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Protein

TRAF-interacting protein with FHA domain-containing protein B

Gene

Tifab

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
TRAF-interacting protein with FHA domain-containing protein B
Alternative name(s):
TIFA-like protein
Gene namesi
Name:TifabBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1311681. Tifab.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147TRAF-interacting protein with FHA domain-containing protein BPRO_0000320694Add
BLAST

Proteomic databases

PaxDbiQ5BK67.
PRIDEiQ5BK67.

Expressioni

Gene expression databases

GenevisibleiQ5BK67. RN.

Interactioni

Subunit structurei

Interacts with TIFA.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5BK67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 10873FHASequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IYRT. Eukaryota.
ENOG410YZ4Y. LUCA.
GeneTreeiENSGT00510000049624.
HOGENOMiHOG000154576.
HOVERGENiHBG095665.
InParanoidiQ5BK67.
OMAiCVWVNGL.
OrthoDBiEOG793B9D.
PhylomeDBiQ5BK67.
TreeFamiTF333218.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BK67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPLTVLQV SLYHPTQGPV AFAKVPLQLQ HDASRLLVGR GQDTHLQLQL
60 70 80 90 100
PQLSRHHLCL EPYLEKGSNL LAFCLKVLTR QSCVWVNGLP LRYLEQVPLH
110 120 130 140
SVNRISFSGI QMLIRKEGGA SLEAFVCYFH LSPSPLIYRP KAQETDE
Length:147
Mass (Da):16,666
Last modified:April 12, 2005 - v1
Checksum:iF8B4BBB3A2ED832A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091188 mRNA. Translation: AAH91188.1.
RefSeqiNP_001020200.1. NM_001025029.1.
XP_006253640.1. XM_006253578.2.
XP_006253641.1. XM_006253579.2.
XP_008769665.1. XM_008771443.1.
UniGeneiRn.160910.

Genome annotation databases

EnsembliENSRNOT00000015878; ENSRNOP00000015878; ENSRNOG00000011947.
GeneIDi364674.
KEGGirno:364674.
UCSCiRGD:1311681. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091188 mRNA. Translation: AAH91188.1.
RefSeqiNP_001020200.1. NM_001025029.1.
XP_006253640.1. XM_006253578.2.
XP_006253641.1. XM_006253579.2.
XP_008769665.1. XM_008771443.1.
UniGeneiRn.160910.

3D structure databases

ProteinModelPortaliQ5BK67.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ5BK67.
PRIDEiQ5BK67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015878; ENSRNOP00000015878; ENSRNOG00000011947.
GeneIDi364674.
KEGGirno:364674.
UCSCiRGD:1311681. rat.

Organism-specific databases

CTDi497189.
RGDi1311681. Tifab.

Phylogenomic databases

eggNOGiENOG410IYRT. Eukaryota.
ENOG410YZ4Y. LUCA.
GeneTreeiENSGT00510000049624.
HOGENOMiHOG000154576.
HOVERGENiHBG095665.
InParanoidiQ5BK67.
OMAiCVWVNGL.
OrthoDBiEOG793B9D.
PhylomeDBiQ5BK67.
TreeFamiTF333218.

Miscellaneous databases

PROiQ5BK67.

Gene expression databases

GenevisibleiQ5BK67. RN.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: SpleenImported.

Entry informationi

Entry nameiTIFAB_RAT
AccessioniPrimary (citable) accession number: Q5BK67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 12, 2005
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.