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Protein

FAS-associated factor 2

Gene

Faf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated factor 2
Alternative name(s):
UBX domain-containing protein 8
Gene namesi
Name:Faf2
Synonyms:Ubxd8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1306577. Faf2.

Subcellular locationi

  • Cytoplasm By similarity
  • Lipid droplet By similarity
  • Endoplasmic reticulum By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346FAS-associated factor 2PRO_0000244066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5BK32.
PRIDEiQ5BK32.

PTM databases

iPTMnetiQ5BK32.
PhosphoSiteiQ5BK32.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017607.
ExpressionAtlasiQ5BK32. baseline and differential.
GenevisibleiQ5BK32. RN.

Interactioni

Subunit structurei

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1. Interacts (via N-terminus) with UBQLN2 (via C-terminus). Interacts with PNPLA2 and UBAC2.By similarity

Protein-protein interaction databases

MINTiMINT-4574167.
STRINGi10116.ENSRNOP00000063246.

Structurei

3D structure databases

ProteinModelPortaliQ5BK32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini258 – 34083UBXPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili176 – 25176Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 UBX domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1363. Eukaryota.
ENOG410XSFS. LUCA.
GeneTreeiENSGT00530000063422.
HOGENOMiHOG000007539.
HOVERGENiHBG101311.
InParanoidiQ5BK32.
KOiK18726.
PhylomeDBiQ5BK32.

Family and domain databases

InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00594. UAS. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BK32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFRFTYYT ILDIFRFALR FIRPDPRSRV TDPVGDIVSF MHSFEEKYGR
60 70 80 90 100
AHPVFYQGTY SQALSDAKRE LRFLLVYLHG DDHQDSDEFC RNALCAPEVI
110 120 130 140 150
SLINSRMLFW ACSTNKPEGY RVSQALRENT YPFLAMIMLK DRRMTVVGRL
160 170 180 190 200
EGLIQPDDLI NQLTFIMDAN QTYLVSERLE REERNQTQVL RQQQDEAYLA
210 220 230 240 250
SLRADQEKER KKREERERKR RKEEEVQQQK LAEERRRQNL QEEKERKLEC
260 270 280 290 300
LPPEPSPDDP DSVKIIFKLP NDSRVERRFH FSQSLTVIHD FLFSLKESPE
310 320 330 340
KFQIEANFPR RVLPCVPSEE WPNPPTLQEA GLSHTEVLFV QDLTDE
Length:346
Mass (Da):41,080
Last modified:April 12, 2005 - v1
Checksum:i3852DEB92B939F44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091224 mRNA. Translation: AAH91224.1.
RefSeqiNP_001017445.1. NM_001017445.1.
UniGeneiRn.111214.
Rn.199132.

Genome annotation databases

EnsembliENSRNOT00000064477; ENSRNOP00000063246; ENSRNOG00000017607.
GeneIDi291000.
KEGGirno:291000.
UCSCiRGD:1306577. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091224 mRNA. Translation: AAH91224.1.
RefSeqiNP_001017445.1. NM_001017445.1.
UniGeneiRn.111214.
Rn.199132.

3D structure databases

ProteinModelPortaliQ5BK32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4574167.
STRINGi10116.ENSRNOP00000063246.

PTM databases

iPTMnetiQ5BK32.
PhosphoSiteiQ5BK32.

Proteomic databases

PaxDbiQ5BK32.
PRIDEiQ5BK32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064477; ENSRNOP00000063246; ENSRNOG00000017607.
GeneIDi291000.
KEGGirno:291000.
UCSCiRGD:1306577. rat.

Organism-specific databases

CTDi23197.
RGDi1306577. Faf2.

Phylogenomic databases

eggNOGiKOG1363. Eukaryota.
ENOG410XSFS. LUCA.
GeneTreeiENSGT00530000063422.
HOGENOMiHOG000007539.
HOVERGENiHBG101311.
InParanoidiQ5BK32.
KOiK18726.
PhylomeDBiQ5BK32.

Miscellaneous databases

PROiQ5BK32.

Gene expression databases

BgeeiENSRNOG00000017607.
ExpressionAtlasiQ5BK32. baseline and differential.
GenevisibleiQ5BK32. RN.

Family and domain databases

InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00594. UAS. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAF2_RAT
AccessioniPrimary (citable) accession number: Q5BK32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.