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Q5BK63 (NDUA9_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Alternative name(s):
Complex I-39kD
Short name=CI-39kD
NADH-ubiquinone oxidoreductase 39 kDa subunit
Sperm flagella protein 3
Gene names
Name:Ndufa9
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Cofactor

Binds 1 FAD per subunit.

Subunit structure

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction By similarity. Interacts with BLOC1S1 By similarity. Interacts with SLC2A4. Ref.3

Subcellular location

Mitochondrion matrix.

Tissue specificity

Expressed by the principal cells of the epididymis. Detected in flagella of epididymal sperm (at protein level). Ref.4

Post-translational modification

Acetylated on lysine residues. BLOC1S1 is required for acetylation By similarity.

Sequence similarities

Belongs to the complex I NDUFA9 subunit family.

Ontologies

Keywords
   Biological processElectron transport
Respiratory chain
Transport
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandFAD
Flavoprotein
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processoxidation-reduction process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrial inner membrane

Inferred from electronic annotation. Source: Ensembl

mitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

respiratory chain

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3535Mitochondrion By similarity
Chain36 – 377342NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
PRO_0000308374

Amino acid modifications

Modified residue1751N6-succinyllysine By similarity
Modified residue1891N6-acetyllysine By similarity
Modified residue3701N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5BK63 [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: 578C531D5223CD5C

FASTA37742,559
        10         20         30         40         50         60 
MAAAVRFQVV RALPMSRPAI SAAATSVFCS SSHRQLHHAV IPHGKGGRSS VSGVVATVFG 

        70         80         90        100        110        120 
ATGFLGRYVV NHLGRMGSQV IIPYRCDIYD TMHLRLMGDL GQLIFLEWDA RDKDSIRKAV 

       130        140        150        160        170        180 
QHSNVVINLI GREWETRNFD FEDVFVNIPR AIAQASKEAG VERFIHVSHL NASMKSSAKS 

       190        200        210        220        230        240 
LRSKAVGEKE VRTVFPDAII IRPSDMFGRE DRFLNHFANY RWFLAVPLVS LGFKTVKQPV 

       250        260        270        280        290        300 
YVADVSKGIA NATKNPDAIG KTFAFTGPNR YLLFHLVKYI FGMTHRTFIP YPLPRFVYSW 

       310        320        330        340        350        360 
IGRLFGLSPF EPWTTKDKVE RIHISDVMAT DLPGLEDLGV QPTPLELKSI EVLRRHRTYR 

       370 
WLSSEIEETK PAKTVNY 

« Hide

References

« Hide 'large scale' references
[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver and Pituitary anterior lobe.
[3]"Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)."
Foster L.J., Rudich A., Talior I., Patel N., Huang X., Furtado L.M., Bilan P.J., Mann M., Klip A.
J. Proteome Res. 5:64-75(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SLC2A4.
[4]"Identification of novel immunodominant epididymal sperm proteins using combinatorial approach."
Khan S.A., Suryawanshi A.R., Ranpura S.A., Jadhav S.V., Khole V.V.
Reproduction 138:81-93(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
Strain: Holtzman.
Tissue: Epididymis and Sperm.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH473964 Genomic DNA. Translation: EDM01826.1.
BC091192 mRNA. Translation: AAH91192.1.
BC168777 mRNA. Translation: AAI68777.1.
RefSeqNP_001094222.1. NM_001100752.1.
UniGeneRn.107963.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ5BK63. 1 interaction.
STRING10116.ENSRNOP00000034135.

Proteomic databases

PaxDbQ5BK63.
PRIDEQ5BK63.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000037176; ENSRNOP00000034135; ENSRNOG00000026930.
GeneID362440.
KEGGrno:362440.
UCSCRGD:1307307. rat.

Organism-specific databases

CTD4704.
RGD1307307. Ndufa9.

Phylogenomic databases

eggNOGCOG0702.
GeneTreeENSGT00390000006865.
HOGENOMHOG000168008.
HOVERGENHBG006546.
InParanoidQ5BK63.
KOK03953.
OMAIFLEWNG.
OrthoDBEOG7TF795.
PhylomeDBQ5BK63.
TreeFamTF105961.

Gene expression databases

GenevestigatorQ5BK63.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR016040. NAD(P)-bd_dom.
IPR008030. NmrA.
[Graphical view]
PfamPF05368. NmrA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio679945.
PROQ5BK63.

Entry information

Entry nameNDUA9_RAT
AccessionPrimary (citable) accession number: Q5BK63
Secondary accession number(s): B5DER7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families