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Protein

Tetratricopeptide repeat protein 5

Gene

Ttc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-RNO-6804760 Regulation of TP53 Activity through Methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 5
Short name:
TPR repeat protein 5
Alternative name(s):
Stress-responsive activator of p300
Short name:
Strap
Gene namesi
Name:Ttc5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1311284 Ttc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063831 – 440Tetratricopeptide repeat protein 5Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BK48
PRIDEiQ5BK48

Expressioni

Gene expression databases

BgeeiENSRNOG00000008850
GenevisibleiQ5BK48 RN

Interactioni

Subunit structurei

Interacts with JMY and p300/EP300.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011741

Structurei

3D structure databases

ProteinModelPortaliQ5BK48
SMRiQ5BK48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 61TPR 1Add BLAST55
Repeati68 – 98TPR 2Add BLAST31
Repeati103 – 130TPR 3Add BLAST28
Repeati136 – 174TPR 4Add BLAST39
Repeati179 – 216TPR 5Add BLAST38
Repeati224 – 253TPR 6Add BLAST30

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEK9 Eukaryota
ENOG410XP1F LUCA
GeneTreeiENSGT00390000006227
HOGENOMiHOG000006922
HOVERGENiHBG054388
InParanoidiQ5BK48
OMAiNMVQSWG
OrthoDBiEOG091G0ARR
PhylomeDBiQ5BK48
TreeFamiTF316804

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.40.50.550, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR032076 TTC5_OB
IPR038645 TTC5_OB_sf
PfamiView protein in Pfam
PF16669 TTC5_OB, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q5BK48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMADEEEEAK QVLQKLQELV DQLYCFRDSY FETHSVEDAG QKQQDVQEEM
60 70 80 90 100
EKTLRQMEEV LGSVQVEAQA LMLKGKALNV TPDYSPEAEV LLSKAVKLEP
110 120 130 140 150
ELVEAWNQLG EVYWKKGDVA AAHTCFSGAL THCKNKVSLQ NLSMVLRQLQ
160 170 180 190 200
TDSGDEHSRH VMDSVRQAKL AVQMDVLDGR SWYILGNAYL SLYFNTGQNP
210 220 230 240 250
KISQQALSAY AQAEKVDRKA SSNPDLHLNR ATLHKYEESY GEALEGFSQA
260 270 280 290 300
ATLDPAWPEP QQREQQLLEF LSRLTNLLAS KGKTKPKKLQ SMLGNLRPAH
310 320 330 340 350
LGPCGDGRYQ SATGQKVTLQ LKPLSTLQPG VNSGTVVLGK VVFSLTTEEK
360 370 380 390 400
VPFTFGLVDS DGPCYAVMVY NVVQSWGVLI GDSVAIPEPN LRHHQIQHKG
410 420 430 440
KDYSFSSVRV ETPLLLVVNG KPQNSSSQAS ATVASRPQCE
Length:440
Mass (Da):48,793
Last modified:April 12, 2005 - v1
Checksum:iD1213D85F881516B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091207 mRNA Translation: AAH91207.1
RefSeqiNP_001013149.1, NM_001013131.1
UniGeneiRn.16620

Genome annotation databases

EnsembliENSRNOT00000011741; ENSRNOP00000011741; ENSRNOG00000008850
GeneIDi305837
KEGGirno:305837
UCSCiRGD:1311284 rat

Similar proteinsi

Entry informationi

Entry nameiTTC5_RAT
AccessioniPrimary (citable) accession number: Q5BK48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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