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Protein

Tetratricopeptide repeat protein 5

Gene

Ttc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-RNO-6804760. Regulation of TP53 Activity through Methylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 5
Short name:
TPR repeat protein 5
Alternative name(s):
Stress-responsive activator of p300
Short name:
Strap
Gene namesi
Name:Ttc5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1311284. Ttc5.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063831 – 440Tetratricopeptide repeat protein 5Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BK48.
PRIDEiQ5BK48.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008850.
GenevisibleiQ5BK48. RN.

Interactioni

Subunit structurei

Interacts with JMY and p300/EP300.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011741.

Structurei

3D structure databases

ProteinModelPortaliQ5BK48.
SMRiQ5BK48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 61TPR 1Add BLAST55
Repeati68 – 98TPR 2Add BLAST31
Repeati103 – 130TPR 3Add BLAST28
Repeati136 – 174TPR 4Add BLAST39
Repeati179 – 216TPR 5Add BLAST38
Repeati224 – 253TPR 6Add BLAST30

Sequence similaritiesi

Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEK9. Eukaryota.
ENOG410XP1F. LUCA.
GeneTreeiENSGT00390000006227.
HOGENOMiHOG000006922.
HOVERGENiHBG054388.
InParanoidiQ5BK48.
OMAiAVMVYNM.
OrthoDBiEOG091G0ARR.
PhylomeDBiQ5BK48.
TreeFamiTF316804.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR032076. TTC5_OB.
[Graphical view]
PfamiPF16669. TTC5_OB. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BK48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMADEEEEAK QVLQKLQELV DQLYCFRDSY FETHSVEDAG QKQQDVQEEM
60 70 80 90 100
EKTLRQMEEV LGSVQVEAQA LMLKGKALNV TPDYSPEAEV LLSKAVKLEP
110 120 130 140 150
ELVEAWNQLG EVYWKKGDVA AAHTCFSGAL THCKNKVSLQ NLSMVLRQLQ
160 170 180 190 200
TDSGDEHSRH VMDSVRQAKL AVQMDVLDGR SWYILGNAYL SLYFNTGQNP
210 220 230 240 250
KISQQALSAY AQAEKVDRKA SSNPDLHLNR ATLHKYEESY GEALEGFSQA
260 270 280 290 300
ATLDPAWPEP QQREQQLLEF LSRLTNLLAS KGKTKPKKLQ SMLGNLRPAH
310 320 330 340 350
LGPCGDGRYQ SATGQKVTLQ LKPLSTLQPG VNSGTVVLGK VVFSLTTEEK
360 370 380 390 400
VPFTFGLVDS DGPCYAVMVY NVVQSWGVLI GDSVAIPEPN LRHHQIQHKG
410 420 430 440
KDYSFSSVRV ETPLLLVVNG KPQNSSSQAS ATVASRPQCE
Length:440
Mass (Da):48,793
Last modified:April 12, 2005 - v1
Checksum:iD1213D85F881516B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091207 mRNA. Translation: AAH91207.1.
RefSeqiNP_001013149.1. NM_001013131.1.
UniGeneiRn.16620.

Genome annotation databases

EnsembliENSRNOT00000011741; ENSRNOP00000011741; ENSRNOG00000008850.
GeneIDi305837.
KEGGirno:305837.
UCSCiRGD:1311284. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091207 mRNA. Translation: AAH91207.1.
RefSeqiNP_001013149.1. NM_001013131.1.
UniGeneiRn.16620.

3D structure databases

ProteinModelPortaliQ5BK48.
SMRiQ5BK48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011741.

Proteomic databases

PaxDbiQ5BK48.
PRIDEiQ5BK48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011741; ENSRNOP00000011741; ENSRNOG00000008850.
GeneIDi305837.
KEGGirno:305837.
UCSCiRGD:1311284. rat.

Organism-specific databases

CTDi91875.
RGDi1311284. Ttc5.

Phylogenomic databases

eggNOGiENOG410IEK9. Eukaryota.
ENOG410XP1F. LUCA.
GeneTreeiENSGT00390000006227.
HOGENOMiHOG000006922.
HOVERGENiHBG054388.
InParanoidiQ5BK48.
OMAiAVMVYNM.
OrthoDBiEOG091G0ARR.
PhylomeDBiQ5BK48.
TreeFamiTF316804.

Enzyme and pathway databases

ReactomeiR-RNO-6804760. Regulation of TP53 Activity through Methylation.

Miscellaneous databases

PROiQ5BK48.

Gene expression databases

BgeeiENSRNOG00000008850.
GenevisibleiQ5BK48. RN.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR032076. TTC5_OB.
[Graphical view]
PfamiPF16669. TTC5_OB. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC5_RAT
AccessioniPrimary (citable) accession number: Q5BK48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.