQIV TMSCSESLKD LFYRTYMLFK
260 270 280 290 300
NGSCKRRSLL CLLIFTLVVY FFVVFGITPV FTLYELGPPL CWNEVYIGYG
310 320 330 340 350
SALGSLSFLS SFLGIWLFSY CLKDIHIAYV GIFTTMVGMM LTAFTRTTLM
360 370 380 390 400
MFLVRISFFF TIMPLSILRS MLSKVVHSTE QGVLFACIAF LETLGGVTST
410 420 430 440 450
SAYNGIYSAT VAWYPGFVFL LSAGLLVLPA VSLCMVKCIG WEEGSYTLLI
460
HDEPSEHTSD S
Length:461
Mass (Da):51,527
Last modified:April 12, 2005 - v1
Checksum:iCB7DCE21883D0656
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091179 mRNA. Translation: AAH91179.1.
RefSeqiNP_001020139.1. NM_001024968.1.
XP_006248895.1. XM_006248833.2.
UniGeneiRn.16498.

Genome annotation databases

EnsembliENSRNOT00000001243; ENSRNOP00000001243; ENSRNOG00000000937.
GeneIDi288454.
KEGGirno:288454.
UCSCiRGD:1307594. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091179 mRNA. Translation: AAH91179.1.
RefSeqiNP_001020139.1. NM_001024968.1.
XP_006248895.1. XM_006248833.2.
UniGeneiRn.16498.

3D structure databases

ProteinModelPortaliQ5BK75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001243.

Proteomic databases

PaxDbiQ5BK75.
PRIDEiQ5BK75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001243; ENSRNOP00000001243; ENSRNOG00000000937.
GeneIDi288454.
KEGGirno:288454.
UCSCiRGD:1307594. rat.

Organism-specific databases

CTDi283537.
RGDi1307594. Slc46a3.

Phylogenomic databases

eggNOGiKOG2816. Eukaryota.
ENOG410ZVCA. LUCA.
GeneTreeiENSGT00530000063076.
HOGENOMiHOG000074207.
HOVERGENiHBG108453.
InParanoidiQ5BK75.
KOiK14613.
OMAiGWEEGSY.
OrthoDBiEOG7DNNVC.
PhylomeDBiQ5BK75.
TreeFamiTF315701.

Miscellaneous databases

PROiQ5BK75.

Gene expression databases

GenevisibleiQ5BK75. RN.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiS46A3_RAT
AccessioniPrimary (citable) accession number: Q5BK75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 12, 2005
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.