Q5BJY3 (IN80C_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
INO80 complex subunit C

Gene names

Name:

Ino80c

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subunit structure	Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 By similarity.
Subcellular location	Nucleus By similarity.

Ontologies

Keywords
Biological process	DNA damage DNA recombination DNA repair Transcription Transcription regulation
Cellular component	Nucleus
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA repair Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	MLL1 complex Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	INO80 complex subunit C		PRO_0000079319
Amino acid modifications
	Cross-link	21		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	22		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	40		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5BJY3 [UniParc]. Last modified April 12, 2005. Version 1. Checksum: 09AD29E0A914A73B	FASTA	191	20,424
	10 20 30 40 50 60 MAAQIPIVAA TSTPTVARNS KKRPASPSHN SSGGGYGASK KKKLSASGFA QGVSIEAMSE 70 80 90 100 110 120 SKMASSELSS GPVEKAAKPL PFKDPNFVHS GHGGAVAGKK NRTWKNLKQI LAAERALPWQ 130 140 150 160 170 180 LNDPNYFSID APPSFKPAKK YSDVSGLLAN YTDPQSKLRF STVEEFSYIR RLPSDVVTGY 190 LTLRKATSIV P

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC091281 mRNA. Translation: AAH91281.1.
IPI	IPI00363459.
RefSeq	NP_001017446.1. NM_001017446.1.
UniGene	Rn.18319.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000022169.
PTM databases
PhosphoSite	Q5BJY3.
Proteomic databases
PaxDb	Q5BJY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000022169; ENSRNOP00000022169; ENSRNOG00000016532.
GeneID	291737.
KEGG	rno:291737.
UCSC	RGD:1310199. rat.
Organism-specific databases
CTD	125476.
RGD	1310199. Ino80c.
Phylogenomic databases
eggNOG	COG5195.
GeneTree	ENSGT00390000014303.
HOGENOM	HOG000039089.
HOVERGEN	HBG103414.
InParanoid	Q5BJY3.
KO	K11667.
OMA	AMARNSK.
OrthoDB	EOG4CZBH3.
Gene expression databases
Genevestigator	Q5BJY3.
GermOnline	ENSRNOG00000016532. Rattus norvegicus.
Family and domain databases
InterPro	IPR013272. YL1_C. [Graphical view]
Pfam	PF08265. YL1_C. 1 hit. [Graphical view]
SMART	SM00993. YL1_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	633084.

Entry information

Entry name

IN80C_RAT

Accession

Primary (citable) accession number: Q5BJY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	April 12, 2005
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program