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Q5BJY1

- Q5BJY1_RAT

UniProt

Q5BJY1 - Q5BJY1_RAT

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Protein
Submitted name:

Msh3 protein

Gene

Msh3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. centromeric DNA binding Source: Ensembl
  3. damaged DNA binding Source: RefGenome
  4. dinucleotide repeat insertion binding Source: Ensembl
  5. DNA-dependent ATPase activity Source: RefGenome
  6. double-strand/single-strand DNA junction binding Source: RefGenome
  7. heteroduplex DNA loop binding Source: RefGenome
  8. oxidized purine DNA binding Source: Ensembl
  9. single guanine insertion binding Source: Ensembl
  10. single-stranded DNA binding Source: Ensembl
  11. Y-form DNA binding Source: RefGenome

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. maintenance of DNA repeat elements Source: RefGenome
  3. meiotic mismatch repair Source: RefGenome
  4. negative regulation of DNA recombination Source: Ensembl
  5. positive regulation of helicase activity Source: Ensembl
  6. reciprocal meiotic recombination Source: RefGenome
  7. somatic recombination of immunoglobulin gene segments Source: RefGenome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_235056. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).

Names & Taxonomyi

Protein namesi
Submitted name:
Msh3 proteinImported
Gene namesi
Name:Msh3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1563954. Msh3.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: Ensembl
  2. MutSbeta complex Source: RefGenome
  3. nuclear chromosome Source: RefGenome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ5BJY1.

Expressioni

Gene expression databases

ExpressionAtlasiQ5BJY1. baseline.
GenevestigatoriQ5BJY1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041452.

Structurei

3D structure databases

ProteinModelPortaliQ5BJY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000029776.
HOVERGENiHBG071048.
PhylomeDBiQ5BJY1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5BJY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
TNLSDSERVM IITGPNMGGK SSYIKQVALV VIMAQIGSYV PAEEATIGIV
60 70 80 90 100
DGIFTRRGAA DNIYKGRSTF MEELTDTAEI IQKATQRSLV ILDELGRGTS
110 120 130 140 150
THDGIAIAYA TLEYFIRDVK SLTLFVTHYP PVCELEKRYP EQVGNYHMGF
160 170 180 190 200
LVNEDGSKQD SGDMEQMPDS VTFLYQITRG IAARSYGLNV AKLADVPREI
210 220 230 240 250
LQKAAHKSKE LEGLVNLRRK RLEYFIDLWT THSVKDLHTR AAELEIQEIQ
260
TSPHNEMKTT LLELK
Length:265
Mass (Da):29,743
Last modified:April 12, 2005 - v1
Checksum:i9585656EEF5A3AC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091283 mRNA. Translation: AAH91283.1.
UniGeneiRn.162551.

Genome annotation databases

UCSCiRGD:1563954. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091283 mRNA. Translation: AAH91283.1 .
UniGenei Rn.162551.

3D structure databases

ProteinModelPortali Q5BJY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000041452.

Proteomic databases

PaxDbi Q5BJY1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:1563954. rat.

Organism-specific databases

RGDi 1563954. Msh3.

Phylogenomic databases

eggNOGi COG0249.
HOGENOMi HOG000029776.
HOVERGENi HBG071048.
PhylomeDBi Q5BJY1.

Enzyme and pathway databases

Reactomei REACT_235056. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).

Gene expression databases

ExpressionAtlasi Q5BJY1. baseline.
Genevestigatori Q5BJY1.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000432. DNA_mismatch_repair_MutS_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00488. MutS_V. 1 hit.
[Graphical view ]
SMARTi SM00534. MUTSac. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: OvaryImported.

Entry informationi

Entry nameiQ5BJY1_RAT
AccessioniPrimary (citable) accession number: Q5BJY1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)