Q5BK32 (FAF2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FAS-associated factor 2

Alternative name(s):
UBX domain-containing protein 8

Gene names

Name:	Faf2
Synonyms:	Ubxd8

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome By similarity.
Subunit structure	Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1 By similarity.
Subcellular location	Cytoplasm By similarity. Lipid droplet By similarity. Endoplasmic reticulum By similarity.
Sequence similarities	Contains 1 UBX domain.

Ontologies

Keywords
Biological process	Unfolded protein response
Cellular component	Cytoplasm Endoplasmic reticulum Lipid droplet
Domain	Coiled coil
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to unfolded protein Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Cdc48p-Npl4p-Ufd1p AAA ATPase complex Inferred from electronic annotation. Source: Compara lipid particle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	FAS-associated factor 2		PRO_0000244066
Regions
	Domain	258 – 340	83	UBX
	Coiled coil	176 – 251	76	Potential
Amino acid modifications
	Modified residue	68	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5BK32 [UniParc]. Last modified April 12, 2005. Version 1. Checksum: 3852DEB92B939F44	FASTA	346	41,080
	10 20 30 40 50 60 MLPFRFTYYT ILDIFRFALR FIRPDPRSRV TDPVGDIVSF MHSFEEKYGR AHPVFYQGTY 70 80 90 100 110 120 SQALSDAKRE LRFLLVYLHG DDHQDSDEFC RNALCAPEVI SLINSRMLFW ACSTNKPEGY 130 140 150 160 170 180 RVSQALRENT YPFLAMIMLK DRRMTVVGRL EGLIQPDDLI NQLTFIMDAN QTYLVSERLE 190 200 210 220 230 240 REERNQTQVL RQQQDEAYLA SLRADQEKER KKREERERKR RKEEEVQQQK LAEERRRQNL 250 260 270 280 290 300 QEEKERKLEC LPPEPSPDDP DSVKIIFKLP NDSRVERRFH FSQSLTVIHD FLFSLKESPE 310 320 330 340 KFQIEANFPR RVLPCVPSEE WPNPPTLQEA GLSHTEVLFV QDLTDE

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC091224 mRNA. Translation: AAH91224.1.
IPI	IPI00362920.
RefSeq	NP_001017445.1. NM_001017445.1.
UniGene	Rn.111214.
3D structure databases
ProteinModelPortal	Q5BK32.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000063246.
Proteomic databases
PaxDb	Q5BK32.
PRIDE	Q5BK32.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000064477; ENSRNOP00000063246; ENSRNOG00000017607.
GeneID	291000.
KEGG	rno:291000.
UCSC	RGD:1306577. rat.
Organism-specific databases
CTD	23197.
RGD	1306577. Faf2.
Phylogenomic databases
eggNOG	NOG302977.
GeneTree	ENSGT00530000063422.
HOGENOM	HOG000007539.
HOVERGEN	HBG101311.
InParanoid	Q5BK32.
OMA	RVLPCVP.
OrthoDB	EOG4BVRTS.
Gene expression databases
Genevestigator	Q5BK32.
GermOnline	ENSRNOG00000017607. Rattus norvegicus.
Family and domain databases
InterPro	IPR006577. UAS. IPR001012. UBX. [Graphical view]
Pfam	PF00789. UBX. 1 hit. [Graphical view]
SMART	SM00594. UAS. 1 hit. [Graphical view]
PROSITE	PS50033. UBX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	631961.

Entry information

Entry name

FAF2_RAT

Accession

Primary (citable) accession number: Q5BK32

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	April 12, 2005
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program