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Protein

Patatin-like phospholipase domain-containing protein 7

Gene

Pnpla7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei980 – 9801

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 297128cNMP 1Add
BLAST
Nucleotide bindingi475 – 599125cNMP 2Add
BLAST
Nucleotide bindingi595 – 715121cNMP 3Add
BLAST

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: RGD
  • lysophospholipase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Patatin-like phospholipase domain-containing protein 7 (EC:3.1.1.-)
Alternative name(s):
Liver NTE-related protein 1
NTE-related esterase
Gene namesi
Name:Pnpla7
Synonyms:Nre, Ntel1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708466. Pnpla7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lysosome, Membrane, Microsome, Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi980 – 9801S → A, C, D or H: Abolishes hydrolytic activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13491349Patatin-like phospholipase domain-containing protein 7PRO_0000293491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411PhosphoserineCombined sources
Glycosylationi358 – 3581N-linked (GlcNAc...)Sequence analysis
Modified residuei377 – 3771PhosphoserineBy similarity
Glycosylationi399 – 3991N-linked (GlcNAc...)Sequence analysis
Glycosylationi747 – 7471N-linked (GlcNAc...)Sequence analysis
Glycosylationi1033 – 10331N-linked (GlcNAc...)Sequence analysis
Glycosylationi1252 – 12521N-linked (GlcNAc...)Sequence analysis
Modified residuei1277 – 12771PhosphoserineCombined sources
Modified residuei1281 – 12811PhosphothreonineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5BK26.
PRIDEiQ5BK26.

PTM databases

iPTMnetiQ5BK26.
PhosphoSiteiQ5BK26.

Expressioni

Tissue specificityi

Expressed in the brain, liver, kidney, lung and testis.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011633.

Structurei

3D structure databases

ProteinModelPortaliQ5BK26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini947 – 1113167PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi978 – 9825GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
HOGENOMiHOG000016081.
HOVERGENiHBG053067.
InParanoidiQ5BK26.
KOiK14676.
PhylomeDBiQ5BK26.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BK26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKEEDVCPE AGYCLGTALS SWGLHFMEEH SQSTMLMGIG IGVLLTLAFV
60 70 80 90 100
GLAAFFVYRK VSRFRRAEPI PQYRFRKRDK VMFYGRKIMR KVTTLPHTLV
110 120 130 140 150
GNTAAPRQRV RKRTKVLSLA KRILRFKKEY PTLQPKEPPP SLLEADLTEF
160 170 180 190 200
DVKNSHLPSE VLYMLKNVRV LGHFEKPLFL ELCKHMVFVQ LQEGEHVFQP
210 220 230 240 250
GEPDISIYVV QDGRLEVCIQ DADGTEVVVK EVLPGDSVHS LLSILDVITG
260 270 280 290 300
HTAPYKTVSA RAAVASTVLW LPAAAFQGVF EKYPETLVRV VQIIMVRLQR
310 320 330 340 350
VTFLALHNYL GLTTELFNPE SQAIPLLSVA SVAGRAKRQM SYGPEEQLER
360 370 380 390 400
SPRLSEFNSS DQRSVAVSGP LLKRSCSVPL PPIHGEIDEL RQAQGSGSNT
410 420 430 440 450
SAFQESQEGA TSDLGMAYNR ARILPHSEEQ LGSSLASKSK KSVVAETSAV
460 470 480 490 500
FHYSEKPRDE PGPSGRTDAI FRAATKDLLT LMKLDDPSLL DGRVAFLHVP
510 520 530 540 550
AGTIVSKQGD QDVNILFVVS GMLHVYQQKI DSLEDTCLFL THPGEMVGQL
560 570 580 590 600
AVLTGEPLMF TIRANRDCSF LSISKAHFYE IMRKRPDVVL GVAHTVVRRM
610 620 630 640 650
SSFVRQIDFA LDWMEVEAGR AIYRQGDKSD CTYIVLSGRL RSVIRKDDGK
660 670 680 690 700
KRLAGEYGRG DLVGVVEMLT HQARATTVHA VRDSELAKLP AGALTSIKRR
710 720 730 740 750
YPQVVTRLIH LLGEKILGSL QQGSGTGHQL GFNTASSKWD LGNPPGNLST
760 770 780 790 800
VAAMPVSEDV PLTAFALELQ HALSAIGPVL LLTSDNIKQR LGSAALDSIH
810 820 830 840 850
EYRLSSWLGQ QEDIHRIVLY QADSTLTPWT QRCIRQADCI LIVGLGDQEP
860 870 880 890 900
ALGELEQMLE STAVRAQKQL ILLHKEEGPA PSRTVEWLNM RSWCSGHLHL
910 920 930 940 950
CCPRRVFSKR SLPKLVEMYT RIFQRPPDRH SDFSRLARIL TGNAIALVLG
960 970 980 990 1000
GGGARGCAQV GILRALAECG IPVDIIGGTS IGAFMGALFA EERSYSQIRI
1010 1020 1030 1040 1050
RAKQWAEDMT SMVKTILDLT YPITSMFSGT GFNSSISNIF KDRQIEDLWL
1060 1070 1080 1090 1100
PYFAITTDIT ASAMRVHTDG ALWRYVRASM SLSGYMPPLC DPKDGHLLMD
1110 1120 1130 1140 1150
GGYINNLPAD VARSMGAKVV IAIDVGSRDE TDLTNYGDAL SGWWLLWKRW
1160 1170 1180 1190 1200
NPLATKVKVL NMAEIQTRLA YVCCVRQLEM VKNSDYCEYL RPPIDSYRTL
1210 1220 1230 1240 1250
DFGKFDEICE VGYQHGPAGF DIWVRSGVLE KMLQDQQGTS KRMDCGVFTC
1260 1270 1280 1290 1300
PNSSFTDLAE IVSRIEPAKV AAVDDESDYQ TEYEEELPAI PKETYADFQS
1310 1320 1330 1340
TGIELDSDSE CEPSMSQGPH SLTSPKQSQD SFPWLPNQDD QGPRLYRPS
Length:1,349
Mass (Da):150,024
Last modified:July 10, 2007 - v2
Checksum:i4312292A0CFE2FDD
GO

