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Protein

Sorting nexin-20

Gene

Snx20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei113Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei115Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei140Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei154Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-20
Gene namesi
Name:Snx20
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1307787. Snx20.

Subcellular locationi

  • Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cell membrane By similarity
  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258211 – 313Sorting nexin-20Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BK61.
PRIDEiQ5BK61.

PTM databases

iPTMnetiQ5BK61.
PhosphoSitePlusiQ5BK61.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014202.

Interactioni

Subunit structurei

Interacts with SELPLG. Interaction with SELPLG is controversial.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019130.

Structurei

3D structure databases

ProteinModelPortaliQ5BK61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 188PXPROSITE-ProRule annotationAdd BLAST118

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2101. Eukaryota.
ENOG410XQM8. LUCA.
GeneTreeiENSGT00530000063759.
HOGENOMiHOG000154363.
HOVERGENiHBG108497.
InParanoidiQ5BK61.
KOiK17931.
OMAiLTAHCPA.
OrthoDBiEOG091G0S8F.
PhylomeDBiQ5BK61.
TreeFamiTF326807.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BK61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPQHPGGP GWTGPRNQCI TRTRQEVLPP GPDLPCPGPE EAQDGPTSNS
60 70 80 90 100
NMTTRELQEH WQKEKSRWKH VRLLFEIASA RIEERKVSKF VMYQVVVIQT
110 120 130 140 150
GSFDSDKAVV ERRYSDFERL QRALLKRFGP ELEDVTFPRK RLTGNLSAET
160 170 180 190 200
ICERRLELRE YLRLLYAVRA VRRSREFADF LTRPELCEAF GCLRAGQYAR
210 220 230 240 250
ALDLLGRVVP LQEKLTAHCP SAPVPALCAM LVCLRDLERP AEAFAVGERA
260 270 280 290 300
LRRLGARESH RYYAPLLDAM VRLAYALGKD LASLQGRLDE SQLRRPTHRG
310
ATLKELTVRE YLS
Length:313
Mass (Da):35,723
Last modified:April 12, 2005 - v1
Checksum:i79D766A3B4F272B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091194 mRNA. Translation: AAH91194.1.
RefSeqiNP_001020170.1. NM_001024999.1.
UniGeneiRn.101842.

Genome annotation databases

EnsembliENSRNOT00000019130; ENSRNOP00000019130; ENSRNOG00000014202.
GeneIDi307742.
KEGGirno:307742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091194 mRNA. Translation: AAH91194.1.
RefSeqiNP_001020170.1. NM_001024999.1.
UniGeneiRn.101842.

3D structure databases

ProteinModelPortaliQ5BK61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019130.

PTM databases

iPTMnetiQ5BK61.
PhosphoSitePlusiQ5BK61.

Proteomic databases

PaxDbiQ5BK61.
PRIDEiQ5BK61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019130; ENSRNOP00000019130; ENSRNOG00000014202.
GeneIDi307742.
KEGGirno:307742.

Organism-specific databases

CTDi124460.
RGDi1307787. Snx20.

Phylogenomic databases

eggNOGiKOG2101. Eukaryota.
ENOG410XQM8. LUCA.
GeneTreeiENSGT00530000063759.
HOGENOMiHOG000154363.
HOVERGENiHBG108497.
InParanoidiQ5BK61.
KOiK17931.
OMAiLTAHCPA.
OrthoDBiEOG091G0S8F.
PhylomeDBiQ5BK61.
TreeFamiTF326807.

Miscellaneous databases

PROiQ5BK61.

Gene expression databases

BgeeiENSRNOG00000014202.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX20_RAT
AccessioniPrimary (citable) accession number: Q5BK61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.