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Protein

Iodotyrosine deiodinase 1

Gene

Iyd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.By similarity

Catalytic activityi

L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH.By similarity

Cofactori

FMNCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100SubstrateBy similarity1
Binding sitei157SubstrateBy similarity1
Binding sitei178SubstrateBy similarity1
Binding sitei275FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 100FMNBy similarity5
Nucleotide bindingi123 – 125FMNBy similarity3
Nucleotide bindingi232 – 235FMNBy similarity4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NADP

Enzyme and pathway databases

ReactomeiR-RNO-209968. Thyroxine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Iodotyrosine deiodinase 1 (EC:1.21.1.1)
Short name:
IYD-1
Alternative name(s):
Iodotyrosine dehalogenase 1
Gene namesi
Name:Iyd
Synonyms:Dehal1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309288. Iyd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 210ExtracellularSequence analysisAdd BLAST187
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 285CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000023028224 – 285Iodotyrosine deiodinase 1Add BLAST262

Proteomic databases

PaxDbiQ5BK17.
PRIDEiQ5BK17.

PTM databases

iPTMnetiQ5BK17.
PhosphoSitePlusiQ5BK17.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016286.
GenevisibleiQ5BK17. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4580405.
STRINGi10116.ENSRNOP00000021893.

Structurei

3D structure databases

ProteinModelPortaliQ5BK17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nitroreductase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3936. Eukaryota.
COG0778. LUCA.
GeneTreeiENSGT00390000004348.
HOGENOMiHOG000146731.
HOVERGENiHBG055004.
InParanoidiQ5BK17.
KOiK17231.
OMAiVHESVGI.
OrthoDBiEOG091G0CP8.
PhylomeDBiQ5BK17.
TreeFamiTF313415.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMiSSF55469. SSF55469. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLLTPVLVA VVCILVIWVF KNADRSLEEK KEEARAQPWV DEDLKDNTEH
60 70 80 90 100
LQVEEDTEEW QESEESVEHI LFSHTRYPEQ EMRMRSQEFY ELLSKRRSIR
110 120 130 140 150
FISSEPVPME VIDNVIKAAG TAPSGAHTEP WTFVVVKDPD MKHKIREIIE
160 170 180 190 200
EEEEINYMKR MGKRWVTDLK KLRTNWIKEY LDTAPVLILI FKQVHGFAVN
210 220 230 240 250
GKKKVHYYNE ISVSIACGIL LAALQNAGLV TVTTTPLNCG PRLRVLLGRP
260 270 280
SHEKLLVLLP VGYPSRGATV PDLKRKTLDQ IMVTV
Length:285
Mass (Da):32,846
Last modified:April 12, 2005 - v1
Checksum:iE89714F0630E5E4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091241 mRNA. Translation: AAH91241.1.
RefSeqiNP_001020171.1. NM_001025000.1.
UniGeneiRn.34836.

Genome annotation databases

EnsembliENSRNOT00000021895; ENSRNOP00000021893; ENSRNOG00000016286.
GeneIDi308129.
KEGGirno:308129.
UCSCiRGD:1309288. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091241 mRNA. Translation: AAH91241.1.
RefSeqiNP_001020171.1. NM_001025000.1.
UniGeneiRn.34836.

3D structure databases

ProteinModelPortaliQ5BK17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4580405.
STRINGi10116.ENSRNOP00000021893.

PTM databases

iPTMnetiQ5BK17.
PhosphoSitePlusiQ5BK17.

Proteomic databases

PaxDbiQ5BK17.
PRIDEiQ5BK17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021895; ENSRNOP00000021893; ENSRNOG00000016286.
GeneIDi308129.
KEGGirno:308129.
UCSCiRGD:1309288. rat.

Organism-specific databases

CTDi389434.
RGDi1309288. Iyd.

Phylogenomic databases

eggNOGiKOG3936. Eukaryota.
COG0778. LUCA.
GeneTreeiENSGT00390000004348.
HOGENOMiHOG000146731.
HOVERGENiHBG055004.
InParanoidiQ5BK17.
KOiK17231.
OMAiVHESVGI.
OrthoDBiEOG091G0CP8.
PhylomeDBiQ5BK17.
TreeFamiTF313415.

Enzyme and pathway databases

ReactomeiR-RNO-209968. Thyroxine biosynthesis.

Miscellaneous databases

PROiQ5BK17.

Gene expression databases

BgeeiENSRNOG00000016286.
GenevisibleiQ5BK17. RN.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMiSSF55469. SSF55469. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIYD1_RAT
AccessioniPrimary (citable) accession number: Q5BK17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.