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Protein

cAMP-responsive element-binding protein-like 2

Gene

Crebl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element-binding protein-like 2
Gene namesi
Name:Crebl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309502. Crebl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181941 – 123cAMP-responsive element-binding protein-like 2Add BLAST123

Post-translational modificationi

Phosphorylated by AMPK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BJU6.

Interactioni

Subunit structurei

Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 86bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 60Basic motifBy similarityAdd BLAST32
Regioni62 – 69Leucine-zipperBy similarity8

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiENOG410J0Q3. Eukaryota.
ENOG4111T4Y. LUCA.
HOGENOMiHOG000111966.
HOVERGENiHBG107761.
InParanoidiQ5BJU6.
PhylomeDBiQ5BJU6.
TreeFamiTF323305.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5BJU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY
60 70 80 90 100
LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIRA LLTGEEQNKS
110 120
QQNSSRHPKA GKTDANTNSL VGN
Length:123
Mass (Da):14,019
Last modified:April 12, 2005 - v1
Checksum:iF1978A47A582D62C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091323 mRNA. Translation: AAH91323.1.
RefSeqiNP_001015027.1. NM_001015027.1.
UniGeneiRn.107553.

Genome annotation databases

GeneIDi362453.
KEGGirno:362453.
UCSCiRGD:1309502. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091323 mRNA. Translation: AAH91323.1.
RefSeqiNP_001015027.1. NM_001015027.1.
UniGeneiRn.107553.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009324.

Proteomic databases

PaxDbiQ5BJU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362453.
KEGGirno:362453.
UCSCiRGD:1309502. rat.

Organism-specific databases

CTDi1389.
RGDi1309502. Crebl2.

Phylogenomic databases

eggNOGiENOG410J0Q3. Eukaryota.
ENOG4111T4Y. LUCA.
HOGENOMiHOG000111966.
HOVERGENiHBG107761.
InParanoidiQ5BJU6.
PhylomeDBiQ5BJU6.
TreeFamiTF323305.

Miscellaneous databases

PROiQ5BJU6.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRBL2_RAT
AccessioniPrimary (citable) accession number: Q5BJU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 12, 2005
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.