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Q5BK64

- RPP40_RAT

UniProt

Q5BK64 - RPP40_RAT

Protein

Ribonuclease P protein subunit p40

Gene

Rpp40

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p40 (EC:3.1.26.5)
    Short name:
    RNaseP protein p40
    Gene namesi
    Name:Rpp40
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1310228. Rpp40.

    Subcellular locationi

    Nucleusnucleolus Curated

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Ribonuclease P protein subunit p40PRO_0000354077Add
    BLAST

    Proteomic databases

    PRIDEiQ5BK64.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5BK64.

    Interactioni

    Subunit structurei

    RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000062962.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG42164.
    GeneTreeiENSGT00390000014167.
    HOGENOMiHOG000006875.
    HOVERGENiHBG055018.
    InParanoidiQ5BK64.
    KOiK14530.
    OMAiKGSCYAL.
    OrthoDBiEOG7ZPNK2.
    PhylomeDBiQ5BK64.
    TreeFamiTF330967.

    Family and domain databases

    InterProiIPR013893. RNase_P_Rpp40.
    [Graphical view]
    PfamiPF08584. Ribonuc_P_40. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5BK64-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATLRRLQEA PRHLLVCEKS NFGHDKSRHK HLVETHYHNY RVSFLIPECG    50
    LLSKKLKDLV MEMGPYYSVK KLPLHELITH EFINTFVKKG SLSALTYNTS 100
    IDEDNTVALL PNGKLILSLD KDTYEETGLQ GHPSRYSGRK SMRFIISIDL 150
    MDLSLNLDSK KYRRISWSFK EKKPLKFDFL LAWHHTGTEE STMMSYFSKY 200
    QIREHQPKVA LSTVRDLQCP VLQSSSLAGE PEEACNALEF FDWLGAVFCN 250
    ADLNNEPHNF ISTYCCPQPN TVAAQACLCT ITGFVLPEKI LVLLEQLCHY 300
    FDEPKLAPWV TLTVQGFADS PVAWREKEHG FHKGGEHLYN FVVFNNQDYW 350
    LQMAVGANDD CPP 363
    Length:363
    Mass (Da):41,640
    Last modified:May 26, 2009 - v2
    Checksum:i11A8BA4ECB7063DF
    GO
    Isoform 2 (identifier: Q5BK64-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:303
    Mass (Da):34,563
    Checksum:i7403A3A350E82256
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6060Missing in isoform 2. 1 PublicationVSP_037347Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03105027 mRNA. No translation available.
    BC091191 mRNA. Translation: AAH91191.1.
    RefSeqiNP_001013073.1. NM_001013055.1. [Q5BK64-2]
    XP_006253852.1. XM_006253790.1. [Q5BK64-1]
    UniGeneiRn.23660.

    Genome annotation databases

    EnsembliENSRNOT00000021877; ENSRNOP00000021877; ENSRNOG00000016226. [Q5BK64-2]
    ENSRNOT00000068617; ENSRNOP00000062962; ENSRNOG00000016226. [Q5BK64-1]
    GeneIDi291071.
    KEGGirno:291071.
    UCSCiRGD:1310228. rat. [Q5BK64-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03105027 mRNA. No translation available.
    BC091191 mRNA. Translation: AAH91191.1 .
    RefSeqi NP_001013073.1. NM_001013055.1. [Q5BK64-2 ]
    XP_006253852.1. XM_006253790.1. [Q5BK64-1 ]
    UniGenei Rn.23660.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000062962.

    Proteomic databases

    PRIDEi Q5BK64.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021877 ; ENSRNOP00000021877 ; ENSRNOG00000016226 . [Q5BK64-2 ]
    ENSRNOT00000068617 ; ENSRNOP00000062962 ; ENSRNOG00000016226 . [Q5BK64-1 ]
    GeneIDi 291071.
    KEGGi rno:291071.
    UCSCi RGD:1310228. rat. [Q5BK64-1 ]

    Organism-specific databases

    CTDi 10799.
    RGDi 1310228. Rpp40.

    Phylogenomic databases

    eggNOGi NOG42164.
    GeneTreei ENSGT00390000014167.
    HOGENOMi HOG000006875.
    HOVERGENi HBG055018.
    InParanoidi Q5BK64.
    KOi K14530.
    OMAi KGSCYAL.
    OrthoDBi EOG7ZPNK2.
    PhylomeDBi Q5BK64.
    TreeFami TF330967.

    Miscellaneous databases

    NextBioi 632067.
    PROi Q5BK64.

    Gene expression databases

    Genevestigatori Q5BK64.

    Family and domain databases

    InterProi IPR013893. RNase_P_Rpp40.
    [Graphical view ]
    Pfami PF08584. Ribonuc_P_40. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.

    Entry informationi

    Entry nameiRPP40_RAT
    AccessioniPrimary (citable) accession number: Q5BK64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3