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Protein

T-cell surface protein tactile

Gene

Cd96

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface protein tactile
Alternative name(s):
Cell surface antigen CD96
T cell-activated increased late expression protein
CD_antigen: CD96
Gene namesi
Name:Cd96
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1565249. Cd96.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 537ExtracellularSequence analysisAdd BLAST516
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 603CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031389222 – 603T-cell surface protein tactileAdd BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi46 ↔ 119PROSITE-ProRule annotation
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161 ↔ 229PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272 ↔ 336PROSITE-ProRule annotation
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5BK49.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023030.
GenevisibleiQ5BK49. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with PVR (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034871.

Structurei

3D structure databases

ProteinModelPortaliQ5BK49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 132Ig-like V-type 1Add BLAST109
Domaini139 – 245Ig-like V-type 2Add BLAST107
Domaini251 – 356Ig-like C2-typeAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi577 – 581Poly-Pro5

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGTS. Eukaryota.
ENOG411142M. LUCA.
GeneTreeiENSGT00390000003446.
HOGENOMiHOG000150673.
HOVERGENiHBG004030.
InParanoidiQ5BK49.
KOiK06517.
OMAiVQMQWSK.
OrthoDBiEOG091G065T.
PhylomeDBiQ5BK49.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
PfamiView protein in Pfam
PF08205. C2-set_2. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKWTYCVV YAIIQIQFFR GAWEELFNAG DNNVYALPGS DVNLTCQTME
60 70 80 90 100
KDLMVQMQWS KVTDEIDMIV VYHPQYGFHY MQGVACESRV AAVETLKDAT
110 120 130 140 150
KWTLNLRNIS SSLSGKYECS FTMYPTGTKT IVYNLIVEPY TQDEHNRTIE
160 170 180 190 200
IETNRTLEIP CFQNTSSEIS PRFTFSWLVE KDGVEDVLFT YDYHVSNSTA
210 220 230 240 250
FKGRVGLGAD YGLRLSPVQI QDDGRTFSCF LRISPLKVWK TSTTVKVFAK
260 270 280 290 300
PEILMTVENT TMDVLGERVF TCLLKNVFPK ASITWLIDGR LFQGNEEGIY
310 320 330 340 350
ITNEEKNSSS GFWELKSVLT RMHNRTSQSN NMTVWCMALS PGPGNKMWNT
360 370 380 390 400
SSQPITFSLD SGTAPTKRLP NVTGSTLGAQ TFPDAEVSPT RYLATSSMTI
410 420 430 440 450
VDENVLTPDP TPQTSNSSMT TKDVNYSQPS SGTDAKNSSR AASSSDGGSR
460 470 480 490 500
PFPSTSPPKW LSLPHTSTGP QEPDSAVSWI PTDAYTSGSS DASLTSHDVI
510 520 530 540 550
IRTTKEFPDV LTTANGTTKI KHGHVTGITV NKPRDGMSWP VAVATLLFFC
560 570 580 590 600
ILLFGLGVRK WCQYQKEIME RPPPFKPPPP PIKYMCIQEP TGRGMPCHEM

EVL
Length:603
Mass (Da):67,228
Last modified:April 12, 2005 - v1
Checksum:i8D46DDC0AE9B6840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091206 mRNA. Translation: AAH91206.1.
RefSeqiNP_001020203.1. NM_001025032.1.
UniGeneiRn.55482.

Genome annotation databases

EnsembliENSRNOT00000035485; ENSRNOP00000034871; ENSRNOG00000023030.
GeneIDi498079.
KEGGirno:498079.
UCSCiRGD:1565249. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTACT_RAT
AccessioniPrimary (citable) accession number: Q5BK49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 12, 2005
Last modified: June 7, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome