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Protein

N-acetylglucosamine-6-phosphate deacetylase

Gene

Amdhd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.By similarity

Catalytic activityi

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Divalent metal cationBy similarity1
Metal bindingi211Divalent metal cation; via tele nitrogenBy similarity1
Metal bindingi232Divalent metal cation; via tele nitrogenBy similarity1
Binding sitei243SubstrateBy similarity1
Active sitei294Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-RNO-446210 Synthesis of UDP-N-acetyl-glucosamine
SABIO-RKQ5BJY6
UniPathwayiUPA00629

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine-6-phosphate deacetylaseBy similarity (EC:3.5.1.25By similarity)
Short name:
GlcNAc 6-P deacetylaseBy similarity
Alternative name(s):
Amidohydrolase domain-containing protein 2By similarity
Gene namesi
Name:Amdhd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1304601 Amdhd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157781 – 409N-acetylglucosamine-6-phosphate deacetylaseAdd BLAST409

Proteomic databases

PaxDbiQ5BJY6
PRIDEiQ5BJY6

Expressioni

Gene expression databases

BgeeiENSRNOG00000006460

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008537

Structurei

3D structure databases

ProteinModelPortaliQ5BJY6
SMRiQ5BJY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 155Substrate bindingBy similarity2
Regioni235 – 236Substrate bindingBy similarity2
Regioni269 – 272Substrate bindingBy similarity4
Regioni328 – 330Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3892 Eukaryota
COG1820 LUCA
GeneTreeiENSGT00390000012605
HOGENOMiHOG000275010
HOVERGENiHBG108170
InParanoidiQ5BJY6
KOiK01443
OMAiHAFNAMP
OrthoDBiEOG091G08JG
PhylomeDBiQ5BJY6
TreeFamiTF315036

Family and domain databases

CDDicd00854 NagA, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR003764 GlcNAc_6-P_deAcase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PIRSFiPIRSF038994 NagA, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR00221 nagA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BJY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGQSAALA PVLQFTNCRI LRGGTLLRED LWVRGGRILD PEKLFFEERR
60 70 80 90 100
VADEQRDCGG RILAPGFIDV QINGGFGVDF SRATEDVGSG VALVARRLLS
110 120 130 140 150
HGVTSFCPTL VTSPPEVYHK VLPQIPVKSG GPHGAGVLGV HLEGPFISRE
160 170 180 190 200
KRGAHPEAYL RSFGANAFHD VLATYGPLDN VCIVTLAPEL DRSHEVIQAL
210 220 230 240 250
TAKGIRVSLG HSVADLRAAE VAVQSGATFI THLFNAMLPF HHRDPGIVGL
260 270 280 290 300
LTSDQLPPGH CIFYGMIADG IHTNPAALRI AHRAHPQGLV LVTDAVPALG
310 320 330 340 350
LGNGRHTLGQ QEVEVDGLIA YIAGTKTLSG SIAPMDVCIR HFLQATGCSV
360 370 380 390 400
ESALEAASLH PAQLLGLEKT KGSLDFGADA DFVVLDDTLH VQATYISGEL

VWQAEEAGL
Length:409
Mass (Da):43,539
Last modified:January 15, 2008 - v2
Checksum:iF2AF4B70CE1484BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073424 Genomic DNA No translation available.
RefSeqiNP_001020161.2, NM_001024990.2
UniGeneiRn.163127

Genome annotation databases

EnsembliENSRNOT00000008537; ENSRNOP00000008537; ENSRNOG00000006460
GeneIDi302972
KEGGirno:302972
UCSCiRGD:1304601 rat

Similar proteinsi

Entry informationi

Entry nameiNAGA_RAT
AccessioniPrimary (citable) accession number: Q5BJY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health