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Protein

cAMP-responsive element-binding protein-like 2

Gene

Crebl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element-binding protein-like 2
Gene namesi
Name:Crebl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309502. Crebl2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181941 – 123cAMP-responsive element-binding protein-like 2Add BLAST123

Post-translational modificationi

Phosphorylated by AMPK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BJU6.

Interactioni

Subunit structurei

Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 86bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 60Basic motifBy similarityAdd BLAST32
Regioni62 – 69Leucine-zipperBy similarity8

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiENOG410J0Q3. Eukaryota.
ENOG4111T4Y. LUCA.
HOGENOMiHOG000111966.
HOVERGENiHBG107761.
InParanoidiQ5BJU6.
PhylomeDBiQ5BJU6.
TreeFamiTF323305.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
PfamiView protein in Pfam
PF07716. bZIP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BJU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY
60 70 80 90 100
LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIRA LLTGEEQNKS
110 120
QQNSSRHPKA GKTDANTNSL VGN
Length:123
Mass (Da):14,019
Last modified:April 12, 2005 - v1
Checksum:iF1978A47A582D62C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091323 mRNA. Translation: AAH91323.1.
RefSeqiNP_001015027.1. NM_001015027.1.
UniGeneiRn.107553.

Genome annotation databases

GeneIDi362453.
KEGGirno:362453.
UCSCiRGD:1309502. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091323 mRNA. Translation: AAH91323.1.
RefSeqiNP_001015027.1. NM_001015027.1.
UniGeneiRn.107553.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009324.

Proteomic databases

PaxDbiQ5BJU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362453.
KEGGirno:362453.
UCSCiRGD:1309502. rat.

Organism-specific databases

CTDi1389.
RGDi1309502. Crebl2.

Phylogenomic databases

eggNOGiENOG410J0Q3. Eukaryota.
ENOG4111T4Y. LUCA.
HOGENOMiHOG000111966.
HOVERGENiHBG107761.
InParanoidiQ5BJU6.
PhylomeDBiQ5BJU6.
TreeFamiTF323305.

Miscellaneous databases

PROiPR:Q5BJU6.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
PfamiView protein in Pfam
PF07716. bZIP_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCRBL2_RAT
AccessioniPrimary (citable) accession number: Q5BJU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 12, 2005
Last modified: May 10, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.