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Protein

T-cell surface protein tactile

Gene

Cd96

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface protein tactile
Alternative name(s):
Cell surface antigen CD96
T cell-activated increased late expression protein
CD_antigen: CD96
Gene namesi
Name:Cd96
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1565249. Cd96.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 537516ExtracellularSequence analysisAdd
BLAST
Transmembranei538 – 55821HelicalSequence analysisAdd
BLAST
Topological domaini559 – 60345CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 603582T-cell surface protein tactilePRO_0000313892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi46 ↔ 119PROSITE-ProRule annotation
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi161 ↔ 229PROSITE-ProRule annotation
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi272 ↔ 336PROSITE-ProRule annotation
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence analysis
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence analysis
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence analysis
Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence analysis
Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5BK49.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023030.
GenevisibleiQ5BK49. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with PVR (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034871.

Structurei

3D structure databases

ProteinModelPortaliQ5BK49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 132109Ig-like V-type 1Add
BLAST
Domaini139 – 245107Ig-like V-type 2Add
BLAST
Domaini251 – 356106Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi577 – 5815Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGTS. Eukaryota.
ENOG411142M. LUCA.
GeneTreeiENSGT00390000003446.
HOGENOMiHOG000150673.
HOVERGENiHBG004030.
InParanoidiQ5BK49.
KOiK06517.
OMAiVQMQWSK.
OrthoDBiEOG091G065T.
PhylomeDBiQ5BK49.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKWTYCVV YAIIQIQFFR GAWEELFNAG DNNVYALPGS DVNLTCQTME
60 70 80 90 100
KDLMVQMQWS KVTDEIDMIV VYHPQYGFHY MQGVACESRV AAVETLKDAT
110 120 130 140 150
KWTLNLRNIS SSLSGKYECS FTMYPTGTKT IVYNLIVEPY TQDEHNRTIE
160 170 180 190 200
IETNRTLEIP CFQNTSSEIS PRFTFSWLVE KDGVEDVLFT YDYHVSNSTA
210 220 230 240 250
FKGRVGLGAD YGLRLSPVQI QDDGRTFSCF LRISPLKVWK TSTTVKVFAK
260 270 280 290 300
PEILMTVENT TMDVLGERVF TCLLKNVFPK ASITWLIDGR LFQGNEEGIY
310 320 330 340 350
ITNEEKNSSS GFWELKSVLT RMHNRTSQSN NMTVWCMALS PGPGNKMWNT
360 370 380 390 400
SSQPITFSLD SGTAPTKRLP NVTGSTLGAQ TFPDAEVSPT RYLATSSMTI
410 420 430 440 450
VDENVLTPDP TPQTSNSSMT TKDVNYSQPS SGTDAKNSSR AASSSDGGSR
460 470 480 490 500
PFPSTSPPKW LSLPHTSTGP QEPDSAVSWI PTDAYTSGSS DASLTSHDVI
510 520 530 540 550
IRTTKEFPDV LTTANGTTKI KHGHVTGITV NKPRDGMSWP VAVATLLFFC
560 570 580 590 600
ILLFGLGVRK WCQYQKEIME RPPPFKPPPP PIKYMCIQEP TGRGMPCHEM

EVL
Length:603
Mass (Da):67,228
Last modified:April 12, 2005 - v1
Checksum:i8D46DDC0AE9B6840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091206 mRNA. Translation: AAH91206.1.
RefSeqiNP_001020203.1. NM_001025032.1.
UniGeneiRn.55482.

Genome annotation databases

EnsembliENSRNOT00000035485; ENSRNOP00000034871; ENSRNOG00000023030.
GeneIDi498079.
KEGGirno:498079.
UCSCiRGD:1565249. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091206 mRNA. Translation: AAH91206.1.
RefSeqiNP_001020203.1. NM_001025032.1.
UniGeneiRn.55482.

3D structure databases

ProteinModelPortaliQ5BK49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034871.

Proteomic databases

PaxDbiQ5BK49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035485; ENSRNOP00000034871; ENSRNOG00000023030.
GeneIDi498079.
KEGGirno:498079.
UCSCiRGD:1565249. rat.

Organism-specific databases

CTDi10225.
RGDi1565249. Cd96.

Phylogenomic databases

eggNOGiENOG410IGTS. Eukaryota.
ENOG411142M. LUCA.
GeneTreeiENSGT00390000003446.
HOGENOMiHOG000150673.
HOVERGENiHBG004030.
InParanoidiQ5BK49.
KOiK06517.
OMAiVQMQWSK.
OrthoDBiEOG091G065T.
PhylomeDBiQ5BK49.

Miscellaneous databases

PROiQ5BK49.

Gene expression databases

BgeeiENSRNOG00000023030.
GenevisibleiQ5BK49. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTACT_RAT
AccessioniPrimary (citable) accession number: Q5BK49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.