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Protein

Lymphocyte activation gene 3 protein

Gene

Lag3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in lymphocyte activation. Binds to HLA class-II antigens (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte activation gene 3 protein
Short name:
LAG-3
Alternative name(s):
CD_antigen: CD223
Gene namesi
Name:Lag3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1302990. Lag3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 442ExtracellularSequence analysisAdd BLAST419
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 525CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000025304224 – 525Lymphocyte activation gene 3 proteinAdd BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 156PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi185 ↔ 235PROSITE-ProRule annotation
Glycosylationi244N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi276 ↔ 327PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi363 ↔ 405PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5BK54.
PRIDEiQ5BK54.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021334.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036771.

Structurei

3D structure databases

ProteinModelPortaliQ5BK54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 163Ig-like V-typeAdd BLAST127
Domaini164 – 246Ig-like C2-type 1Add BLAST83
Domaini258 – 341Ig-like C2-type 2Add BLAST84
Domaini345 – 412Ig-like C2-type 3Add BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni493 – 52215 X 2 AA tandem repeats of E-XAdd BLAST30

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPP. Eukaryota.
ENOG410Z3KP. LUCA.
GeneTreeiENSGT00390000017331.
HOGENOMiHOG000113275.
HOVERGENiHBG004952.
InParanoidiQ5BK54.
KOiK06565.
OMAiERFVWSP.
OrthoDBiEOG091G0PJF.
PhylomeDBiQ5BK54.
TreeFamiTF335942.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 2 hits.
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQDLFLDLL LLQLLWEAPV VSSGPGKELS VVWAQEGAPV HLPCSLEFPH
60 70 80 90 100
LDPNFLRRGW VTWQHRPDSD QPASIPALDL LQGMPSTRRH PPHRYTVLSV
110 120 130 140 150
APGGLRSGRQ PLLSHVQLEK RGPQRGDFSL WLRPATRKDA GEYHAFVRLP
160 170 180 190 200
DRDFSCSLRL RVGQASMIAS PPGTLKPSDW VILNCSFSRP DRPVSVHWFQ
210 220 230 240 250
GQSRVPVHNS PRHYLAESFL LLPQVSPLDS GTWGCVLTYR DGFNVSITYN
260 270 280 290 300
LKVQGLEPVA PLTVYAAEGS RVELPCHLPP VVGTPSLLIA KWTPPGGGPE
310 320 330 340 350
LPVTGKSGNF TLQLENVGRA QAGTYTCSIH LQGRQLSAAV TLAVITVTPK
360 370 380 390 400
SFGLPGSPQK LLCEVVPASG EGRFVWRPLS DLSRSSLGPV LELQEAKLLA
410 420 430 440 450
EQWQCQLYEG QKLLGATVYT AESSSGAWSA KRISGDLKGG HLFLSLILGA
460 470 480 490 500
LALFLLVTGA FGFHLWRRQL LRRRFSALEH GIRPPPVQSK IEELEREPET
510 520
EMEPETEPDP EPQPEPELEP ESRQL
Length:525
Mass (Da):57,988
Last modified:April 12, 2005 - v1
Checksum:i13CA457327052C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ438937 mRNA. Translation: ABE68618.1.
BC091201 mRNA. Translation: AAH91201.1.
RefSeqiNP_997678.2. NM_212513.2.
XP_008761504.1. XM_008763282.2.
UniGeneiRn.198703.

Genome annotation databases

EnsembliENSRNOT00000028965; ENSRNOP00000036771; ENSRNOG00000021334.
GeneIDi297596.
KEGGirno:297596.
UCSCiRGD:1302990. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ438937 mRNA. Translation: ABE68618.1.
BC091201 mRNA. Translation: AAH91201.1.
RefSeqiNP_997678.2. NM_212513.2.
XP_008761504.1. XM_008763282.2.
UniGeneiRn.198703.

3D structure databases

ProteinModelPortaliQ5BK54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036771.

Proteomic databases

PaxDbiQ5BK54.
PRIDEiQ5BK54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028965; ENSRNOP00000036771; ENSRNOG00000021334.
GeneIDi297596.
KEGGirno:297596.
UCSCiRGD:1302990. rat.

Organism-specific databases

CTDi3902.
RGDi1302990. Lag3.

Phylogenomic databases

eggNOGiENOG410IFPP. Eukaryota.
ENOG410Z3KP. LUCA.
GeneTreeiENSGT00390000017331.
HOGENOMiHOG000113275.
HOVERGENiHBG004952.
InParanoidiQ5BK54.
KOiK06565.
OMAiERFVWSP.
OrthoDBiEOG091G0PJF.
PhylomeDBiQ5BK54.
TreeFamiTF335942.

Miscellaneous databases

PROiQ5BK54.

Gene expression databases

BgeeiENSRNOG00000021334.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 2 hits.
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAG3_RAT
AccessioniPrimary (citable) accession number: Q5BK54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.