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Protein

Calpain-13

Gene

Capn13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable non-lysosomal thiol-protease.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931By similarity
Active sitei249 – 2491By similarity
Active sitei273 – 2731By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-13 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 13
Short name:
CANP 13
Gene namesi
Name:Capn13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1562682. Capn13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668Calpain-13PRO_0000259584Add
BLAST

Proteomic databases

PaxDbiQ5BK10.
PRIDEiQ5BK10.

Expressioni

Gene expression databases

BgeeiENSRNOG00000032375.
GenevisibleiQ5BK10. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039021.

Structurei

3D structure databases

ProteinModelPortaliQ5BK10.
SMRiQ5BK10. Positions 512-668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 331298Calpain catalyticPROSITE-ProRule annotationAdd
BLAST
Domaini537 – 57236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini635 – 66834EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
KOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ5BK10.
KOiK08581.
OMAiLTEMEWM.
OrthoDBiEOG091G03KK.
PhylomeDBiQ5BK10.
TreeFamiTF314748.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029544. CANP13/Calpain-C.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF282. PTHR10183:SF282. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BK10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHDTEALEE TSVVKFKNQD FRFLRDRCLS RGQLFIDDTF PAEASSIGQK
60 70 80 90 100
LLMGKRLPKL EWKRPQDLSF GPPHFILEGA SRFDIQQGRA GDCWFLAALG
110 120 130 140 150
SLTQNPQCLQ KILMNQSFSY QYAGIFHFRF WQCGQWVEVV IDDRLPVVGN
160 170 180 190 200
NFCFVHPRRG NQEFWPCLME KAYAKLLGSY SQLHYGYLPD ALVDLTGGVV
210 220 230 240 250
TRINLHSSPS DLLMVVKTAV QTGSMVACAT PKWLTEESEV MENGLVSQHA
260 270 280 290 300
YTVTGAEKIQ YRRGWEEIIR LWNPWGNTEW RGRWGDGSQE WWETHGSRKS
310 320 330 340 350
QLYENKDDGE FWMSCRDFHE NFSCLYICSQ FPITMDPGVT PNESWRQMRF
360 370 380 390 400
KNQVISGNTA GGDGRDIQYL FDVQEPMDGN NVIVAFTVMP QSLKTEEWPF
410 420 430 440 450
PLQFQVFKVD SQFQKFQKRL PPAFFSQFRD AAQGIDYVTK RNFTKSFHLS
460 470 480 490 500
PGTYVVVASA HGKEVEFLLR IFLKMPHKDR NPNSSFNLKA LKGSLSENES
510 520 530 540 550
PKSSFHRYMD QGLDIDASQL QSLLNQEYLT GPPGDTFSLD QCQSIMALMD
560 570 580 590 600
LKVNGRLDRE EFARLQSRLI HCQHVFQHIQ RSQGVLRSSD LWEVIESTDF
610 620 630 640 650
LSGVLLSKEL LSLMTLRYSD SSGRLSFPSL VCFLIRLETM SKAFRNLSKD
660
GKSIYLTEME WMKLVMYS
Length:668
Mass (Da):76,939
Last modified:April 12, 2005 - v1
Checksum:i654F7BDEA9D3C6F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091250 mRNA. Translation: AAH91250.1.
RefSeqiNP_001020304.1. NM_001025133.1.
XP_006239839.1. XM_006239777.2.
XP_006239840.1. XM_006239778.2.
XP_006239841.1. XM_006239779.2.
UniGeneiRn.15541.

Genome annotation databases

EnsembliENSRNOT00000047853; ENSRNOP00000039021; ENSRNOG00000032375.
GeneIDi362701.
KEGGirno:362701.
UCSCiRGD:1562682. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091250 mRNA. Translation: AAH91250.1.
RefSeqiNP_001020304.1. NM_001025133.1.
XP_006239839.1. XM_006239777.2.
XP_006239840.1. XM_006239778.2.
XP_006239841.1. XM_006239779.2.
UniGeneiRn.15541.

3D structure databases

ProteinModelPortaliQ5BK10.
SMRiQ5BK10. Positions 512-668.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039021.

Protein family/group databases

MEROPSiC02.020.

Proteomic databases

PaxDbiQ5BK10.
PRIDEiQ5BK10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047853; ENSRNOP00000039021; ENSRNOG00000032375.
GeneIDi362701.
KEGGirno:362701.
UCSCiRGD:1562682. rat.

Organism-specific databases

CTDi92291.
RGDi1562682. Capn13.

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
KOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ5BK10.
KOiK08581.
OMAiLTEMEWM.
OrthoDBiEOG091G03KK.
PhylomeDBiQ5BK10.
TreeFamiTF314748.

Miscellaneous databases

PROiQ5BK10.

Gene expression databases

BgeeiENSRNOG00000032375.
GenevisibleiQ5BK10. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029544. CANP13/Calpain-C.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF282. PTHR10183:SF282. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAN13_RAT
AccessioniPrimary (citable) accession number: Q5BK10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is unlikely that this protein binds calcium as none of the 2 EF-hand domains seem to contain a canonical calcium-binding site.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.