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Q5BJY3

- IN80C_RAT

UniProt

Q5BJY3 - IN80C_RAT

Protein

INO80 complex subunit C

Gene

Ino80c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    INO80 complex subunit C
    Gene namesi
    Name:Ino80c
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi1310199. Ino80c.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. Ino80 complex Source: Ensembl
    2. MLL1 complex Source: UniProtKB
    3. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191INO80 complex subunit CPRO_0000079319Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki21 – 21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki22 – 22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki40 – 40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ5BJY3.
    PRIDEiQ5BJY3.

    PTM databases

    PhosphoSiteiQ5BJY3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5BJY3.

    Interactioni

    Subunit structurei

    Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000022169.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG5195.
    GeneTreeiENSGT00390000014303.
    HOGENOMiHOG000039089.
    HOVERGENiHBG103414.
    InParanoidiQ5BJY3.
    KOiK11667.
    OMAiKMASSEL.
    OrthoDBiEOG786H5F.
    PhylomeDBiQ5BJY3.
    TreeFamiTF323529.

    Family and domain databases

    InterProiIPR029525. INO80C/Ies6.
    IPR013272. YL1_C.
    [Graphical view]
    PANTHERiPTHR31200:SF1. PTHR31200:SF1. 1 hit.
    PfamiPF08265. YL1_C. 1 hit.
    [Graphical view]
    SMARTiSM00993. YL1_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5BJY3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAQIPIVAA TSTPTVARNS KKRPASPSHN SSGGGYGASK KKKLSASGFA    50
    QGVSIEAMSE SKMASSELSS GPVEKAAKPL PFKDPNFVHS GHGGAVAGKK 100
    NRTWKNLKQI LAAERALPWQ LNDPNYFSID APPSFKPAKK YSDVSGLLAN 150
    YTDPQSKLRF STVEEFSYIR RLPSDVVTGY LTLRKATSIV P 191
    Length:191
    Mass (Da):20,424
    Last modified:April 12, 2005 - v1
    Checksum:i09AD29E0A914A73B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC091281 mRNA. Translation: AAH91281.1.
    RefSeqiNP_001017446.1. NM_001017446.1.
    UniGeneiRn.18319.

    Genome annotation databases

    EnsembliENSRNOT00000022169; ENSRNOP00000022169; ENSRNOG00000016532.
    GeneIDi291737.
    KEGGirno:291737.
    UCSCiRGD:1310199. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC091281 mRNA. Translation: AAH91281.1 .
    RefSeqi NP_001017446.1. NM_001017446.1.
    UniGenei Rn.18319.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000022169.

    PTM databases

    PhosphoSitei Q5BJY3.

    Proteomic databases

    PaxDbi Q5BJY3.
    PRIDEi Q5BJY3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022169 ; ENSRNOP00000022169 ; ENSRNOG00000016532 .
    GeneIDi 291737.
    KEGGi rno:291737.
    UCSCi RGD:1310199. rat.

    Organism-specific databases

    CTDi 125476.
    RGDi 1310199. Ino80c.

    Phylogenomic databases

    eggNOGi COG5195.
    GeneTreei ENSGT00390000014303.
    HOGENOMi HOG000039089.
    HOVERGENi HBG103414.
    InParanoidi Q5BJY3.
    KOi K11667.
    OMAi KMASSEL.
    OrthoDBi EOG786H5F.
    PhylomeDBi Q5BJY3.
    TreeFami TF323529.

    Miscellaneous databases

    NextBioi 633084.
    PROi Q5BJY3.

    Gene expression databases

    Genevestigatori Q5BJY3.

    Family and domain databases

    InterProi IPR029525. INO80C/Ies6.
    IPR013272. YL1_C.
    [Graphical view ]
    PANTHERi PTHR31200:SF1. PTHR31200:SF1. 1 hit.
    Pfami PF08265. YL1_C. 1 hit.
    [Graphical view ]
    SMARTi SM00993. YL1_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiIN80C_RAT
    AccessioniPrimary (citable) accession number: Q5BJY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3