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Protein

Protein cornichon homolog 2

Gene

Cnih2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.2 Publications

GO - Biological processi

  • localization within membrane Source: MGI
  • negative regulation of anterograde synaptic vesicle transport Source: UniProtKB
  • negative regulation of receptor localization to synapse Source: UniProtKB
  • regulation of AMPA receptor activity Source: UniProtKB
  • regulation of membrane potential Source: MGI
  • regulation of NMDA receptor activity Source: UniProtKB
  • synaptic transmission, glutamatergic Source: MGI
  • transport Source: InterPro

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 2
Short name:
CNIH-2
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 2
Cornichon-like protein
Gene namesi
Name:Cnih2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1304930. Cnih2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 72LumenalSequence analysisAdd BLAST41
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 138CytoplasmicSequence analysisAdd BLAST45
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160LumenalSequence analysis1

GO - Cellular componenti

  • AMPA glutamate receptor complex Source: UniProtKB
  • cell junction Source: UniProtKB-KW
  • dendrite Source: UniProtKB
  • dendritic shaft Source: UniProtKB
  • dendritic spine Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • postsynaptic density Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222271 – 160Protein cornichon homolog 2Add BLAST160

Proteomic databases

PaxDbiQ5BJU5.
PRIDEiQ5BJU5.

PTM databases

iPTMnetiQ5BJU5.
PhosphoSitePlusiQ5BJU5.
SwissPalmiQ5BJU5.

Expressioni

Tissue specificityi

Brain. Expressed in the neocortex, hippocampal formation, and cerebellum (at protein level).2 Publications

Gene expression databases

BgeeiENSRNOG00000020247.
GenevisibleiQ5BJU5. RN.

Interactioni

Subunit structurei

Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 Interacts with CACGN8 (By similarity). Interacts with GRIA1.By similarity2 Publications

Protein-protein interaction databases

DIPiDIP-59551N.
STRINGi10116.ENSRNOP00000027421.

Structurei

3D structure databases

ProteinModelPortaliQ5BJU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2729. Eukaryota.
ENOG4111MWH. LUCA.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiQ5BJU5.
KOiK20368.
OMAiNFHLYSR.
OrthoDBiEOG091G0KIX.
PhylomeDBiQ5BJU5.

Family and domain databases

InterProiView protein in InterPro
IPR003377. Cornichon.
IPR033466. Cornichon_conserved.
PfamiView protein in Pfam
PF03311. Cornichon. 1 hit.
SMARTiView protein in SMART
SM01398. Cornichon. 1 hit.
PROSITEiView protein in PROSITE
PS01340. CORNICHON. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5BJU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTFAAFCY MLTLVLCASL IFFVIWHIIA FDELRTDFKN PIDQGNPARA
60 70 80 90 100
RERLKNIERI CCLLRKLVVP EYSIHGLFCL MFLCAAEWVT LGLNIPLLFY
110 120 130 140 150
HLWRYFHRPA DGSEVMYDAV SIMNADILNY CQKESWCKLA FYLLSFFYYL
160
YSMVYTLVSF
Length:160
Mass (Da):18,931
Last modified:April 12, 2005 - v1
Checksum:i00330E5E609B28BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091325 mRNA. Translation: AAH91325.1.
RefSeqiNP_001020303.1. NM_001025132.1.
UniGeneiRn.18785.

Genome annotation databases

EnsembliENSRNOT00000027421; ENSRNOP00000027421; ENSRNOG00000020247.
GeneIDi361705.
KEGGirno:361705.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCNIH2_RAT
AccessioniPrimary (citable) accession number: Q5BJU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: April 12, 2005
Last modified: June 7, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families