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Protein

INO80 complex subunit C

Gene

Ino80c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
INO80 complex subunit C
Gene namesi
Name:Ino80c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1310199. Ino80c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191INO80 complex subunit CPRO_0000079319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki21 – 21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki22 – 22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki40 – 40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5BJY3.
PRIDEiQ5BJY3.

PTM databases

PhosphoSiteiQ5BJY3.

Expressioni

Gene expression databases

GenevisibleiQ5BJY3. RN.

Interactioni

Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022169.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG5195.
GeneTreeiENSGT00390000014303.
HOGENOMiHOG000039089.
HOVERGENiHBG103414.
InParanoidiQ5BJY3.
KOiK11667.
OMAiKFLNTDS.
OrthoDBiEOG786H5F.
PhylomeDBiQ5BJY3.
TreeFamiTF323529.

Family and domain databases

InterProiIPR029525. INO80C/Ies6.
IPR013272. YL1_C.
[Graphical view]
PANTHERiPTHR31200:SF1. PTHR31200:SF1. 1 hit.
PfamiPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BJY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQIPIVAA TSTPTVARNS KKRPASPSHN SSGGGYGASK KKKLSASGFA
60 70 80 90 100
QGVSIEAMSE SKMASSELSS GPVEKAAKPL PFKDPNFVHS GHGGAVAGKK
110 120 130 140 150
NRTWKNLKQI LAAERALPWQ LNDPNYFSID APPSFKPAKK YSDVSGLLAN
160 170 180 190
YTDPQSKLRF STVEEFSYIR RLPSDVVTGY LTLRKATSIV P
Length:191
Mass (Da):20,424
Last modified:April 12, 2005 - v1
Checksum:i09AD29E0A914A73B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091281 mRNA. Translation: AAH91281.1.
RefSeqiNP_001017446.1. NM_001017446.1.
UniGeneiRn.18319.

Genome annotation databases

EnsembliENSRNOT00000022169; ENSRNOP00000022169; ENSRNOG00000016532.
GeneIDi291737.
KEGGirno:291737.
UCSCiRGD:1310199. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091281 mRNA. Translation: AAH91281.1.
RefSeqiNP_001017446.1. NM_001017446.1.
UniGeneiRn.18319.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022169.

PTM databases

PhosphoSiteiQ5BJY3.

Proteomic databases

PaxDbiQ5BJY3.
PRIDEiQ5BJY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022169; ENSRNOP00000022169; ENSRNOG00000016532.
GeneIDi291737.
KEGGirno:291737.
UCSCiRGD:1310199. rat.

Organism-specific databases

CTDi125476.
RGDi1310199. Ino80c.

Phylogenomic databases

eggNOGiCOG5195.
GeneTreeiENSGT00390000014303.
HOGENOMiHOG000039089.
HOVERGENiHBG103414.
InParanoidiQ5BJY3.
KOiK11667.
OMAiKFLNTDS.
OrthoDBiEOG786H5F.
PhylomeDBiQ5BJY3.
TreeFamiTF323529.

Miscellaneous databases

NextBioi633084.
PROiQ5BJY3.

Gene expression databases

GenevisibleiQ5BJY3. RN.

Family and domain databases

InterProiIPR029525. INO80C/Ies6.
IPR013272. YL1_C.
[Graphical view]
PANTHERiPTHR31200:SF1. PTHR31200:SF1. 1 hit.
PfamiPF08265. YL1_C. 1 hit.
[Graphical view]
SMARTiSM00993. YL1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiIN80C_RAT
AccessioniPrimary (citable) accession number: Q5BJY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: April 12, 2005
Last modified: June 24, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.