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Q5BK32 (FAF2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FAS-associated factor 2
Alternative name(s):
UBX domain-containing protein 8
Gene names
Name:Faf2
Synonyms:Ubxd8
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome By similarity.

Subunit structure

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1 By similarity.

Subcellular location

Cytoplasm By similarity. Lipid droplet By similarity. Endoplasmic reticulum By similarity.

Sequence similarities

Contains 1 UBX domain.

Ontologies

Keywords
   Biological processUnfolded protein response
   Cellular componentCytoplasm
Endoplasmic reticulum
Lipid droplet
   DomainCoiled coil
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to unfolded protein

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentCdc48p-Npl4p-Ufd1p AAA ATPase complex

Inferred from electronic annotation. Source: Ensembl

lipid particle

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346FAS-associated factor 2
PRO_0000244066

Regions

Domain258 – 34083UBX
Coiled coil176 – 25176 Potential

Amino acid modifications

Modified residue681N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5BK32 [UniParc].

Last modified April 12, 2005. Version 1.
Checksum: 3852DEB92B939F44

FASTA34641,080
        10         20         30         40         50         60 
MLPFRFTYYT ILDIFRFALR FIRPDPRSRV TDPVGDIVSF MHSFEEKYGR AHPVFYQGTY 

        70         80         90        100        110        120 
SQALSDAKRE LRFLLVYLHG DDHQDSDEFC RNALCAPEVI SLINSRMLFW ACSTNKPEGY 

       130        140        150        160        170        180 
RVSQALRENT YPFLAMIMLK DRRMTVVGRL EGLIQPDDLI NQLTFIMDAN QTYLVSERLE 

       190        200        210        220        230        240 
REERNQTQVL RQQQDEAYLA SLRADQEKER KKREERERKR RKEEEVQQQK LAEERRRQNL 

       250        260        270        280        290        300 
QEEKERKLEC LPPEPSPDDP DSVKIIFKLP NDSRVERRFH FSQSLTVIHD FLFSLKESPE 

       310        320        330        340 
KFQIEANFPR RVLPCVPSEE WPNPPTLQEA GLSHTEVLFV QDLTDE 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC091224 mRNA. Translation: AAH91224.1.
RefSeqNP_001017445.1. NM_001017445.1.
UniGeneRn.111214.
Rn.199132.

3D structure databases

ProteinModelPortalQ5BK32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4574167.
STRING10116.ENSRNOP00000063246.

Proteomic databases

PaxDbQ5BK32.
PRIDEQ5BK32.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000064477; ENSRNOP00000063246; ENSRNOG00000017607.
GeneID291000.
KEGGrno:291000.
UCSCRGD:1306577. rat.

Organism-specific databases

CTD23197.
RGD1306577. Faf2.

Phylogenomic databases

eggNOGNOG302977.
GeneTreeENSGT00530000063422.
HOGENOMHOG000007539.
HOVERGENHBG101311.
InParanoidQ5BK32.
OMARVLPCVP.
OrthoDBEOG7NSB26.
PhylomeDBQ5BK32.

Gene expression databases

GenevestigatorQ5BK32.

Family and domain databases

InterProIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR001012. UBX.
[Graphical view]
PfamPF00789. UBX. 1 hit.
[Graphical view]
SMARTSM00594. UAS. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio631961.
PROQ5BK32.

Entry information

Entry nameFAF2_RAT
AccessionPrimary (citable) accession number: Q5BK32
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 12, 2005
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families