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Q5BJY6 (NAGA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative N-acetylglucosamine-6-phosphate deacetylase
EC=3.5.1.25
Alternative name(s):
Amidohydrolase domain-containing protein 2
GlcNAc 6-P deacetylase
Gene names
Name:Amdhd2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.

Sequence similarities

Belongs to the nagA family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processN-acetylglucosamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionN-acetylglucosamine-6-phosphate deacetylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 409409Putative N-acetylglucosamine-6-phosphate deacetylase
PRO_0000315778

Sequences

Sequence LengthMass (Da)Tools
Q5BJY6 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: F2AF4B70CE1484BC

FASTA40943,539
        10         20         30         40         50         60 
MRSGQSAALA PVLQFTNCRI LRGGTLLRED LWVRGGRILD PEKLFFEERR VADEQRDCGG 

        70         80         90        100        110        120 
RILAPGFIDV QINGGFGVDF SRATEDVGSG VALVARRLLS HGVTSFCPTL VTSPPEVYHK 

       130        140        150        160        170        180 
VLPQIPVKSG GPHGAGVLGV HLEGPFISRE KRGAHPEAYL RSFGANAFHD VLATYGPLDN 

       190        200        210        220        230        240 
VCIVTLAPEL DRSHEVIQAL TAKGIRVSLG HSVADLRAAE VAVQSGATFI THLFNAMLPF 

       250        260        270        280        290        300 
HHRDPGIVGL LTSDQLPPGH CIFYGMIADG IHTNPAALRI AHRAHPQGLV LVTDAVPALG 

       310        320        330        340        350        360 
LGNGRHTLGQ QEVEVDGLIA YIAGTKTLSG SIAPMDVCIR HFLQATGCSV ESALEAASLH 

       370        380        390        400 
PAQLLGLEKT KGSLDFGADA DFVVLDDTLH VQATYISGEL VWQAEEAGL

« Hide

References

[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed: 15057822] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AABR03073424 Genomic DNA. No translation available.
IPIIPI00368721.
RefSeqNP_001020161.2. NM_001024990.2.
UniGeneRn.163127.

3D structure databases

HSSPHSSP built from PDB template 1UN7 based on UniProtKB O34450.
ProteinModelPortalQ5BJY6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5BJY6.

Proteomic databases

PRIDEQ5BJY6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000008537; ENSRNOP00000008537; ENSRNOG00000006460.
GeneID302972.
KEGGrno:302972.
UCSCNM_001024990. rat.

Organism-specific databases

CTD51005.
RGD1304601. Amdhd2.

Phylogenomic databases

eggNOGroNOG07552.
GeneTreeENSGT00390000012605.
HOVERGENHBG108170.
InParanoidQ5BJY6.
OMADGVHTHP.
OrthoDBEOG45HRXK.
PhylomeDBQ5BJY6.

Gene expression databases

ArrayExpressQ5BJY6.
GenevestigatorQ5BJY6.

Family and domain databases

InterProIPR006680. Amidohydro_1.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01443.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00221. NagA. 1 hit.
ProtoNetSearch...

Other

NextBio650430.

Entry information

Entry nameNAGA_RAT
AccessionPrimary (citable) accession number: Q5BJY6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 16, 2011
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents