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Q5BK64

- RPP40_RAT

UniProt

Q5BK64 - RPP40_RAT

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Protein
Ribonuclease P protein subunit p40
Gene
Rpp40
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p40 (EC:3.1.26.5)
Short name:
RNaseP protein p40
Gene namesi
Name:Rpp40
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi1310228. Rpp40.

Subcellular locationi

Nucleusnucleolus Reviewed prediction

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Ribonuclease P protein subunit p40
PRO_0000354077Add
BLAST

Proteomic databases

PRIDEiQ5BK64.

Expressioni

Gene expression databases

GenevestigatoriQ5BK64.

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062962.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG42164.
GeneTreeiENSGT00390000014167.
HOGENOMiHOG000006875.
HOVERGENiHBG055018.
InParanoidiQ5BK64.
KOiK14530.
OMAiKGSCYAL.
OrthoDBiEOG7ZPNK2.
PhylomeDBiQ5BK64.
TreeFamiTF330967.

Family and domain databases

InterProiIPR013893. RNase_P_Rpp40.
[Graphical view]
PfamiPF08584. Ribonuc_P_40. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5BK64-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATLRRLQEA PRHLLVCEKS NFGHDKSRHK HLVETHYHNY RVSFLIPECG    50
LLSKKLKDLV MEMGPYYSVK KLPLHELITH EFINTFVKKG SLSALTYNTS 100
IDEDNTVALL PNGKLILSLD KDTYEETGLQ GHPSRYSGRK SMRFIISIDL 150
MDLSLNLDSK KYRRISWSFK EKKPLKFDFL LAWHHTGTEE STMMSYFSKY 200
QIREHQPKVA LSTVRDLQCP VLQSSSLAGE PEEACNALEF FDWLGAVFCN 250
ADLNNEPHNF ISTYCCPQPN TVAAQACLCT ITGFVLPEKI LVLLEQLCHY 300
FDEPKLAPWV TLTVQGFADS PVAWREKEHG FHKGGEHLYN FVVFNNQDYW 350
LQMAVGANDD CPP 363
Length:363
Mass (Da):41,640
Last modified:May 26, 2009 - v2
Checksum:i11A8BA4ECB7063DF
GO
Isoform 2 (identifier: Q5BK64-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.

Show »
Length:303
Mass (Da):34,563
Checksum:i7403A3A350E82256
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6060Missing in isoform 2.
VSP_037347Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03105027 mRNA. No translation available.
BC091191 mRNA. Translation: AAH91191.1.
RefSeqiNP_001013073.1. NM_001013055.1. [Q5BK64-2]
XP_006253852.1. XM_006253790.1. [Q5BK64-1]
UniGeneiRn.23660.

Genome annotation databases

EnsembliENSRNOT00000021877; ENSRNOP00000021877; ENSRNOG00000016226. [Q5BK64-2]
ENSRNOT00000068617; ENSRNOP00000062962; ENSRNOG00000016226. [Q5BK64-1]
GeneIDi291071.
KEGGirno:291071.
UCSCiRGD:1310228. rat. [Q5BK64-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03105027 mRNA. No translation available.
BC091191 mRNA. Translation: AAH91191.1 .
RefSeqi NP_001013073.1. NM_001013055.1. [Q5BK64-2 ]
XP_006253852.1. XM_006253790.1. [Q5BK64-1 ]
UniGenei Rn.23660.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000062962.

Proteomic databases

PRIDEi Q5BK64.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021877 ; ENSRNOP00000021877 ; ENSRNOG00000016226 . [Q5BK64-2 ]
ENSRNOT00000068617 ; ENSRNOP00000062962 ; ENSRNOG00000016226 . [Q5BK64-1 ]
GeneIDi 291071.
KEGGi rno:291071.
UCSCi RGD:1310228. rat. [Q5BK64-1 ]

Organism-specific databases

CTDi 10799.
RGDi 1310228. Rpp40.

Phylogenomic databases

eggNOGi NOG42164.
GeneTreei ENSGT00390000014167.
HOGENOMi HOG000006875.
HOVERGENi HBG055018.
InParanoidi Q5BK64.
KOi K14530.
OMAi KGSCYAL.
OrthoDBi EOG7ZPNK2.
PhylomeDBi Q5BK64.
TreeFami TF330967.

Miscellaneous databases

NextBioi 632067.
PROi Q5BK64.

Gene expression databases

Genevestigatori Q5BK64.

Family and domain databases

InterProi IPR013893. RNase_P_Rpp40.
[Graphical view ]
Pfami PF08584. Ribonuc_P_40. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.

Entry informationi

Entry nameiRPP40_RAT
AccessioniPrimary (citable) accession number: Q5BK64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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