Sequence cautioni

The sequence AAH91230 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti956 – 9572GC → CT in AAH91230 (PubMed:15489334).Curated
Sequence conflicti1071 – 10711A → S in AAH83547 (PubMed:15489334).Curated
Sequence conflicti1217 – 12193PAG → RTV in AAH83547 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083547 mRNA. Translation: AAH83547.2.
BC091230 mRNA. Translation: AAH91230.1. Different initiation.
AY100477 mRNA. Translation: AAM44077.1.
RefSeqiNP_653339.2. NM_144738.2.
UniGeneiRn.162643.

Genome annotation databases

GeneIDi246246.
KEGGirno:246246.
UCSCiRGD:708466. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083547 mRNA. Translation: AAH83547.2.
BC091230 mRNA. Translation: AAH91230.1. Different initiation.
AY100477 mRNA. Translation: AAM44077.1.
RefSeqiNP_653339.2. NM_144738.2.
UniGeneiRn.162643.

3D structure databases

ProteinModelPortaliQ5BK26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011633.

PTM databases

iPTMnetiQ5BK26.
PhosphoSiteiQ5BK26.

Proteomic databases

PaxDbiQ5BK26.
PRIDEiQ5BK26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246246.
KEGGirno:246246.
UCSCiRGD:708466. rat.

Organism-specific databases

CTDi375775.
RGDi708466. Pnpla7.

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
HOGENOMiHOG000016081.
HOVERGENiHBG053067.
InParanoidiQ5BK26.
KOiK14676.
PhylomeDBiQ5BK26.

Miscellaneous databases

PROiQ5BK26.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLPL7_RAT
AccessioniPrimary (citable) accession number: Q5BK26
Secondary accession number(s): Q5XIX2, Q8K3H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 6, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.