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Q5BK63

- NDUA9_RAT

UniProt

Q5BK63 - NDUA9_RAT

Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Gene

Ndufa9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    Cofactori

    Binds 1 FAD per subunit.Curated

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
    Alternative name(s):
    Complex I-39kD
    Short name:
    CI-39kD
    NADH-ubiquinone oxidoreductase 39 kDa subunit
    Sperm flagella protein 3
    Gene namesi
    Name:Ndufa9Imported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1307307. Ndufa9.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535MitochondrionBy similarityAdd
    BLAST
    Chaini36 – 377342NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialPRO_0000308374Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei175 – 1751N6-succinyllysineBy similarity
    Modified residuei189 – 1891N6-acetyllysineBy similarity
    Modified residuei370 – 3701N6-acetyllysineBy similarity

    Post-translational modificationi

    Acetylated on lysine residues. BLOC1S1 is required for acetylation By similarity.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ5BK63.
    PRIDEiQ5BK63.

    Expressioni

    Tissue specificityi

    Expressed by the principal cells of the epididymis. Detected in flagella of epididymal sperm (at protein level).1 Publication

    Gene expression databases

    GenevestigatoriQ5BK63.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction By similarity. Interacts with BLOC1S1 By similarity. Interacts with SLC2A4.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ5BK63. 1 interaction.
    STRINGi10116.ENSRNOP00000034135.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I NDUFA9 subunit family.Sequence Analysis

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0702.
    GeneTreeiENSGT00390000006865.
    HOGENOMiHOG000168008.
    HOVERGENiHBG006546.
    InParanoidiQ5BK63.
    KOiK03953.
    OMAiIFLEWNG.
    OrthoDBiEOG7TF795.
    PhylomeDBiQ5BK63.
    TreeFamiTF105961.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR008030. NmrA-like.
    [Graphical view]
    PfamiPF05368. NmrA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5BK63-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAVRFQVV RALPMSRPAI SAAATSVFCS SSHRQLHHAV IPHGKGGRSS    50
    VSGVVATVFG ATGFLGRYVV NHLGRMGSQV IIPYRCDIYD TMHLRLMGDL 100
    GQLIFLEWDA RDKDSIRKAV QHSNVVINLI GREWETRNFD FEDVFVNIPR 150
    AIAQASKEAG VERFIHVSHL NASMKSSAKS LRSKAVGEKE VRTVFPDAII 200
    IRPSDMFGRE DRFLNHFANY RWFLAVPLVS LGFKTVKQPV YVADVSKGIA 250
    NATKNPDAIG KTFAFTGPNR YLLFHLVKYI FGMTHRTFIP YPLPRFVYSW 300
    IGRLFGLSPF EPWTTKDKVE RIHISDVMAT DLPGLEDLGV QPTPLELKSI 350
    EVLRRHRTYR WLSSEIEETK PAKTVNY 377
    Length:377
    Mass (Da):42,559
    Last modified:January 11, 2011 - v2
    Checksum:i578C531D5223CD5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473964 Genomic DNA. Translation: EDM01826.1.
    BC091192 mRNA. Translation: AAH91192.1.
    BC168777 mRNA. Translation: AAI68777.1.
    RefSeqiNP_001094222.1. NM_001100752.1.
    UniGeneiRn.107963.

    Genome annotation databases

    EnsembliENSRNOT00000037176; ENSRNOP00000034135; ENSRNOG00000026930.
    GeneIDi362440.
    KEGGirno:362440.
    UCSCiRGD:1307307. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473964 Genomic DNA. Translation: EDM01826.1 .
    BC091192 mRNA. Translation: AAH91192.1 .
    BC168777 mRNA. Translation: AAI68777.1 .
    RefSeqi NP_001094222.1. NM_001100752.1.
    UniGenei Rn.107963.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5BK63. 1 interaction.
    STRINGi 10116.ENSRNOP00000034135.

    Proteomic databases

    PaxDbi Q5BK63.
    PRIDEi Q5BK63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000037176 ; ENSRNOP00000034135 ; ENSRNOG00000026930 .
    GeneIDi 362440.
    KEGGi rno:362440.
    UCSCi RGD:1307307. rat.

    Organism-specific databases

    CTDi 4704.
    RGDi 1307307. Ndufa9.

    Phylogenomic databases

    eggNOGi COG0702.
    GeneTreei ENSGT00390000006865.
    HOGENOMi HOG000168008.
    HOVERGENi HBG006546.
    InParanoidi Q5BK63.
    KOi K03953.
    OMAi IFLEWNG.
    OrthoDBi EOG7TF795.
    PhylomeDBi Q5BK63.
    TreeFami TF105961.

    Miscellaneous databases

    NextBioi 679945.
    PROi Q5BK63.

    Gene expression databases

    Genevestigatori Q5BK63.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR008030. NmrA-like.
    [Graphical view ]
    Pfami PF05368. NmrA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LiverImported and Pituitary anterior lobe.
    3. "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)."
      Foster L.J., Rudich A., Talior I., Patel N., Huang X., Furtado L.M., Bilan P.J., Mann M., Klip A.
      J. Proteome Res. 5:64-75(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SLC2A4.
    4. "Identification of novel immunodominant epididymal sperm proteins using combinatorial approach."
      Khan S.A., Suryawanshi A.R., Ranpura S.A., Jadhav S.V., Khole V.V.
      Reproduction 138:81-93(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
      Strain: Holtzman.
      Tissue: Epididymis and Sperm.

    Entry informationi

    Entry nameiNDUA9_RAT
    AccessioniPrimary (citable) accession number: Q5BK63
    Secondary accession number(s): B5DER7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3