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Protein

Ribonuclease P protein subunit p40

Gene

Rpp40

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p40 (EC:3.1.26.5)
Short name:
RNaseP protein p40
Gene namesi
Name:Rpp40
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1310228. Rpp40.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Ribonuclease P protein subunit p40PRO_0000354077Add
BLAST

Proteomic databases

PRIDEiQ5BK64.

Expressioni

Gene expression databases

GenevisibleiQ5BK64. RN.

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062962.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG42164.
GeneTreeiENSGT00390000014167.
HOGENOMiHOG000006875.
HOVERGENiHBG055018.
InParanoidiQ5BK64.
KOiK14530.
OMAiKKGSCYA.
OrthoDBiEOG7ZPNK2.
PhylomeDBiQ5BK64.
TreeFamiTF330967.

Family and domain databases

InterProiIPR013893. RNase_P_Rpp40.
[Graphical view]
PfamiPF08584. Ribonuc_P_40. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BK64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATLRRLQEA PRHLLVCEKS NFGHDKSRHK HLVETHYHNY RVSFLIPECG
60 70 80 90 100
LLSKKLKDLV MEMGPYYSVK KLPLHELITH EFINTFVKKG SLSALTYNTS
110 120 130 140 150
IDEDNTVALL PNGKLILSLD KDTYEETGLQ GHPSRYSGRK SMRFIISIDL
160 170 180 190 200
MDLSLNLDSK KYRRISWSFK EKKPLKFDFL LAWHHTGTEE STMMSYFSKY
210 220 230 240 250
QIREHQPKVA LSTVRDLQCP VLQSSSLAGE PEEACNALEF FDWLGAVFCN
260 270 280 290 300
ADLNNEPHNF ISTYCCPQPN TVAAQACLCT ITGFVLPEKI LVLLEQLCHY
310 320 330 340 350
FDEPKLAPWV TLTVQGFADS PVAWREKEHG FHKGGEHLYN FVVFNNQDYW
360
LQMAVGANDD CPP
Length:363
Mass (Da):41,640
Last modified:May 26, 2009 - v2
Checksum:i11A8BA4ECB7063DF
GO
Isoform 2 (identifier: Q5BK64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:303
Mass (Da):34,563
Checksum:i7403A3A350E82256
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6060Missing in isoform 2. 1 PublicationVSP_037347Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03105027 mRNA. No translation available.
BC091191 mRNA. Translation: AAH91191.1.
RefSeqiNP_001013073.1. NM_001013055.1. [Q5BK64-2]
XP_006253852.1. XM_006253790.1. [Q5BK64-1]
UniGeneiRn.23660.

Genome annotation databases

EnsembliENSRNOT00000021877; ENSRNOP00000021877; ENSRNOG00000016226. [Q5BK64-2]
ENSRNOT00000068617; ENSRNOP00000062962; ENSRNOG00000016226. [Q5BK64-1]
GeneIDi291071.
KEGGirno:291071.
UCSCiRGD:1310228. rat. [Q5BK64-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03105027 mRNA. No translation available.
BC091191 mRNA. Translation: AAH91191.1.
RefSeqiNP_001013073.1. NM_001013055.1. [Q5BK64-2]
XP_006253852.1. XM_006253790.1. [Q5BK64-1]
UniGeneiRn.23660.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062962.

Proteomic databases

PRIDEiQ5BK64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021877; ENSRNOP00000021877; ENSRNOG00000016226. [Q5BK64-2]
ENSRNOT00000068617; ENSRNOP00000062962; ENSRNOG00000016226. [Q5BK64-1]
GeneIDi291071.
KEGGirno:291071.
UCSCiRGD:1310228. rat. [Q5BK64-1]

Organism-specific databases

CTDi10799.
RGDi1310228. Rpp40.

Phylogenomic databases

eggNOGiNOG42164.
GeneTreeiENSGT00390000014167.
HOGENOMiHOG000006875.
HOVERGENiHBG055018.
InParanoidiQ5BK64.
KOiK14530.
OMAiKKGSCYA.
OrthoDBiEOG7ZPNK2.
PhylomeDBiQ5BK64.
TreeFamiTF330967.

Miscellaneous databases

NextBioi632067.
PROiQ5BK64.

Gene expression databases

GenevisibleiQ5BK64. RN.

Family and domain databases

InterProiIPR013893. RNase_P_Rpp40.
[Graphical view]
PfamiPF08584. Ribonuc_P_40. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.

Entry informationi

Entry nameiRPP40_RAT
AccessioniPrimary (citable) accession number: Q5BK64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 26, 2009
Last modified: July 22, 2015
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.