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Protein

Lymphocyte activation gene 3 protein

Gene

Lag3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in lymphocyte activation. Binds to HLA class-II antigens (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2132295 MHC class II antigen presentation

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte activation gene 3 protein
Short name:
LAG-3
Alternative name(s):
CD_antigen: CD223
Gene namesi
Name:Lag3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1302990 Lag3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 442ExtracellularSequence analysisAdd BLAST419
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 525CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000025304224 – 525Lymphocyte activation gene 3 proteinAdd BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 156PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi185 ↔ 235PROSITE-ProRule annotation
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi276 ↔ 327PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi363 ↔ 405PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5BK54
PRIDEiQ5BK54

Expressioni

Gene expression databases

BgeeiENSRNOG00000021334

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036771

Structurei

3D structure databases

ProteinModelPortaliQ5BK54
SMRiQ5BK54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 163Ig-like V-typeAdd BLAST127
Domaini164 – 246Ig-like C2-type 1Add BLAST83
Domaini258 – 341Ig-like C2-type 2Add BLAST84
Domaini345 – 412Ig-like C2-type 3Add BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni493 – 52215 X 2 AA tandem repeats of E-XAdd BLAST30

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPP Eukaryota
ENOG410Z3KP LUCA
GeneTreeiENSGT00390000017331
HOGENOMiHOG000113275
HOVERGENiHBG004952
InParanoidiQ5BK54
KOiK06565
OMAiGIHPPQA
OrthoDBiEOG091G0PJF
PhylomeDBiQ5BK54
TreeFamiTF335942

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR013151 Immunoglobulin
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQDLFLDLL LLQLLWEAPV VSSGPGKELS VVWAQEGAPV HLPCSLEFPH
60 70 80 90 100
LDPNFLRRGW VTWQHRPDSD QPASIPALDL LQGMPSTRRH PPHRYTVLSV
110 120 130 140 150
APGGLRSGRQ PLLSHVQLEK RGPQRGDFSL WLRPATRKDA GEYHAFVRLP
160 170 180 190 200
DRDFSCSLRL RVGQASMIAS PPGTLKPSDW VILNCSFSRP DRPVSVHWFQ
210 220 230 240 250
GQSRVPVHNS PRHYLAESFL LLPQVSPLDS GTWGCVLTYR DGFNVSITYN
260 270 280 290 300
LKVQGLEPVA PLTVYAAEGS RVELPCHLPP VVGTPSLLIA KWTPPGGGPE
310 320 330 340 350
LPVTGKSGNF TLQLENVGRA QAGTYTCSIH LQGRQLSAAV TLAVITVTPK
360 370 380 390 400
SFGLPGSPQK LLCEVVPASG EGRFVWRPLS DLSRSSLGPV LELQEAKLLA
410 420 430 440 450
EQWQCQLYEG QKLLGATVYT AESSSGAWSA KRISGDLKGG HLFLSLILGA
460 470 480 490 500
LALFLLVTGA FGFHLWRRQL LRRRFSALEH GIRPPPVQSK IEELEREPET
510 520
EMEPETEPDP EPQPEPELEP ESRQL
Length:525
Mass (Da):57,988
Last modified:April 12, 2005 - v1
Checksum:i13CA457327052C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ438937 mRNA Translation: ABE68618.1
BC091201 mRNA Translation: AAH91201.1
RefSeqiNP_997678.2, NM_212513.2
XP_008761504.1, XM_008763282.2
UniGeneiRn.198703

Genome annotation databases

EnsembliENSRNOT00000028965; ENSRNOP00000036771; ENSRNOG00000021334
GeneIDi297596
KEGGirno:297596
UCSCiRGD:1302990 rat

Similar proteinsi

Entry informationi

Entry nameiLAG3_RAT
AccessioniPrimary (citable) accession number: Q5BK54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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