Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iodotyrosine deiodinase 1

Gene

Iyd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.By similarity

Catalytic activityi

L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH.By similarity

Cofactori

FMNBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126Substrate; via amide nitrogenBy similarity1
Binding sitei153SubstrateBy similarity1
Binding sitei157SubstrateBy similarity1
Binding sitei178SubstrateBy similarity1
Binding sitei275FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 100FMNBy similarity5
Nucleotide bindingi124 – 125FMNBy similarity2
Nucleotide bindingi233 – 235FMNBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN, NADP

Enzyme and pathway databases

ReactomeiR-RNO-209968 Thyroxine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Iodotyrosine deiodinase 1 (EC:1.21.1.1)
Short name:
IYD-1
Alternative name(s):
Iodotyrosine dehalogenase 1
Gene namesi
Name:Iyd
Synonyms:Dehal1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309288 Iyd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 210ExtracellularSequence analysisAdd BLAST187
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 285CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000023028224 – 285Iodotyrosine deiodinase 1Add BLAST262

Proteomic databases

PaxDbiQ5BK17
PRIDEiQ5BK17

PTM databases

iPTMnetiQ5BK17
PhosphoSitePlusiQ5BK17

Expressioni

Gene expression databases

BgeeiENSRNOG00000016286
GenevisibleiQ5BK17 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021893

Structurei

3D structure databases

ProteinModelPortaliQ5BK17
SMRiQ5BK17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nitroreductase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3936 Eukaryota
COG0778 LUCA
GeneTreeiENSGT00390000004348
HOGENOMiHOG000146731
HOVERGENiHBG055004
InParanoidiQ5BK17
KOiK17231
OMAiGANHQPW
OrthoDBiEOG091G0CP8
PhylomeDBiQ5BK17
TreeFamiTF313415

Family and domain databases

Gene3Di3.40.109.10, 1 hit
InterProiView protein in InterPro
IPR029479 Nitroreductase
IPR000415 Nitroreductase-like
PfamiView protein in Pfam
PF00881 Nitroreductase, 1 hit
SUPFAMiSSF55469 SSF55469, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BK17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLLTPVLVA VVCILVIWVF KNADRSLEEK KEEARAQPWV DEDLKDNTEH
60 70 80 90 100
LQVEEDTEEW QESEESVEHI LFSHTRYPEQ EMRMRSQEFY ELLSKRRSIR
110 120 130 140 150
FISSEPVPME VIDNVIKAAG TAPSGAHTEP WTFVVVKDPD MKHKIREIIE
160 170 180 190 200
EEEEINYMKR MGKRWVTDLK KLRTNWIKEY LDTAPVLILI FKQVHGFAVN
210 220 230 240 250
GKKKVHYYNE ISVSIACGIL LAALQNAGLV TVTTTPLNCG PRLRVLLGRP
260 270 280
SHEKLLVLLP VGYPSRGATV PDLKRKTLDQ IMVTV
Length:285
Mass (Da):32,846
Last modified:April 12, 2005 - v1
Checksum:iE89714F0630E5E4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091241 mRNA Translation: AAH91241.1
RefSeqiNP_001020171.1, NM_001025000.1
UniGeneiRn.34836

Genome annotation databases

EnsembliENSRNOT00000021895; ENSRNOP00000021893; ENSRNOG00000016286
GeneIDi308129
KEGGirno:308129
UCSCiRGD:1309288 rat

Similar proteinsi

Entry informationi

Entry nameiIYD1_RAT
AccessioniPrimary (citable) accession number: Q5BK17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health