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Q5BK32

- FAF2_RAT

UniProt

Q5BK32 - FAF2_RAT

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Protein

FAS-associated factor 2

Gene
Faf2, Ubxd8
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome By similarity.

GO - Molecular functioni

  1. lipase inhibitor activity Source: Ensembl

GO - Biological processi

  1. lipid particle organization Source: Ensembl
  2. response to unfolded protein Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated factor 2
Alternative name(s):
UBX domain-containing protein 8
Gene namesi
Name:Faf2
Synonyms:Ubxd8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi1306577. Faf2.

Subcellular locationi

Cytoplasm By similarity. Lipid droplet By similarity. Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. Cdc48p-Npl4p-Ufd1p AAA ATPase complex Source: Ensembl
  2. lipid particle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346FAS-associated factor 2PRO_0000244066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5BK32.
PRIDEiQ5BK32.

Expressioni

Gene expression databases

GenevestigatoriQ5BK32.

Interactioni

Subunit structurei

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1 By similarity.

Protein-protein interaction databases

MINTiMINT-4574167.
STRINGi10116.ENSRNOP00000063246.

Structurei

3D structure databases

ProteinModelPortaliQ5BK32.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini258 – 34083UBXAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili176 – 25176 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 UBX domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG302977.
GeneTreeiENSGT00530000063422.
HOGENOMiHOG000007539.
HOVERGENiHBG101311.
InParanoidiQ5BK32.
OMAiRVLPCVP.
OrthoDBiEOG7NSB26.
PhylomeDBiQ5BK32.

Family and domain databases

InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00594. UAS. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BK32-1 [UniParc]FASTAAdd to Basket

« Hide

MLPFRFTYYT ILDIFRFALR FIRPDPRSRV TDPVGDIVSF MHSFEEKYGR    50
AHPVFYQGTY SQALSDAKRE LRFLLVYLHG DDHQDSDEFC RNALCAPEVI 100
SLINSRMLFW ACSTNKPEGY RVSQALRENT YPFLAMIMLK DRRMTVVGRL 150
EGLIQPDDLI NQLTFIMDAN QTYLVSERLE REERNQTQVL RQQQDEAYLA 200
SLRADQEKER KKREERERKR RKEEEVQQQK LAEERRRQNL QEEKERKLEC 250
LPPEPSPDDP DSVKIIFKLP NDSRVERRFH FSQSLTVIHD FLFSLKESPE 300
KFQIEANFPR RVLPCVPSEE WPNPPTLQEA GLSHTEVLFV QDLTDE 346
Length:346
Mass (Da):41,080
Last modified:April 12, 2005 - v1
Checksum:i3852DEB92B939F44
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC091224 mRNA. Translation: AAH91224.1.
RefSeqiNP_001017445.1. NM_001017445.1.
UniGeneiRn.111214.
Rn.199132.

Genome annotation databases

EnsembliENSRNOT00000064477; ENSRNOP00000063246; ENSRNOG00000017607.
GeneIDi291000.
KEGGirno:291000.
UCSCiRGD:1306577. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC091224 mRNA. Translation: AAH91224.1 .
RefSeqi NP_001017445.1. NM_001017445.1.
UniGenei Rn.111214.
Rn.199132.

3D structure databases

ProteinModelPortali Q5BK32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4574167.
STRINGi 10116.ENSRNOP00000063246.

Proteomic databases

PaxDbi Q5BK32.
PRIDEi Q5BK32.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000064477 ; ENSRNOP00000063246 ; ENSRNOG00000017607 .
GeneIDi 291000.
KEGGi rno:291000.
UCSCi RGD:1306577. rat.

Organism-specific databases

CTDi 23197.
RGDi 1306577. Faf2.

Phylogenomic databases

eggNOGi NOG302977.
GeneTreei ENSGT00530000063422.
HOGENOMi HOG000007539.
HOVERGENi HBG101311.
InParanoidi Q5BK32.
OMAi RVLPCVP.
OrthoDBi EOG7NSB26.
PhylomeDBi Q5BK32.

Miscellaneous databases

NextBioi 631961.
PROi Q5BK32.

Gene expression databases

Genevestigatori Q5BK32.

Family and domain databases

InterProi IPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view ]
Pfami PF00789. UBX. 1 hit.
[Graphical view ]
SMARTi SM00594. UAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50033. UBX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiFAF2_RAT
AccessioniPrimary (citable) accession number: Q5BK32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 12, 2005
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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