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Q5BK32

- FAF2_RAT

UniProt

Q5BK32 - FAF2_RAT

Protein

FAS-associated factor 2

Gene

Faf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.By similarity

    GO - Molecular functioni

    1. lipase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. lipid particle organization Source: Ensembl
    2. response to unfolded protein Source: UniProtKB-KW

    Keywords - Biological processi

    Unfolded protein response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAS-associated factor 2
    Alternative name(s):
    UBX domain-containing protein 8
    Gene namesi
    Name:Faf2
    Synonyms:Ubxd8
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1306577. Faf2.

    Subcellular locationi

    Cytoplasm By similarity. Lipid droplet By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. Cdc48p-Npl4p-Ufd1p AAA ATPase complex Source: Ensembl
    2. lipid particle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Lipid droplet

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346FAS-associated factor 2PRO_0000244066Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei68 – 681N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ5BK32.
    PRIDEiQ5BK32.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5BK32.

    Interactioni

    Subunit structurei

    Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1 By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-4574167.
    STRINGi10116.ENSRNOP00000063246.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5BK32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini258 – 34083UBXPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili176 – 25176Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 UBX domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG302977.
    GeneTreeiENSGT00530000063422.
    HOGENOMiHOG000007539.
    HOVERGENiHBG101311.
    InParanoidiQ5BK32.
    OMAiRVLPCVP.
    OrthoDBiEOG7NSB26.
    PhylomeDBiQ5BK32.

    Family and domain databases

    InterProiIPR012336. Thioredoxin-like_fold.
    IPR006577. UAS.
    IPR029071. Ubiquitin-rel_dom.
    IPR001012. UBX_dom.
    [Graphical view]
    PfamiPF00789. UBX. 1 hit.
    [Graphical view]
    SMARTiSM00594. UAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50033. UBX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5BK32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPFRFTYYT ILDIFRFALR FIRPDPRSRV TDPVGDIVSF MHSFEEKYGR    50
    AHPVFYQGTY SQALSDAKRE LRFLLVYLHG DDHQDSDEFC RNALCAPEVI 100
    SLINSRMLFW ACSTNKPEGY RVSQALRENT YPFLAMIMLK DRRMTVVGRL 150
    EGLIQPDDLI NQLTFIMDAN QTYLVSERLE REERNQTQVL RQQQDEAYLA 200
    SLRADQEKER KKREERERKR RKEEEVQQQK LAEERRRQNL QEEKERKLEC 250
    LPPEPSPDDP DSVKIIFKLP NDSRVERRFH FSQSLTVIHD FLFSLKESPE 300
    KFQIEANFPR RVLPCVPSEE WPNPPTLQEA GLSHTEVLFV QDLTDE 346
    Length:346
    Mass (Da):41,080
    Last modified:April 12, 2005 - v1
    Checksum:i3852DEB92B939F44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC091224 mRNA. Translation: AAH91224.1.
    RefSeqiNP_001017445.1. NM_001017445.1.
    UniGeneiRn.111214.
    Rn.199132.

    Genome annotation databases

    EnsembliENSRNOT00000064477; ENSRNOP00000063246; ENSRNOG00000017607.
    GeneIDi291000.
    KEGGirno:291000.
    UCSCiRGD:1306577. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC091224 mRNA. Translation: AAH91224.1 .
    RefSeqi NP_001017445.1. NM_001017445.1.
    UniGenei Rn.111214.
    Rn.199132.

    3D structure databases

    ProteinModelPortali Q5BK32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4574167.
    STRINGi 10116.ENSRNOP00000063246.

    Proteomic databases

    PaxDbi Q5BK32.
    PRIDEi Q5BK32.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000064477 ; ENSRNOP00000063246 ; ENSRNOG00000017607 .
    GeneIDi 291000.
    KEGGi rno:291000.
    UCSCi RGD:1306577. rat.

    Organism-specific databases

    CTDi 23197.
    RGDi 1306577. Faf2.

    Phylogenomic databases

    eggNOGi NOG302977.
    GeneTreei ENSGT00530000063422.
    HOGENOMi HOG000007539.
    HOVERGENi HBG101311.
    InParanoidi Q5BK32.
    OMAi RVLPCVP.
    OrthoDBi EOG7NSB26.
    PhylomeDBi Q5BK32.

    Miscellaneous databases

    NextBioi 631961.
    PROi Q5BK32.

    Gene expression databases

    Genevestigatori Q5BK32.

    Family and domain databases

    InterProi IPR012336. Thioredoxin-like_fold.
    IPR006577. UAS.
    IPR029071. Ubiquitin-rel_dom.
    IPR001012. UBX_dom.
    [Graphical view ]
    Pfami PF00789. UBX. 1 hit.
    [Graphical view ]
    SMARTi SM00594. UAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50033. UBX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiFAF2_RAT
    AccessioniPrimary (citable) accession number: Q5BK32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3