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Protein

HAUS augmin-like complex subunit 8

Gene

Haus8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 8
Alternative name(s):
HEC1/NDC80-interacting centrosome-associated protein 1
Sarcoma antigen NY-SAR-48 homolog
Gene namesi
Name:Haus8
Synonyms:Hice1, Ny-sar-48
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1311565. Haus8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 385384HAUS augmin-like complex subunit 8PRO_0000319939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei100 – 1001PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5BK57.
PRIDEiQ5BK57.

Expressioni

Gene expression databases

ExpressionAtlasiQ5BK57. differential.
GenevisibleiQ5BK57. RN.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038415.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili131 – 248118Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the HAUS8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEK2. Eukaryota.
ENOG4112BWM. LUCA.
GeneTreeiENSGT00390000010974.
HOGENOMiHOG000112854.
InParanoidiQ5BK57.
KOiK16591.
OMAiESRYLQY.
OrthoDBiEOG7JHM6B.
PhylomeDBiQ5BK57.
TreeFamiTF332998.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASERDAG KPAASGAGAV PKTKGRKVQG GRVVESRYLQ YDKKTKKVSV
60 70 80 90 100
AAKGEKPPTE GRKASTVPRS REESKVMGTS NLQSTMLEGH GLNPPDLDLS
110 120 130 140 150
AIDDKSMSRK APQLERSVAG TDKSTSLLRP DQKRTLRKKR RDLQETMDMM
160 170 180 190 200
ESQTLLMTLL SVKVENNLAL LEEKAEKDLA AMCHEKERLQ RQALELRRQL
210 220 230 240 250
LLRQKHQELA AALDAQTEVL SPLPPVLERF KEEYKTLGRA LDTTRHELSM
260 270 280 290 300
QAVHMEGSGQ ELLDDLEPAL RTTLQLLGDL SICSPEDSAQ VQGASTQQPG
310 320 330 340 350
ASAQLNCLLK ELKGLVAEKD LELCRLVSQV VELSSQASKE AALTNQEVWE
360 370 380
EAQGTLTSSQ GYFSPDVRKD HSPTQDRTNS SSLDP
Length:385
Mass (Da):42,332
Last modified:February 26, 2008 - v2
Checksum:iAB10EBAA5E962407
GO

Sequence cautioni

The sequence AAH91198.1 differs from that shown. Reason: Frameshift at position 228. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091198 mRNA. Translation: AAH91198.1. Frameshift.
RefSeqiNP_001020142.2. NM_001024971.2.
UniGeneiRn.106450.

Genome annotation databases

EnsembliENSRNOT00000090775; ENSRNOP00000071943; ENSRNOG00000052038.
GeneIDi290626.
KEGGirno:290626.
UCSCiRGD:1311565. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091198 mRNA. Translation: AAH91198.1. Frameshift.
RefSeqiNP_001020142.2. NM_001024971.2.
UniGeneiRn.106450.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038415.

Proteomic databases

PaxDbiQ5BK57.
PRIDEiQ5BK57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000090775; ENSRNOP00000071943; ENSRNOG00000052038.
GeneIDi290626.
KEGGirno:290626.
UCSCiRGD:1311565. rat.

Organism-specific databases

CTDi93323.
RGDi1311565. Haus8.

Phylogenomic databases

eggNOGiENOG410IEK2. Eukaryota.
ENOG4112BWM. LUCA.
GeneTreeiENSGT00390000010974.
HOGENOMiHOG000112854.
InParanoidiQ5BK57.
KOiK16591.
OMAiESRYLQY.
OrthoDBiEOG7JHM6B.
PhylomeDBiQ5BK57.
TreeFamiTF332998.

Miscellaneous databases

NextBioi631310.
PROiQ5BK57.

Gene expression databases

ExpressionAtlasiQ5BK57. differential.
GenevisibleiQ5BK57. RN.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiHAUS8_RAT
AccessioniPrimary (citable) accession number: Q5BK57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 17, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.