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Protein

HAUS augmin-like complex subunit 8

Gene

Haus8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-380259. Loss of Nlp from mitotic centrosomes.
R-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-380320. Recruitment of NuMA to mitotic centrosomes.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 8
Alternative name(s):
HEC1/NDC80-interacting centrosome-associated protein 1
Sarcoma antigen NY-SAR-48 homolog
Gene namesi
Name:Haus8
Synonyms:Hice1, Ny-sar-48
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1311565. Haus8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003199392 – 385HAUS augmin-like complex subunit 8Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei100PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5BK57.
PRIDEiQ5BK57.

Expressioni

Gene expression databases

BgeeiENSRNOG00000052038.
ExpressionAtlasiQ5BK57. differential.
GenevisibleiQ5BK57. RN.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038415.

Structurei

3D structure databases

SMRiQ5BK57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili131 – 248Sequence analysisAdd BLAST118

Sequence similaritiesi

Belongs to the HAUS8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEK2. Eukaryota.
ENOG4112BWM. LUCA.
GeneTreeiENSGT00390000010974.
HOGENOMiHOG000112854.
InParanoidiQ5BK57.
KOiK16591.
OMAiIMCKEKE.
OrthoDBiEOG091G0B15.
PhylomeDBiQ5BK57.
TreeFamiTF332998.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASERDAG KPAASGAGAV PKTKGRKVQG GRVVESRYLQ YDKKTKKVSV
60 70 80 90 100
AAKGEKPPTE GRKASTVPRS REESKVMGTS NLQSTMLEGH GLNPPDLDLS
110 120 130 140 150
AIDDKSMSRK APQLERSVAG TDKSTSLLRP DQKRTLRKKR RDLQETMDMM
160 170 180 190 200
ESQTLLMTLL SVKVENNLAL LEEKAEKDLA AMCHEKERLQ RQALELRRQL
210 220 230 240 250
LLRQKHQELA AALDAQTEVL SPLPPVLERF KEEYKTLGRA LDTTRHELSM
260 270 280 290 300
QAVHMEGSGQ ELLDDLEPAL RTTLQLLGDL SICSPEDSAQ VQGASTQQPG
310 320 330 340 350
ASAQLNCLLK ELKGLVAEKD LELCRLVSQV VELSSQASKE AALTNQEVWE
360 370 380
EAQGTLTSSQ GYFSPDVRKD HSPTQDRTNS SSLDP
Length:385
Mass (Da):42,332
Last modified:February 26, 2008 - v2
Checksum:iAB10EBAA5E962407
GO

Sequence cautioni

The sequence AAH91198 differs from that shown. Reason: Frameshift at position 228.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091198 mRNA. Translation: AAH91198.1. Frameshift.
RefSeqiNP_001020142.2. NM_001024971.2.
UniGeneiRn.106450.

Genome annotation databases

EnsembliENSRNOT00000090775; ENSRNOP00000071943; ENSRNOG00000052038.
GeneIDi290626.
KEGGirno:290626.
UCSCiRGD:1311565. rat.

Similar proteinsi

Entry informationi

Entry nameiHAUS8_RAT
AccessioniPrimary (citable) accession number: Q5BK57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families